The Binding of Isaac drinking game is played with two types of drinkers, Players and Spectators. The game is supposed to be played with one person playing the game drinking for certain events while 2 or more "spectators" watch with them as well as having their own drinks.
Drink some Ipecac. Whoever pukes the last wins.
Just try not to take after your father, Isaac.
For the player:
- Whenever you take damage, take 1 shot.
- When you take a pedestal item, take 1 drink.
- If you miss a tinted rock or can't blow one up due to having no bombs, take 1 drink.
- When you enter a Devil Deal Room, take 1 drink.
- When you take an item in a Deal with the Devil, the number of heart containers spent is equal to the number of drinks you take.
- When you take a pill, only for it to be a negative pill effect, take 1 drink.
- When you lose the run, chug for 5 seconds.
- When you defeat any guaranteed bosses (Mom, for example) take 1 drink
- If you find a quality 3 item, take a sip. If you find a quality 4 item, take a shot. If you find Death Certificate, take two shots and ignore any item that appears in the Death Certificate area.
For spectators:
- When the player defeats a boss, take 1 shot.
- When the player goes down a floor, take 2 shots.
- When the player blows up a tinted rock, take 1 drink.
- If an item appears after a fire is extinguished, take 1 drink.
- Whenever a miniboss is defeated (any of the seven deadly sins), take 3 drinks.
- When the player finds an Angel Room and enters it, take 1 drink.
- When the player gets a positive pill effect, take 1 drink.
- When the player wins a run, chug for 5 seconds.
- If the player's last floor ends up being Home or The Void, take 1 drink.
- When the player beats a final boss from a DLC, finish your drink.
