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    Dr. William Masters 

Dr. William "Bill" Masters

Played by: Michael Sheen
https://static.tvtropes.org/pmwiki/pub/images/williammasters.jpg

  • Abusive Parents: Bill's dad was physically abusive and his mom ignored it.
  • Accidental Pun: Bill's "I hope I've aroused your curiosity... if nothing else." is met with laughter by his audience during a meeting, much to his chagrin. He then proceeds to turn it into a successful catchphrase to conclude his sales presentations.
  • Adaptational Attractiveness
  • The Alcoholic: Bill is attending court-mandated AA meetings in season 4 though they have yet to admit they have a drinking problem.
  • Anguished Declaration of Love: Masters to Johnson at the end of "Manhigh".
  • Anti-Hero: The series is about Bill Masters and he is not a bad guy, he takes the Hippocratic oath very seriously and big ego aside, he wants to help people with his groundbreaking work. However his inability to express his emotions in a healthy way and his arrogance oftentimes leads to him making the lives of his wife and Ginny (who are much nicer people) hell, and several times, his manipulative, possessive schemes to assert control over Virginia turn him very close to a Villain Protagonist.
  • Beard of Sorrow: Bill sports one in the season 4 premiere. (He shaves it off before the episode's over.)
  • Betty and Veronica: The Archie between Virginia and Libby.
  • Blackmail: Masters gets Barton Scully's support for his study by hinting that he knows that Scully has been having sex with male prostitutes.
  • Calling Your Orgasms: When Bill and Ginny first start having sex For Science!, he calmly announces each stage of sexual response as it occurs: plateau, orgasm, AND resolution. As they start having feelings for each other, the announcements become rather less calm.
  • The Cobbler's Children Have No Shoes: Bill Masters has an appalling sex life, relationship with his wife, and inability to discuss the subject with her.
  • The Comically Serious: Bill's straight, joyless and occasionally pompous personality is the source of much deadpan hilarity.
  • Distracted by the Sexy: Bill and Virginia almost always keep up their cool, scientific observer demeanors, but when Bill sees her topless for the first time, he's obviously rattled (both from seeing that his partner is a sexual being and by the realization of his own attraction to her).
  • Fatal Flaw: Pride. And a lot of it.
  • Forbidden Fruit: While an academic success, the book about the study barely sells its first edition. Masters has the idea to wrap it in plain brown paper to elicit curiosity from the public as something mysterious and illicit. It quickly finds a second wind among readers.
  • Historical Beauty Upgrade

    Virginia Johnson 

Virginia Johnson

Played by: Lizzy Caplan
https://static.tvtropes.org/pmwiki/pub/images/virginiajohnson.jpg

  • Ethical Slut: She picked her own time to lose her virginity (and not within marriage) and is comfortable with her body and with casual sex, making her probably the most well-adjusted person in the series. But even when she and Bill start having sex with each other within the study, she makes it absolutely clear there has to be an emotional firewall between that and Bill's marriage, because she doesn't want to hurt Libby. She quits the study at one point late in season one when she realizes Bill has been using it as an excuse to have an affair with her.
  • Girl Friday: Invoked and averted, Masters initially hires Ginny because he's been told he needs a female accomplice, but it becomes pretty clear, pretty fast that she's just as important in the implementation of the study as he is.

    Libby Masters 

Elizabeth “Libby” Masters (née Ellis)

https://static.tvtropes.org/pmwiki/pub/images/libbymasters.jpg

    Dr. Austin Langham 

Dr. Austin Langham

Played by: Teddy Sears
https://static.tvtropes.org/pmwiki/pub/images/austinlangham.jpg

    Dr. Ethan Haas 

Dr. Ethan Haas

https://static.tvtropes.org/pmwiki/pub/images/ethanhaas.jpg

    Betty Dimello 

Betty Dimello

https://static.tvtropes.org/pmwiki/pub/images/bettydimello.jpg

Recurring

Scullys

    Barton Scully 

Barton Scully

Played by: Beau Bridges
https://static.tvtropes.org/pmwiki/pub/images/barton_scully.jpg

    Margaret Scully 

Margaret Scully

Played by: Allison Janney
https://static.tvtropes.org/pmwiki/pub/images/margaretscully.jpg

    Vivian Scully 

Vivian Scully

Played by: Rose McIver
https://static.tvtropes.org/pmwiki/pub/images/vivianscully.jpg

Masters

    Estabrooks Masters 

Estabrooks "Essie" Masters

Played by: Ann Dowd


    Francis Masters Jr. 

Francis "Frank" Masters Jr.

Played by: Christian Borle


    Johnny Masters 

Johnny Masters

Played by: Jaeden Lieberher
https://static.tvtropes.org/pmwiki/pub/images/johnnymasters.png

Johnsons

    George Johnson 

George Johnson

Played by: Mather Zickel
https://static.tvtropes.org/pmwiki/pub/images/georgejohnson.jpg

    Henry Johnson 

Henry Johnson

Played by: Cole Sand (Seasons 1-2), Noah Robbins (Seasons 3-4)


    Tessa Johnson 

Tessa Johnson

Played by: Kayla Madison (Seasons 1-2), Isabelle Fuhrman (Seasons 3-4)


Doctors

    Dr. Lillian DePaul 

Dr. Lillian DePaul

https://static.tvtropes.org/pmwiki/pub/images/brave_new_world_dr_lillian_depaul_and_virginia_johnson_discuss_mandatory_cervical_testing1.png

    Dr. Charles Hendricks 

Dr. Charles Hendricks


    Dr. Douglas Greathouse 

Dr. Douglas Greathouse

Played by: Danny Huston
https://static.tvtropes.org/pmwiki/pub/images/parallax_dr_doug_greathouse_played_by_danny_huston.jpg

    Dr. Art Dreesen 

Dr. Art Dreesen

Played by: Jeremy Strong


    Dr. Nancy Leveau 

Dr. Nancy Leveau

Played by: Betty Gilpin


Others

    Jane Martin 

Jane Martin

Played by: Helene Yorke


    Lester Linden 

Lester Linden

Played by: Kevin Christy
https://static.tvtropes.org/pmwiki/pub/images/love_and_marriage_lester_holds_ulysses.jpg

    Gene Moretti 

Gene Moretti

Played by: Greg Grunberg


    Dale 

Dale

Played by: Finn Wittrock


    Barbara Sanderson 

Barbara Sanderson

Played by: Betsy Brandt
https://static.tvtropes.org/pmwiki/pub/images/kyrie_eleison_bills_new_secretary_barbara_sanderson_played_by_betty_brandt.jpg

    Coral 

Coral

Played by: Keke Palmer
https://static.tvtropes.org/pmwiki/pub/images/keke_palmer_in_masters_of_sexr.jpg

    Robert Franklin 

Robert Franklin

Played by: Jocko Sims
https://static.tvtropes.org/pmwiki/pub/images/giants_robert_played_by_jocko_sims_talks_to_libby_about_coral.jpg

    Helen 

Helen

Played by: Sarah Silverman


    Flo Packer 

Flo Packer

Played by: Artemis Pebdani


    Shep Tally 

Shep Tally

Played by: Adam Arkin


    Dan Logan 

Dan Logan

Played by: Josh Charles


    Nora Everett 

Nora Everett

Played by: Emily Kinney
https://static.tvtropes.org/pmwiki/pub/images/surrogates_nora_compares_sex_to_a_watch.jpg

    Paul Edley 

Paul Edley

Played by: Ben Koldyke


    Ronald Sturgis 

Ronald Sturgis

Played by: Colin Woodell


    Louise Bell 

Louise Bell

Played by: Niecy Nash
https://static.tvtropes.org/pmwiki/pub/images/masters_of_sex_season_4_episode_2_photos_inventory_05_450x600.jpg

    Dody Oliver 

Dody Oliver

Played by: Kelli O'Hara


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