History Main / IntoxicationEnsues

** Also: supposedly Patti LaBelle's trippy monologue in the Labelle version of Cat Stevens' "Moon Shadow" was the result of an unwitting acid trip.

* The notorious "Guacamole Incident" from the early years of ''WebOriginal/{{Fenspace}}'', which resembles (and was very likely directly inspired by) the actions of the "Merry Pranksters" as mentioned in the RealLife section... Except that unlike LSD, the effects of ingesting Handwavium are [[ForcedTransformation a lot more drastic, and permanent]]. The incident contributed to massive public hysteria about the substance and soured relations between the United States and the nascent Fenspace Convention members for nearly a decade.

* The ''WesternAnimation/{{Amphibia}}'' episode "Adventures in Catsitting" ends with Anne returning home high on dental painkillers and extremely delirious and incoherent as a result, blurting out an [[WordSaladPhilosophy incredibly nonsensical]] IceCreamKoan about Domino while squeezing Hop Pop's cheeks. [[spoiler: Funnily enough she’s not wrong, since there is an all-powerful guardian who looks like Domino.]]

* "Large Brother, Where Fart Thou" sees Bob and Linda going to their accountant in order to file their taxes last minute. The accountant has been gifted a plate of cookies from a client, and everyone's enjoyed a few by the time the client calls to say ''those'' cookies were meant for his ill mother and are loaded with marijuana. Everyone gets alternatively blissed out and paranoid, very fast.

This type of one-shot drug use is far more likely to cause {{Hilarity|Ensues}} than to be used in the service of a DrugsAreBad aesop. If there's a WillTheyOrWontThey situation already established between two characters, the writers may be tempted to bring in KissingUnderTheInfluence.

* ''Manga/MyBrideIsAMermaid'' has all the female cast and Saru drinking Uoihatsu, a mermaid drink that makes a person "act on their instincts". This leads to a group of drunken junior high schoolers running around a movie set, and hilarity ensues.

* In Jeff Smith's ''ComicBook/{{Bone}}'', Thorn and Fone Bone get tipsy from hiding in the woods and eating nothing but berries. The berries could have fermented. This happens in RealLife, and birds get drunk from the juice and fly into things. HilarityEnsues.

* ''Franchise/{{Superman}}'':
** In comics, one adventure Superman had resulted in acting in a very... [[https://static.tvtropes.org/pmwiki/pub/images/kerai/supe.jpg festive]] manner while under the influence of Pink Kryptonite, which does exactly what it sounds like it does.

* A drug which does this appears in the early ''Franchise/{{Tintin}}'' albums. In "The Blue Lotus", even Tintin does show the effects after a villain drugs him, although we later find out the drug was exchanged for water. (He was just faking in order to escape.)

* In ''[[http://www.jeffreysmorris.com/fanfic/efic/thebuzz.html The Buzz,]]'' all of [[{{Series/Emergency}} Station 51]], minus the paramedics, get stoned on pot brownies. HilarityEnsues.

* In ''[[Fanfic/SkyholdAcademyYearbook Disorienuptials]]'', [[VideoGame/DragonAgeII Varric]] has to have his wisdom teeth removed. Luckily for everyone else in his circle of acquaintance, his best friend Hawke is on hand to record the hilarious things he says and does when he's still under the effects of the sedative. HilarityEnsues.

* In ''Franchise/HarryPotter'' fanfic ''[[https://www.fanfiction.net/s/1020773/17/The-Well-of-Shadows The Well of Shadows]]'' Professors Hillary and Gregory Proteus, [[spoiler:who are Harry and Ginny's future selves]] do this to Severus Snape. The first we hear about this is when Snape greets his class with a bright "Gooooood mornin' all you happy kiddies!!". [[HilarityEnsues Hilarity and disbelief ensue]].

* In the old movie ''Film/AnimalsAreBeautifulPeople'', the animals eat marula fruit once they've fallen from the trees, when they're widely accessible to everyone. Unfortunately, they're a bit overripe by this point, and the juice has become alcoholic. HilarityEnsues.
* In ''Film/BadBoysII'', Marcus accidentally ingests Ecstasy, and starts acting weirdly - just as he and Mike get to their boss's house to report progress in an investigation...
* ''Film/BlindDate'' Kim Basinger's character is allergic to alcohol (with [[HilarityEnsues predictable results]] when she imbibes). Bruce Willis injects a box of chocolates with brandy in order to sabotage her wedding to John Larroquette's {{Jerkass}}.

* In ''Film/{{Carefree}}'' (1938), Tony gives Amanda a drug intended to lower her inhibitions, and then her fiance bursts in and drags her off to a radio broadcast where she's supposed to sing. Amanda acts on her impulses by breaking a large pane of sheet glass, kicking a policeman, and merrily insulting the radio show's sponsor. (A variation on the regular trope, as the drug is administered with her knowledge by a medical professional.)

* In ''[[Film/GrandmasBoy2006 Grandma's Boy]]'', Grandma Lilly (played by Doris Roberts) grabs the gang's weed stash, confuses it for lea leaves, and HilarityEnsues.

* In ''Film/HistoryOfTheWorldPartI'', during the Roman Empire part of the movie, Josephus and Comicus are on the run from the Roman Soldiers. Josephus makes a rather large makeshift joint, and lights it, to use as a smokescreen. The soldiers, hot in pursuit, pass right through the cloud, and... well, [[IntoxicationEnsues Trope Ensues]].
-->'''Stoned Soldier:''' Do you care if it falls?
-->'''Stoned Soldier:''' What?
-->'''Stoned Soldier:''' The Roman Empire?
-->'''Stoned Soldier:''' [laughs] Fuck it!

* In ''Them Thar Hills'', Creator/LaurelAndHardy take a trailer to the country for health reasons, and camp out by a well that's just been used as a moonshine dump. They attribute the funny taste of the water to healthy minerals. Soon they're snockered along with a young lady who's staying with them while her husband looks for gasoline. HilarityEnsues Then, in ''Blotto'' it's subverted when they set out to get drunk, and get giddy, silly, and maudlin, before finding out their wives had switched their hooch with a nonalcoholic substitute.

-->'''[[Podcast/{{Rifftrax}} Mike Nelson]]''': So she got the kind of pot brownie that A) works instantly and B) gets you drunk.
* In ''Creator/CheechAndChong's Film/UpInSmoke'', Man accidentally gives Pedro LSD, causing him to freak out.

* In Sherilyn Kenyon's ''Acheron'' the title character, an 11,000 year old Atlantean deity, gets totally and unexpectedly trashed on 7Up.

* In ''Literature/HarryPotterAndTheOrderOfThePhoenix'', Ron gets hit with a curse that makes him silly for a time. Later, in ''Literature/HarryPotterAndTheHalfBloodPrince.'' Ron accidentally consumes an entire box of sweets dosed with a powerful love potion (originally meant for Harry.)
** The curse is a bit of FridgeHorror. Between his incoherency and the fact that blood was coming out of his mouth, it was implied that his loopy behavior might have been caused by internal bleeding.
* The fandom isn't sure ''just'' what happened in the ''Literature/HaruhiSuzumiya'' short story ''Remote Island Syndrome''; all we know is that [[UnreliableNarrator Kyon]] mentions secondhand stories from Itsuki that he and Haruhi got drunk and acted "[[NoodleIncident quite disgracefully]]", which isn't shown in the anime. Naturally, {{WMG}}s abound.

* In Creator/DavidFosterWallace's ''Literature/InfiniteJest'', one of Michael Pemulis' favorite methods of revenge ([[BestServedCold served pleasantly chilled]]) is spiking your drink with something mind-altering. Preferably a psychedelic or deliriant.

* Max on Valium, from ''Literature/MaximumRide''. She has to get drugged up [[spoiler:to get rid of the chip in her arm]]. HilarityEnsues.
--> "I love you! I love you sooo much!!!"
* Creator/NeilGaiman's ''Literature/{{Neverwhere}}'' has a scene where Richard and Door drink some wine from Atlantis: apparently, when wine ages, it gets more potent. Richard gets tipsy on the way out and wonders if Door wants him to [[KissingUnderTheInfluence kiss her]]. Thankfully, he doesn't go for it.
* In Creator/PGWodehouse's ''Literature/RightHoJeeves'', Gussie Fink-Nottle (a teetotaler and all-around spinelesss goof) gets roped into giving a speech for the award ceremonies at a local grammar school. To 'stiffen his fibers', he drinks a great deal of whiskey, and then a jug-full of orange juice which both Bertie and Jeeves have spiked with alcohol. Cue (genuine) [[HilarityEnsues hilarity]].

* In ''[[Literature/HilaryTamar The Shortest Way To Hades]]'' by Sarah Caudwell, Julia and Selena eat pot-laced fudge while at APartyAlsoKnownAsAnOrgy, leading them to "cast off all conventional restraints and devote [themselves] without shame to the pleasures of the moment." For Selena, this means reading a copy of ''Literature/PrideAndPrejudice'' while ignoring anyone who tries to talk to her; for Julia, it means trying to explain the effect of Section 478 of the Taxes Act.

* Twice in Creator/JohnWCampbell's story "Literature/TheTenthWorld": First, it's mentioned that when Penton and Blake were on Venus, they got drugged out of their minds after mistaking sodium bromide for sodium chloride. Later, Blake gets drunk on excess oxygen when his spacesuit malfunctions, and his resulting irrational behavior ends up saving the day.

** "[[Recap/AngelS05E05LifeOfTheParty Life of the Party]]" has Wesley and Fred get drunk and [[HilarityEnsues hilarity ensued]]. They didn't really drink enough to get drunk though, Lorne temporarily had reality altering powers which caused them to act that way when he said they "should be drunk by now."

* In the ''Series/MorkAndMindy'' episode, "Mork and the Family Reunion", Mindy accidentally eats [[WeirdWorldWeirdFood an Orkan delicacy called flek]], and begins performing spontaneous gymnastics and acting, well, Mork-like. Later, Mindy's uncle (played by none other than Creator/RobinWilliams' RapidFireComedy idol, Jonathan Winters) eats some and HilarityEnsues big time.

* In the second episode of ''Series/NurseJackie'', the tyrannical hospital administrator accidentally gets a full dose of Percocet after stealing what she ''thought'' was Jackie's coffee sweetener. Hilarity ensued.

* ''WebAnimation/HomestarRunner'': In the Strong Bad e-mail "[[https://www.youtube.com/watch?v=zKghH10WTB4 caffeine]]", Strong Bad slips some instant coffee into his younger brother Strong Sad's orange juice. HilarityEnsues (for real) as the caffeine turns Strong Sad into a hyperactive TalkativeLoon.

* Odd and Ulrich from ''WesternAnimation/CodeLyoko'' had a GRatedDrug-type of this when two Mantas merged to use a laser that made them think Earth was Lyoko and vice versa. Mixed with HilarityEnsues.

* The Merry Pranksters introduced a lot of people to LSD by mixing it with various drinks (like orange juice and Kool-Aid), especially at parties called "Acid Tests". Although they would generally indicate which punch was laced with acid and which one wasn't, a number of people would either come in late or miss the hint and not know they were getting dosed. Since [[HilarityEnsues hilarity did not always ensue]], stories of these incidents contributed to the backlash that led to the drug's prohibition, prompting hallucinogen users to [[NiceJobBreakingItHero blame the Pranksters for ruining acid for everyone]].
* Ever watch a cat come off of tranquilizers? HilarityEnsues.

[[folder:Films -- Animated]]

[[folder:Films -- Live-Action]]

* ''Series/ShakespeareAndHathawayPrivateInvestigators'': In "The Chameleon's Dish", Lou drinks a cup of tea intended for her client. The tea has been spiked with magic mushrooms and Lou winds up tripping: commenting on the beautiful blues and greens of Frank's face, and talking to fairy she thinks is perched on her hand.

** Peter at one point tries crack cocaine; Brian tries to talk him out of it but typically Peter doesn't listen and when Brian comes to check on him later, Peter is huddled on the couch shuddering and claiming "the gub'ment took my baby!".

* In ''WesternAnimation/CentralPark'', Season 1 "[[Recap/CentralParkS1E4GarbageBallet Garbage Ballet]]", Paige is sick and may have took too much cough syrup as she starts acting delirious, like imagining [[Hallucinations Cole's sock as a rat]] and starts getting paranoid about rats.