- All-Star Cast: The film features three Oscar winners (Meryl Streep, Julia Roberts and Chris Cooper), four Oscar nominees (Sam Shepard, Juliette Lewis, Abigail Breslin and Benedict Cumberbatch) plus Emmy nominated Ewan McGregor.
- Fake American: Scottish-born Ewan McGregor and English-born Benedict Cumberbatch both play Americans.
- Meaningful Release Date: The film based on the play was released on Christmas Day. Considering the subject matter and the Downer Ending, it's safe to assume that this was meant to be sarcastic.
- Self-Adaptation: This is the third time Tracy Letts writes the film adaptation of one of his plays.
- What Might Have Been:
- Tracy Letts wanted the original stage cast to reprise their roles in the film version. Ultimately, none of the original actors appear in the movie.
- Juliette Lewis replaced the earlier cast member, Andrea Riseborough, and Chloë Moretz auditioned for the part of Jean Fordham.
- During initial casting Harvey Weinstein suggested Judi Dench as Violet and Nicole Kidman as Barbara. Letts voted against the idea, saying American actors should play the roles.
- Gary Cole was offered the role of Steve Heidebrecht, which he played in the London stage version. He declined. Jim Carrey was also considered.
- Annette Bening, Glenn Close, Jane Fonda, Jessica Lange and Sissy Spacek were considered for Violet Weston.
- Kathy Bates was in talks to play Mattie Fae Aiken.
- Renée Zellweger was considered for Karen Weston.
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