2000-2009 | 2010-2019 | 2020-present
- 2 in the AM PM
- 3...2...1... Internet: Ran entirely in 2009.
- The 30 Second Bunnies Theatre
- Ahmed and Salim. Debuted on January 20, 2009.
- Animator vs. Animation
- Arfenhouse
- asdfmovie. Debuted on August 10, 2008.
- Awesome Series
- Ayuda Mundial
- Baman Piderman
- Banana-nana-Ninja!
- Big Bunny
- Billy la Bufanda. Debuted in 2007.
- A Black And White Cartoon
- Bloody Bunny. Debuted in 2008.
- Bonus Stage. Ran from 2003 to 2006.
- Broken Saints
- Captain Distraction
- Cartoon Monsoon
- CCC
- Charlie the Unicorn
- The Cloak
- Clock Suckers
- Cocomelon
- Colin Mochrie vs. Jesus H. Christ
- Cox and Combes' Washington
- Cyriak
- DarkMatter2525
- A Day in Dracula's Life
- Dead Fantasy
- Death Comes to Time
- Decline of Video Gaming
- The Demented Cartoon Movie
- Dog Judo
- Doll Face
- Dramatic Hearts
- Draw with Me
- Dr. Tran
- Ducktalez
- Dumbland
- Eddsworld
- Extra Credits
- The Fairly Oddparents: Crimson Chin Webtoons
- Fairy Foxes
- Scott Falco
- FF7: About Random Battles
- Flashdeck Animations
- Floating Hands
- forrestfire Films
- Four Swords Misadventures
- GEOWeasel
- Ghost Motel
- Girl Chan In Paradise
- Gotham Girls
- Greasy Tales
- Greeny Phatom
- Guest From The Future 2
- Haloid
- Happy Tree Friends. Debuted on December 24, 1999. Most of its run took place in this decade.
- Hard Drinkin' Lincoln
- Homestar Runner. Debuted in January 2000.
- House of Cosbys
- How It Should Have Ended. Debuted on July 6, 2005.
- James Lee
- Jerry
- Jiz
- Katbot. Debuted in 2001.
- The Kingdom Hearts Chronicles
- Koishi Komeiji's Heart-Throbbing Adventure. Debuted in 2009.
- Let's Go! Tamagotchi. Originally released in 2007.
- Lobo (Webseries). Debuted on June 15, 2000.
- Looney Tunes webtoons
- 2001 - Toon Marooned
- 2001 - Judge Granny
- 2001-03 - Mysterious Phenomena of the Unexplained
- 2001 - The Junkyard Run
- 2001 - Planet of the Taz
- 2001 - The Matwix
- 2003 - Sports Blab
- 2003 - Aluminum Chef
- Madness Combat
- Mameshiba
- Medical Island
- Meet the Millers
- Mi Perro Chocolo
- The Most Amazing Story Ever Told. First series made circa 2001, second around 2003.
- Mundo Canibal: The animations began in 1998, but it got its own site in 2001 and became popular in 2004.
- Napster Bad
- NCHProductions: Debuted in 2006.
- One Minute Fly: Debuted in 2008.
- Panathinaikos Bear: Debuted in 2004.
- Red vs. Blue: Started 2003.
- Red vs. Blue: The Blood Gulch Chronicles (2003–2007)
- Red vs. Blue: The Recollection (2008–2010)
- The Return Of Ganondorf
- Robotbox and Cactus: Ran from 2004 to 2006.
- Rock N Roll Dad
- Ruby Rocket Private Detective. Debuted 2007
- Salad Fingers
- Saturday Morning Watchmen
- Savlonic
- Seth Mac Farlanes Cavalcade Of Cartoon Comedy
- Simon's Cat. Debuted on March 4, 2008.
- Sock Series
- Sonic: Night of the Werehog
- Space Tree: Ran from 2004 to 2007.
- The Strangerhood
- StrifeToons: All 4 episodes were released in 2006.
- Super Freakin' Parody Rangers
- Super Mario 64 Bloopers
- Super Mario Bros. Z
- Super Mario Långben
- Super Smash Adventures
- SXR 123
- Tankmen
- TektonTV
- T E T R I S ' D
- There she is!! (debuted in 2003 and saw its final installment in 2008.)
- The Thwomps
- TimberWolf
- TMNT Rebels
- Toho Kingdom Toons
- TOME
- Toon Marooned
- Tomorrow's Nobodies
- Toys Gone Wild
- Trix the Musical
- Ultimate Muscle Roller Legend
- The Ultimate Showdown of Ultimate Destiny
- Unforgotten Realms
- Venin Abyss
- Vete A La Versh
- Waterman
- Weebl & Bob
- Wendell & Wuggums
- X Finds Out His Value
- Xiao Xiao
- XIN
- Xionic Madness
- Xombie
- Zero Punctuation
