Memetic Mutation: Practically every line became memetic on the Reddit it was posted.
MY PENIS was GONE.Explanation Page 9 featured Frank waking up and realizing that his penis was removed from his groin, which has its famous line being said through many of r/LodedDiper's posts.
I am going to EAT your PENIS, FrankExplanation Robert's exclamation of his plan has inspired a few jokes about him being asexual.
But Robert... wouldn't that make you gay?Explanation Frank pointing out the ridiculousness of Robert's plan has inspired multiple memes, sometimes used in conjunction with the "I'm not gay, Greg" meme.
Page 22Explanation Page 22 featured Frank going on a rampage after his penis was destroyed, and the page shown has its dialogue by other users replaced by opinion they don't like.
Signature Scene: Multiple of them, which is surprising for an LLB:
Frank waking up on Page 9 and realizing that his penis is GONE.
Robert announcing on page 16 his plan to eat Frank's penis.
Take That, Scrappy!: Frank YEETS Manny out of the car window for telling Robert about his affair.