Anime and Manga
- In Chainsaw Man Makima has a painting in her home of Gustave Doré's Satan's Fall
- The Crow (1994): T-Bird—one of Top Dollar's enforcers—comes across the book while raiding Shelley and Eric's apartment, and becomes enamored of one of the passages. When a revived Eric is preparing to kill T-Bird in his favorite car, the bad guy finally recognizes Eric and has a full meltdown, repeating that line over and over:Abashed the Devil stood and felt how awful goodness was... how awful goodness was... how awful goodness was! (car speeds off the pier and explodes)
- Se7en: Paradise Lost is one of the books inspiring the Serial Killer.
- Kamen Rider 555: Paradise Lost: Just look at the title.
- A bit of A. E. Housman's poem "Terence, this is stupid stuff", included in his book A Shropshire Lad, reads:Oh many a peer of England brews
Livelier liquor than the Muse,
And malt does more than Milton can
To justify God’s ways to man. - Frankenstein: In chapter 15, Paradise Lost is one of the many books that the monster reads.
- The Hand Of Ethelberta: In chapter 27, Ethelberta reads some lines from Paradise Lost.
- The His Dark Materials trilogy takes its name from a line in Book 2 of Paradise Lost.
- Sir Gibbie: In chapter 25, Donal reads Paradise Lost to Gibbie.
- Star Trek: The Original Series has Khan referencing the famous line “Better to reign in Hell than to serve in Heaven.”
Music
- Hollywood Undead has a song titled “Paradise Lost”.
Web Animation
- Homestar Runner: In the Strong Bad Email "record book", Strong Sad is somehow able to transcribe Paradise Lost onto a single grain of rice in four languages. Unfortunately for him, Strong Bad isn't impressed by this.
Video Games
- Deus Ex in the Illuminati ending uses the quote "better to reign in hell than to serve in heaven"
- In Space Funeral, the bad guy quotes the book in an...unusual manner.
- A Vampyre Story: A book titled "Paradise Found" can be found on a bookcase.