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* ''VideoGame/PlagueInc'' started out as a ''Pandemic'' clone, but, a number of updates later, has surpassed the original. One of the main changes is that, in ''Pandemic'', the world searches for a vaccine, which can be a moot point if everyone is already infected. In ''Plague Inc'', the world searches for a cure, which is distributed within ''days'' to everyone in the world and is a nearly-instant game over.
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* ''VideoGame/PlagueInc'' started out as a ''Pandemic'' clone, but, a number of updates later, has surpassed the original. One of the main changes is that, in ''Pandemic'', the world searches for a vaccine, which can be a moot point if everyone is already infected. In ''Plague Inc'', the world searches for a cure, which is distributed within ''days'' to everyone in the world and is a nearly-instant game over. There are many different types of plague the player can choose with different strengths, weaknesses, and challenges, including:
** Bacteria, a well-balanced plague that can evolve to resist medication and hostile conditions.
** Virus, a rapidly-mutating disease that can be difficult to control.
** Fungus, a slow-spreading plague that can be carried by wind currents, circumventing the need for ships and planes to spread.
** Parasite, an organism that cannot gain DNA points as quickly as the other disease types that can evolve to remain hidden in its hosts.
** Prion, a slow-killing cerebral illness that excels at impeding research into a cure.
** Nano-Virus, an artificial disease that must evolve, infect, and kill quickly to prevent being deactivated.
** Bio-weapon, an escaped pathogen that kills quickly, necessitating careful evolution to keep humans alive long enough to outlast humanity.
** Neurax Worm, a brain parasite with two paths to victory: total human extinction, or total human assimilation.
** Necroa Virus, a disease that can reanimate the dead, leading to a war between humans and an impending ZombieApocalypse.
** Simian Flu, an attempt at expanding intelligence and curing Alzheimer's disease that kills humans while mentally elevating apes.
** Shadow Plague, a sentient disease that can transform humans into vampires.
** Bacteria, a well-balanced plague that can evolve to resist medication and hostile conditions.
** Virus, a rapidly-mutating disease that can be difficult to control.
** Fungus, a slow-spreading plague that can be carried by wind currents, circumventing the need for ships and planes to spread.
** Parasite, an organism that cannot gain DNA points as quickly as the other disease types that can evolve to remain hidden in its hosts.
** Prion, a slow-killing cerebral illness that excels at impeding research into a cure.
** Nano-Virus, an artificial disease that must evolve, infect, and kill quickly to prevent being deactivated.
** Bio-weapon, an escaped pathogen that kills quickly, necessitating careful evolution to keep humans alive long enough to outlast humanity.
** Neurax Worm, a brain parasite with two paths to victory: total human extinction, or total human assimilation.
** Necroa Virus, a disease that can reanimate the dead, leading to a war between humans and an impending ZombieApocalypse.
** Simian Flu, an attempt at expanding intelligence and curing Alzheimer's disease that kills humans while mentally elevating apes.
** Shadow Plague, a sentient disease that can transform humans into vampires.
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* ''Literature/{{Kane}}'': An unnamed plague appears in the BackStory to "The Cold Light". Brought by a traveller on a caravan, it ravaged the rich and green land of Demornte, drastically reducing its population. The few survivors all gathered in the capital Sebbei, where they spend the rest of their lives in despair and despondency, while the rest of the country is practically deserted.
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* ''Literature/{{Kane}}'': ''Literature/KaneSeries'': An unnamed plague appears in the BackStory to "The Cold Light". Brought by a traveller on a caravan, it ravaged the rich and green land of Demornte, drastically reducing its population. The few survivors all gathered in the capital Sebbei, where they spend the rest of their lives in despair and despondency, while the rest of the country is practically deserted.
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* The MEV-1 virus from ''Film/{{Contagion}}''.
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* The MEV-1 virus from ''Film/{{Contagion}}''.''Film/Contagion2011''.
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* ''WesternAnimation/{{Star WarsTheCloneWars}} gives us the Blue Shadow Virus. It is described as a deadly disease with no one in the galaxy being immune and the Separatist Doctor Vindi is making the repercussions worse, since the disease is normally not airborne, but Vindis tempering caused a more aggressive strain. It's toned down a bit, as it's the villains intent to cause a pandemic, but it never comes that far. In the following episode though, it's spread in Vinds bunker due to some virus bombs getting into the wrong hands, causing Padmé Amidala, Ahsoka Tano, Captain Rex and all the remaining clones to be infected. All the scenes in the bunker just ooze dread, from Ahsoka trying to keep everybody's spirits high, to Padmés concern for everyone and the clones themselves just being resigned to their fates, as they are mostly considered expendable and believe no one would cure them anyways.
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* ''WesternAnimation/{{Star WarsTheCloneWars}} ''WesternAnimation/StarWarsTheCloneWars'' gives us the Blue Shadow Virus. It is described as a deadly disease with no one in the galaxy being immune and the Separatist Doctor Vindi is making the repercussions worse, since the disease is normally not airborne, but Vindis tempering caused a more aggressive strain. It's toned down a bit, as it's the villains intent to cause a pandemic, but it never comes that far. In the following episode though, it's spread in Vinds bunker due to some virus bombs getting into the wrong hands, causing Padmé Amidala, Ahsoka Tano, Captain Rex and all the remaining clones to be infected. All the scenes in the bunker just ooze dread, from Ahsoka trying to keep everybody's spirits high, to Padmés concern for everyone and the clones themselves just being resigned to their fates, as they are mostly considered expendable and believe no one would cure them anyways.
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* ''WesternAnimation/{{Star Wars: The Clone Wars}} gives us the Blue Shadow Virus. It is described as a deadly disease with no one in the galaxy being immune and the Separatist Doctor Vindi is making the repercussions worse, since the disease is normally not airborne, but Vindis tempering caused a more aggressive strain. It's toned down a bit, as it's the villains intent to cause a pandemic, but it never comes that far. In the following episode though, it's spread in Vinds bunker due to some virus bombs getting into the wrong hands, causing Padmé Amidala, Ahsoka Tano, Captain Rex and all the remaining clones to be infected. All the scenes in the bunker just ooze dread, from Ahsoka trying to keep everybody's spirits high, to Padmés concern for everyone and the clones themselves just being resigned to their fates, as they are mostly considered expendable and believe no one would cure them anyways.
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* ''WesternAnimation/{{Star Wars: The Clone Wars}} WarsTheCloneWars}} gives us the Blue Shadow Virus. It is described as a deadly disease with no one in the galaxy being immune and the Separatist Doctor Vindi is making the repercussions worse, since the disease is normally not airborne, but Vindis tempering caused a more aggressive strain. It's toned down a bit, as it's the villains intent to cause a pandemic, but it never comes that far. In the following episode though, it's spread in Vinds bunker due to some virus bombs getting into the wrong hands, causing Padmé Amidala, Ahsoka Tano, Captain Rex and all the remaining clones to be infected. All the scenes in the bunker just ooze dread, from Ahsoka trying to keep everybody's spirits high, to Padmés concern for everyone and the clones themselves just being resigned to their fates, as they are mostly considered expendable and believe no one would cure them anyways.
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* ''WesternAnimation/{{Star Wars: The Clone Wars}} gives us the Blue Shadow Virus. It is described as a deadly disease with no one in the galaxy being immune and the Separatist Doctor Vindi is making the repercussions worse, since the disease is normally not airborne, but Vindis tempering caused a more aggressive strain. It's toned down a bit, as it's the villains intent to cause a pandemic, but it never comes that far. In the following episode though, it's spread in Vinds bunker due to some virus bombs getting into the wrong hands, causing Padmé Amidala, Ahsoka Tano, Captain Rex and all the remaining clones to be infected. All the scenes in the bunker just ooze dread, from Ahsoka trying to keep everybody's spirits high, to Padmés concern for everyone and the clones themselves just being resigned to their fates, as they are mostly considered expendable and believe no one would cure them anyways.
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* ''VideoGame/PhoenixPoint'' has the Pandoravirus, which is revealed early on to be an alien bioweapon that fell onto Earth in prehistory and was sequestered in permafrost until global warming allowed it to spread into the oceans in the late 2020s. Many of the infected who didn't die walked into the sea. The second major outbreak came with fogbanks of MysteriousMist carrying the disease covering coastal cities and swarms of mutant creatures coming back out of the sea, bringing about the collapse of global civilization. At the game's starting point in the AfterTheEnd era there are signs that the virus is gearing up to infect the Earth's remaining land biomass.
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* In Book 3 of ''[[Literature/TheBelgariad The Mallorean]]'', a nasty plague is seen initially passing from a prostitute to a sailor going AWOL, and its eventual path toward the capital of Mallorea, the largest city in the world. It becomes a massive complication for the protagonists, as Emperor Zakath refuses to let them continue on their journey until the plague has run its course, but ends up aiding them as they find a way to escape, and Zakath is unable to pursue them. The most disturbing part of the disease is the victims [[NightmareFuel are left with a hideous rictus grin on the faces of their corpses.]]
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* The {{Gendercide}} plague Redface Pox in ''Manga/{{Ooku}}: The Inner Chambers'', that only affected males and left feudal Japan a (predominantly) LadyLand. [[spoiler: Bears are carriers for the plague, apparently.]]
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* The {{Gendercide}} plague Redface Pox in ''Manga/{{Ooku}}: The Inner Chambers'', ''Manga/OokuTheInnerChambers'', that only affected males and left feudal Japan a (predominantly) LadyLand. [[spoiler: Bears are carriers for the plague, apparently.]]
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* ''Literature/TheRealBoy'': A devastating plague struck the island of Aletheia long ago, killing not only people but also animals and even plants. Large swathes of Aletheia are still uninhabitable wastelands.
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* ''Literature/TheRomanMysteries'' features an historic pandemic that starts at the end of ''The Twelve Tasks of Flavia Gemina'' and becomes on of the main plot points of ''The Enemies of Jupiter''.
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* ''Literature/TheRomanMysteries'' features an historic pandemic that starts at the end of ''The Twelve Tasks of Flavia Gemina'' and becomes on one of the main plot points of ''The Enemies of Jupiter''.
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* ''The Scarlet Plague'' by Jack London takes place in 2037, 60 years after the "Red Death" (which started in San Fran, USA) killed off most of the planet. By a point, our narrator, James Smith starts to wonder if he's and worries about being the last person to remember life before the plague.
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* ''The Scarlet Plague'' ''Literature/TheScarletPlague'' by Jack London takes place in 2037, 60 years after the "Red Death" (which started in San Fran, USA) killed off most of the planet. By a point, our narrator, James Smith starts to wonder if he's and worries about being the last person to remember life before the plague.
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* UsefulNotes/{{Covid19|pandemic}}, a disease pandemic caused by the coronavirus [=SARS-CoV-2=], was first identified in the city of Wuhan, Hubei province, China and spread globally in the first half of 2020. This in turn led to significant increases in mortality around the world and rolling lockdowns globally. Late 2020 saw the advent of vaccines to inoculate the population against the disease, but in turn the virus has started mutating to be more contagious and at least one variant can get around vaccines, so the fight continues.
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* UsefulNotes/{{Covid19|pandemic}}, UsefulNotes/{{COVID|19pandemic}}[[UsefulNotes/COVID19Pandemic -19]], a disease pandemic caused by the coronavirus [=SARS-CoV-2=], was first identified in the city of Wuhan, Hubei province, China and spread globally in the first half of 2020. This in turn led to significant increases in mortality around the world and rolling lockdowns globally. Late 2020 saw the advent of vaccines to inoculate the population against the disease, but in turn the virus has started mutating to be more contagious and at least one variant can get around vaccines, so the fight continues.
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* UsefulNotes/{{CoViD19|pandemic}}, a disease pandemic caused by the coronavirus [=SARS-CoV-2=], was first identified in the city of Wuhan, Hubei province, China and spread globally in the first half of 2020. This in turn led to significant increases in mortality around the world and rolling lockdowns globally. Late 2020 saw the advent of vaccines to inoculate the population against the disease, but in turn the virus has started mutating to be more contagious and at least one variant can get around vaccines, so the fight continues.
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* UsefulNotes/{{CoViD19|pandemic}}, UsefulNotes/{{Covid19|pandemic}}, a disease pandemic caused by the coronavirus [=SARS-CoV-2=], was first identified in the city of Wuhan, Hubei province, China and spread globally in the first half of 2020. This in turn led to significant increases in mortality around the world and rolling lockdowns globally. Late 2020 saw the advent of vaccines to inoculate the population against the disease, but in turn the virus has started mutating to be more contagious and at least one variant can get around vaccines, so the fight continues.
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* UsefulNotes/Covid19, a disease pandemic caused by the coronavirus [=SARS-CoV-2=], was first identified in the city of Wuhan, Hubei province, China and spread globally in the first half of 2020. This in turn led to significant increases in mortality around the world and rolling lockdowns globally. Late 2020 saw the advent of vaccines to inoculate the population against the disease, but in turn the virus has started mutating to be more contagious and at least one variant can get around vaccines, so the fight continues.
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* UsefulNotes/Covid19, UsefulNotes/{{CoViD19|pandemic}}, a disease pandemic caused by the coronavirus [=SARS-CoV-2=], was first identified in the city of Wuhan, Hubei province, China and spread globally in the first half of 2020. This in turn led to significant increases in mortality around the world and rolling lockdowns globally. Late 2020 saw the advent of vaccines to inoculate the population against the disease, but in turn the virus has started mutating to be more contagious and at least one variant can get around vaccines, so the fight continues.
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Ebola is vaccine-preventable since late 2019-early 2020
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* [[http://en.wikipedia.org/wiki/Ebola_virus_disease Ebola]]. As a virus, it's innately difficult to treat and it's rare enough that there are no specific drugs for it. A vaccine that works on humans has yet to be developed. Oh, and it makes your [[BodyHorror innards dissolve into a bloody pulp that you then bleed out]]. Thankfully, it had been confined to Africa '''[[ParanoiaFuel ...had]]'''. [[note]]One confirmed person-to-person infection in the United States, and one in Spain, thankfully it never spread farther than that.[[/note]] An important point is that Ebola is ''so'' virulent that it kills its victims before they can get very far -- it's not airborne (you need to come into contact with the bodily fluids of a visibly-infected person in order to catch it), making transmission easily prevented by proper hygiene, which tends to keep it in isolated villages (until the 2014 outbreak -- which is itself ''mostly'' confined to a few desperately poor West African countries with extraordinarily weak public health systems).
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* [[http://en.wikipedia.org/wiki/Ebola_virus_disease Ebola]]. As a virus, it's innately difficult to treat and it's rare enough that there are no specific drugs for it. A vaccine that works on humans has yet to be developed.courtesy of MSD was in development since the mid-2000s, but it's approved for medical use since late 2019-early 2020. Oh, and it makes your [[BodyHorror innards dissolve into a bloody pulp that you then bleed out]]. Thankfully, it had been confined to Africa '''[[ParanoiaFuel ...had]]'''. [[note]]One confirmed person-to-person infection in the United States, and one in Spain, thankfully it never spread farther than that.[[/note]] An important point is that Ebola is ''so'' virulent that it kills its victims before they can get very far -- it's not airborne (you need to come into contact with the bodily fluids of a visibly-infected person in order to catch it), making transmission easily prevented by proper hygiene, which tends to keep it in isolated villages (until the 2014 outbreak -- which is itself ''mostly'' confined to a few desperately poor West African countries with extraordinarily weak public health systems).
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new trope
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** In ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]'', the Blight diseases are a downplayed example. They are related to the Corprus Disease, a MysticalPlague[=/=][[TheCorruption Corruption]] conjured by the PhysicalGod BigBad using power channeled from the [[CosmicKeystone Heart]] of a [[GodIsDead "dead" god]], of which there is no cure. There ''is'' a cure for the Blight diseases, however it is more expensive/magicka-draining than the cures for common diseases.
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** In ''[[VideoGame/TheElderScrollsIIIMorrowind Morrowind]]'', the Blight diseases are a downplayed example. They are related to the Corprus Disease, a MysticalPlague[=/=][[TheCorruption Corruption]] conjured by the PhysicalGod BigBad using power channeled from the [[CosmicKeystone Heart]] of a [[GodIsDead "dead" god]], of which there is no cure.ThereIsNoCure. There ''is'' a cure for the Blight diseases, however it is more expensive/magicka-draining than the cures for common diseases.
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* The ''entire'' plot of ''VideoGame/Left4Dead'' revolves around this -- the main characters are some of the only people with natural immunity to TheVirus that turns everyone else into crazed killing machines. There is no cure -- they can only run for their lives.
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* The ''entire'' plot of ''VideoGame/Left4Dead'' revolves around this -- the main characters are some of the only people with natural immunity to TheVirus that turns everyone else into crazed killing machines. There is no cure ThereIsNoCure -- they can only run for their lives.
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* In ''Literature/{{Clade}}'', a pandemic with a 25% mortality rate ravages the world. Adam, Noah, and Lijuan hide out for as long as possible in an isolated house in the country. They occasionally visit the nearby town, which has been thoroughly looted, so there's not much to scavenge. When rioters start a wildfire, the three have to flee to the beach. Eventually scientists learn how to synthesize antibodies, ending the pandemic.
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* The back-story of ''Anime/YukiYunaIsAHero'' involves this. A virus devastated the world 300 years ago but [[WorldTree Shinju-Sama]] protected the people of Shikoku by putting a protective barrier around the island and providing them with water and food. This happened 300 years ago and the people [[WorldLimitedToThePlot still live like that]], in a sheltered protective dome where the Shinju-sama and its representatives, the Taisha, have complete authority.
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* The back-story of ''Anime/YukiYunaIsAHero'' involves this. A virus devastated the world 300 years ago but [[WorldTree Shinju-Sama]] protected the people of Shikoku by putting a protective barrier around the island and providing them with water and food. [[spoiler: However, this is a fabrication. The outside world was actually destroyed by the Vertex, which were sent by the Heavenly Gods to wipe out humanity.]] This happened 300 years ago and the people [[WorldLimitedToThePlot still live like that]], in a sheltered protective dome where the Shinju-sama and its representatives, the Taisha, have complete authority.
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** In ''ComicBook/TheLeperFromKrypton'', Lex Luthor engineers a strain of Virus-X, a dangerous and incurable alien pathogen which had scourged Krypton several centuries before, and then he spreads it with the aim to kill Superman and blackmail the world into paying him a fortune for a non-existent cure.
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* In ''Film/{{Faust}}'' the demon Mephisto brings a plague to Faust's town. Faust's despair at being unable to save the plague victims is what leads him to make a DealWithTheDevil.
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* In ''Film/{{Faust}}'' ''Film/{{Faust}}'', the demon Mephisto brings a plague to Faust's town. Faust's despair at being unable to save the plague victims is what leads him to make a DealWithTheDevil.
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* ''Literature/CrusadeInJeans'': The crusade is beset by a plague that claims the lives of quite a lot of children. Dolf, being from the future, understands germ theory and implements quarantine and hygiene measures to stop the disease. He explains it to the medieval people he's surrounded by in religious terms, describing bacteria as tiny demons sent to sicken the lord's chosen.
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* ''Literature/CrusadeInJeans'': The crusade is beset by a plague that claims the lives of quite a lot of children. Dolf, being from the future, understands germ theory and implements quarantine and hygiene measures to stop the disease. He explains it to the medieval people he's surrounded by in religious terms, describing bacteria as tiny demons sent to sicken the lord's chosen.
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* One of the members of the [[ComicBook/GreenLantern Green Lantern Corps]] is actually a sentient smallpox virus named Leezle Pon, who stays out of meetings because it would infect the other Green Lanterns. The Sinestro Corps, on the other hand, has its own sentient virus known as Despotellis, who is responsible for [[spoiler:killing Kyle Rayner's mother]].
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* ''ComicBook/GreenLantern'': One of the members of the [[ComicBook/GreenLantern Green Lantern Corps]] Corps is actually a sentient smallpox virus named Leezle Pon, who stays out of meetings because it would infect the other Green Lanterns. The Sinestro Corps, on the other hand, has its own sentient virus known as Despotellis, who is responsible for [[spoiler:killing Kyle Rayner's mother]].
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* This is the driving force of the ''Franchise/{{Superman}}'' storyline ''ComicBook/TheFallOfMetropolis'' as Metropolis is seemingly inflicted by a malady that has inflicted the likes of Lex Luthor II, Superboy and the Newsboy Legion. Cadmus Project ultimately learns this was from fallout created by Engine City and is ultimately fixed, however [[AndIMustScream not before Luthor's locked in his body for a good while.]]
* The [[Comicbook/XMen Legacy Virus]] killed off a few {{mutants}}. One strain of it was capable of infecting ordinary humans too; Moira [=McTaggert=] was the most well-known non-mutant victim.
* The [[Comicbook/XMen Legacy Virus]] killed off a few {{mutants}}. One strain of it was capable of infecting ordinary humans too; Moira [=McTaggert=] was the most well-known non-mutant victim.
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* This is ''ComicBook/{{Superman}}'':
** ''ComicBook/ThePlagueOfTheAntibioticMan'': A strange plague of unknown origin and nature -whose symptoms include loss of consciousness, fever and odd purple splotches all over thedriving force of skin- is decimating the ''Franchise/{{Superman}}'' storyline ''ComicBook/TheFallOfMetropolis'' as Metropolis population of Central City, and Superman suspects it has been caused by one of his enemies.
** In ''ComicBook/TheFallOfMetropolis'', Superman's city is seemingly inflicted by a malady that has inflicted the likes of Lex Luthor II, Superboy and the Newsboy Legion. Cadmus Project ultimately learns this was from fallout created by Engine City and is ultimately fixed, however [[AndIMustScream not before Luthor's locked in his body for a good while.]]
* ''ComicBook/XMen'': The[[Comicbook/XMen Legacy Virus]] Virus killed off a few {{mutants}}.mutants. One strain of it was capable of infecting ordinary humans too; Moira [=McTaggert=] was the most well-known non-mutant victim.
** ''ComicBook/ThePlagueOfTheAntibioticMan'': A strange plague of unknown origin and nature -whose symptoms include loss of consciousness, fever and odd purple splotches all over the
** In ''ComicBook/TheFallOfMetropolis'', Superman's city is seemingly inflicted by a malady that has inflicted the likes of Lex Luthor II, Superboy and the Newsboy Legion. Cadmus Project ultimately learns this was from fallout created by Engine City and is ultimately fixed, however [[AndIMustScream not before Luthor's locked in his body for a good while.]]
* ''ComicBook/XMen'': The
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* ''Fanfic/GuardiansWizardsAndKungFuFighters'': The first epilogue chapter reveals that, centuries ago, Meridian was afflicted by one called the "White Death", which was caused by a white insect that infected crops, causing white spots, fevers, convulsions, and in many cases, death. Once they discovered the source, they burned their crops to kill the insects, even if it meant causing famine once the plague was gone, and it prompted [[spoiler:Jonathan Ludmoore]] to create a new order to revitalize medical knowledge in Meridian, especially after seeing how the survivors fared, and learning that the remaining side effects could be heritable.
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* ''Webcomic/{{Unsounded}}'': Illness is a major issue in Kasslyne because the human healers have no understanding of it, with cold and flu analogs being very deadly. They're better at treating infection, only because the Tains left words that casters can use to kill bacteria. The problem is with the Gefendur culling of the Tains as heretics and destruction of their culture modern Kasslynians don't even know what bacteria actually are, thinking them ghosts.
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* ''Fanfic/MyDreamIsYours'' has a downplayed example with Dream-Transfer-itis, which isn't lethal in nature but it does cause SleepDeprivation in its victims and can spread rapidly in offices and other close-knit areas. Considering Odd Squad Headquarters in general are also [[DangerousWorkplace Dangerous Workplaces]] that can cause someone's premature death in an instant, sleep deprivation is a very dangerous thing to have.
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* In Fanfic/TalesOfTheHungerGames, the Capitol is ravaged by a measles outbreak around the time of the talent competition for District One's 100th Hunger Games. President Gaul is reluctant to cancel any of the related festivities and the outbreak worsens throughout that Games and the Grand Final. The historians chronicling the Hunger Games also agree that it's one of the reasons why the post-Games riots were violent and horrific.
** The lore episode of Fanfic/PanemReborn, a fan-created continuation of the series, mentions that the Capitol still suffered from the measles epidemic a year later, as seen with Emilia Cardew's 101th Hunger Games.
** The lore episode of Fanfic/PanemReborn, a fan-created continuation of the series, mentions that the Capitol still suffered from the measles epidemic a year later, as seen with Emilia Cardew's 101th Hunger Games.
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Alphabetizing Fan Works folder
* Present in the background of the ''Anime/{{Robotech}}''/''Series/BabylonFive'' spin-off ''A Different Kind of Contact'' and its prequel: [[AllThereInTheManual a codex entry]] explains how any first contact could unleash one on one or both parties due them not having immunity to the other party's illnesses, and provides examples such as the (historical) smallpox epidemics unleashed by the Spaniards in America completely by accident, the Xon invasion of Centauri lands being halted by an outbreak of the Centauri equivalent of common cold, and an epidemics of ''actual'' common cold killing 10% of Kumlakshi's population before being contained by anti-virals. That's why first contact is handled in such way to ''avoid'' it, unprotected first contact is universally a death sentence, and the Centauri consider the allegation of them trying to exterminate the Narn as completely ridiculous: if they wanted, they wouldn't spend so much on a vaccination program aimed precisely to prevent their extinction by plague.
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* The ''Series/{{Glee}}'' and ''WesternAnimation/AvatarTheLastAirbender'' FusionFic ''FanFic/SolarWinds'' has a mysterious plague spreading across the entire world. Most, if not all of the still-living victims have been quarantined on an abandoned island in the Fire Nation. [[spoiler:Fire Lord Sue plans to get rid of the plague by simply blowing up the volcano on the island]].
* Present in the background of the ''Anime/{{Robotech}}''/''Series/BabylonFive'' spin-off ''A Different Kind of Contact'' and its prequel: [[AllThereInTheManual a codex entry]] explains how any first contact could unleash one on one or both parties due them not having immunity to the other party's illnesses, and provides examples such as the (historical) smallpox epidemics unleashed by the Spaniards in America completely by accident, the Xon invasion of Centauri lands being halted by an outbreak of the Centauri equivalent of common cold, and an epidemics of ''actual'' common cold killing 10% of Kumlakshi's population before being contained by anti-virals. That's why first contact is handled in such way to ''avoid'' it, unprotected first contact is universally a death sentence, and the Centauri consider the allegation of them trying to exterminate the Narn as completely ridiculous: if they wanted, they wouldn't spend so much on a vaccination program aimed precisely to prevent their extinction by plague.
* Present in the background of the ''Anime/{{Robotech}}''/''Series/BabylonFive'' spin-off ''A Different Kind of Contact'' and its prequel: [[AllThereInTheManual a codex entry]] explains how any first contact could unleash one on one or both parties due them not having immunity to the other party's illnesses, and provides examples such as the (historical) smallpox epidemics unleashed by the Spaniards in America completely by accident, the Xon invasion of Centauri lands being halted by an outbreak of the Centauri equivalent of common cold, and an epidemics of ''actual'' common cold killing 10% of Kumlakshi's population before being contained by anti-virals. That's why first contact is handled in such way to ''avoid'' it, unprotected first contact is universally a death sentence, and the Centauri consider the allegation of them trying to exterminate the Narn as completely ridiculous: if they wanted, they wouldn't spend so much on a vaccination program aimed precisely to prevent their extinction by plague.
* In the ''Animal Crossing'' fanfic ''Fanfic/MyNameIsMolly'', a plague threatened to lead to the extinction of all of humanity. Healthy children were shipped off to far-off villages, but only after they were changed into {{Funny Animal}}s and removed of their memories.
* The ''Series/{{Glee}}'' and ''WesternAnimation/AvatarTheLastAirbender'' FusionFic ''FanFic/SolarWinds'' has a mysterious plague spreading across the entire world. Most, if not all of the still-living victims have been quarantined on an abandoned island in the Fire Nation. [[spoiler:Fire Lord Sue plans to get rid of the plague by simply blowing up the volcano on the island]].
* ''Fanfic/WhatAWonderfulWorld'' has the Black Vein that caused the "Epidemic of 756". Qrow, Raven and Summer were infected by it in the past.
* ''Fanfic/WhatAWonderfulWorld'' has the Black Vein that caused the "Epidemic of 756". Qrow, Raven and Summer were infected by it in the past.
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* In the ''Animal Crossing'' fanfic ''Fanfic/MyNameIsMolly'', a plague threatened to lead to the extinction of all of humanity. Healthy children were shipped off to far-off villages, but only after they were changed into {{Funny Animal}}s and removed of their memories.
* ''Fanfic/WhatAWonderfulWorld'' has the Black Vein that caused the "Epidemic of 756". Qrow, Raven and Summer were infected by it in the past.
* ''Fanfic/WhatAWonderfulWorld'' has the Black Vein that caused the "Epidemic of 756". Qrow, Raven and Summer were infected by it in the past.
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* In ''VisualNovel/VirtuesLastReward'', there's radical-6, a disease that [[spoiler:slows the brain function of its victims and eventually causes them to become insane and suicidal.]] Over the course of the game it is gradually revealed that [[spoiler:the game takes place many years after the player thought it did, after the pandemic has killed most of Earth's population, and that [[SetRightWhatOnceWentWrong the point of the game is to fix that]].]]
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* In ''VisualNovel/VirtuesLastReward'', there's radical-6, Radical-6, a disease that [[spoiler:slows the brain function of its victims and eventually causes them to become insane and suicidal.]] suicidal]]. Over the course of the game it is gradually revealed that [[spoiler:the game takes place many years after the player thought it did, after the pandemic has killed most of Earth's population, and that [[SetRightWhatOnceWentWrong the point of the game is to fix that]].]]that]]]]. Also, [[spoiler:all of you were deliberately infected with Radical-6 before the game began so that you wouldn't realize you're actually on the Moon, since your slower brain function made the Moon's lower gravity feel like Earth's normal gravity]].
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* In ''VideoGame/TheOuterWorlds'', the FirstTown of Edgewater suffers from a terrible, deadly plague. [[spoiler:Except not really, it's actually just malnutrition because literally the only thing the town eats is saltuna from the local cannery... which might not be so bad if the cans ''actually contained saltuna''. Saltuna aren't native to that particular planet, so the cannery just fills its cans with pretty much whatever it can find. Mostly sawdust]].
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* One of the many things the rabbits of ''Literature/WatershipDown'' have to fear is the dreaded "white blindness", a fast-acting disease that causes fatigue, fever and, well, [[ExactlyWhatItSaysOnTheTin blindness]], but most terrifyingly leaves you oblivious to EverythingTryin"https://youtube.com/shorts/Ssvp6qcq_-UgToKillYou. [[DiseaseByAnyOtherName Humans know it]] as myxomatosis.
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* One of the many things the rabbits of ''Literature/WatershipDown'' have to fear is the dreaded "white blindness", a fast-acting disease that causes fatigue, fever and, well, [[ExactlyWhatItSaysOnTheTin blindness]], but most terrifyingly leaves you oblivious to EverythingTryin"https://youtube.com/shorts/Ssvp6qcq_-UgToKillYou.EverythingTryingToKillYou. [[DiseaseByAnyOtherName Humans know it]] as myxomatosis.
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Note: the word "plague" originally described a specific disease, TheBlackDeath. While The Black Death is still called "plague", the word is now [[TropeNamer often used]] to describe [[YouKeepUsingThatWord any widespread disease]].
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* ''Literature/{{Starsnatcher}}'' features an extraterrestrial AfterTheEnd variation. A plague which is, appropriately, known as [[ExactlyWhatItSaysOnTheTin the Plague]] wiped out an entire extraterrestrial civilization and it's going to wipe out humanity next. It was originally designed to infect machines. Via radio wave transmissions, it travels from solar system to solar system and forces the computers it hijacks to print biological pathogens which infect organic life. [[TheVirus Those infected tend to turn into omnicidal, super-durable zombies.]]
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Adding an example and added some context to other examples.
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%%* ''The Scarlet Plague'' by Jack London.
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*{{Creator/Amoridere}}'s ''Sneezing Blood'' and its sequels tells a narrative of a mysterious "blood plague", where the outbreak starts with the PatientZero sneezing and then the spread continues from there. Three things that are clear is what it does (and [[BloodFromEveryOrifice it's not pretty]]), no treatments can help, and, by ''Blood at the Borders'', the country is on the verge of collapse because of it.
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* One of the many things the rabbits of ''Literature/WatershipDown'' have to fear is the dreaded "white blindness", a fast-acting disease that causes fatigue, fever and, well, [[ExactlyWhatItSaysOnTheTin blindness]], but most terrifyingly leaves you oblivious to EverythingTryingToKillYou. [[DiseaseByAnyOtherName Humans know it]] as myxomatosis.
%%* ''The White Plague'' by Creator/FrankHerbert (only fatal to women).
%%* ''The White Plague'' by Creator/FrankHerbert (only fatal to women).
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* One of the many things the rabbits of ''Literature/WatershipDown'' have to fear is the dreaded "white blindness", a fast-acting disease that causes fatigue, fever and, well, [[ExactlyWhatItSaysOnTheTin blindness]], but most terrifyingly leaves you oblivious to EverythingTryingToKillYou.EverythingTryin"https://youtube.com/shorts/Ssvp6qcq_-UgToKillYou. [[DiseaseByAnyOtherName Humans know it]] as myxomatosis.
%%* ''The *''The White Plague'' by Creator/FrankHerbert (only has it where mad scientist, after the deaths of his family, creates a virus that's only fatal to women).women but can be carried by men. This plague has the effect of almost ending the human race creating a GenderRarityValue.
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* ''Literature/TheWaterAndTheWild'': There's a deadly disease in the fairy world that has spread like wildfire, and has no known cure. Currently, it's been isolated to the wisp forest, but the wisp species are now in danger of extinction. [[spoiler:Lottie's parents were claimed by the plague years ago, too.]]
