So! You will help me find that treasure right Mario? The boat's waiting for you!
— Princess Peach, Paper Mario: The Thousand-Year Door (at the end, of course)
"Here I go again on my own, going down the only road I've ever known..."
— Whitesnake, "Here I Go Again"
Um, did he just bring them back? Did— did he just save the world from aliens, and then bring all the aliens back again?!
— Rory, Doctor Who, "The Eleventh Hour"
Is this what it all comes to? Not much now. To think that it brought civilization right to the brink. A giant step backward in man's evolution toward eternity and redemption—the ultimate scientific nightmare! I can't believe the politicians would dare to tempt fate again...
— Colonel Shikishima, AKIRA
Aw, jeez, here we go...
—Pikachu, Pokémon Detective Pikachu
How do I always end up back in this damn city?
—Kazuma Kiryu, Yakuza 6
Harold: Oh, NO!
George: Here we go again!
George: Here we go again!
— The ending of every Captain Underpants book ever (except for the last one), as well as the movie adaptation.
Scoops: Looks like everything is back to normal!
Dr. Toodles: "Normal?" Well, now... I wouldn't say that! (Evil Laugh)
Dr. Toodles: "Normal?" Well, now... I wouldn't say that! (Evil Laugh)
—Ollie & Scoops, "Gimme a Hand"
"It's been one of those days..."
— Mario, Hotel Mario
"Ah shit. Here we go again... Worst place in the world. Rollin' Heights Balla Country. I ain't represented Grove Street in 5 years, but the Ballas won't give a shit."
— Carl "CJ" Johnson, in an inversion of the trope, Grand Theft Auto: San Andreas, "In The Beginning"
Franklin: Oh, shit. Here we go again.
Lamar: That's that LD Organics, nigga. That's the bomb...
Franklin: ...the bomb... Man, this shit fire.
Lamar: Work like a charm every time, nigga. Come on, man.
Franklin: Fuck...
Lamar: That's that LD Organics, nigga. That's the bomb...
Franklin: ...the bomb... Man, this shit fire.
Lamar: Work like a charm every time, nigga. Come on, man.
Franklin: Fuck...
—Grand Theft Auto Online, "Fire It Up"
Tali: Commander Shepard, this is Admiral Zaal'Koris vas Qwib-Qwib. (sotto voce) Do not ask about the name.
Shepard: You have a ship named Qwib-Qwib?