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* {{Zigzagged|Trope}} in ''Manga/IGotMyWishAndReincarnatedAsTheVillainessLastBoss''. There's no doubt that Elizabeth was a sickly girl in her previous life and spent her entire life in the hospital, and the first scene follows the conventional portrayal of the death of a consumptive heroine, being very depressing as well as her spent a significant part of it lamenting her condition. She was also, at a minimum, [[GenericCuteness generically cute]] with no physical signs of being a chronically bedridden person. That said, the second scene establishes her, while kind, is also a {{Determinator}}, making her a subversion of sorts in that she isn't delicate in spirit.
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* ''Anime/IdolDensetsuEriko'': Fuyumi is a 12 year old girl who adores Eriko's music, but has an unspecified illness and has to be admitted to the hospital as a result. She is happy when Eriko sings for her from the rooftops.
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*''Anime/ADogOfFlanders1975'': Alois comes down with a sickness in one episode (that is possibly related to the stress of her abusive father constantly manipulating her) and is so sick can't even leave her bed. Nello tries to visit her, but the Cogez family butler tells him that she isn't in a state where she'd like to be seen by him. She does, however, ask Nello to draw for her, and he does, even if he can't see her face-to-face in his frequent visits. Alois eventually gets better, and is happy to spend time with ber best friend Nello again.
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* ''Manga/HikaruNoDensetsu'': Shiina Hazuki was this in the manga. Her Olympic abilities were severely impacted by her aplastic anemia, and she was constantly in and out of hospitals as a result. In the anime, this is downplayed as she goes to the hospital (it's not specified what exactly for) and she mentions there are a lot of obstacles to her becoming a gymnast.
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** ''Manga/JoJosBizarreAdventureJoJolion'' has Holly's AlternateUniverse counterpart, Holly Joestar-Kira. A former opthamologist (i.e. an eye doctor), she ironically ends up hospitalized for some strange mental issues, which included loss of memory and other eccentric behavior, like mistaking a nurse for a pair of boots. The truth turns out to be ''far'' more complicated: [[spoiler: She's a a first-born daughter of a branch of the Higashikata family via her ancestor, Rina Higashikata. Unlike sons, who get symptoms at age 10, daughters begin displaying symptoms of the mysterious stone disease later in life. Holly's son, Yoshikage Kira, began noticing her memory loss and other symptoms, and presumably excised parts of her brain and other organs that began to turn to stone with his Stand, Killer Queen, as she doesn't have any external scarring. For a proper cure, Kira sought out the Locacaca from the Rock Humans with Josefumi's help, thus spurring the entire plot of ''JoJolion'' due to the result of the heist. Later on, however, it's revealed that she was actually experimented on by the Locacaca Research Group with Locacacas, which may be the real cause of her illness, rather than the Higashikata Family's Rock Disease]].

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** ''Manga/JoJosBizarreAdventureJoJolion'' has Holly's AlternateUniverse counterpart, Holly Joestar-Kira. A former opthamologist (i.e. an eye doctor), she ironically ends up hospitalized for some strange mental issues, which included loss of memory and other eccentric behavior, like mistaking a nurse for a pair of boots. The truth turns out to be ''far'' more complicated: [[spoiler: She's a a first-born daughter of a branch of the Higashikata family via her ancestor, Rina Higashikata. Unlike sons, who get symptoms at age 10, daughters begin displaying symptoms of the mysterious stone disease later in life. Holly's son, Yoshikage Kira, began noticing her memory loss and other symptoms, and presumably excised parts of her brain and other organs that began to turn to stone with his Stand, Killer Queen, as she doesn't have any external scarring. For a proper cure, Kira sought out the Locacaca from the Rock Humans with Josefumi's help, thus spurring the entire plot of ''JoJolion'' ''[=JoJolion=]'' due to the result of the heist. Later on, however, it's revealed that she was actually experimented on by the Locacaca Research Group with Locacacas, which may be the real cause of her illness, rather than the Higashikata Family's Rock Disease]].

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