Deadpool's final moments with Death are suddenly in Film Noir style, unlike the rest of the game.
There's a scene where Deadpool runs off without the player, and the player has to follow him around the corner with just the camera.
Critical Dissonance: The critics were not impressed with the unoriginal gameplay mechanics, but the game was much better received by Deadpool fans for its writing by Deadpool (volume 2) writer Daniel Way.
Ending Fatigue: Even for the biggest fans of Deadpool killing bad guys all day, it gets tiresome when That One Boss Mr. Sinister throws mook after mook and boss after boss and clone after clone at him.
Deadpool: Whew! That was a whole lot of omigod here come more of them.
Deadpool: What, did Sinister get these guys in bulk?
Enjoy the Story, Skip the Game: The actual gameplay part of the game is pretty lacking and nothing special, but most players enjoy spending several hours watching Deadpool do whatever the hell he wants while quipping.
Hilarious in Hindsight: At one point in the game, Deadpool's two voices are transferred to Rogue by way of kissing. A few years later, they kissed in the finale of Uncanny Avengers, minus the voices in Deadpool's head.
It's Easy, So It Sucks!: The game involves fighting the same sets of enemies from start to finish and it's a bit too generous with health ammo pick-ups, even on the higher difficulty settings. With every other enemy dropping them, you easily recover health quickly even in huge crowds, and can be as trigger happy as you like with any of the guns without worry about running out of ammo.
Moral Event Horizon: To players, Sinister crosses this with his plot to eradicate the world. To Deadpool, it's when Sinister steals his contract.
Nausea Fuel: If you make him do it, Deadpool will take a dump in his own toilet. He'll also cut and try to climb his own intestines, which is as painful as it is gross to look at.
So Okay, It's Average: While players love the humor, the gameplay is regarded as nothing special since it's mostly fighting the same enemies with the same charging-into-melee tactic every time, except for the Difficulty Spike at the end. Also, it doesn't help that it's really short.
That One Achievement: So you wanna "Be Like Joe" and achieve game completion? You'll have to chain 300 hits without some asshole poking you and ruining the combo.
They Wasted a Perfectly Good Character: The X-Men are knocked out in the plane crash as soon as they arrive on Genosha, their role in the game more or less an excuse to get Deadpool involved in the main story, a role that could have been filled by Cable. Any opportunities for Deadpool to bounce off of them, or drag them into the game's absurdity are almost completely bypassed, save for a brief segment where you control Rogue after absorbing Deadpool's powers.
Vindicated by History: Many people straight-up called this a bad game upon release. After the release of the first Deadpool film and the next-gen console re-release, more people warmed up to it.
What Do You Mean, It's Not for Kids?: Just because it's a Marvel video game based on a colorful comic book character doesn't mean it's for the little ones! It's all about bloody deaths and cursing, not unlike the movies.
that the game is a parody of macho, testosterone poisoned, chauvinistic meathead protagonists like Duke Nukem and other edgy anti-heroes from the 90s, or a deconstruction of overblown shooter franchises like Call of Duty. Deadpool is... really not that serious.