- Awesome, Dear Boy:
- Jeffrey Dean Morgan's reasoning for joining the movie.I grew up watching like Godzilla and King Kong, so one of the reasons I became an actor was so I could do a monster movie. I hadn’t gotten to do a monster movie yet, and then, you throw Dwayne into the mix and I know his track record, he’s got a little bit of a Midas touch going, so it seemed like a no-brainer.
- Malin Åkerman freely admits to taking the role of Claire Wyden purely to play a Card-Carrying Villain.
- Jeffrey Dean Morgan's reasoning for joining the movie.
- Deleted Role: Alexandra Daddario was originally planned to be featured in a cameo in a mid-credits scene/alternate ending that ended up deleted, although it was included in the Blu-ray release of the film. This would have been the third time Daddario appeared in a movie with Dwayne Johnson, after San Andreas and Baywatch.
- Dueling Movies: Rampage was released the same year as The Meg another Giant-monster movie starring a Hollywood Action Hero (Jason Statham)
- Fake American: American Kate Caldwell is played by English actress Naomie Harris.
- Production Posse:
- It is the third time Brad Peyton directs Dwayne Johnson after Journey 2: The Mysterious Island and San Andreas.
- It is the second collaboration between Johnson and screenwriter Ryan Condal after Hercules.
- Promoted Fanboy:
- Star and executive producer Dwayne Johnson was a big fan of the original video game, frequently playing the arcade game as a teenager in Hawaii.
- Producer John Rickard was also a fan, stating that once he saw Warner Bros. owned the rights to adapt the game, memories of the arcade came and he got interested.
- Release Date Change: The film was originally going to be released on April 20, 2018, but then got moved to the prior week due to the release date of Avengers: Infinity War being moved to April 27.
- What Could Have Been:
- The movie was originally going to have a sad ending, with George dying after the other monsters were defeated, but Dwayne Johnson fought to change it to end on a much lighter note.
- In the deleted scenes of the Blu-ray, there are two scenes that act as a mid-credits scene/alternate ending, revealing that there was a fourth canister that has mutated an octopus/squid. It also serves as a Alexandra Daddario cameo.
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