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* Kaori Asaka from ''Manga/TheSummerYouWereThere'' suffers from an unnamed respiratory disease, one she's had since she was young. It causes her to gasp for breath and even collapse if she overexerts herself and worsens as she ages- midway through the story, even an ordinary outing without any strenuous exertion causes her to collapse. She expects that she will not live past the end of the summer because of this disease, [[spoiler:and dies of it in the penultimate chapter, at the age of 15]].
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* In ''Anime/DigimonAdventure02TheBeginning'', Lui's father is comatose and hooked up to a life support system at their family home, and his mother is paranoid that Lui even being in the same room could lead to his death if it were tampered with in any way. Lui's father appears to undergo a miraculous recovery thanks to Lui's wish to Ukkomon [[spoiler:but his body is actually just being puppetted around to please Lui]].

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* In ''Anime/DigimonAdventure02TheBeginning'', Lui's father is comatose and hooked up to a life support system at their family home, and his mother is paranoid that Lui even being in the same room could lead to his death if it were tampered with in any way. Lui's father appears to undergo a miraculous recovery thanks to Lui's wish to Ukkomon [[spoiler:but his body is actually just being puppetted puppeteered around to please Lui]].
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* In ''Anime/DigimonAdventure02TheBeginning'', Lui's father is comatose and hooked up to a life support system at their family home, and his mother is paranoid that Lui even being in the same room could lead to his death if it were tampered with in any way. Lui's father appears to undergo a miraculous recovery thanks to Lui's wish to Ukkomon [[spoiler:but his body is actually just being puppetted around to please Lui]].
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* [[MagicalGirl Liadain]] of ''Literature/NowhereStars'' started out with a perfectly legible, if terminal, auto-immune disorder. Multiple failed marrow transplants. Once she got her [[BadPowersBadPeople powers]] of sickness, rot, and health drain, however, she was no longer afflicted by anything so mundane, No, at the point that she was draining abstract 'health' from people, she was dying because her magic was now a story about dying from illness instead of based on proasic reality.

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* [[MagicalGirl Liadain]] of ''Literature/NowhereStars'' started out ''Literature/NowhereStars'': Initially [[AvertedTrope Averted]], and then weirdly ''[[InvokedTrope invoked]]''. [[DarkMagicalGirl Liadain Shiel]] was born with a perfectly legible, if terminal, auto-immune disorder. Multiple fictional but realistically-portrayed immuno-deficiency disorder, which several rejected marrow transplants failed marrow transplants. Once she got her [[BadPowersBadPeople powers]] of sickness, rot, and health drain, to improve. After becoming a MagicalGirl, however, she was no longer afflicted by anything so mundane, No, at the point that she was draining abstract 'health' from people, she was dying because her it stopped being a mundane illness and became a ''supernatural'' one. Because magic was now a follows TheoryOfNarrativeCausality more than any concrete rules, it essentially ''became'' this trope; as one doctor describes it, it became "a story about a girl dying from illness instead of based on proasic reality.a disease."
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May result in WringEveryLastDropOutOfHim.

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May result in WringEveryLastDropOutOfHim.WringEveryLastDropOutOfHim, when a character is on the brink of death, but takes a while to actually die.
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* In ''Anime/MyNeighborTotoro'', the disease that Satsuki and Mei's mother has is never revealed, though it is [[WordOfDante believed by many fans]] to be tuberculosis. The movie is based on Creator/HayaoMiyazaki’s childhood and it’s what his mother had before she was cured with antibiotics in 1955.

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* In ''Anime/MyNeighborTotoro'', the disease that Satsuki and Mei's mother has is never revealed, though it is [[WordOfDante believed by many fans]] to be tuberculosis. The movie is based on Creator/HayaoMiyazaki’s childhood and it’s what his mother had before she was cured with antibiotics in 1955. [[note]] Tho, Yoshiko (Miyazaki's mother) had a specific kind of TB called "Pott's disease" and not the respiratory kind that we're familiar with[[/note]]
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* ''Fanfic/KedaborysElmoreChronicles'': The titular illness of "The Disease" is never clarified. The symptoms include a fever, coughing, and wheezing, the latter two end up becoming a chronic condition, but the disease is never named, and the doctor instead chooses to name the illness it could ''not'' be (these being scarlet fever, strep throat, and whooping cough).
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* [[MagicalGirl Liadain]] of ''Literature/NowhereStars'' started out with a perfectly legible, if terminal, auto-immune disorder. Multiple failed marrow transplants. Once she got her [[BadPowersBadPeople powers]] of sickness, rot, and health drain, however, she was no longer afflicted by anything so mundane, No, at the point that she was draining abstract 'health' from people, she was dying because her magic was now a story about dying from illness instead of based on proasic reality.
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* Alan Stuart in ''LightNovel/MyNextLifeAsAVillainessAllRoutesLeadToDoom'' had a nondescript disorder in his early years, causing him to be completely bedridden for the first fives years of his life, and people once thought he was going to die of it as a child. However, the disease's lasting effect is more pronounced on his healthy ''twin brother'' Geordo, as Alan's condition indirectly caused a ''very'' bad case of ParentalNeglect on Geordo, which became his CynicismCatalyst.

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* Alan Stuart in ''LightNovel/MyNextLifeAsAVillainessAllRoutesLeadToDoom'' ''Literature/MyNextLifeAsAVillainessAllRoutesLeadToDoom'' had a nondescript disorder in his early years, causing him to be completely bedridden for the first fives years of his life, and people once thought he was going to die of it as a child. However, the disease's lasting effect is more pronounced on his healthy ''twin brother'' Geordo, as Alan's condition indirectly caused a ''very'' bad case of ParentalNeglect on Geordo, which became his CynicismCatalyst.
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* The Twelve-Year Disease in ''VideoGame/TalesOfBerseria'' has no symptoms besides fever and frailty. [[spoiler:It's what Velvet's brother Laphicet had, and it's ultimately fatal--he figured it out because he read extensively during his periods of illness and so volunteered to be sacrificed to Innominat. Later, the party finds another child who has it and goes on a hunt for a lost ancient cure.]]
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A common mutation anywhere is the IncurableCoughOfDeath; a terminal illness with no symptoms of any kind besides coughing. More likely than not evolved from VictorianNovelDisease, which tends to have a surprisingly similar set of syndromes -- though, unlike this trope, most novels from the time period of [=VND=]'s heyday would at least give a definite name to the condition they were aiming for.[[note]]consumption (aka tuberculosis) is among the most common examples of diseases that were used as plot devices in Victorian novels, for example[[/note]] The character may insist the illness is DefinitelyJustACold. Not to be confused with SoapOperaRapidAgingSyndrome, which isn't actually a disease so much as a PlotHole that sucks up babies and children and spits out [[SheIsAllGrownUp teenagers or even adults]].

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A common mutation anywhere is the IncurableCoughOfDeath; a terminal illness with no symptoms of any kind besides coughing. More likely than not evolved from VictorianNovelDisease, which tends to have a surprisingly similar set of syndromes -- though, unlike this trope, most novels from the time period of [=VND=]'s heyday would at least give a definite name to the condition they were aiming for.[[note]]consumption [[note]]Consumption (aka tuberculosis) is among the most common examples of diseases that were used as plot devices in Victorian novels, for example[[/note]] example.[[/note]] The character may insist the illness is DefinitelyJustACold. Not to be confused with SoapOperaRapidAgingSyndrome, which isn't actually a disease so much as a PlotHole that sucks up babies and children and spits out [[SheIsAllGrownUp teenagers or even adults]].
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A common mutation anywhere is the IncurableCoughOfDeath; a terminal illness with no symptoms of any kind besides coughing. More likely than not evolved from VictorianNovelDisease, which tends to have a surprisingly similar set of syndromes - though, unlike this trope, most novels from the time period of [=VND=]'s heyday would at least give a definite name to the condition they were aiming for.[[note]]consumption (aka tuberculosis) is among the most common examples of diseases that were used as plot devices in Victorian novels, for example[[/note]] The character may insist the illness is DefinitelyJustACold. Not to be confused with SoapOperaRapidAgingSyndrome, which isn't actually a disease so much as a PlotHole that sucks up babies and children and spits out [[SheIsAllGrownUp teenagers or even adults]].

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A common mutation anywhere is the IncurableCoughOfDeath; a terminal illness with no symptoms of any kind besides coughing. More likely than not evolved from VictorianNovelDisease, which tends to have a surprisingly similar set of syndromes - -- though, unlike this trope, most novels from the time period of [=VND=]'s heyday would at least give a definite name to the condition they were aiming for.[[note]]consumption (aka tuberculosis) is among the most common examples of diseases that were used as plot devices in Victorian novels, for example[[/note]] The character may insist the illness is DefinitelyJustACold. Not to be confused with SoapOperaRapidAgingSyndrome, which isn't actually a disease so much as a PlotHole that sucks up babies and children and spits out [[SheIsAllGrownUp teenagers or even adults]].

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* In ''Anime/TheBorrowerArrietty'', the male protagonist Sho has had a heart condition ever since he was a child. Just a short period of physical activity can cause him pain.



* Trisha from ''Anime/FullmetalAlchemist'' died of such a disease. It's never stated what it was but fans consider it either stress-related or cancer. Averted in the manga, where it's said she had a disease that was going around.

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* Trisha from ''Anime/FullmetalAlchemist'' ''Anime/FullmetalAlchemist2003'' died of such a disease. It's never stated what it was but fans consider it either stress-related or cancer. Averted in the manga, where it's said she had a disease that was going around.



* One of these is the reason that ''Franchise/{{Batman}}'' villain Mr. Freeze placed his wife in cryogenic suspension, a concept introduced in ''WesternAnimation/BatmanTheAnimatedSeries''.

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* One of these is the reason that ''Franchise/{{Batman}}'' ''ComicBook/{{Batman}}'' villain Mr. Freeze placed his wife in cryogenic suspension, a concept introduced in ''WesternAnimation/BatmanTheAnimatedSeries''.



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[[folder:Film]][[folder:Film -- Animation]]
* In ''Anime/{{Arrietty}}'', the male protagonist Sho has had a heart condition ever since he was a child. Just a short period of physical activity can cause him pain.
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[[folder:Film -- Live-Action]]



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[[folder:Web Video]]Videos]]
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* From Wiki/{{Killerbunnies}}, we have Anwen's condition and not too much information is known about it besides the fact that will eventually kill her, along with it being progressive.

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* From Wiki/{{Killerbunnies}}, Website/{{Killerbunnies}}, we have Anwen's condition and not too much information is known about it besides the fact that will eventually kill her, along with it being progressive.
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A common mutation anywhere is the IncurableCoughOfDeath; a terminal illness with no symptoms of any kind besides coughing. More likely than not evolved from VictorianNovelDisease. The character may insist the illness is DefinitelyJustACold. Not to be confused with SoapOperaRapidAgingSyndrome, which isn't actually a disease so much as a PlotHole that sucks up babies and children and spits out [[SheIsAllGrownUp teenagers or even adults]].

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A common mutation anywhere is the IncurableCoughOfDeath; a terminal illness with no symptoms of any kind besides coughing. More likely than not evolved from VictorianNovelDisease. VictorianNovelDisease, which tends to have a surprisingly similar set of syndromes - though, unlike this trope, most novels from the time period of [=VND=]'s heyday would at least give a definite name to the condition they were aiming for.[[note]]consumption (aka tuberculosis) is among the most common examples of diseases that were used as plot devices in Victorian novels, for example[[/note]] The character may insist the illness is DefinitelyJustACold. Not to be confused with SoapOperaRapidAgingSyndrome, which isn't actually a disease so much as a PlotHole that sucks up babies and children and spits out [[SheIsAllGrownUp teenagers or even adults]].
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* The terminal disease that Mary suffered from in ''VideoGame/SilentHill2'' is not specified, but it started with an IncurableCoughOfDeath and eventually left her bedridden and in constant pain, along with causing hair loss and some kind of severe psoriasis-type skin condition. [[spoiler:It's also not what ultimately killed her.]]
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* ''Series/StarTrekTheNextGeneration'': In the [[Franchise/StarTrekExpandedUniverse novel]] "Strike Zone" the Selelvian Jaan Baat-Utuul-Bayn-Devin learns he has a terminal illness the Selelvians call "The Rot" and has about six months to live. Picard wants to transfer him off the ''Enterprise'' right away, but backs down when Dr. Pulaski confronts him and says that Jaan is not contagious and can continue his work for some time before the end. Becoming desperate too escape his fate, Jaan unwittingly gives Wesley Crusher a telepathic compulsion to research a cure to his illness and later betrays the ''Enterprise'' to the Kreel Aneel, who tells him the Kreel have the cure for The Rot. What Jaan doesn't realize until too late is that Aneel intends to kill him once Jaan [[YouHaveOutlivedYourUsefulness outlives his usefulness]] to the Kreel on the grounds that death cures everything. Wesley suffers an emotional collapse after learning Jaan was killed and undergoes counseling before returning to duty.
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** ''Series/StarTrekPicard'': In the first season Picard learns that he has a terminal brain abnormality that will kill him before too long. [[spoiler: His original body dies at the end of the season but his friends [[BrainUploading transfer his mind]] into a quantum simulation where Data lives before transferring his consciousness into a new android body, or golem, that was sculpted to resemble Picard's original body at the age when the organic body died.

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** ''Series/StarTrekPicard'': In the first season Picard learns that he has a terminal brain abnormality that will kill him before too long. [[spoiler: His original body dies at the end of the season but his friends [[BrainUploading transfer his mind]] into a quantum simulation where Data lives before transferring his consciousness into a new android body, or golem, that was sculpted to resemble Picard's original body at the age when the organic body died.died]].
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* ''Franchise/StarTrek'':
** ''Series/StarTrekTheNextGeneration'': In "[[Recap/StarTrekTheNextGenerationS2E6TheSchizoidMan The Schizoid Man]]" the USS ''Enterprise'' crew comes across Data's "grandfather" Ira Graves and finds he's suffering from a terminal illness called Darnay's disease. Initially planning to [[BrainUploading copy his brain]] into a computer, upon meeting Data Graves instead uploads himself into Data's positronic brain instead until he realizes that he was wrong to do so. He then transfers his knowledge into the ''Enterprise'' computer but his personality is lost in the process.
** ''Series/StarTrekDeepSpaceNine'': In "[[Recap/StarTrekDeepSpaceNineS05E19TiesOfBloodAndWater Ties of Blood and Water]]" the elderly Cardassian dissident Tekeny Ghemor travels to [=DS9=] in order to see Major Kira, who the Obsidian Order once tried to convince both that she was his [[MissingChild long lost daughter]] in "[[{{Recap/StarTrekDeepSpaceNineS03E05SecondSkin}} Second Skin]]." Ghemor has the terminal illness Yarim Fe and wants to pass on all his secrets to Kira in the Shri-tal ritual. He does this in the hopes the Federation can use what he knows against Gul Dukat and his new Dominion allied government.
** ''Series/StarTrekPicard'': In the first season Picard learns that he has a terminal brain abnormality that will kill him before too long. [[spoiler: His original body dies at the end of the season but his friends [[BrainUploading transfer his mind]] into a quantum simulation where Data lives before transferring his consciousness into a new android body, or golem, that was sculpted to resemble Picard's original body at the age when the organic body died.

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-->-- ''[[http://www.fanfiction.net/u/1263379/gabriel_blessing Gabriel Blessing]] comment on the real illness behind [[Manga/{{Sekirei}} Chiho]]'s condition''

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-->-- ''[[http://www.fanfiction.net/u/1263379/gabriel_blessing Gabriel Blessing]] '''Creator/GabrielBlessing''''s comment on the real illness behind [[Manga/{{Sekirei}} Chiho]]'s condition''
condition
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* The ''Franchise/KingdomHearts'' AU fic ''[[ Two Hearts One Beat]]'' has Sora dying from an unspecified disease as a four-year-old. What little we learn is that his heart is weak, but this seems to be referring to his Heart in the metaphysical ''Kingdom Hearts'' sense: [[VideoGame/KingdomHeartsBirthBySleep when Sora gives his body up to Ventus's Heart]] in his final moments, the rest of his body immediately starts recovering, allowing Ventus to grow up as Sora without anyone knowing.

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* The ''Franchise/KingdomHearts'' AU fic ''[[ ''[[https://archiveofourown.org/works/15332802/ Two Hearts One Beat]]'' has Sora dying from an unspecified disease as a four-year-old. What little we learn is that his heart is weak, but this seems to be referring to his Heart in the metaphysical ''Kingdom Hearts'' sense: [[VideoGame/KingdomHeartsBirthBySleep when Sora gives his body up to Ventus's Heart]] in his final moments, the rest of his body immediately starts recovering, allowing Ventus to grow up as Sora without anyone knowing.
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* The ''Franchise/KingdomHearts'' AU fic ''[[ Two Hearts One Beat]]'' has Sora dying from an unspecified disease as a four-year-old. What little we learn is that his heart is weak, but this seems to be referring to his Heart in the metaphysical ''Kingdom Hearts'' sense: [[VideoGame/KingdomHeartsBirthBySleep when Sora gives his body up to Ventus's Heart]] in his final moments, the rest of his body immediately starts recovering, allowing Ventus to grow up as Sora without anyone knowing.
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* In ''LightNovel/EndoAndKobayashiLiveTheLatestOnTsundereVillainessLieselotte'', Lieselotte's late uncle August had always been sickly since birth, and by the time he could have married his [[ArrangedMarriage officially betrothed fiancee]] [[spoiler:Elizabeth]], he's already too weak to get out of his bed. This is important to [[spoiler:Fiene]]'s backstory, as his fiancee's family issued a ParentalMarriageVeto out of this exact reason, despite [[PerfectlyArrangedMarriage they're completely in love with each other]]. This is why [[spoiler:Fiene]] is raised as a commoner despite her parents being some of the most {{Blue Blood}}ed people in the setting, since the two decided to sleep together anyway so that [[SomeoneToRememberHimBy she can have his child]], knowing well that they're technically [[RoyalBastard committing adultery]].

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* In ''LightNovel/EndoAndKobayashiLiveTheLatestOnTsundereVillainessLieselotte'', ''Literature/EndoAndKobayashiLive The Latest on Tsundere Villainess Lieselotte'', Lieselotte's late uncle August had always been sickly since birth, and by the time he could have married his [[ArrangedMarriage officially betrothed fiancee]] [[spoiler:Elizabeth]], he's already too weak to get out of his bed. This is important to [[spoiler:Fiene]]'s backstory, as his fiancee's family issued a ParentalMarriageVeto out of this exact reason, despite [[PerfectlyArrangedMarriage they're completely in love with each other]]. This is why [[spoiler:Fiene]] is raised as a commoner despite her parents being some of the most {{Blue Blood}}ed people in the setting, since the two decided to sleep together anyway so that [[SomeoneToRememberHimBy she can have his child]], knowing well that they're technically [[RoyalBastard committing adultery]].
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* One of these is the reason that ''Franchise/{{Batman}}'' villain Mr. Freeze placed his wife in cryogenic suspension.

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* One of these is the reason that ''Franchise/{{Batman}}'' villain Mr. Freeze placed his wife in cryogenic suspension.suspension, a concept introduced in ''WesternAnimation/BatmanTheAnimatedSeries''.
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* Creator/LittleKuriboh parodied this in his [[https://www.youtube.com/watch?v=1bvGhzLQbCY Patreon video]]. He was diagnosed with a specific and chronic, but not fatal, colon condition, and Martin and his wife [[{{Melodrama}} wept and wailed about it]].

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* Creator/LittleKuriboh parodied this in his [[https://www.youtube.com/watch?v=1bvGhzLQbCY Patreon video]]. He was diagnosed with a specific and chronic, but not fatal, colon condition, and Martin and his wife [[Creator/MarinMiller spouse]] [[{{Melodrama}} wept and wailed about it]].
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* In ''Anime/DragonBallZ'', Goku suffers from a mysterious heart virus during the Android Saga. According to Future Trunks, it took his timeline's Goku's life and many others before a cure is discovered. Trunks gives Goku this cure and is given to him when he is finally affected by it, but it lays him up for a good while, which is particularly bad as Androids 16, 17, and 18 are active and hunting him down. ''WebVideo/DragonBallZAbridged'' changes it to a cholesterol-induced heart attack caused by eating too much bacon, and makes it so that Goku doesn't take the medicine pre-emptively because it was grape flavored.

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* In ''Anime/DragonBallZ'', Goku suffers from a mysterious heart virus during the Android Saga. According to Future Trunks, it took his timeline's Goku's life and many others before a cure is discovered. Trunks gives Goku this cure and is it’s given to him when he is finally affected by it, but it lays him up for a good while, which is particularly bad as Androids 16, 17, and 18 are active and hunting him down. ''WebVideo/DragonBallZAbridged'' changes it to a cholesterol-induced heart attack caused by eating too much bacon, [[TrademarkFavoriteFood bacon]], and makes it so that Goku doesn't take [[ObsessedWithFood Goku]] stopped taking the medicine pre-emptively when he was supposed to because it was grape flavored.grape-flavored (later revealed to be less an instance of DoesNotLikeSpam and more of his BizarreAlienBiology making him cough blood and sweat purple painfully).
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* ''VideoGame/WildArms4'': One character, [[spoiler:Raquel, one of your party members]], is slowly dying of an unspecified condition. Its only shown symptom is occasional IncurableCoughOfDeath, although the dialogue implies that there are more symptoms hidden beneath their clothes. The cause of this condition is eventually revealed to be "toxins from the reactor", implying it to be radiation poisoning, but the symptoms do not really match with the real thing. Naturally, this condition didn't stop them from living with it for years, being an extremely good fighter, and eventually [[spoiler:becoming a mother, and living on for a couple more years]].
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The trope's been cut by TRS.


* Any Creator/KeyVisualArts game will have at least one IllGirl that suffers from this, with the exception of ''VisualNovel/{{Planetarian}}'' where the disease is [[spoiler:low battery power with no way to recharge]]. Thus one of the alternate titles for this page, "Key AIDS".

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* Any Creator/KeyVisualArts game will have at least one IllGirl ill girl that suffers from this, with the exception of ''VisualNovel/{{Planetarian}}'' where the disease is [[spoiler:low battery power with no way to recharge]]. Thus one of the alternate titles for this page, "Key AIDS".

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The anime trope of the IllGirl suffers from the same plague of vague. See its page for the full story but the gist of it is the same; some kind of frailty to gain sympathy.

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The anime trope of the IllGirl DelicateAndSickly suffers from the same plague of vague. See its page for the full story but the gist of it is the same; some kind of frailty to gain sympathy.



* In the ''Anime/SpeedRacer'' episode "The Desperate Racer," Hap Hazard desperately wants to win a race so that he can cure his sick sister [[IllGirl Eloisa]]. What sickness Eloisa has is not elaborated upon.

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* In the ''Anime/SpeedRacer'' episode "The Desperate Racer," Hap Hazard desperately wants to win a race so that he can [[HealthcareMotivation cure his sick sister [[IllGirl Eloisa]]. What sickness Eloisa has is not elaborated upon.
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* One of these is the reason that ''Franchise/{{Batman}}'' villain Mr. Freeze placed his wife in cryogenic suspension.

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