History DelicateAndSickly / AnimeAndManga

** Hikari (Kari) Yagami in ''Anime/DigimonAdventure'', younger sister of Taichi (Tai), who gets the IncurableCoughOfDeath during one episode. It's later stated that Hikari had not properly healed from a huge cold that left her bedridden and unable to join the kids who'd become the Digidestined in their fateful school trip. Said cold came back with a vengeance when they were in the Digital World, causing Hikari to fall down with a fever that was just as bad as back home -- only that in this particular SickEpisode, they had no ways to properly treat her, and for worse Machinedramon was tracking them. It triggered Taichi's bad memories of the incident in which, years ago, he accidentally caused Hikari to almost die of pneumonia. She seems to have grown out of this by the time of [[Anime/DigimonAdventure02 the sequel series]].

** Also, fellow student and revolutionary Kallen Stadtfeld/Kozuki uses the ''image'' of the Ill Girl to cover up her frequent absences from school so she can go play revolutionary. Maintaining the illusion limits her somewhat, but fortunately there's usually a distraction around to keep others from asking when she makes an unexpected display of physical prowess. Lampshaded in the 2nd picture drama, where Shirley [[SkinshipGrope grabs a naked Kallen from behind]] while they're bathing and comments on how Kallen is ''much'' stronger and athletic than she's supposed to be.

** ''Anime/DigimonDataSquad'' has Relena Norstein, which led to her older half-brother Touma joining sides with [[SmugSnake Kurata]] to get her "cured." This is a prime example of the writers not defining the disease: she's in a wheelchair, although she can walk short distances, and [[spoiler:[[DistantFinale Touma wins the Nobel Prize for curing her]],]] but it's incredibly vague otherwise.

* [[spoiler:The "Sleeping Knights" guild]] in ''Literature/SwordArtOnline'' [[spoiler:is made up entirely of terminally ill players logged into the game via a special medical device calls the "Medicuboid". Yuuki (mentioned above under "Female examples") suffers from AIDS, while another member, Siune, has leukemia]].

* In ''Manga/{{Gangsta}}'' the entire Twilight ''race'' is essentially compromised of Ill Boys and Ill Girls. All of them are born addicted to a PsychoSerum that they must take daily to prevent the withdrawal symptoms -- only for the drug to eventually accumulate in their systems, breaking down their bodies and killing them. The whole reason they're called Twilights is because the this effect makes it a damn miracle if any of them live to hit thirty.

* [[spoiler:The "Sleeping Knights" guild]] in ''Anime/SwordArtOnline'' [[spoiler:is made up entirely of terminally ill players logged into the game via a special medical device calls the "Medicuboid". Yuuki (mentioned above under "Female examples") suffers from AIDS, while another member, Siune, has leukemia.]]

* Shigeo "Mob" Kageyama of ''Manga/MobPsycho100'' has chronic anemia and frequently passes out from overexhertion despite his dilligent committment to the Body Improvement Club. While this is normally played for laughs, it also proves to be a DramaPreservingHandicap when [[spoiler:Toichiro initiates his plan to take over Seasoning City just after Salt Middle School's annual 5 km marathon and Mob, already exhausted and [[GameBreakingInjury injured]] from the run, passes out early into Claw's assault.]]

* ''Literature/FullMetalPanic'': Though it's never mentioned in the anime, Kurz Weber is stated to have joined Mithril in order to pay the hospital bills of a young girl who was critically injured in a mission he was involved in. [[spoiler:More exactly, during the assassination of the man responsible for the deaths of Kurz's parents. Kurz, who was supposed to take the shot, stopped when he realized that the poor girl would also be hit; his ColdSniper mentor, Wilhelm Casper, had fewer scruples and fired anyhow]].

* ''Literature/{{Moshidora}}'': Yuki Miyata's illness is not specified, aside of being a congenital one; her hospitalization requires her best friend Minami to take her place as the local CuteSportsClubManager. [[spoiler: Unfortunately, Yuki does NOT get better, and Minami suffers an HeroicBSOD when she dies.]]

* ''Literature/SwordArtOnline'': [[spoiler:Yuuki Konno contracted AIDS when she was born. By the time she was introduced in ''Mother's Rosario'', she was already blind, bedridden and on the verge of death in the real world.]]

* ''Literature/VenusToMamoru'': Parodied and played melodramatically. During the Valentine's Day episode, a contest is on to see who can give Mamoru chocolate in the most creative way possible. Shione orchestrates a "Last Leaf" situation with her brother claiming her lack of fashion sense is a disease affecting "one in six billion people" that will kill her. In the end, Shione "dies", but not before giving Mamoru her chocolate...[[AnimeHair shaped like her hairstyle]].

* Three male characters in ''Literature/{{Another}}'' have this. Our protagonist Kouichi Sakakibara has pneumothorax ([[http://en.wikipedia.org/wiki/Pneumothorax collapsed lung]]),[[spoiler:and he's hospitalized due to it for almost a month at the start of the story, making him miss his first day at [[NewTransferStudent his new school]] and thus missing several details about what will go on]]; Ikuo Takabayashi has [[HeartTrauma a heart condition]] [[spoiler:[[KilledOffForReal and it takes away his life]]]], and Daisuke Wakui is asthmatic.

* Suzu's best friend Seishuu in ''Literature/TheTwelveKingdoms'' got a head injury as a little child, in the same incident with monsters that got his mother killed. As a consequence, he sustained brain damage and suffers constant headaches. [[spoiler: He later [[HeroicRROD goes blind as a side-effect]], which gets him killed when [[LookBothWays he cannot see a carriage going towards him and gets hit point-blank]].]]

* In ''Literature/TheTwelveKingdoms'', the holy beasts named ''kirin'' choose [[FisherKing each of the rulers]] for the realms. If said king or queen doesn't do well and the land suffers, they get struck with a fatal illness named ''shitsudou'', manifesting itself via FacialMarkings and physical weakness that quickly kills them. Only the full redemption (which has never happened) or the RedemptionEqualsDeath ([[spoiler: Joukaku of Kei and Shishou of Sai]]) of the sovereign can save them from death. Kirins of ''both'' genders (Hourin, Kourin and Sairin are females; Keiki is male) have gotten it due to their masters's mistakes or madnesses: [[spoiler:Sairin and Keiki]] get better, [[spoiler: Hourin and Kourin]] do not.

** Also voiced by Creator/AiOrikasa as the previous example: [[ChildProdigy Hiroki Sawada]] of the NonSerialMovie ''Anime/CaseClosedThePhantomOfBakerStreet'' -- but [[InformedFlaw not at all related to the plot]]. [[spoiler: And that's not [[IntelligenceEqualsIsolation what kil]][[DrivenToSuicide led him]], either, but definitively adds to his WoobieDestroyerOfWorlds status.]]

** Subverted by Doc Q of the Blackbeard Pirates. He's not 'handsome', but he and Van Auger are the least {{Gonk}} of the crew. He's definitely sickly (along with [[TheAllegedSteed his horse]]) and often coughs blood, but this does not stop him from being an effective member of the crew, [[spoiler:especially since it's revealed he has the power of [[ThePlaguemaster Sick-Sick Fruit.]]]] He also had the highest bounty of the original crew, before they had gained their infamy.

* In the ''Anime/CowboyBebop'' episode "Waltz for Venus," Spike befriends a smuggler named Roco who is trying to earn enough money to pay for his blind sister Stella's eye operation. [[spoiler:It ends in tragedy as despite Spike's best efforts, Roco is fatally shot. Stella is healed, but the first person she sees is Spike, which clues her in to her brother's death]].

* ''LightNovel/FullMetalPanic'': Though it's never mentioned in the anime, Kurz Weber is stated to have joined Mithril in order to pay the hospital bills of a young girl who was critically injured in a mission he was involved in. [[spoiler:More exactly, during the assassination of the man responsible for the deaths of Kurz's parents. Kurz, who was supposed to take the shot, stopped when he realized that the poor girl would also be hit; his ColdSniper mentor, Wilhelm Casper, had fewer scruples and fired anyhow]].

* ''LightNovel/SwordArtOnline'': [[spoiler:Yuuki Konno contracted AIDS when she was born. By the time she was introduced in ''Mother's Rosario'', she was already blind, bedridden and on the verge of death in the real world.]]

* ''LightNovel/VenusToMamoru'': Parodied and played melodramatically. During the Valentine's Day episode, a contest is on to see who can give Mamoru chocolate in the most creative way possible. Shione orchestrates a "Last Leaf" situation with her brother claiming her lack of fashion sense is a disease affecting "one in six billion people" that will kill her. In the end, Shione "dies", but not before giving Mamoru her chocolate...[[AnimeHair shaped like her hairstyle]].
* ''Anime/WeissKreuz'':
** Fujimiya Aya fills this role for most of the story after she's hit by a car and ends up comatose, prompting her older brother Ran to become an assassin to pay her hospital bills -- and to actually assume her name in tribute. [[spoiler:She ultimately gets better.]]
** In one episode Ran encounters another Ill Girl, whose brother has entered a DeadlyGame to pay her medical bills.

** Otohime Mutsumi has a severe case of anemia and passes out almost everywhere. During her CrashIntoHello with Keitaro, she fell over, with BlankWhiteEyes ''and'' BloodFromTheMouth. Keitaro checks for a pulse...and there isn't one. Cue FreakOut. She got better, but it seems her fainting spells are closer to actually dying then "normal" fainting.
** Naru ''used'' to be an Ill Girl as a child. She has asthma, and while she's mostly fine in teenage/adult years, in her childhood her attacks were much more serious. [[spoiler: Several years ago, Naru's parents sent her to Hinata Sou hoping that she'd recover due to the zone's benign climate, but she was very lonely and depressed. That was the time when she befriended two older kids, Keitarou and Mutsumi, and the three made ThePromise.]]

** Kanata, Konata's mother and Soujiro's wife, was apparently sickly in life and died early on of an unknown illness. That, and the couple being {{childhood friend}}s and Kanata being [[OlderThanTheyLook older than she looked]], makes [[OtakuSurrogate Konata]] remark that her parents' relationship sounds like a DatingSim plot.

** Nami falls ill after [[EverythingsBetterWithDinosaurs Little Garden]], when she's bitten by a prehistoric bug. As a consequence, she gets a dangerously high fever and [[SickEpisode the journey to Alabasta must be put on hold as they find a doctor]]. Though that meant Luffy and Sanji must take her up a freezing cold DeathMountain, Nami is cured just in time: according to Dr. Kureha and Chopper, three days later she'd be dead.

** Luna's sort-of temporary love interest in the movie (and in a side-story of the [[Manga/SailorMoon manga]]) was an ill boy HotScientist named Kakeru Ohzora. The MacGuffin of the movie (a crystal belonging to the BigBad, Princess Kaguya), which is in his possession, saps his LifeEnergy away as the movie passes -- he starts relatively healthy, then starts to cough and later is weakened and bedridden. [[spoiler: He gets better]]

* August Riefenstahl in ''LightNovel/EndoAndKobayashiLiveTheLatestOnTsundereVillainessLieselotte''. He's quite old compared to this trope's norm--he died at 24 and it was the last year of his life that is plot relevant. He's always been in frail health, but the fact that his younger brother Bruno has an ({{Inverted|trope}} case of) BigBrotherInstinct on him implies he is indeed considered delicate in-universe.

* In ''LightNovel/AscendanceOfABookworm'', Myne is a peasant girl who looks [[OlderThanTheyLook younger than her actual age]] due to constantly getting sick. She has no stamina, little strength and is highly prone to fevers. As such she typically needs to get other people to do physical labor for her to actually make things and, even setting that aside, is subject to a mysterious fever that could easily kill her the moment she lets her guard down.

** Elena is the daughter of the orangizer of the Fireball Race and has a weak heart since birth. During the race, she catches a fever while navigating with Hayato and as her fever worsens, he calls in HSR-III to take her to the hospital. She gets better at the end of the episode.

** Yuki suffered from respiratory issues when he was younger, which Hattori still keeps an eye on.

** [[spoiler:Akito is another example - she suffers from an unclear illness, implied to be the one that killed her father, though it could also be psychosomatic). She's also the feared leader of the Sohma clan and an ''incredibly'' abusive person who is responsible for much of her family's dysfunction]].

** Clara suffered from a temporary but plot-important illness [[spoiler:that has her brother rat out Jeudi and Lundi [[HealthcareMotivation to get enough money for her medicines]]).

** Trafalgar Law was gravely ill for most of his childhood, due to the Amber Lead Syndrome (a illness similar to asbestos that killed Law's family and people due to the World Government's negligence). Law was the SoleSurvivor of his homeland and was so broken by it that he became a CreepyChild, whose only wish was to kill as many people as possible before dying. Doquixote Doflamingo took Law in and, in EvilMentor style, raised him as a killer -- but Doflamingo's younger brother Rocinante took pity on Law and traveled all over to find him his cure, despite Law trying to kill him when they met. He succeeded and got Law to eat the Ope-Ope Fruit, which saved his life... [[spoiler: but wasn't fast enough to save ''his'' own life, and died at the hand of his cruel older brother (who not only wanted the Ope-Ope Fruit for his own gain, but was ''already'' pissed off after finding out that Rocinante was TheMole for the Marines). This was terrible for the now healthy Law, who had grown to love [[BigBrotherMentor Rocinante]] like an older brother/father-figure, and ultimately gave him his biggest purpose in life: to become a pirate '''and kill Doflamingo'''. He and Luffy don't get to kill him -- but they '''''do''''' dismantle his evil empire, reveal his deals to the world, and defeat him in a massive fight that ends in him being imprisoned at Impel Down, which may count as a FateWorseThanDeath.]]

** ''Manga/JoJosBizarreAdventureJoJolion'' has Holly's AlternateUniverse counterpart, Holly Joestar-Kira. A former opthamologist (i.e. an eye doctor), she ironically ends up hospitalized for what is seemingly an AmbiguousDisorder, which included loss of memory and other eccentric behavior, like mistaking a nurse for a pair of boots. The truth turns out to be ''far'' more complicated: [[spoiler: She's a a first-born daughter of a branch of the Higashikata family via her ancestor, Rina Higashikata. Unlike sons, who get symptoms at age 10, daughters begin displaying symptoms of the mysterious stone disease later in life. Holly's son, Yoshikage Kira, began noticing her memory loss and other symptoms, and presumably excised parts of her brain and other organs that began to turn to stone with his Stand, Killer Queen, as she doesn't have any external scarring. For a proper cure, Kira sought out the Locacaca from the Rock Humans with Josefumi's help, thus spurring the entire plot of ''JoJolion'' due to the result of the heist. Later on, however, it's revealed that she was actually experimented on by the Locacaca Research Group with Locacacas, which may be the real cause of her illness, rather than the Higashikata Family's Rock Disease]].

** Hikari (Kari) Yagami in ''Anime/DigimonAdventure'', younger sister of Taichi (Tai), who gets the IncurableCoughOfDeath during one episode. It's later stated that Hikari had not properly healed from a huge cold that left her bedridden and unable to join the kids who'd become the Digidestined in their fateful school trip. Said cold came back with a vengeance when they were in the Digital World, causing Hikari to fall down with a fever that was just as bad as back home -- only that in this particular SickEpisode, they had no ways to properly treat her, and for worse Machinedramon was tracking them. It triggered Taichi's bad memories of the incident in which, years ago, he accidentally caused Hikari to almost die of pneumonia.

* ''Anime/CombattlerV'': [[spoiler:Chizuru Nanbara's illness is explained as a malformed heart valve, and it kicks in at a critical moment [[HeroicRROD during battle. While it keeps her away from action for a while, she's successfully operated on and returns to the battlefield.]]

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** ''Manga/FushigiYuugiGenbuKaiden'' has Takiko Okuda ''and'' her MissingMom, Yoshie. Takiko caught tuberculosis from the deceased Yoshie while tending to her in her own world. She insists it's just a cold, as her father makes plans to take her back to Tokyo for medical treatment.

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* Megumi aka Megu, Suigintou's medium and MoralityPet from ''Manga/RozenMaiden''. She has extremely low self-esteem as a result, and Suigintou sorta empathizes with her.

* Toki Onjouji and Yuu Matsumi from ''Manga/SakiAchigaHen''. The former has a tendency to faint at any given moment, and the latter gets chilled very easily to the point where she has to wear a cardigan, mittens, and a muffler even ''during the summer''.
* Though no one takes her seriously, Mokuzu Umino of ''Manga/SatouKashiNoDanganWaUchinukenai'' claims that her painful limp and clumsiness were caused by a witches spell that turned her into a human with an imperfect pair of legs. She says this same spell will turn her into sea foam in one months time if she does not fulfill her wish of finding a "precious friend." She also must drink copious amounts of water before speaking or exerting herself in any way. [[spoiler: It turns out Mokuzu's been abused by her father Masachika for years: her limp is due to a hip injury received as a baby, and to top if off she is deaf in one ear due to her dad's beatings as well. And even worse, she is later ''[[OffingTheOffspring beaten to death]]'' by him.]]
* Chiho, Uzume's Ashikabi from ''Manga/{{Sekirei}}'' has a mysterious unnamed illness that keeps her hospitalized. It later becomes a pivotal plot point towards the middle of the second season (Pure Engagement).
* Asa Shigure from ''VisualNovel/{{Shuffle}}'' suffers a mysterious illness that often leaves her bedridden, and starts becoming worse as time passes. [[spoiler: It's not an illness, but PowerIncontinence: her weak half-demon body cannot handle the strong magic inherited from her mother, the demon Ama, but Asa utterly refuses to use said power because Ama suffered ''horribly'' due to them, thus Asa doesn't want her mother to be sad. Rin has to [[TakeAThirdOption take a VERY risky third option]] to force her release said energy, and almost dies for it.]]
* [[spoiler:Sora]] from ''Manga/SomedaysDreamersIISora'' seems to be mostly in good health, having little trouble with physical exercise or performing straining magical rituals -- until she suddenly appears to have been suffering from a terminal heart condition for a while already, leading to a severe {{mood whiplash}} in the series.

* [[spoiler: Yuuki Konno]] from ''LightNovel/SwordArtOnline''. [[spoiler:She contracted AIDS when she was born. By the time she was introduced in ''Mother's Rosario'', she was already blind, bedridden and on the verge of death in the real world.]]
* ''Very'' cruel version: [[spoiler:Miyuki Aiba/Shana Carter aka Tekkaman Rapier/Teknoman Shana]] from ''Anime/TekkamanBlade''. [[spoiler:She's actually a Tekkaman whose transformation process was incomplete, therefore she suffered horrible pains and her lifespan was dramatically shortened... therefore, she chose to go down fighting and perform an HeroicSacrifice than die of her illness.]]
* Haruna from ''[[Anime/TenchiMuyo Tenchi Forever!]]'' is this. After fleeing with her lover, [[spoiler:Yosho/Katsuhiko]], she became ill during their trip. [[spoiler:She died]] before the couple arrived on Earth.
* Kosumo Koganehara from Creator/MichiyoAkaishi's ''Manga/TowaKamoShirenai'' was born with a [[HeartTrauma a weak heart]], and in fact the manga starts when she has a seizure during her treatment in the USA and needs an urgent transplant, but her extremely rare blood type doesn't allow for an easy one. The donor that saves her life just ''happens'' to be Himiko, a {{Miko}} and MagicalGirlWarrior who has just died via an HeroicSacrifice to save a child, so Kosumo inherits her powers alongside her heart and blood and must take up her demon slaying mission -- with the help of Himiko's TallDarkAndHandsome guardian, Hitsuji.
** And later there is another: [[spoiler: the 98th Himiko, the one who came before the aforementioned Himiko we know. She was a fellow {{Miko}} who died of cancer when the 99th Himiko was 10-years-old, which wasn't helped by her already suffering of a years-long depression and being separated from her bodyguard and lover Hishou.]]
* Subverted quite cruelly with Aiko from the ''Manga/VampirePrincessMiyu'' OAV, who was thought to be in a ConvenientComa due to either illness or DemonicPossession, but Himiko later discovered that [[spoiler: she summoned the main Shinma in despair after blaming herself for her parent's deaths, having survived the accident that caused their demises. Ever since then, she lays on her old futon located in her her decadent BigFancyHouse and simply... sleeps, while the Shinma wreaks havoc around. She only wakes up when Himiko confronts the Shinma, but Miyu stops her when she's about to drink Himiko's blood, and once the Shinma is defeated Aiko dies.]]
* In the ''Miyu'' SpinOff series of sorts ''Vampire Princess Yui'', this is also subverted. It's believed that Yui is an Ill Girl with severe anemia, but the truth is that her Guardian powers have just awakened and, since she had no real idea of what was going on, she lacked of the blood "meals" she needed. (It's not helped by how Yui at first refuses to drink blood from humans if she can help it, so her BattleButler Nagi gives her his blood instead.)
* Parodied and played melodramatically in ''LightNovel/VenusToMamoru''. During the Valentine's Day episode, a contest is on to see who can give Mamoru chocolate in the most creative way possible. Shione orchestrates a "Last Leaf" situation with her brother claiming her lack of fashion sense is a disease affecting "one in six billion people" that will kill her. In the end, Shione "dies", but not before giving Mamoru her chocolate...[[AnimeHair shaped like her hairstyle]].
* Fujimiya Aya fills this role for most of ''Anime/WeissKreuz'' after she's hit by a car and ends up comatose, prompting her older brother Ran to become an assassin to pay her hospital bills -- and to actually assume her name in tribute. [[spoiler:She ultimately gets better.]]

* Kotori Monou from ''Manga/{{X 1999}}'' has a serious heart condition. One of her older brother Fuuma's first scenes in the manga has him reading out loud a list with the remedies that Kotori has to take that day.

* [[spoiler:Zeno's wife]] Kaya in ''Manga/YonaOfTheDawn''. She had the IncurableCoughOfDeath, and voluntarily quarantined herself so that she wouldn't infect others.

* Shizuka Kawai (a.k.a. Serenity Wheeler) from ''Franchise/YuGiOh'' prior to her operation. (In the [[Anime/YuGiOhFirstAnimeSeries first anime series]], she has an unspecified disease, but in the [[Manga/YuGiOh manga]] and [[Anime/YuGiOh second anime series]], she's going blind.)
** It turns out that [[spoiler: Pegasus]]'s FreudianExcuse was centered around one of these: [[spoiler: his deceased fiancée and VictoriousChildhoodFriend Cecilia, who died of illness few before their wedding.]]
* One of these, Madoka [[spoiler: Shibuya]], is rather important in the BackStory of ''Manga/{{Zetsuai 1989}}''. [[spoiler: Madoka was both a Kouji fangirl and the already fatally ill daughter of the president of Kouji's record company, and he had a PetTheDog moment by visiting her before she kicked it. Her older brother Katsumi decided to [[BecauseYouWereNiceToMe repay Kouji's kind action]] by becoming his manager.]]

* [[spoiler: Jintan Yadomi's MissingMom Touko]] in ''[[Anime/AnoHanaTheFlowerWeSawThatDay Ano Hana]]''. [[spoiler: Touko actually died a while before Menma did... and ThePromise that Menma made with her (making Jintan cry and show emotions) is Menma's forgotten [[GhostlyGoals Ghostly Goal]].]]

* Kozue Ayuhara from the old-school anime ''Manga/AttackNumberOne'' is ill and has to quit sports awhile and move where she can rest because of it, until she comes back and joins the volleyball team.
* The third season of ''Anime/BakutenShootBeyblade'' has Monica, the younger sister of Moses. Her illness is never named but is quite serious as she needs a pricey operation badly. Moses became a blader at BEGA [[HealthcareMotivation specifically to help pay for it]].

* ''Manga/BlackJack'': The title character had ''five'' patients of this type in the new anime series:
** Pinoko, his adopted daughter assistant. [[spoiler:She was originally a [[BodyHorror sentient tumor in the body of a young girl]], whom he extirped and gave a doll-like body out of pity since he found out that she strongly wished to live, just like Black Jack wanted to after the accident that killed his mother and left him paralyzed for years. Pinoko's sister had a FreakOut and disowned her, so Black Jack took the kid around as his adoptive daughter and assistant.]];

** Megumi Kisaragi, a female doctor whom Black Jack fancied, but had advanced ovarian cancer. [[spoiler: After having her affected inner organs removed, she changed her name to Kei and left, living her life as a male, despite not being outright said if she went through a sex change or not]].

* {{Deconstructed}} in a ''Manga/CaseClosed'' case: Our Villain of the Week had a bad heart, but it was she who killed the loanshark who [[DrivenToSuicide drove her boyfriend to suicide]] over the money for "that operation" (see FingerLickingPoison for the murder itself). God, is she a bitchy ''chain smoker''. In her confession, she mentions that her boyfriend was her MoralityPet and the only one who ever loved her after her parent's deaths. Be careful when threatening an Ill Girl's loved ones: if she gets better, she'll kill you!
** The other moral: in RealLife, [[{{deconstruction}} being chronically sick can make a person]] [[BrokenBird pretty bitchy]].

** A plot point in a later case. [[spoiler:A lady named Hatsune Kamon had a congenital illness named [[http://en.wikipedia.org/wiki/Turner_Syndrome Turner Syndrome]], which only appears in women since it's associated to X chromosomes. It made her look ''extremely'' different from her [[HalfIdenticalTwin half-identical]] [[LongLostSibling long-separated]] twin brother Raita Banba... [[TwinCest the guy]] [[SurpriseIncest she was going to marry]]. Alongside '''several''' other factors, [[DespairEventHorizon this totally broke poor Hatsune's heart and mind]] once she found out, and she ultimately was DrivenToSuicide. [[FromBadToWorse And for even worse]], Raita was mistakenly accused of killing her, and Conan/Kogoro had to work hard to get him free.]]

* In ''Manga/ChibiMarukochan'', Koharu-chan, the intelligent Nagayama-kun's little sister, in most episodes is sick either at home or in the hospital. Koharu-chan is worried that she might have to repeat a year of school and be left behind by her classmates. Nagayama-kun and his classmates try to cheer her up. Maruko-chan drew an animation for her to enjoy.
* Chopin in ''Manga/Classi9'' is a male example. He is sick so often Liszt knows exactly what to do when someone else gets sick and the cast uses his personal pharmacy when Ren gets a cold. His weak constitution isn't helped by his PerformanceAnxiety and he already passed out on stage before chapter 7, which takes a toll on his health. TruthInTelevision as the real life Chopin's cause of death is still debatable because ther are doubts on which illness finally killed him, he was also sick a major part of his life and did prefer small and cozy venues to big concerts.
* ''Anime/CodeGeass'': Nunnally Lamperouge/vi Britannia, the younger sister of the main character, is both blind and contained in a wheelchair after she witnessed and barely survived their mother's brutal murder. He promises her that by the time she gets well, the world will be a better place. He never mentions ''how'' -- to him, [[WellIntentionedExtremist it doesn't matter how many people have to die or be manipulated]] to destroy the TheEmpire. Further, [[spoiler:she didn't actually see it, having been a false witness due to a memory-altering Geass. Also, she gets better with time: in the series, she stays in a wheelchair but regains her sight ''and'' becomes the Empress of Britannia, and in the ''[[Manga/CodeGeassNightmareOfNunnally Nightmare of Nunnally]]'' manga she heals completely and stays under the wing of Empress Euphemia Li Britannia.]]

* [[spoiler: Chizuru Nanbara]] from ''Anime/CombattlerV''. Her illness is explained [[spoiler: (malformed heart valve)]], it kicks in at a critical moment [[spoiler: ([[HeroicRROD during battle!]])]], and [[spoiler: while it keeps her away from action for a while, she's successfully operated on and returns to the battlefield.]]
* In the ''Anime/CowboyBebop'' episode "Waltz for Venus," Spike befriends a smuggler named Roco who is trying to earn enough money to pay for his blind sister Stella's eye operation. [[TearJerker It ends in tragedy.]]
* Subverted quite quickly in ''Manga/TheDaughterOfTwentyFaces'', in that the "ill girl" is in fact the main character who recovers quite quickly when taken away from the source of her "illness" by the eponymous GentlemanThief Twenty-Faces.

* Tsubaki Kakyouin aka "Tsubaki-hime" and [[spoiler:Muraki's fiancée]] Ukyou Sakuraiji, both from ''Manga/DescendantsOfDarkness''. We have next to none clues on Ukyou but we know that Tsubaki has an extremely weak heart, [[spoiler: which led Muraki and other people to kidnap her OnlyFriend Eileen and then kill her to harvest her heart. When poor Tsubaki learns about this, [[MindRape she]] [[SplitPersonalityTakeover does not]] [[RoaringRampageOfRevenge take]] [[ICannotSelfTerminate it]] [[KillTheCutie well]].]]
* Hikari (Kari) Yagami in ''Anime/DigimonAdventure'', younger sister of Taichi (Tai), who gets the IncurableCoughOfDeath during one episode. It's later stated that Hikari had not properly healed from a huge cold that left her bedridden and unable to join the kids who'd become the Digidestined in their fateful school trip. Said cold came back with a vengeance when they were in the Digital World, causing Hikari to fall down with a fever that was just as bad as back home -- only that in this particular SickEpisode, they had no ways to properly treat her, and for worse Machinedramon was tracking them. It triggered Taichi's bad memories of the incident in which, years ago, he accidentally caused Hikari to almost die of pneumonia.
** Relena Norstein from ''Anime/DigimonDataSquad'', which led to her older half-brother Touma joining sides with [[SmugSnake Kurata]] to get her "cured." This is a prime example of the writers not defining the disease: she's in a wheelchair, although she can walk short distances, and [[spoiler:[[DistantFinale Touma wins the Nobel Prize for curing her]],]] but it's incredibly vague otherwise.

* [[spoiler:Anemone]] from ''Anime/EurekaSeven''. [[spoiler: This DarkActionGirl has to ''live'' drugged to get away with the process she underwent to become Coralian-like, which causes her horrible side-effects like headaches, {{psychic nosebleed}}s and wild mental unstability. The doctor even says her resistance to the drugs was her greatest value.]] [[JerkassWoobie OUCH!]]

* Hyatt in ''Manga/ExcelSaga'' is a particularly over-the-top parody of this, as she tries to go about her duties as an agent of [=ACROSS=] despite her tendencies to [[DeathByFallingOver collapse]], cough up contaminated blood (which kills small birds and sickens humans), faint, or even drop dead and then spontaneously come back to life. She ''always'' comes back to life, once even being charred to a decent crisp only to sit up later, as if nothing had happened. This appears to be an empathetic illness, at least in the manga. For several volumes Hyatt went some time without her usual blood and death routine, but the revelation that the competent Excel was an impostor brought it back.
* In ''Anime/FafnerInTheAzureDeadAggressor'' Shouko Kazama is the ultimate Ill Girl who suffers from some incapacitating disease that makes her a recluse of sorts. The trope is subverted though since [[spoiler:her death is not caused by her illness, instead Shouko sacrifices herself for the sake of the island in a grand HeroicSacrifice]].
* [[spoiler: Ultear Milkovich]] from ''Manga/FairyTail'' was this in the past. [[spoiler: Then she fell in the hands of a bunch of {{Mad Scientist}}s whom her mother asked for help, not knowing about their intentions; they ''did'' heal the little girl, but they told Ur that she had died and ''then'' told their ex-patient that her mother had abandoned her... just so they could make the desperate Ultear their DarkActionGirl TykeBomb.]]
** [[spoiler: Layla Heartfilia]] had been born with frail health and it contributed to her death when she had to use her own life energy to open the [[spoiler:Eclipse Gate]].

** Rin (stomach ulcers [[spoiler: coming from her BrokenBird personality and the stress of her [[AbusiveParents horrible former home life]] ]]) and [[spoiler: Akito (unclear illness; maybe the same sickness that killed her father, or maybe psychosomatic)]]. Even though they're sick, they both scare the living crap out of people: Rin because she's headstrong and harsh, [[spoiler: Akito because she's the feared leader of the Sohma clan.]]
* Subverted with Izumi Curtis from ''Manga/FullMetalAlchemist'': a [[EeriePaleSkinnedBrunette pale]], slender, [[SexyMentor attractive]] IronWoobie with frequent attacks of BloodFromTheMouth [[spoiler: as a result of having tried human transmutation to bring back her stillborn child, and losing her inner organs to The Truth as a result.]]. It's sometimes PlayedForLaughs when she coughs up blood on someone who upsets her, she can kick that someone's ass, {{bears|AreBadNews}}' asses, and her [[HugeGuyTinyGirl gigantic]] [[BigBeautifulMan husband]]'s ass, and it generally need not be said that no one [[DontYouDarePityMe should just pity her]], because she's so fierce. Also, [[spoiler: she gets better... though only in the manga and the ''Brotherhood'' series, as in the first anime she passes away in between the events of the GrandFinale and TheMovie.]]
* Though it's never mentioned in the anime, Kurz Weber of ''LightNovel/FullMetalPanic'' is stated to have joined Mithril in order to pay the hospital bills of a young girl who was critically injured in a mission he was involved in. [[spoiler:More exactly, during the assassination of the man responsible for the deaths of Kurz's parents. Kurz, who was supposed to take the shot, stopped when he realized that the poor girl would also be hit; his ColdSniper mentor, Wilhelm Casper, had fewer scruples and fired anyhow]].
* Mitsuki Koyama from ''Manga/FullMoon'' has a [[LittlestCancerPatient cancerous tumor]] that prevents her from singing, and gives her exactly one year left to live. When she transforms into "Full Moon", she temporarily loses this tumor, and gains an amazing singing voice.
** Notably Mitsuki's mother and grandmother were both ill girls in the manga. Fuzuki(the grandmother)was shown to be very sickly in her youth though she apparently to grew out of it. Hazuki(the mother) is implied to be an ill girl in a flashback when it is stated by Fuzuki that she isn't healthy enough to have a baby after Hazuki announces her pregnancy.
* Takiko Okuda ''and'' her MissingMom Yoshie from ''Manga/FushigiYuugiGenbuKaiden''. Takiko caught tuberculosis from the deceased Yoshie while tending to her in her own world. She insists it's just a cold, as her father makes plans to take her back to Tokyo for medical treatment.
** Then we have [[spoiler: Mitsukake's girlfriend Shouka]] from [[Manga/FushigiYuugi the original series]], who actually [[spoiler: ''did'' die. And then CameBackWrong.]]

* An episode of ''Anime/GalaxyAngel'' has an ill Mint in a hospital while watching the leaves on a tree -- she hopes to live long enough to watch a leaf fall off -- and it promptly does, at which point she notes she was referring to ''another'' leaf, which also falls off. As she tries to refer to a ''third'' leaf, ''all'' the leaves are blown off by a strong wind. Another character, Chitose, is an obvious parody, claiming to have been confined to a hospital most of her life. More likely it's another product of her attention whoring; she was enough of a [[TheScrappy Scrappy]] in [[VideoGame/GalaxyAngel the game]] that even the anime writers didn't like her, and her personality was exaggerated to that of a {{wangst}}y histrionic (although to be fair, everyone else was exaggerated too).
* Veronica from ''Manga/{{Gangsta}}'', the mysterious Twilight woman that once resided at Benriya with protagonists Nicolas and Worick. It appears she overdosed on the Cereber drug and became terminally ill, at one point while visiting a brothel Alex sees (through a partly closed door) Nic possibly tending to Veronica on her sickbed. Whoever she is or whether she’s still alive, Nic appears to have had a close relationship with Veronica and flashes back to her sometimes when interacting with his new LoveInterest Alex.
* In the second season of ''Manga/GetBackers'', one of Ban and Ginji's missions is to get a very rare type of blood ([[http://en.wikipedia.org/wiki/Bombay_blood named the "Bombay Blood"]]) for an Ill Girl named Yumiko, who needs an urgent transfusion or she'll die in few days. It turns out that Akabane has a dose of it and they have to fight him and his partner Maguruma. [[spoiler: It's also revealed that Ginji [[TheLostLenore had an Ill Girl friend]] in the Infinite Fortress days and she died due to lack of treatment, so he's [[MyGreatestFailure determined to not fail again]] for Yumiko's sake]]. They get the Bombay Blood, and Yumiko is saved.
* There are several in the ''Franchise/{{Gundam}}'' meta-series.

* [[spoiler:Countess Larissa Mikhailovna]] from ''Manga/HaikaraSanGaTooru'' has tuberculosis and because of that, [[YourDaysAreNumbered she has a very shortened lifespan]]. [[spoiler:In a subversion, she didn't die from the disease, but from a FallingChandelierOfDoom while making a DivingSave to save Shinobu.]]
* Three of these show up in ''Anime/HanaNoKoLunlun'':

** Lucero, the little girl from the OrphanageOfLove in the Italy arc, who's blind. Her friends decide to search for an old treasure buried near the orphanage to sell it and get the money for the orperation. [[spoiler: The treasure is actually an old bomb.]]

* TheMovie of ''Anime/HappinessChargePrettyCure'' has [[spoiler:a wheelchair-bound character, Tsumugi-chan, who was a ballet student before something happened that paralyzed her]].
* Inori's older sister Seri in ''VideoGame/HarukanaruTokiNoNakaDe''; Inori even has the BigBrotherInstinct towards her because of this, despite him actually being younger. A flashback in the ''Hachiyou Shou'' TV anime reveals that this is part of the reason Seri got close with Iktidar, who saved her when she was threatened by several men while helpless from her condition. [[spoiler:Somehow, being an Ill Girl didn't stop Seri from having Ikutidaru's baby.]]
* Three show up in ''Manga/HonooNoAlpenRose'': Clara (temporary but plot-important illness [[spoiler: that has her brother rat out Jeudi and Lundi [[HealthcareMotivation to get enough money for her medicines]] ]]), Marie ([[spoiler: confined to a wheelchair, but starts to walk after befriending Lundi]], and specially [[spoiler: Jeudi's MissingMom Helene (weak heart and almost total blindness after the accident that separated her from Jeudi.)]]
** It's horribly subverted in the case of the third, too: [[spoiler: the villain Toulonchamp and his [[DaddysLittleVillain daughter]] Mathilda ''have been slowly poisoning her for years'' so they force her parents to collaborate in their schemes.]]
* Kiku from ''Manga/IdatenJump'', also [[spoiler: [[{{Ninja}} Kouhei]]'s little sister]] and the local YamatoNadeshiko. [[spoiler: Her illness turns out to be a consequence of the disbalance between the X Zone and Earth, and once it's fixed she starts to get better.]]
* Subverted in ''Manga/IkkiTousen'': [[spoiler:Ryoufou Housen]] is dying of an undisclosed illness, but she's still a fearsome DarkActionGirl [[spoiler:and actually goes down fighting. In the anime, she [[DeathIsCheap gets]] [[BackFromTheDead better later]], though that also included some LaserGuidedAmnesia... ''and dying again'' in the end.]]
* Subversion, possible parody: Kagome's never-ending parade of fake illnesses in ''Manga/InuYasha'' [[HilarityEnsues causes much sympathy and embarrassment.]]

* ''Manga/JoJosBizarreAdventure'': Jotaro's mother Holly, if "PowerIncontinence activated by the BigBad's resurgence" counts as an disease.
* Anju Marker from ''Manga/{{Karin}}'' is ''believed'' to be this. [[OurVampiresAreDifferent That's far from the truth, obviously.]]
* [[YamatoNadeshiko Kikuri Tanima]] from ''VideoGame/TheKingOfFighters'' ''The Sun and the Moon ~ Prologue'' RadioDrama is the sister of [[AntiHero Iori Yagami's]] bandmate [[MsFanservice Konoe]], and she suffers more than one seizure during the drama -- one of these lands her in the hospital. [[spoiler: And she does NOT get better... in fact the CD drama is a WholeEpisodeFlashback, and Kikuri has already been dead ''for at least five years''.]]
* Lynn's half-sister Sarah Russell from ''Manga/{{Lady}}'' has always had a very frail health. She has to be homeschooled since she often spends her days feverish in bed, and once in a while passes out if she's too stressed. All of this messes up badly with her self-esteem, and at first she's rather mean to Lynn out of fear that, since Lynn is TheCutie, everyone else will like her better.
* Otohime Mutsumi from ''Manga/LoveHina'', who has a severe case of anemia and passes out almost everywhere. During her CrashIntoHello with Keitaro, she fell over, with BlankWhiteEyes ''and'' BloodFromTheMouth. Keitaro checks for a pulse...and there isn't one. Cue FreakOut. She got better, but it seems her fainting spells are closer to actually dying then "normal" fainting.

* Parodied in ''Anime/MagicalProjectS'', where one of the [[MonsterOfTheWeek Love-love Monsters]] is called "fake sick girl", who even gives the speech about not seeing the last leaf fall from a tree. When the person talking with her mentions that the tree is quite full and healthy, she blows it up with a cannon hidden in her bed.
* Anju Kitahara in the anime version of ''Manga/MarmaladeBoy''. She has [[HeartTrauma a weak heart]] and might not live for long if she doesn't go through a ''very'' dangerous operation in the USA, but [[PluckyGirl she attempts to remain cheerful]] and befriends her beloved Yuu's girlfriend Miki, telling her [[IWantMyBelovedToBeHappy that she won't break them up]] and is as happy as she can with being Yuu's UnluckyChildhoodFriend. [[spoiler:She's operated and gets better, and when Yuu breaks up with Miki she has a small chance to get Yuu for herself, but ultimately she (and Miki's other love interest Kei) give up when they get back together.]]
* ''Manga/MermaidMelodyPichiPichiPitch'' has Michal Amagi, a Tomoe Hotaru-esque figure that also happens to be Lucia's [[ClingyJealousGirl romantic rival]] and the little sister of one of the villains. [[spoiler: It's a wonder she survives, really.]]
* Chiyuki from ''Manga/MillenniumSnow'' has a heart condition and isn't expected to live for too long. Then, she becomes the blood source of the local vampire Tooya, which extends her lifespan to match his own.
* Yuki Miyata from ''Literature/{{Moshidora}}''. Her illness is not specified, aside of being a congenital one; her hospitalization requires her best friend Minami to take her place as the local CuteSportsClubManager. [[spoiler: Unfortunately, Yuki does NOT get better, and Minami suffers an HeroicBSOD when she dies.]]
* Leonora Fenton in ''Anime/MyDaddyLongLegs'' seems to have classic symptoms of tuberculosis of the lungs. It's actually a heart condition [[spoiler: that gets corrected by surgery]].
* ''Manga/NegimaMagisterNegiMagi'' has [[TheWoobie Ako Izumi]] briefly filling the role after she catches some sort of disease upon arriving in Magicus Mundus. It varies a little bit in that she gets the cure early on, but it's so expensive that it forces her and two of her friends (Natsumi Murakami and Akira Ookochi) to sell themselves into slavery. This in turn leads to Negi having to enter a tournament to win the money to buy their freedom.
* Toji Suzuhara's off camera sister in ''Anime/NeonGenesisEvangelion'': After the injuries she suffers among the civilians caught in the middle of the fight in the first two episodes, Toji is eventually recruited as the pilot of Unit 03 in exchange for her being transferred to NERV's medical facilities. However, [[spoiler:Toji himself is severely crippled when an Angel takes over his Eva.]]
** In ''Anime/{{Rebuild|OfEvangelion}}'', we get to see Toji doting on his little sister as she finally gets out of the hospital, [[spoiler: and Asuka ends up piloting Unit 03 in his place.]]

** Rocinante and Doflamingo's mother had a bad health, which got even worse after the patriarch of the Doquixote family [[DefectorFromDecadence left the World Nobles to live among the populace]] [[RichesToRags and they lost everything]]. She ultimately died of her illness, [[EvenBadMenLoveTheirMamas which Doflamingo]] blamed on their father and, among other things, led him [[SelfMadeOrphan to kill]] [[PatriCide him]].
** [[AntiVillain Senor Pink's]] wife Russian became a catatonic EmptyShell after a brutal BreakTheCutie process that included [[OutlivingOnesOffspring the death of their baby son Gimlet]], her finding out her husband wasn't a traveling businessman but a pirate (aka the type of people she despised the most), ''and'' suffering brain damage after being caught in a landslide. She could only smile when Pink dressed up like a baby, and in the present she's strongly implied to have died of a broken heart and her bad health.

* [[spoiler: Tamaki's French MissingMom, Anne-Sophie Grantaine]] in ''Manga/OuranHighSchoolHostClub''. More exactly, [[spoiler: she has lupus]].
* Himari Takakura from ''Anime/{{Penguindrum}}''. Her illness isn't exactly clear, but it seems to be due to a weak heart. In fact, the plot is kickstarted when [[FirstEpisodeResurrection she dies and is revived in the first episode]]. [[spoiler: And it won't be the first time she kicks it.]]
* Someone subverted in ''Manga/{{Planetes}}'', where during a hospital stay Hachimaki meets a girl who he believes to be chronically ill, but does not want to be rude by asking. In reality, she is a child who was born on the moon, and is staying in the hospital to provide medical information to scientists and doctors.
* [[spoiler: Homura Akemi]] from ''Anime/PuellaMagiMadokaMagica'', before meeting Madoka and her friends, was this. She spent most of her life in the local hospital due to [[HeartTrauma a severe heart illness.]] It's not specified how she got rid of it, but most likely did it with [[spoiler:her MagicalGirl powers]]. This is also the basis of her attitude towards [[spoiler:Madoka]], as her social isolation and orphanhood means the latter is the first and {{only friend}} she could made for the past ''14 years''.

*** According to WordOfGod, [[spoiler:Nagisa's mother turned out to be this, as she was dying, and Nagisa's wish was to share a cheesecake with her mother before she died. Whether or not Nagisa was also ill has not been specified]].

** [[CuteClumsyGirl Eisuke Hondou]]'s important [[{{Backstory}} backstories]] were all when he was hospitalized; first due to leukuemia and then due to accident. In the first case, he was saved due to his older sister's marrow donation, [[spoiler: which changed his blood type and tipped Conan/Shinichi off in regards to said sister's own identity and role.]]
** [[spoiler: Seiji Asou]] from the [[spoiler: Moonlight Sonata]] case used to be this as a young boy. In fact, when he was hospitalised in Tokyo, his family (including his father, a famous pianist) was killed in strange circumstances, related to the authorities from the island he grew up in and the shady dealings they had with his dad. For the rest of the story, see [[spoiler:HarmlessLadyDisguise]].
** Also voiced by Creator/AiOrikasa as the previous example: [[ChildProdigy Hiroki Sawada]] of the NonSerialMovie ''[[Anime/CaseClosedThePhantomOfBakerStreet The Phantom of Baker Street]]'' -- but [[InformedFlaw not at all related to the plot]]. [[spoiler: And that's not [[IntelligenceEqualsIsolation what kil]][[DrivenToSuicide led him]], either, but definitively adds to his WoobieDestroyerOfWorlds status.]]