Buffy the Vampire Slayer: In the second season episode "Halloween", Buffy encourages Willow to dress up in something outrageous for Halloween, but Willow is scared of doing this, so she opts for the simple ghost costume. When Buffy sees this, she calls Willow "Casper".
Family Matters: In the prologue to "Miracle on Elm Street", Steve Urkel accidentally gets Carl Winslow covered in flour in an attempt to bake gingerbread cookies. When Urkel tells Carl that he looks like Casper the Friendly Ghost, Carl tells Urkel "Get Out!" Urkel then tells Carl "I said friendly.", to which Carl says "Get out!" in a spooky voice.
Homicide: Life on the Street: In a first season episode, Howard thinks the ghost of a murder victim has been contacting her in her sleep to tell her who did it. Naturally, when Crosetti and Lewis hear about this, they sing the theme song to "Casper the Friendly Ghost".
In Kindred Spirits on the Roof, Yuna Toomi agrees to help two ghosts, Megumi Nagatani and Sachi Enoki, enable same-sex couples to get together. When Megumi proudly says ghosts don't have to take exams, Yuna thinks, "I get it, Casper."
Danny Phantom: Casper High School is named for the titular ghost.
Gravity Falls: The picture of the Level 1 ghost in the Journal looks like Casper.
Robot Chicken: A sketch from "Book of Corrine" features Casper's brother, Jasper the Douchebag Ghost, being mean to people by hurting and cursing at them.
At the beginning of "Treehouse of Horror", the camera pans through a graveyard full of humorously-marked tombstones, including one for "Casper the Friendly Boy".
In "The Fabulous Faker Boy", Principal Skinner tells Marge that he wants Bart to be less like Dennis the Menace and more like Casper the Friendly Ghost if the latter were still alive.
In "Toons From the Crypt", the second segment, "Concord the Kindly Condor" is an Affectionate Parody of Casper, with Concord in the role of the titular ghost, and Concord's older brothers in the roles of the Ghostly Trio.
In "Night Ghoulery", the second segment, "Sneezer the Sneezy Ghost" is an Affectionate Parody of Casper, with Sneezer in the role of the titular ghost.
