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"You seem rather melancholic, Ikuro?"
Peculiar Parasitic Phenomenon is a story of action and romance, but there are several occasions where the heroes are forced into heartbreaking situations or ruminations.— Mikitaka Hazekura in Chapter 8
- The story starts with Mikitaka reminiscing about his home planet which had been destroyed, which gives off a melancholic feeling, as well as his ruminations about having some issues adapting to Earth and being the odd man out.
- In general, Ikuro's Laser-Guided Amnesia sometimes makes him look vulnerable and lost, especially whenever he's also reminded that he's a Fish out of Temporal Water, having lost eight years after the events of *Baoh*.Ikuro felt like a time traveler, the world passing by him, leaving him behind.
- It reaches the critical point in Chapter 25 where Maynard exploits Ikuro's vulnerability by letting him get his hands on the dossier Doress complied with his background. Ikuro becomes distraught when he learns that his family and the friends who tried to find him were killed by Doress, apparently leaving no chance for Ikuro to really reclaim his life before Baoh. He himself also cries when he realizes that even with joggling his memory with the dossier he can't remember anything new but for the moment of his parents' death.
- While Kars going berserk upon recovering his memories is pure Nightmare Fuel, it's also heartbreaking as his reason for doing so isn't even about Joseph sending him to space, but about him killing Esidisi, Wamuu and Santana whom Kars didn't appreciate until they were gone. Kars devolves into Berserker Tears rather quickly and basically shuts down once he's trapped inside Super Fly. It wears especially heavy on Mikitaka, his son, and Ikuro, his unofficial ward who began to consider him a Parental Substitute.
- Chapter 19 has a cheerful Josuke spiral into a panic attack once he sees Diamant off-duty in an outfit that makes him look unassuming and gets caught in thoughts of how the most monsterous people he met also looked like someone he passed on the street without a second thought. Josuke then developing mild paranoia of Doress agents is also somewhat painful to watch, even if he's right to be paranoid.
- Chapter 21 shows a flashback of Manishu watching DIO's dreams, and DIO actually shows regret for killing Jonathan, implied to be something he dreams about often.
- D13 Trouble No More is a Lotus-Eater Machine that Manishu uses as a therapy device of sorts once he commits to his Heel–Face Turn. In particular, he can use it to create apparitions of departed people, autonomous and true to the real deal if there are multiple contrasting perceptions of that person around him. This ability is first shown in Chapter 21 where Manishu recreates Kakyoin via his and Jotaro's memories, allowing Jotaro and Kakyoin a tender moment.
- Next chapter shows him using Joseph, Kars and Santana's memories to recreate Caesar, Esidisi and Wamuu, allowing a dramatic, if brief reunion that's supposed to let them let go of some regrets they had, never getting to say what they wanted to them.
- Johngalli A's backstory. It's revealed that he was diagnosed with his vision issues early on in his life and his parents chose to dump him on their trip to Cairo when he was 12. When DIO encounters him and saves him from Pet Shop, even the vampire is a bit touched, seeing something of himself in Johngalli.
- While there's no sympathy for Yoma, the version of Yoma created after Maynard's tampering with time gives a two-folded Tear Jerker. Before Yoma became obsessed with athletics, he's shown to be a regular friendly young man with aspirations of a writer. Him turning into a malformed madman implicitly in part due to the divine intervention is saddening and even more so his new fate of being a mute paraplegic after Requiem's attack.
- Yuya's Heroic Sacrifice when he's erased by Maynard in Chapter 28, protecting Ikuro from his attempts to Make Wrong What Once Went Right.
