Tear Jerker / The Flintstones

• In "The Entertainer", Fred unsuccessfully tries not to get Mistaken for Cheating, when he becomes an executive entertainer in order to earn extra money and buy Wilma a gift. Thankfully, Greta Gravel sets Wilma straight, but it's still a pretty tough scene to watch, especially when Wilma tearfully starts packing to leave...
  Betty: (to Fred) I guess that's what you were up to... gallivanting around while your wife was visiting her sick mother!
  Wilma: I'm the one who's sick now... my own husband! (cries) How could you, Fred?
• The Flintstones' neighbors and best friends, Betty and Barney Rubble, clearly wish to have a baby, but unfortunately, it is strongly implied that they are unable to have a child of their own. In "Little Bamm-Bamm", Fred Flintstone gets fed up with them visiting every night to see his daughter (and their goddaughter), Pebbles, and carelessly orders them to leave his house. He even goes so far as to say, "Get your own baby and leave mine alone!" Seeing poor Betty break down into tears later is a pretty heartbreaking scene. Thankfully, his wife, Wilma, tells him off for his behavior and he apologizes. What's more, the Rubbles get their own child the very next day.
  • Later, when it seems that Stonyfeller has been awarded custody of Bamm-Bamm, a heartbroken Barney bids him a tearful farewell, and leaves, being Driven to Suicide. Thankfully, Fred, Wilma, and Betty arrive in time to stop him (and it turned out he didn’t even check how shallow the water was) when they find out that Stonyfeller's wife is pregnant, so Bamm-Bamm officially belongs to the Rubbles.
• In "Dino Disappears", Pebbles, Wilma, and eventually Fred start crying when they find out that Dino has run away from home. Barney arrives on the scene in a cheerful mood, but shortly starts crying with the others as well, before taking Fred to look for Dino.
• Similarly, in Hop Happy Fred scolds Barney, saying that they can't invite the Rubbles' new pet Hoppy to the picnic but can invite the Flintstones' pet Dino. Barney declines, stating that if Hoppy can't go, Dino shouldn't be able to go either. Then, after the argument, Fred finally agrees and regrets to tell Dino that Hoppy is not invited to this picnic so he has to stay home too. Dino whines like a sad dog.
  Barney: THEY BOTH GO OR THEY BOTH STAY!
  Fred: OKAY, OKAY! (to Dino) Sorry, Dino. Hoppy can't go, so you'll have to stay home too. (He leaves poor Dino howling like a sad dog)