The 100 Girlfriends Who Really, Really, Really, Really, Really Love You: In Chapter 82.5 (a collection of Fractured Fairy Tales), Kurumi plays Gretel, and is abandoned by Hansel after she eats the breadcrumbs that her brother drops to help them find their way out of the woods, leaving her in danger of being eaten by the witch after she devours the entire gingerbread house.
Crayon Shin-chan has a Hansel and Gretel spoof as one of their many Fractured Fairy Tale parodies, where Shin-Chan is the youngest sibling to a pair of Hansel and Gretel expies. The Gretel expy even mentions the fairytale by name when leaving behind a Trail of Bread Crumbs, that she's using metal ball bearings instead of breadcrumbs, "unlike those two idiots named Hansel and Gretel"... only for the balls to be collected by a a gambler who's on his way to a pachinko machine club, so they still end up getting lost in the woods.
Doraemon: Nobita's Dorabian Nights has Nobita and friends visiting various fairy tale universes, one of them being Hansel and Gretel. Where the Wicked Witch from Snow White accidentally visits the Candy House and tries offering her an apple.
Shrek 2: In the beginning, Shrek and Fiona are shown to have a honeymoon in a gingerbread house, with a sign reading "Hansel's Honeymoon Hideway" next to it. In another scene, Fairy Godmother is searching for a story book where ogres could get a happy ending, she keeps mentioning titles where ogres never get one, one of these happens to be Hansel And Gretel. And yet in another scene, Hansel and Gretel themselves appear to enter to the royal ball, leaving crumbs after them.
Puss in Boots: The Last Wish: Goldilocks finds a book she used to read as a kid in one scene, the inside of the cover has a library card that contains the names of Hansel and Gretel.
In A Child Is Waiting, Jean suggests having the children sing one of the songs from the play.
In Nightbooks, The Gingerbread House makes an appearance. The actual Wicked Witch from the story appears, apparently the one who kidnapped Natacha in the first place. She's killed when the heroes force her into an oven.
In the Buffy the Vampire Slayer episode "Gingerbread", the deaths of a boy and a girl spark a massive witch-hunt among the parents of Sunnydale until a chance comment by Angel helps Buffy realise that the town knows literally nothing about the dead children. Tracing past historical records, the Scooby Gang determine that the "children" are actually the inspiration for the tale of Hansel and Gretel, and their true nature is a demonic force that drives humans to kill each other.
In the Supernatural episode "About a Boy", Dean and Sam Winchester face Katija, the witch from the tale of Hansel and Gretel; in reality, Hansel killed Gretel and ate her heart to join Katija in immortality. The witch now uses her magic to de-age her adult targets to teenagers, as she enjoys the taste of children but it's harder for children to legitimately go missing in the present.
In the opening of Smile Pretty Cure! Let's Go! Märchen World, Akane visits the gingerbread house and can't resist having a taste.
Bubsy in: Fractured Furry Tales: Hansel and Gretel appear as the final bosses, wherein they kidnapped the Witch who is really Mother Goose and locked her in a cage. They also try to kill Bubsy by tossing apples at him.
Hazel Rainart in RWBY is based on Hansel. Hazel's story asks the question, "what would happen to Hansel if Gretel died?" Hazel's sister Gretchen Rainart was a student at Beacon Academy to become a Huntress, but she died in a training incident. Hazel, after crossing the Despair Event Horizon, was recruited by Salem so that he could take revenge on Professor Ozpin, whom Hazel blames for getting Gretchen killed.
Adventures of Sonic the Hedgehog: In "Sonically Ever After", Sonic, Tails, and Dr. Robotnik are accidentally transported into a book of fairy tales by Scratch and Grounder. One of the stories they end up in is Hansel and Nettle. Sonic takes on the role of Hansel, and Tails takes on the role of Nettle. Robotnik takes on the role of the Witch, and lures Sonic and Tails into a trap due to the house in the story being made of chili dogs.
Oh Yeah! Cartoons: An episode of Tales From the Goose Lady is entitled "Hamzel and Grande". In this story, Hamzel and Grande are two greedy fat kids who keep trying to eat the Witch's candy house. Every time the Witch tries to stop them, they cry for help and a nearby Woodsman, assuming the Witch is trying to eat the kids, attacks her with his ax. The pattern repeats itself until the Witch's home is nearly entirely gone. She then constructs a new house made out of liver, which repulses Hamzel and Grande... but it turns out the Woodsman loves liver and starts eating the house while the Witch breaks down into tears.
Rocko's Modern Life: In "Yarn Benders", Rocko and Heffer tell Filburt the story of Hansel and Debbie to help him get over a cold. Heffer takes on the role of Hansel, Rocko takes on the role of Debbie, and Filburt takes on the role of the Witch. Rocko and Heffer also argue over whether the Witch's house should be made of healthy snacks or pizza, until Filburt suggests that the house be made of fish sticks.
In "Angelica Breaks a Leg", Angelica pretends to break her leg so Stu and Didi will dote on her, and gets her wish due to a mix-up in the medical records. at one point, she wants Didi to tell her a story. Didi suggests Hansel and Gretel, along with The Three Little Pigs and The Little Engine That Could, but Angelica suggests that she instead make up a story about an angel named Angelica.
In "Finsterella", Phil and Lil fight over the book of Hansel and Gretel. Later, during Chuckie's dream sequence, Chuckie answers the door to Phil and Lil dressed as Hansel and Gretel, who are looking for directions. He replies, "You're even more lost than you think; you're in the wrong story."
Teen Titans have an episode which is a straight-up Whole-Plot Reference to Hansel and Gretel, where an evil witch called Mother Mae-Eye turns the Titans Tower into a candy tower and brainwashes the Titans into believing she's their "mother". Right before trying to bake them in an oversized oven. It's... one of the weird ones.
Unikitty!: In Bedtime Stories, Unikitty and her friends use a machine to enter into a storybook to change its stories it is containing. One of them happens to be Hansel And Gretel where they save the titular characters and fight the witch.
