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- Paramount+ features the characters in its "Mountain of Entertainment" promos.
- "Bonfire" has Cartman among the people singing the Halo theme to an annoyed Master Chief.
- Kenny bites it in "Storm", being crushed by an oversized bucket of water from Flashdance. Tim McGraw rides on by to say a variant of the famous line. The commercial ends with Kenny's ghost ascending past the Paramountain on his way to heaven.
- FLCL has at least three of these. One comes in the form of a 30 second Art Shift, though the other two aren't as blatant.
- Panty & Stocking with Garterbelt: During the "Help! We Are Angels" segment, when PSG is playing under the northern lights, Chuck can be seen wearing Kenny's parka.
- Pokémon Crossing: In one chapter, one of the characters drinks a smorgasvein.
- American Beauty: A student at Jane's school is wearing a South Park t-shirt.
- BASEketball: At different points in the movie, Coop (played by Trey Parker) imitates Cartman and Mr. Garrison.
- Chip 'n Dale: Rescue Rangers (2022): Randy makes a cameo as a customer in the bathhouse.
- Harry Potter and the Goblet of Fire: When it appears that Harry has drowned in the lake after taking the Gillyweed Neville gave him, Neville has the reaction: "Oh my god. I've killed Harry Potter!"
- Meet the Parents: Denny has a South Park poster in his room.
- Animorphs: In The Solution, Rachel has a dream in which she morphs into an elephant in a crowded mall. She crushes a kid in an orange jacket, prompting someone to say, "Oh, my God! She killed Kenny!"
- The Amanda Show: In the "Blockblister" sketches, one of the movies seen on the "New Releases" board is South Pork.
- Boy Meets World does this a lot in Season 5. The most memorable example is when a character named Kenny is killed, leaving another character to yell out, "Oh my god, they killed Kenny!".
- The Fairly OddParents: Fairly Odder: After Viv gets laughed at during a party, she imitates Cartman's voice and shouts a G-rated version of his catchphrase, "Boo you guys! I'm going home!"
- Les Guignols de l'Info made a parody sketch of the series entitled "Droite Park" ("Right-wing Park") with Nicolas Sarkozy as Kyle, François Bayrou as Stan, Philippe Séguin as Cartman, Valéry Giscard d'Estaing as Kenny, and Jacques Chirac as the singer.
- iCarly does this in the episode iBust a Thief during the short cartoon "Bitty Big Heads."
- Jessie: After Luke's Stalker with a Crush steals his favorite stuffed animal, Kenny the Koala, she reveals to Jessie that she ripped off the head. After Jessie presents it to Luke, he cries, "Oh no! They killed Kenny!"
- Mad TV: A 1998 episode featured an animated sketch called "South Parknuts", a mash-up of Peanuts and South Park.
- Student Bodies: In "Snowed In", when Emily and Mags bring the injured Flash into the office, Victor cries out "Oh, my God, they killed Flash! You bastards!"
Music
- The Cantopop song Kenny Song has its lyrics be inspired by the Trope Namer of They Killed Kenny Again. The Cantonese title is the Cantonese name for the show itself.
- Rising Zan: The Samurai Gunman has the titular hero battling a sub-boss called Push-Man. After defeating Push-Man, the Queen Servant who summoned him then exclaims "Oh my god! He killed Push-man! You bastard!"
- In one cutscene of Alpha Centauri, the POV character is channel surfing and comes across a show that crosses over South Park with, well, Alpha Centauri.Cartman('s expy): "Get off mah land, you Peacekeeping son-of-a-bit-!"
- In Fallout 3, DJ Threedog often starts his adresses with a shout of "Hello, children!," referencing Chef.
- The Nostalgia Critic:
- In his review of Rock-A-Doodle, Critic says that the miniaturized Duke sounds like Cartman.
- One of his editorials is a Top 11 countdown of his favorite South Park episodes.
- In his review of The Brave Little Toaster, during the scene where Toaster, Blanky, Kirby, and Lampy disguise themselves as a phantom to scare Elmo St. Peters and save Radio, Critic shows an image of Professor Chaos in "The Simpsons Already Did It" as he says "Toy Story... will do it!"
- The Runaway Guys
- In one Wheel of Fortune video, Chugga says he thought the answer to the Bonus Round was "HEALTHY SLUT", leading Jon to quip, "Ohhhh, naggers!"
- In episode 21 of New Super Mario Bros. U, Chugga sings "Blame Canada" from the movie, leading Jon to take offense.
- Stopmotion Chess uses South Park sound effects in the remixed version.
- Zsdav Adventures: When Freezzy gets shot in Zsdav adventures: A film (The Movie).Agzt01: Oh my god! He killed Freezzy! You bastard!
- Arthur: In "The Contest", Buster's story is a parody of the show, specifically an alien abduction story like in the first episode.
- Drawn Together:
- In "A Tale of Two Cows", Live-Action Cow rampages through South Park and kills everyone... except Kenny.Spanky: Now this place is funny. I bet if we lived here, more people would watch.
- In The Movie, Suck My Taint Girl is animated in the South Park style.
- In "A Tale of Two Cows", Live-Action Cow rampages through South Park and kills everyone... except Kenny.
- Family Guy:
- In "Bigfat", Quagmire invites Peter to join him on a trip to Canada, and Peter says he wanted to go there before South Park beat him to it (referencing "South Park: Bigger, Longer & Uncut" and "It's Christmas in Canada").
- In "Emmy-Winning Episode", South Park appears on a library computer of shows that have won many Emmy's.
- In the opening credits for "V is for Mystery", Brian and Stewie discover Kenny's corpse.
- In "Family Guy: Through the Years", Peter states that Family Guy has underwent many hardships over the years including a "pretty good ribbing by those South Park guys", referencing the "Cartoon Wars" episodes where South Park did a parody of Family Guy.
- Futurama: In "Bender's Big Score", Cartman's head can be seen in the head museum.
- Logorama: The South Park sign can be seen after the oil erupts from the oil rigs.
- The Patrick Star Show: In "The Starry Awards", Dr. Plankenstein and his crew get Squashed Flat by a hammer. They go into the 2D world looking like cardboard cutouts and animated in the South Park style.
- The Powerpuff Girls (1998): In "Imaginary Fiend", the titular character knocks Blossom into a pile of coats and she comes out dressed like Cartman, saying "He tripped me, seriously".
- Rick and Morty:
- In "The Rickchurian Mortydate", Rick references the Minecraft episode to convince Morty that they missed the bandwagon by several years and are free to move on to the next plot point.
- In "The Vat of Acid Episode", after the plane crash in the mountains, three of the four survivors are dressed as South Park characters. The unnamed man is dressed like Stan, the unnamed woman is dressed like Kyle, and Morty is dressed like Kenny. Morty's Girlfriend, on the other hand, is not dressed like Cartman.
- In "FullMeta JackRick", Morty tells Story Lord that having Jesus beat them up was already done in South Park.
- Robot Chicken: In a sketch from "Boogie Bardstown in: No Need, I Have Coupons", Chef is a contestant on MasterChef Celebrity Showdown, where he has to cook with the thing he fears most: thetans.
- The Simpsons:
- At the beginning of "The Bart of War", Bart and Milhouse watch an episode of South Park before Marge turns it off, saying it's "not life-affirming".
- In "Homer the Whopper", one of Comic Book Guy's online chat buddies has the username "IKilledKenny6475".
- The chalkboard gag for "The Squirt and the Whale" has Bart writing "South Park — We'd stand beside you if we weren't so scared", referencing the terrorist threats and subsequent censorship over "200" and "201".
- In "Gorgeous Grampa", Mr. Burns' Villain Song has him rattling off various pop culture villains (complete with his shadow morphing into their silhouettes), including Cartman.
- In "O Brother, Where Bart Thou?", Bart and his friends talk to each other at the bus stop while dressed as the boys, complete with them facing front; Bart is dressed as Stan, Milhouse as Kyle, Nelson as Cartman, and Ralph as Kenny. Ralph is then struck by the school bus and goes flying.Otto: Oh my God, I killed Kenny!
Milhouse: Ralph.
Otto: No, I killed Kenny yesterday. What'd I do now? - At the end of "Treehouse of Horror XXV", many different versions of the Simpsons appear, including one clan animated in the South Park style.
- The Couch Gag for "The Cad and the Hat" has Homer going through the sets of different cartoons, including a South Park parody full of kids spewing Cluster Bleep-Bombs.Homer: Is this a TV show, or did I walk into a third-grade shoebox diorama?
- In "The Heartbroke Kid", after gaining weight from eating lots of junk food, Bart gets sent to a fat camp run by coach Tab Spangler. One exercise was the patients pulling Tab on a chariot while he whips them, making them answer how they gained weight.Bart: Bart Simpson, I'm just big-boned.
Tab: No such thing.
[cracks whip] - In "Whistler's Father", after discovering Maggie's talent for whistling, Lisa tries to deny that her sister is more gifted by claiming they can both be good like Trey Parker and Matt Stone.Lisa: We can both be good, like the South Park guys, except Trey does everything. Trey does everything!
- In "Treehouse of Horror XXXIII", one of the theme parks at the end of the "SimpsonsWorld" segment is South Park Park. The dome is in the shape of Stan's head.