Adaptational Alternate Ending:
When Dr. Strange sends the other two versions of Peter Parker back to their own respective universes, Peter-One is also affected. However, the villains are not affected, since they're not actually from different universes.
Adaptational Backstory Change:
- All the villains killed Spider-Man in their respective universes.
- After the Green Goblin attacks Peter, it is revealed that Dr. Strange placed Peter in a magic simulation, in an attempt to teach him that there are consequences to his actions.
- The motivation for removing the villains powers changes from saving their lives to keeping their respective universes safe.
- Eddie & Venom are still summoned to the MCU thanks to Dr. Strange's Accidental Misnaming when trying to find Peter-One. However, Dr. Strange believes that the third time had no effect.