- A 2014 Google Play commercial has a little girl on her tablet reading the original story to Clifford himself.
- Clifford (specifically, his animated counterpart from the 2019 series) appears in a commercial for GEICO from 2022, where he interacts with real people. In the commercial, he plays with a tree like it's a stick, drinks water from a neighbor's pool and splashes people with it during a backyard barbecue, and sleeps in a neighbor's driveway when the neighbors try to get him to move so they can back their car out.
Film-Animated
- In We're Back! A Dinosaur's Story, a Clifford balloon appears at the Macy's Thanksgiving Day Parade.
- Sonic the Hedgehog 2 (2022): At one point, Sonic refers to Knuckles as "Clifford the Big Red Rage Monster".note
- In Experimental Film, Clark yells while watching TV, "Clifford is SO big! The Big Red Dog, wooof!"
- In the book Pet Trouble: Oh, No, Newf! Heidi mentions being given the book as a young child along with other dog-related paraphenelia from various relatives.
- Goosebumps (1995): In "The Cuckoo Clock of Doom", when Michael is six years old, his father reads him Clifford the Big Red Dog as a bedtime story.note
- A late-game quest in Shadows Over Loathing crosses over The Colour Out of Space and Clifford the Big, Red Dog. Exposure to the Meteorite's energies is what made him so big and smart.
- Sunstriker Animated Universe: Clifford appears as a character in the universe.
- The Nostalgia Critic: In his review of Thomas and the Magic Railroad, the Critic describes the show the film is based on as "The show PBS puts on when Clifford the Dog is too intimidating", and shows a promotional image of Clifford and Emily Elizabeth.
- As Told by Ginger: In "A Lesson in Tightropes", Carl and Hoodsey are seen reading Joann's steamy romance novels.Carl: And isn't Clifford [the novel's male character] the name of a dog?
- Family Guy:
- In "Turkey Guys", one of the knockoff balloons in the JCPenney Thanksgiving Day Parade is "Clifton the Small Blue Dog".
- In "Dog Bites Bear", Stewie tells Brian that Rupert used to call him various dog-related insults, including "Clifford the Big Red Sphincter".
- In "Dead Dog Walking", Brian gets sent to the pound to be euthanized, and he finds a hydrophobic Clifford in the cage next to his, asking "Did you also eat a kid?".
- In "Throw It Away", Peter stays at Quagmire's house after Lois kicks him out, and he interrupts his sex to ask him to read Clifford to him.
- MAD: The sketch "Cliffordfield" is a mash-up of Clifford and Cloverfield.
- Robot Chicken:
- A sketch from "Federated Resources" shows Clifford causing a lot of collateral damage in the neighborhood, leading to him getting neutered with a digging crane.
- A sketch from "Sundancer Craig in: 30% of the Way to Crying" has Emily Elizabeth carrying a now-deceased Clifford in a dump truck and dumping his body in the Grand Canyon. When a man catches Emily and tells her "Hey, no dumping!", she says that rules don't apply to her, and the two shoot at each other.
- The Simpsons: In "Todd, Todd, Why Hast Thou Forsaken Me?", when Ned sends Todd to live with the Simpsons in an attempt to scare him back into God's arms, he tells Marge to read Todd a good bedtime story. When Marge suggests Clifford the Big Red Dog, Ned rejects it, calling it Clifford the Big Red Satanic Abomination.
- Skull Island (2023): In "Maritime Pilot", Annie says that if a monster were to have wrecked her captors' ship, it would have to have been bigger than her "dog". Charlie sarcastically asks of said dog is Clifford, but due to being raised on a primitive island, Annie has no idea who he is.
