- Dyeing for Your Art: Laura Linney gained 20 pounds for this film, mainly by eating Krispy Kreme glazed donuts. It's not noticeable at all.
- Fake American: Northern Irish-born Liam Neeson portrays the American Alfred Kinsey.
- Screwed by the Lawyers: On the DVD Commentary, Bill Condon revealed that he wanted to include, in a montage, a clip from I Love Lucy, in which a character makes a joking reference to Dr. Alfred Kinsey's research. Condon says that he was unable to use the clip, because Lucie Arnaz denied him the rights, offering very little explanation, aside from claiming that her parents would never allow themselves to be associated with Kinsey.
- What Could Have Been: Jeff Bridges, Michael Douglas, Ralph Fiennes, Tom Hanks and Kevin Spacey were considered for Dr. Alfred Kinsey.
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