There will be a reference to Rampage's gameplay mechanics.
For example, George will climb to the top of a building and slam on its roof until the entire thing collapses, or maybe punch the window of a building and pull out some food or burn his hand on a lit candle.- Somewhat. George does indeed climb up to the top of a tower and start pounding it and eventually causes it to collapse but he did it to destroy the frequency antenna. Ralph however does clear entire floors rather than just make a beeline for the top of buildings, as does Lizzie.
Each of the monsters will be able to do something similar to their Special Atacks from the games.
George will stomp and crush an entire building as predicted above, Ralph will howl at a frequency that will shatter all the windows of the surrounding buildings, and Lizzie will (somehow) have fire breath. Lizzie will be sadly underused.
She barely shows up in the trailer, and when she does it's when Okoye and Caldwell are first arriving in the city. All the other scenes that have those two in the city only show George and Ralph.- Jossed, while Lizzie doesn’t appear in full until the climax, she is both the most powerful monster and the last one standing after she kills Ralph.
Assuming Lizzie is not killed by the military in her first appearance, she becomes the movie's big bad that George and Ralph have to fight together.
She's clearly the biggest and most evil-looking of the three monsters. Claire Wyden will douse herself in the genetic editing chemicals and turn into a monster herself for the climax.
She will have an appearance similar to Eustace DeMonic.- Or alternatively she could become this movie's version of V.E.R.N.
- Jossed she gets eaten by George along with the cure.
There will be a Sequel Hook
Wyden's lab will have cages with more animals for testing. Mainly a white rat, a lobster, and a rhinoceros. With the new animals having the titles of V.E.R.N. 1, 2, 3, etc for placeholders.- {{Possibly set up,}} though in the form of allusions that could set up a sequel-Agent Russell seeks out the last remaining back up of the pathogen/mutagen research on his own, without letting anybody else know what he was doing, and made sure to get it from Claire Wyden's brother before letting him get himself crushed by debris(which he noticed but chose to keep to himself), despite claiming he wanted to arrest him. Additionally, when he reunites David and Caldwell, he remains suspiciously silent about his procurement of said research.
If the animals do get cured instead of being killed..
Instead of turning back into normal animals, they'll turn into normal human beings, like in the game.- Jossed only George gets cured and all it does is stop his aggression.
Okoye will refer to Wyden's facility as "Scumlabs".
And Wyden will like it.- Jossed - nobody does.
The animals mutations will work in stages.
By the middle of the movie the monsters will be as we saw them in the trailer but at the end they will mutate again and become upright bipeds like in the game.- Jossed - while the animals mutate throughout the movie, as we see them in the trailer are their end-of-movie forms.
There will be a reference to The Asylum and its mostly-similar movie premises
The first scientist to even bring up cross-breeding the crocodile with some deepsea creature gets punched in the face.There will be a nod to Rocky from Total Destruction.
Someone will make a joke about Okoye using the serum to become giant as well, or a scientist will shoot down the idea of the serum created some 'rock golem.' You've got the Rock, ya gotta do something with that.The movie might actually have more Black Comedy and self-awareness than the trailer wants you to believe.- Confirmed. It had moments of levity to spare.
Ralph will be killed off by the end of the second act...
...to make room for Lizzie as the main antagonist monster. We will likely get glimpses of Lizzie throughout, and towards the end of the second act, she will finally appear and kill Ralph, thereby setting her up to be the main threat that Davis and George will team up to defeat.- Confirmed, although Ralph still makes it all the way to the end battle. She bites off Ralph's head, and after getting the cure, George and David team up to take her down.
One of the monsters will eat Claire Wyden
Presumably Lizzie- Sort of confirmed, except it's actually George that eats her along with the cure.
Project: Rampage was inspired by the video game.
There's a Rampage arcade machine in Energyne's offices. The name and the idea of creating giant, aggressive animals came from the game. (Leaving it a huge coincidence that they ended up with a gorilla named George and a wolf named Ralph.)- George is a huge coincidence, but Agent Russell says that weirdos on the internet named Ralph. Its possible that Rampage was just a lot bigger and a better known reference point in this universe.
- Not quite a coincidence with Ralph, as Russell explicitly states while showing video of him to Okoye and Kate that internet trolls named the wolf Ralph. Since we know the videogame exists in universe, it was likely WHY the internet named him so.
Lizzie and Ralph aren't dead.
Regeneration is explicitly one of their abilities, and at least Lizzie's wounds weren't much worse than what George ended up walking off. If we get a sequel, we'll see the three monsters all living together in a Monster Island-like wildlife reserve - after receiving the cure, of course.- Lizzie maybe, but Ralph I'm pretty sure is dead, after all Lizzie did rip his head off and eat it.
- Losing an entire head is a more grievous wound than a narrow spear through the brain, but you don't break up a power trio like this. If Lizzie and George are alive, then so is Ralph.
- Another horrifying possibility is that we will see a Ralph-Lizzie hybrid. After the government, or some third party on their behalf, recover Lizzie's corpse and experiment a new variation of the mutagens on it, both Lizzie and Ralph's head inside her will be revived. The reaction will cause their DNA to fuse, generating a creature with the characteristics of both.
A new Lizzie and Ralph will appear in a sequel.
Since both Lizzie and Ralph are dead, we will either discover that they had offspring that was born altered or they will get cloned.- They may also get more humanoid appearances, closer to the games, while still differentiating Lizzie from Godzilla.
- The could also be cured of their aggression early on, and team up with George to fight whatever new monsters appear.
Alternatively, the sequel will feature...
Ruby, Curtis, and Boris. Specifically, the rat that Russell gave to the one soldier in exchange for his phone will become Curtis. The sequel will show that several more canisters landed than the three we were shown. One landed in the African savanna where an endangered rhinoceros encounters it, and one lands in the cargo hold of a lobster fishing trawler where it sprays one of the captured lobsters.- Alternatively Curtis could be the mutant rat from the beginning who survived the destruction of the space station, ended up back on earth and continued to grow.
George will mutate further
Much like Ralph likely picked up quills, flight, and ears from what he ate George will further mutate if or when there's a sequel picking up parts of the plants and ... people he's eaten. A sequel will involve Paavo
Paavo is the young and rowdy gorilla that, early in the movie, was seen almost attacking an intern until George intervened. Either by just coincidence, or active malice on the part of the next human villain (like using the mutagen on a primate at the Wildlife Reserve just to spite Davis), Paavo will be exposed to a mutagen and grow big like George did, if not even bigger. He won't be actively ferocious however, just very scared; it will be George to reach out to him, also because he knows he's an orphan whose family was killed by poachers, just like George himself. A sequel will feature a faction who wants George dead for the events of the movie
In the end, George was the one who prevented Chicago from being leveled by MOABs with so many survivors still inside, and the public may be informed that he was innocent and manipulated (in fact, he defended people as soon as he was freed from control). It doesn't change, unfortunately, that George still directly caused many deaths, on top of massive property damage. People who were there in Chicago during his frenzied rampage and lost relatives, friends or colleagues to him, Ralph or Lizzie, wouldn't be keen on forgiving George and feed on part of the public's sentiment that he could still be a menace if he went out of control for whatever reason. There may be even someone who, more cinically, thinks giving George shelter and food is too costly; and someone else (most probably from the military) who is secretly organizing plans to kill him. The latter ones may be manipulated by a villain for his/her own gains (offing George to eliminate the one who may stop his/her new monsters), only to later realize that and eventually side with the heroes. A sequel will tell more about Davis's past, which will come back to haunt him
We know he was part of anti-poaching unit back when he saved George, but reading his dossier aboard the military plane, Russell states there are a lot of redacted parts, and we get to know nothing more over the course of the movie. Davis may have been a mercenary or a black ops operative when he was younger; his last name, Okoye, suggests a mixed origin, and he may have grown up in some war-torn part of Africa. Either way, some event caused him an epiphany and a change of ways; Davis decided to dedicate himself to the protection of nature and moved to America. However some old colleague from his potentially blood-soaked past may turn up as a new villain or his/her right hand.