- In JoJo's Bizarre Adventure: Stone Ocean, after Enrico Pucci realizes the crux of fulfilling the Evil Plan has emerged, he rejoices in the moment by playing Handel's Messiah, all while a badly wounded man lays next to him.
- Kill la Kill: Mako gets the hallelujah chorus from "Messiah" every time she makes a dramatic speech. Her official leitmotif is "Light Your Heart Up".
- In Legend of the Galactic Heroes, the attempted assassination of the Kaiser and Prince during a party with a bomb is set to part of Handel's Music for the Royal Fireworks.
Film: Live Action
- The Great Mr Handel is a stylized 1942 biopic, showing how Handel evolved from his work in opera to his composition of Messiah.
- Great Expectations: Herbert nicknames Pip "Handel," after the composer of the piece "The Harmonious Blacksmith" (reasoning that Pip was originally a blacksmith, and they get along harmoniously).
- In I Think I Love You, Petra tells her mother she and her friends are going to see Handel's Messiah when they're actually going to a David Cassidy concert.
- KILL la KILL - IF: Mako's theme music is a very chipper and peppy remix of "Messiah", sampling the "Hallelujah" chorus to a xylophone and sounds of bubbles popping.
- ToeJam & Earl: "Hallelujah!" is played after receiving a 1-Up.
- Hark! A Vagrant: "Big Dreams":
Audience: Hey! HEY! Play Piano Man. I said play some god damn Billy Joel.
George Frederic Handel: to self ~Someday Handel, someday you will make it big~
- It's Christmastime Again, Charlie Brown: When Peppermint Patty is writing her essay on George Handel's "Messiah", neither her nor Marcie happen to know Handel's first name, leading her to guess that it's Joe.
