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Dren is an attempt to create The Seether.
Let's see, she is not born like other girls, she may not look like other girls, and it's pretty clear that she's hard to dispatch ("Can't fight the Seether!")

Dren looks like Mewtwo.
She does! Which follows that she might have been an attempt to create a living "Pokemorph". Poor thing. Nobody deserves that kind of life.
  • Not really. Mewtwo's structure is more feline (though bipedial and somewhat humanoid), they got fur, a pair of cat-like ears (yes, those are their ears), they only have three fingers on each hand on two toes on each foot, and they have that weird tube-thing on the back of their head. Dren, on the other hand, is more humanoid in structure, has no fur, has four fingers on each hand and four/five toes on each foot, and doesn't have a tube-thingy on the back of her head. Not to mention that unlike Mewtwo, Dren's tail has a stinger and Dren has wings...which Mewtwo lacks. They look NOTHING alike.

Insanity is genetic within Elsa's family.
Think about it. Her mother was clearly crazy, Elsa, as Clive noted, is rather fucked up herself, particularly noted when she mutilates Dren, and the fact that she was trying to use a highly unethical and illegal hybrid as a daughter. And well, let's not even get into male Dren.
  • You really don't need genes to perpetuate a cycle of abuse. Elsa's horribly bipolar treatment of Dren was enough, along with the poor creature's advanced growth ensured an incredibly imbalanced psyche well on their own.

Dren's human DNA came from Elsa's mom.
It was all part of her sick Freudian thing. She wanted to have some revenge on her mother, that's shy she remade her as a "lesser" humanoid creature and why she wanted to raise her! On the other hand she did love her mother and/or Dren which was what drove her to act caring at times. She transferred her love/hate for her mother onto poor Dren.
  • I'm pretty sure Dren's human DNA came from Elsa herself. When Clive looks at Dren all made up, he recognizes Elsa in her.

The baby will be a perfectly normal human child...
Elsa's, I mean. By the end of the movie she was pregnant with Clive's perfectly human son, because Dren, as a hybrid, was actually infertile and she/he only inseminated Elsa with Clive's sperm, you know, just like succubi/incubi did in medieval lore.
  • Alternatively, it will be a normal human child because Clive had unprotected sex with Elsa that one time before and impregnated her then.

Elsa is a Farscape fan.
And the naming of Dren was totally passive-aggressive.

Dren was an attempt to create a human-Xenomorph hybrid.
It's never really clear what Dren's non-human half is, as it matches no other earthly creature. But what if it's something not of this Earth?

Both Dren and the Xenomorphs possess stinger-tails, very humanoid anatomy, and Ugly Cute baby forms. Dren's inhuman behavior could be the result of her Xenomorph thought processes conflicting with her more human brain, and her ability to change genders might be the fault of a "conflict" between the human genetic code for there to be a sex and the Xenomorph genetic code to possess no gender.

  • Couple of problems: First, to my knowledge Xenomorphs are not amphibians and obviously humans aren't, but Dren is. Second, they show early on, she's not human and something else, she's a mix of human and a whole bunch of different animals, plus Elsa says none of her components are predatory, which rather rules out Xenomorphs.
  • Also Xenomorphs don't have stingers, they have chitinous blades on their tails, rather like a Stegosaurus' Thagomizer. (Early designs included stingers, but the final design was a blade that later films enlarged.)

There's at least one other hybrid out there?
Dren turns into a male briefly after having sex with Clive. Why did she take so much longer to change than Ginger? She didn't need her female aspects anymore because she had already reproduced. Dren developed as a fetus very rapidly, and this trait went on to her and Clive's offspring (Okay so it took several days in Dren's case, but her and Clive's child would have wildly different DNA, so who knows). She gave birth to it in the bathing tank briefly before Clive and Elsa found her in deteriorating condition. After everything was over, by the time anybody checked the tank, Dren's child had already taken off into the woods.

Dren's not dead!
Because the last several times they left Dren for dead it was up within the hour. For all we know Dren could have recovered perfectly and is quietly being prepped for the next stage of the experiment himself. He could then evolve quite rapidly...

Dren is at least partially modeled after Giegue
At least subconsciously. Elsa could've been a Mother fan.

Having sexual intercourse causes Clive and Elsa's creations to change sexes.
Ginger didn't become male until after she and Fred "bonded" for the first time. Similarly, Dren became a dude soon after having sex with Clive.
  • A possible justification is that, in Dren's life-cycle, if after intercourse the female doesn't get pregnant, she turns into a male and goes off to mate again.

The future of the descendants of Dren and Elsa
As per WMG above, Male!Dren isn't dead, but very much alive (we saw her/his healing factor before) and is used, together with the child of him and Elsa (if it is her and Elsa's child at all, see WMGs above), to create a new species of super soldiers (the world of Splice is more advanced than our's and this Rogers-guy just doesn't cut it anymore these days. Enough to take down some old coot with facial skin problems, OK, but to struggle wih the challenges of the 21st century?' Nah! They're gonna have all of Dren's strengths (super-human speed, agility, dexterity and healing factor) and none of her/his weaknesses), who will be called the Drenites and will, in the end, live alongside humanity.

Dren is bascially the more messed up version of a Indoraptor
  • As much I hate to admit it, but it makes some sense in a twisted way:
-Both are experiments Gone Horribly Wrong in the name for Corrupt Corporate Executive and the big bucks-Both are Hybrid creations-Both are known to think and do things out of spite.

The big difference....well duh, Indoraptor's much more likeable and not as gross


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