- Bianca Castafiore from The Adventures of Tintin sings the Jewel Song in all her appearances.
- Isaac Asimov's The Rest of the Robots: During the introduction, Dr Asimov compares Faust to Frankenstein, as both works are about dangerous knowledge. He develops the Faustian conflict further in the introduction, explaining that Faust must face Mephistopheles, but the plot did not require some sort of failing on Faust's end.
- Kamen Rider Build: The Nebulous Evil Organisation Sento fights for the first quarter is named "Faust" as a nod to the tale. The ROGUE prequel reveals Night Rogue deliberately chose the name as a nod to the tale, given how their work involves selling their souls in the metaphorical sense to obtain scientific knowledge. He also directly compares his co-founder Blood Stalk (and the one who corrupted him) to Mephistopheles.
- French Baguette Intelligence: In The Metaverse Nightmares - Does Reality Matter?
, Gringo compares advanced virtual reality to Faust's deal with Mephistopheles; able to have anything he wants, at the cost of finding everything unsatisfying because nothing requires effort to accomplish.
- In Limbus Company, one of the Sinners is named Faust, a smug genius inventor who is responsible for the creation of the Limbus Company bus, Mephistopheles, who turns humans into fuel.
- In Make Mine Music, Willie the Whale dreams of playing Mephistopheles.
