Here are the shout-outs of Fullmetal Alchemist.
- Ed references The Fly (1958) as an example of transmuting people, with a person and a fly becoming a fly-man. Even if that was solely in the realm of movies, it gave Ed the inspiration to try human transmutation.
- At one point, Kimblee says "the life force is strong with you."
- There are many references to historical alchemists, their beliefs and practices littered throughout the manga.
- The scene in Gluttony's stomach where Ed boils a shoe into food is likely a reference to the Charlie Chaplin film The Gold Rush—Ed refers to getting the idea from a film he saw. note
- On their first visit to Rush Valley, Winry starts Squeeing over a "Gotts 11th Year Model Automail". Compare Götz von Berlichingen's Real Life prosthetic hand.
- The chimeras, especially the ones who worked for Kimblee, seems to be based on zoanthropes.
- Giolio Comanche the Silver Alchemist is a lot creepier once you notice the similarities to Cowboy Bebop's Mad Pierrot. (Less creepy if you see Rich Uncle Pennybags instead).
- One of the residents of Rush Valley bares a remarkable similarity to Jet Black, complete with similar robotic limbs.
- Father's apotheosis is eerily similar to the awakening of Lilith in End of Evangelion.
- The eclipse backdrop and the importance of "sacrifices" also evoke Berserk.
- The mannequin soldiers are likewise very similar in nature and looks to the mass-production Evangelions.
- Envy's Eldritch Abomination form could be a shout out to Thomas Hobbes' Leviathan. The cover depicts a creature covered with human bodies, like Envy. The connection? In some religious mythology, the Leviathan is a representation of the sin Envy.
- During Edward's fight with Kimblee, he slashes his right transmutation circle. That circle contains a triangle which contains a circle. The slash wound divides the circle in two exact halves. A line, a circle, and a triangle - where we saw it before?.
- Hughes' military identification code is USO-800. This is likely shoutout to Uso 800 potion from Doraemon.
- The military order that changes the fighting in Ishval from a Civil War to a War of Extermination is 3066. note
- The Konami Code is visible on Fuery's locker in Chapter 47.
- The Overly Long Name gag in one of Brotherhood's omake shorts is a reference to Jugemu, a Japanese folktale which has often been used in rakugo performances.