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* Vamp from the ''Franchise/MetalGear'' series has natural HealingFactor which is further augmented by experimental nano-machines in his body. When he's fought as a boss in ''Videogame/MetalGearSolid4GunsOfThePatriots'', Snake manages to inject him with a nano-suppressing syringe, [[spoiler:taking away enough of his healing for Raiden to kill him in the knife fight that follows]].
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** A way of distracting the healing factor could be used as in many instances, the regeneration power focuses on the most grave threat and moves on to lesser threats so a powerful toxin, disease, or radiation might take the full strength of the healing ability to combat leaving the body vulnerable to more mundane damage like wounds, contusions, and bone breaks.
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%% Image selected via crowner in the Image Suggestion thread: http://tvtropes.org/pmwiki/crowner.php/ImagePickin/ImageSuggestions72
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[[quoteright:201:[[WesternAnimation/StarVsTheForcesOfEvil http://static.tvtropes.org/pmwiki/pub/images/toffe_regeneration_failure_3.png]]]]
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* ''Franchise/{{Pokemon}}'': The move Heal Block prevents the target Pokemon from healing, whether by its own moves, abilities, terrain, or items (for the last one, only Generation V and onward).

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* ''Franchise/{{Pokemon}}'': The move Heal Block prevents the target Pokemon from healing, whether by its own moves, abilities, terrain, or items (for the last one, only Generation V and onward). Pokemon with the ability Liquid Ooze will also cause opponents that attempt to use draining moves on them to take damage instead of regenerating health.
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* in ''VideoGame/MassEffect2'', krogan and vorcha enemies can regenerate health when damaged. Burning them with an incendiary attack, or using Warp on them will stop them from regenerating.

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* in In ''VideoGame/MassEffect2'', krogan and vorcha enemies can regenerate health when damaged. Burning them with an incendiary attack, or using Warp on them will stop them from regenerating.
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* in ''VideoGame/MassEffect2'', krogan and vorcha enemies can regenerate health when damaged. Burning them with an incendiary attack, or using Warp on them will stop them from regenerating.
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* ''Franchise/{{Pokemon}}'': The move Heal Block prevent the target Pokemon from healing, whether by its own moves, abilities, terrain, or items (for the last one, only Generation V and onward).

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* ''Franchise/{{Pokemon}}'': The move Heal Block prevent prevents the target Pokemon from healing, whether by its own moves, abilities, terrain, or items (for the last one, only Generation V and onward).
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From where?


* Similar to carbonadium, the Muramasa Blade can nullify healing factors.

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* Similar to carbonadium, the Muramasa Blade can nullify healing factors.
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* ''VideoGame/DiabloII'': Some items may have the "Prevents Monster Healing" affix, which temporarily disables enemies' passive recovery of life points.
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** [[spoiler:Deadpool]] vs. [[spoiler:Deathstroke]]: The [[spoiler:Carbonadium sword of Deadpool's was capable of removing Deathstroke's healing factor, allowing the Merc with a Mouth to decapitate him.]]

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* AchillesHeel: There may be a specific place, such as the head, where something is the most vulnerable

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* AchillesHeel: There may be a specific place, such as [[DecapitationRequired the head, head]], where something is the most vulnerable


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[[AC:WebAnimation]]
* ''WebAnimation/DeathBattle'' has several fights where this is used by a character to defeat their regenerating opponent.
** [[spoiler:Kirby]] vs. [[spoiler:Majin Buu]]: The fight ends with [[spoiler: Kirby inhaling and blasting Buu's own attack back at him]], pushing him into the sun. While the former didn't [[spoiler:kill Buu due to his ability to regenerate from a single atom]], getting blasted into the sun and thus having his atoms ionized certainly did.
** [[spoiler:Wolverine]] vs. [[spoiler:Raiden]]: While the former had [[spoiler:a very powerful HealingFactor ''and'' an adamantium skeleton, the latter's HF Muramasa, being a {{Vibroweapon}}, was capable of weakening the Adamantium's molecular bonds. Eventually, Raiden ends up slicing Wolverine's head off and cutting that to bits, preventing the mutant from regenerating ever again.]]
** [[spoiler:Hulk]] vs. [[spoiler:Doomsday]]: Both combatants had a powerful healing factor, but [[spoiler:Doomsday was able to overtax Hulk's by stabbing him with venomous bone claws several times and leaving said claws embedded in there]].
** [[spoiler:Sephiroth]] vs. [[spoiler:Vergil]]: [[spoiler:Vergil]] had a top-notch healing factor that could easily allow him to shrug off impalement and even getting bisected. [[spoiler:Sephiroth's Super Nova manages to overtax it via the heat and power of an exploding sun, allowing him to finish the weakened Vergil off]].
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* ''VideoGame/PlantsVsZombiesHeroes'' has the Sneezing Zombie teammate, which prevents the plants and Plant Hero from healing as long as it's on the field. This is only useful against Plant Heroes with the Solar Class since they have the most healing-based cards, but is especially effective against them, shutting down the dangerous Heartichoke[[note]]Directly damages the Zombie Hero equal to the amount of health healed by plant teammates and the Plant Hero[[/note]] and Astro Vera[[note]]When played, heal the Plant Hero for 10 health AND increase their maximum HP by 10[[/note]].
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* Similar to carbonadium, the Muramasa Blade can nullify healing factors.
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* ''VideoGamem/{{Overwatch}}'': Ana's [[TrickGrenade Biotic Grenade]] prevents enemies from healing temporarily, whether by HealingFactor or other healing sources.

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* ''VideoGamem/{{Overwatch}}'': Ana's [[TrickGrenade [[TrickBomb Biotic Grenade]] prevents enemies from healing temporarily, whether by HealingFactor or other healing sources.
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If that was the case, he'd have died when Goku did his instant-transmission Kamehameha and blew off his torso.


** [[UltimateLifeForm Cell]] is the TropeNamer for FromASingleCell, he can regenerate from any amount of damage so long as his "core" (a special cluster of cells in his head) remains intact. So the one way to beat him is to disintegrate him all at once.

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** [[UltimateLifeForm Cell]] is the TropeNamer for FromASingleCell, he can regenerate from any amount of damage so long as his "core" (a special cluster of cells in his head) ''one'' [[MeaningfulName cell]] remains intact. So the one way to beat him is to disintegrate him all at once.

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* ''Manga/{{Toriko}}'' has shown various way to deal with characters and creatures with HealingFactor.
** Brunch defeats Elg, a centaur that can create clones through regeneration, by putting him and his clones under an endless loop of electrification.
** Midora bypasses Ichiyru's healing factor from [[RealityWarping Minority World]], an ability that causes everything to behave in opposite ways than normally they do due to minor particles that defy physical law, by damaging him faster than he can regenerate with the PowerOfTheVoid.
** Chiyo dices one of the branches of the Coral King into small and delicate pieces with a [[RazorWind long ranged slashes]] and inhibit its regeneration by applying [[TheParalyzer Knocking]].
** Overwhelming an someone to the point that their cells admit defeat will prevent them from regenerating and leave them at the mercy of the attacker.
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* ''Videogame/FinalFantasyVIII'' has the [[Summon Magic GF Brothers]], a pair of [[DishingOutDirt Earth-elemental]] [[ALoadOfBull minotaurs]] who gain the health-boosting 'Regen' buff when in contact with the ground. You can make the boss fight against them easier by casting the Float spell upon them to interfere with the Regen effect.

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* ''Videogame/FinalFantasyVIII'' has the [[Summon Magic [[SummonMagic GF Brothers]], a pair of [[DishingOutDirt Earth-elemental]] [[ALoadOfBull minotaurs]] who gain the health-boosting 'Regen' buff when in contact with the ground. You can make the boss fight against them easier by casting the Float spell upon them to interfere with the Regen effect.
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* ''Videogame/FinalFantasyVIII'' has the [[Summon Magic GF Brothers]], a pair of [[DishingOutDirt Earth-elemental]] [[ALoadOfBull minotaurs]] who gain the health-boosting 'Regen' buff when in contact with the ground. You can make the boss fight against them easier by casting the Float spell upon them to interfere with the Regen effect.
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* In ''WesternAnimation/StarVsTheForcesOfEvil'', Queen Moon used black magic to neutralize Toffee's healing factor, making him unable to regenerate. That's why he's [[WoundThatWillNotHeal missing his finger]].

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* In ''WesternAnimation/StarVsTheForcesOfEvil'', Queen Moon used black magic to neutralize Toffee's healing factor, making him unable to regenerate. That's why he's [[WoundThatWillNotHeal missing his finger]]. [[spoiler:Later Star goes GoldenSuperMode and blasts him with so much magic at once his healing factor can't keep up and he's left barely alive and unable to come back from getting a pillar crushing what's left of him]].
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The Regeneration wasn't negated.


* ''Webcomic/TheOrderOfTheStick'': Belkar [[http://www.giantitp.com/comics/oots0326.html accidentally defeats a hydra]] by chopping off its heads until there isn't enough blood to supply all of them. A passing goblin notices the comatose hydra and sets up an enormously successful barbecue shack thanks to a never-ending supply of meat.

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* ''Webcomic/TheOrderOfTheStick'': Belkar [[http://www.giantitp.com/comics/oots0326.html accidentally defeats a hydra]] by chopping off its heads until there isn't enough blood to supply all of them. A passing goblin notices the comatose hydra and sets up an enormously successful barbecue shack thanks to a never-ending supply of meat.
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* ''VideoGamem/{{Overwatch}}'': Ana's [[TrickGrenade Biotic Grenade]] prevents enemies from healing temporarily, whether by HealingFactor or other healing sources.

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** 1st Edition ''Deities & Demigods Cyclopedia'', Myth/GreekMythology section: each minute the giant Antaeus is in contact with the ground, he heals all damage and gains 25 additional HitPoints. The hero Heracles (Hercules) defeats him by lifting him off the ground and inflicting damage on him while doing so.
** 1st and 2nd Edition. When someone wears a Ring of Regeneration, they can only be prevented from regenerating if their body is totally destroyed by fire or acid.

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** 1st Edition AD&D ''Deities & Demigods Cyclopedia'', Myth/GreekMythology section: each minute the giant Antaeus is in contact with the ground, he heals all damage and gains 25 additional HitPoints. The hero Heracles (Hercules) defeats him by lifting him off the ground and inflicting damage on him while doing so.
** 1st and 2nd Edition. Edition AD&D. When someone wears a Ring of Regeneration, they can only be prevented from regenerating if their body is totally destroyed by fire or acid.acid.
** 2nd Edition AD&D TabletopGame/{{Planescape}} boxed supplement ''Planes of Conflict''. The Quesar live in the Upper Outer Plane of Elysium. They regenerate 1 HitPoint per round, even after being killed, as long as they're in daylight. To prevent them from regenerating you just have to keep them out of daylight, such as moving them underground or casting a spell to create darkness or summon thick cloud cover.
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* Gems in ''WesternAnimation/StevenUniverse'' can [[FromASingleCell fully replace most of their bodies]] after some time because they're [[SelfConstructedBeing projection]] of their [[HeartDrive gemstones]]. Damage to the gemstone itself [[BodyHorror mangles the rest of their body]], is apparently very difficult to heal (Rose and Steven's healing powers are the only known way), and enough will [[DeaderThanDead kill them permanently]]. Gems trying to take other gems alive generally "poof" their bodies, then put their unharmed gemstone in a ContainmentField that prevent regeneration. The standard strategy of the less merciful seems to be poofing the projected body before shattering the gemstone, while [[spoiler:Bismuth's [[PileBunker Breaking Point]]]] was designed specifically to shatter gems mid-fight.

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* Gems in ''WesternAnimation/StevenUniverse'' can [[FromASingleCell fully replace most of their bodies]] after some time because they're [[SelfConstructedBeing projection]] of their [[HeartDrive gemstones]]. Damage to the gemstone itself [[BodyHorror mangles the rest of their body]], is apparently very difficult to heal (Rose and Steven's healing powers are the only known way), and enough will [[DeaderThanDead kill them permanently]]. Gems trying to take other gems alive generally "poof" their bodies, then put their unharmed gemstone in a ContainmentField that prevent prevents regeneration. The standard strategy of the less merciful seems to be poofing the projected body before shattering the gemstone, while [[spoiler:Bismuth's [[PileBunker Breaking Point]]]] was designed specifically to shatter gems immediately mid-fight.

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* In ''WesternAnimation/StarVsTheForcesOfEvil'', Queen Moon used black magic to neutralize Toffee's healing factor, making him unable to regenerate.

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* In ''WesternAnimation/StarVsTheForcesOfEvil'', Queen Moon used black magic to neutralize Toffee's healing factor, making him unable to regenerate. That's why he's [[WoundThatWillNotHeal missing his finger]].
* Gems in ''WesternAnimation/StevenUniverse'' can [[FromASingleCell fully replace most of their bodies]] after some time because they're [[SelfConstructedBeing projection]] of their [[HeartDrive gemstones]]. Damage to the gemstone itself [[BodyHorror mangles the rest of their body]], is apparently very difficult to heal (Rose and Steven's healing powers are the only known way), and enough will [[DeaderThanDead kill them permanently]]. Gems trying to take other gems alive generally "poof" their bodies, then put their unharmed gemstone in a ContainmentField that prevent regeneration. The standard strategy of the less merciful seems to be poofing the projected body before shattering the gemstone, while [[spoiler:Bismuth's [[PileBunker Breaking Point]]]] was designed specifically to shatter gems mid-fight.
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** One of Hercules' task was to kill the Hydra. which he succeeded when his nephew Iolaos started to cauterize the stumps with his torch.

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** One of Hercules' task was to kill the Hydra. Hydra, which he regrows any heads you cut off. He succeeded when his nephew Iolaos started to cauterize the stumps with his torch.
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* ''Manga/OnePiece'': Buggy the Clown, who is capable of DetachmentCombat, was initially defeated by Nami stealing most of his body parts before he could reassemble himself.

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* ''Manga/OnePiece'': Buggy the Clown, who is capable of DetachmentCombat, was initially defeated by Nami stealing tying most of his body parts in a bundle before he could reassemble himself.
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* PlayingWithFire: Fire can cauterize wounds to prevent regeneration

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* PlayingWithFire: Fire can cauterize wounds to prevent regenerationregeneration (including [[FireKeepsItDead from death]])
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* ''ClassicalMythology''

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* ''ClassicalMythology''Myth/ClassicalMythology:



* ''The Lambton Worm'' is an English legend about a dragon which kills by constriction and is difficult to kill because it can re-attach parts of its body that are cut off. It is eventually killed by a Prince who lures it into the River Wear while wearing armour forged from razor blades - the blades hurt the beast when it tries to constrict him, and the river flow washes its severed body parts away.

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* ''The Lambton Worm'' is an English legend about a dragon which kills by constriction and is difficult to kill because it can re-attach parts of its body that are cut off. It is eventually killed by a Prince who lures it into the River Wear while wearing armour forged from razor blades - -- the blades hurt the beast when it tries to constrict him, and the river flow washes its severed body parts away.



* ''TheOrderOfTheStick'': Belkar [[http://www.giantitp.com/comics/oots0326.html accidentally defeats a hydra]] by chopping off its heads until there isn't enough blood to supply all of them. A passing goblin notices the comatose hydra and sets up an enormously successful barbecue shack thanks to a never-ending supply of meat.

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* ''TheOrderOfTheStick'': ''Webcomic/TheOrderOfTheStick'': Belkar [[http://www.giantitp.com/comics/oots0326.html accidentally defeats a hydra]] by chopping off its heads until there isn't enough blood to supply all of them. A passing goblin notices the comatose hydra and sets up an enormously successful barbecue shack thanks to a never-ending supply of meat.
Is there an issue? Send a MessageReason:
None


* In ''WesternAnimation/StarVsTheForcesofEvil'', Queen Moon used black magic to neutralize Toffee's healing factor, making him unable to regenerate.

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* In ''WesternAnimation/StarVsTheForcesofEvil'', ''WesternAnimation/StarVsTheForcesOfEvil'', Queen Moon used black magic to neutralize Toffee's healing factor, making him unable to regenerate.
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Created from YKTTW

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Fighting something with a HealingFactor is very difficult, usually requiring extreme force, special powers or tools, or clever tricks.

Ways of dealing with HealingFactor are:
* PlayingWithFire: Fire can cauterize wounds to prevent regeneration
* KryptoniteFactor: A special weapon or element, whether it be magical or scientific, can often do harm while ignoring a character's HealingFactor. Sometimes, this weapon or element will be connected to how the HealingFactor came about in the first place.
* Excessive Damage: HealingFactor may have a limit of how much damage can be regenerated
** Complete Annihilation: Given situations like FromASingleCell, that is the only way to deal with such
* AchillesHeel: There may be a specific place, such as the head, where something is the most vulnerable
* Preventing body parts from reattaching: Something that can [[PullingThemselvesTogether reform itself]] can be defeated or severely hampered if a single body part is prevented from reattaching to the rest of the body
* Inflicting a WoundThatWillNotHeal
* [[PowerParasite Stealing]] the HealingFactor

SubTrope of PowerNullifier. Compare with SeeTheInvisible. Often the means of defeating a RevivingEnemy.
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!!Examples:
[[AC:Anime and Manga]]
* ''Franchise/DragonBall'' features quite a few characters with {{Healing Factor}}s who have had to be stopped.
** Namekians are the original regenerators in the franchise. They can heal dismembered limbs so long as their heads remain intact, although if they sustain enough damage they can die with their whole bodies remaining.
** [[UltimateLifeForm Cell]] is the TropeNamer for FromASingleCell, he can regenerate from any amount of damage so long as his "core" (a special cluster of cells in his head) remains intact. So the one way to beat him is to disintegrate him all at once.
** [[EldritchAbomination Majin Buu]] is an even more insane example, being capable of regenerating if [[UpToEleven even a single atom]] of him remains. The only known way to kill him is a SpiritBomb empowered by the population of everyone.
** [[MadGod Future Zamasu]] used the Super Dragon Balls to wish for immortality and no matter how much damage he takes he will always keep healing. He retains his immortality as Fusion Zamasu, [[FusionDance after fusing with Goku Black]], although it was gimped so that his body could be destroyed. However, free of his body he AscendedToAHigherPlaneOfExistence and [[TheAssimilator assimilated with the universe]]. The only way to beat such an EldritchAbomination was to summon [[TopGod Zen'o]] to [[OneHitKill erase]] [[ThereIsNoKillLikeOverkill the multiverse]] [[CessationOfExistence from existence]].
* ''Manga/OnePiece'': Buggy the Clown, who is capable of DetachmentCombat, was initially defeated by Nami stealing most of his body parts before he could reassemble himself.
* ''Manga/MyHeroAcademia'': Endeavor defeats a Noumu with a "Super Regeneration" Quirk by making his flames hot enough to turn blue and carbonize the head off.

[[AC:Comic Books]]
* One ''{{ComicBook/Wolverine}}'' story has Sabretooth gloating that he actually thought up the one way to beat a HealingFactor... as his foot is holding Wolverine's head underwater.
* ComicBook/{{Deadpool}}'s WalkingArsenal includes a sword made of carbonadium, a radioactive element capable of negating {{Healing Factor}}s. This allowed him to [[OneManArmy kill everyone]] [[ComicBook/DeadpoolKillsTheMarvelUniverse in one story line]] including all of the quick healers.

[[AC:FilmAnimated]]
* The primary villain of ''WesternAnimation/HeavyMetal2000'' stumbles upon a fluid that can grant him ResurrectiveImmortality, provided he takes regular doses. Tyler goes on a quest for the source after attaining the key. He ends up squished under a huge stone door where regeneration would avail him naught. Further, TheMole unmasks himself, and attains access to the wellspring of eternal life. However, once the huge stone door closes, he's trapped in that chamber. As TheHero remarks: "Forever is a long time to spend all alone."

[[AC:Films -- Live Action]]
* The beginning of ''[[Film/Hercules1958 Hercules Unchained]]'' has a fight against Antaeus, who recovers from all injury whenever he touches the ground. Unlike the original Greek myth, Hercules defeats Antaeus by throwing him into the sea.
* In ''Film/TheWolverine'', Wolverine has a bio-mechanical healing suppressant device implanted in him, thanks to Viper. For a large portion of the film, Wolverine finds he is no longer healing and needs to have his wounds stitched up.
* In ''Film/{{Logan}}'', it's finally revealed that the long term effects of adamantium exposure is healing factor degeneration. Wolverine has had adamantium bound to his skeleton for years and isn't healing as well as he could. [[spoiler:Ultimately, his healing factor is completely compromised and he dies.]]

[[AC:Literature]]
* ''Literature/{{Animorphs}}'': Morphing normally heals all injuries, but there have been notable exceptions, few of which are explained beyond DramaPreservingHandicap: suffering ModeLock (Tobias is stuck in hawk morph at the beginning of the series so an injury would be particularly devastating, when the ability is restored he can heal but still has to live as a bird), a genetic disease (a crashed Andalite refuses to fight because the disease stays with him when he demorphs, while another is allergic to the morphing process and cannot repair his severed tail), time travel (Tobias breaks his wing while in the Cretaceous and can't restore it), and possibly old age (Jake ends up in a BadFuture where Rachel is a complete wreck in a wheelchair, with no indication that she'd lost her morphing ability).

[[AC:Mythology]]
* ''ClassicalMythology''
** One of Hercules' task was to kill the Hydra. which he succeeded when his nephew Iolaos started to cauterize the stumps with his torch.
** The giant Antaeus challenged travelers to a wrestling match to the death, without mentioning that every time he was in contact with his mother the Earth (i.e., thrown to the ground), [[HopelessBossFight his health and energy were completely restored]]. When Heracles came along, he solved the problem by hoisting Antaeus in the air with one hand and strangling him with the other.
* Often werewolves are given a healing factor that is neutralized by silver.
* ''The Lambton Worm'' is an English legend about a dragon which kills by constriction and is difficult to kill because it can re-attach parts of its body that are cut off. It is eventually killed by a Prince who lures it into the River Wear while wearing armour forged from razor blades - the blades hurt the beast when it tries to constrict him, and the river flow washes its severed body parts away.

[[AC:TabletopGames]]
* ''TabletopGame/DungeonsAndDragons''
** [[AllTrollsAreDifferent Trolls]] in ''TabletopGame/DungeonsAndDragons'' possess a HealingFactor which can only be overcome by injuring them with fire or acid.
** 1st Edition ''Deities & Demigods Cyclopedia'', Myth/GreekMythology section: each minute the giant Antaeus is in contact with the ground, he heals all damage and gains 25 additional HitPoints. The hero Heracles (Hercules) defeats him by lifting him off the ground and inflicting damage on him while doing so.
** 1st and 2nd Edition. When someone wears a Ring of Regeneration, they can only be prevented from regenerating if their body is totally destroyed by fire or acid.
* In ''TabletopGame/BigEyesSmallMouth'', any special attack with the No Regeneration modifier cannot be healed using the Healing or Regeneration attributes, and has to be healed naturally. The Incurable modifier is a stronger version of this, and basically inflicts [[WoundThatWillNotHeal Wounds That Will Not Heal]].

[[AC:VideoGames]]
* ''Franchise/{{Pokemon}}'': The move Heal Block prevent the target Pokemon from healing, whether by its own moves, abilities, terrain, or items (for the last one, only Generation V and onward).
* ''VideoGame/ResidentEvil4'': Regenerators and Iron Maidens can only be killed by using a special scope on a rifle to aim at specific places were the Las Plagas parasites are inside their bodies.
* A few particularly powerful wizards in ''Videogame/{{Arcanum}}'' have the ability to summon a regenerative cocoon at the moment of death, healing their wounds and increasing their lifespans. The Vendigroth Device is a weapon which was specifically designed to combat this technique, and exploits [[MagicVersusScience the fragile balance between magic and science]] to invert the cocoon and make it rip the mage apart instead.
* The Serpent boss in ''Videogame/GoldenSunTheLostAge'' has a regeneration ability which lets it recover about 2/3rds of its max hitpoints at the end of every turn. However, the area above it has a series of light puzzles which, if completed, allow you to [[WeakenedByTheLight shine up to four beams of light onto it]], potentially cutting its healing to a measly 30hp/turn instead.
* ''VideoGame/WarcraftIII'':
** The expansion introduced several freely available healing items that restore health and/or mana over time (Scroll of Regeneration, Clarity Potion...) with the caveat that the effect ends as soon as the unit takes damage.
** Inverted with the Phoenix and Destroyer units, who have ''negative'' health and mana regeneration respectively. The Phoenix respawns every time it dies (unless its egg is destoryed), while the Destroyer has several spells that let it eat mana or status buffs to empower its attacks.

[[AC:Webcomic]]
* ''Webcomic/OnePunchMan'': Melzargard's head has a small marble-like brain which allows them to regenerate endlessly. If a marble is destroyed, the associated head melts instantly, and Melzargard dies once they're all destroyed. This is mitigated somewhat by the fact that he has multiple heads and can freely move his brains within his body. [[spoiler:However, his regeneration always begins with his heads, meaning that the brain can be easily found if his body is completely destroyed and forced to regenerate from scratch.]]
* ''TheOrderOfTheStick'': Belkar [[http://www.giantitp.com/comics/oots0326.html accidentally defeats a hydra]] by chopping off its heads until there isn't enough blood to supply all of them. A passing goblin notices the comatose hydra and sets up an enormously successful barbecue shack thanks to a never-ending supply of meat.

[[AC:WesternAnimation]]
* In ''WesternAnimation/StarVsTheForcesofEvil'', Queen Moon used black magic to neutralize Toffee's healing factor, making him unable to regenerate.
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