Marla's standoff with Mrs. Booth. After Marla gets stabbed multiple times by Mrs. Booth, Booth is shot by Amy, and then Marla grabs Booth's hook and jams it in the back of her head to finish her off while screaming an epic war cry.
Marla: You are nobody's mother.
Mike putting an end to the threat of Candle Cove once and for all: he lets Eddie drag him into it, and distracts him with a card game they never finished, long enough for Marla to kill his body, cutting off Eddie's connection to the real world.
Jules taking a level in badass following the Time Skip, spending an entire year tracking down The House and marching in there armed and dangerous, determined to not let anything stop her from saving Margot.
Jules escaping from and destroying The Orb after an entire season of it tormenting her. After doing so she only spares the briefest of moments pondering on just what it is, before deciding to forget about it and focus on saving Margot.
Seth's incredibly satisfyingKarmic Death after Margot releases his "family". Afterwards, his hollowed out victims descend on his corpse, with the clear intention of disposing of what left of him.
Margot coming to terms with her father's death and finally leaving The House with Jules.
Butcher's Block
Zoey eating parts of her own leg rather than succumb to the temptation to eat the Peaches' victims.
Shutting up Robert Peach mid-gloat by shooting him repeatedly. This creepy, unsettling, and rather aggravating villain who's been reveling in killing people and eating them and then laughing about it gets exactly what he deserves, and does not get to come back and try again.
After his father tries to kill him, then later attempts to switch sides, guns him down too.
Saving Scissor Lady from Smart Mouth, bashing the little bastard's head in with his own hammer.
Louise, despite insisting she's not the Cool Old Lady aunt and is just a landlord, tries to keep control of a situation and help out the younger, more vulnerable Alice and Zoe, and personally decapitates Robert after he tries to pull a Not Quite Dead. Then, she faces down Joseph Peach in his Butcher form to buy the others time. Though it doesn't work, she still lives through it.
The truly amazing (and far too short) scene where Pretzel Jack fights against Tall Boy. He uses his contortion to his advantage, ragdolling to dodge a swing before backflipping away, snatching Tall Boy's weapon away from him and sawing his head in half. This is all scored to 80s synthwave.