It doesn't help that they could have easily given both of their children psychic powers to defend themselves while also making it essential they work together to overpower the AI. Instead, Dr. Pascalle doesn't give Lillia anything, which leads to her becoming The Load who can't do anything but beg Rion for help.
The children being made psychics could have been avoided entirely by simply going to Rita and giving her the powers instead. Rita has no allegiance to the AI beyond the fact she wants to keep her brother safe, and she already has experience with telekinesis; if they had simply gone to Rita and worked with her, they could have avoided so much trouble using their children to fix their mistakes.
All of the Galerians and even Dorothy. Are they actually telling the truth that Rion is merely a clone, or are they lying through their teeth or were programmed to lie upon death in hopes of messing with Rion and leaving him psychologically vulnerable to pick off? Various notes found throughout the hospital make this extremely vague; after all, if there was an attempt to clone Rion, it could only be done at Mushroom Tower, and there are no notes or equipment that indicate otherwise. If Rion really, truly died, they would have typed up a "specimen report" or an autopsy, instead of reporting that Rion came back to consciousness. If anything, Cain would most likely be the clone of Rion, as there was no indication that Rion ever came in contact with Dr. Pascal or any of Dorothy's obedient staff in the past to get his DNA.
Complete Monster: Dorothy is an advanced rogue AI and responsible for all the evil in the duology. Having become obsessed with achieving godhood, Dorothy hijacks the computer system of the city's hospital and performs horrible experiments on its patients and staff, just so she could prove herself to be equal to god by creating the titular Galerians. Discovering that her creators are planning on shutting her down, Dorothy forcefully injects a young and innocent Galerian with PPEC to turn him into a sadistic killer and sends him to commit a bloodbath at their household, killing and transforming her creator's 14-year-old son, Rion Steiner, into a Galerian so she can find the sole survivor of the massacre. The sequel explores even more of her atrocities, as Dorothy had created a sapient backup program to resurrect her in case of defeat, keeping him captive and torturing him for the equivalent of thousands of years, leaving him as a bitter and resentful individual. A tyrannical egomaniac, Dorothy had no compassion, not even for her own children.
Cult Classic: The series is not well known, and judging from the gameplay mechanic, it's a classic Resident Evil clone, but still, the Cyberpunk setting, the weird characters (with most, including the protagonist, being Creepy Children), and the crafted story, despite its plot holes, it feels pretty unique. The concept was revisited a few years later with Second Sight and Bioshock, with varying degrees of success.
Vindicated by History: Upon its release in the early 2000s, Galerians was seen as but a rehash of its more successful defining Survival Horror sibling, Resident Evil, and its timing upon the release of the Playstation 2 would eclipse its existence even more so. Into the 2010s, where zombie apocalypse horror is as common as water, Resident Evil shooting itself by the foot with its divisive sixth main installment, and where resurgence in retro Playstation games came about much like the reinterest in 2D games, Galerians would be then valued for its 1990s cold bio-cyberpunk setting, an emphasis on mystery and psychological horror, touching upon taboo subjects like drug addiction and those on the extreme fringes of a just as extreme cold, calculated society, and allowing for a display of violent and mesmerizing deaths by psychic powers akin to Scanners and AKIRA.
