The Infected in 28 Days Later have red eyes. They're also very aggressive.
The HAL 9000 computer in 2001: A Space Odyssey uses cameras with glowing red lenses to watch the crew of the Discovery.
A rare yellow-colored variation of this trope happens at the end of Angel Heart when Louis Cypher is telling Harry Angel that he was the missing cannibal serial killer Johnny Favorite and that Johnny's (And therefore, Harry's) soul is his, for a brief couple seconds, his eyes turn yellow.
In Apollo 18, one of the symptoms of the parasite infection is a red ring around the host's irises.
Blood Ransom: In the second half of the movie, Crystal gains the ability to turn her irises red on command and the vampirism progresses.
Brightburn: Brandon's eyes turn red when he's about to use his laser vision.
In Child's Play (2019), Chucky (and presumably, any other Buddi doll, although we don't see it) does this whenever acting beyond his programming.
Cthulhu: "Do it, Russell! Make sacrifice! Look into the red eye of your god!"
Dark Angel: The Ascent: Veronica's eyes turn red every time she gets angry, revealing her true nature as a demon.
Don't Listen: Sometimes, people's eyes turn red as the blood vessels in them seem to overtake the white schlera. This is to signify that they're under the witch ghost's power.
Vampires in Fright Night (1985). Jerry Dandridge and Amy Peterson in their humanoid forms, Jerry Dandridge in bat form, and "Evil" Ed Thompson in wolf form all have red eyes. Hammer Horror vampires often have red — or rather, very bloodshot — eyes.
Gozer's dog demons Zuul and Vinz Clortho both have glowing red eyes.
After Tully is possessed by one of the dog demons, his eyes flash red when he becomes angry. Dana Barrett's eyes also become red after she is possessed.
While in his female human form, the evil deity Gozer the Gozerian has red eyes.
In Godzilla: Tokyo S.O.S., the title character tries to charbroil Mothra's newly borne twin larvae with his atomic breath. Mothra jumps in front of her children to save them and is promptly set alight for her troubles. She explodes and, at that point, her children's eyes turn from a benevolent blue to a hellish red and they proceed to team-up with Mechagodzilla to beat the hell out of Godzilla.
Space-Godzilla has glowing, red, eyes with cat-like slits as opposed to Godzilla's fiery, human-like ones.
Godzilla sports bright red eyes occasionally in Godzilla vs. Kong, generally as a result of Kong royally pissing him off.
Mogwai in the Gremlins series when they've eaten after midnight and become evil.
Voldemort in Harry Potter and the Philosopher's Stone, staying true to the original story. Later films were much less accurate, giving him Creepy Blue Eyes. According to the creative director this was to give an Uncanny Valley effect as Voldemort is more appalling if there's still a trace of humanity in his face. This idea works, especially in Goblet of Fire.
Horrific: In Crypt of the Undead, the undead executioners have red eyes, as does anyone possessed by the ghosts of the witches.
In Horror Express, whoever the alien possesses or has zombified is noted with glowing red eyes when the train cars are dark. The effects that go with this go away in the light.
It's not the eyes, but the robots in I, Robot turn on a red chest light when being controlled by the villain. Justified: it's explained that the red light indicates when a robot is downloading a firmware update from US Robotics. VIKI uses this connection to upload her (twisted) logic and understanding of the Three Laws into the consumer-model NS-5's.
In Judge Dredd, the deadly ABC robot controlled by Rico has glowing red eyes.
Iron Man 2: The Mk II eyes light up blue like all Iron Man suits — as War Machine, they are red.
Thor: The Frost Giants have blood-red eyes, and it's the only other color they have on their icy blue bodies. Loki also gets red eyes and blue skin when he touches the Frost Giants' source of power, showing he's one of them, but this is never brought up again.
Iron Man 3: The Extremis virus turns the eyes of whoever been injected with it, glowing red. In fact it's the red eyes that is first real indication to Happy Hogan that Savin is up to no good.
Thor: The Dark World: those who are under the influence of the Aether aka Reality Stone have their eyes turn dark red. Similarly using the Power Stone in Guardians of the Galaxy (2014) turns the user's eyes purple, the Mind Stone blue, etc.
Ant-Man and Ant-Man and the Wasp: Subverted by Hank Pym, Scott Lang, Janet and Hope van Dyne. They have red lenses in their Ant-Man or Wasp helmets, but they're quite a nice bunch.
Yondu's eyes are red, which, similar to the Frost Giants, contrasts with his blue skin. We get a nice closeup of them during Guardians of the Galaxy Vol. 2 when he's using his arrow to kill dozens of mutineering Ravagers.
The Mask: When the criminal Dorian Tyrell puts on the magical mask of Loki and his massively evil hidden dark side comes out, his eyes become red.
The Matrix: The Sentinel "search and destroy" robots (which threaten the humans in the real world throughout the trilogy) have multiple glowing red eyes.
Although we never actually get to see their real eyes, the glowing red goggles of the Red Eyes gang in Mystery Men seem to reflect this trope.
This happens to Falcor in The Never Ending Story 2, when he refuses to carry the sorceress Xayide.
Oblivion (2013): You didn't expect the HAL 9000-eyed drones to be up to any good, did you?
One Hour Photo has Robin Williams in a calm dream sequence, but when he opens his eyes, they are blood red and some blood trickles out of one. He then puts his hands on his eyes, screaming out "AAAAHHHHHHH!" while blood flies all over the place from his eyes.
Popeye and a very late Olive Oyl in The Movie carrying the newly discovered Swee'Pea at the door of Olive's house after being late for a date with Bluto=big trouble. Bluto, seething with anger, sees Popeye, Olive, and the baby through red eyes, pummels Popeye into the ocean below, and, in the next scene, persuades the taxman to tax the prestigious Oyl family into bankruptcy as revenge.
In The School for Good and Evil (2022), Sophie, who is being corrupted towards evil, is shown with glowing red eyes as an unseen figure cradles her face.
In Short Circuit 2, Johnny 5's remaining eye turns red with fury when he realises that Oscar tried to have him destroyed but only incarcerated his human friends.
Star Wars: The "Sith eyes" seen on Darth Sidious, and later Darths Maul and Vader in the prequels (technically red-rimmed gold, but it still counts). Lore tell us that "Sith eyes" happen when a Force-wielder is deeply immersed in the Dark side. Maul, having been raised in the Dark Side since he was a child, is naturally always sporting these. Darth Vader is seen with these eyes first when he slaughters the Separatists and then after Obi-Wan dismembers him. In the suit, his eyes turn yellow after Obi-Wan sliced open his helmet on a barren moon. Palpatine's mastery of the dark side allowed him to conceal his yellow eyes whenever he was masquerading as a benevolent politician. After his fight with Mace Windu, Palpatine stopped bothering to conceal his eyes.
This trope is applied sometimes with Count Dooku, a.k.a. Darth Tyranus, who is seen with Sith eyes few times in animation and novels but not in the prequel movies. Usually happens when he's shooting lightning, due to Force lightning being a dark side ability.
The eyes of Cad Bane from The Clone Wars, the Nemoidians and Grand Admiral Thrawn may fit this trope better on a superficial level (being pure red), but this is only because that's the natural eye color of their respective races — not Sith sorcery.
In the theatrical version of A New Hope, Vader's eye lenses had a dull reddish tint to them due to the materials used. It probably wasn't intentional, due to the fact that later edits removed the reddishness in order to hide David Prowse's eyes. However the red lenses are brought back in Rogue One and they look great◊.
Played with in Solo when Qi'ra contacts the previous unseen leader of Crimson Dawn, revealed to be Darth Maul. While she doesn't have them herself, the glow of Maul's red lightsaber reflects on her eyes, giving them a red color, symbolising her decision to stay with Crimson Dawn rather than escape with Han.
In The Rise of Skywalker, C-3PO of all characters briefly has red ominous glowing eyes and speaks in a harsh deep voice when he is forced to translate a message in the Sith language.
The older "ghost" in The Stone Tape first appears as a pair of glowing eyes hovering in the darkness. Then to show how inhuman it is one eye begins to orbit the other as it approaches the heroine.
In Teen Wolf, Scott's eyes flash red and his voice drops to an evil growl to intimidate the hard-ass old man into selling him a keg of beer.
Most of the Terminators from, well, the Terminator franchise have glowing red eyes, which become even more obvious when only their endoskeletons are showing.
The Hood, the villain of the live-action Thunderbirds film, has these when he uses his psychic powers. His heroic niece, Tintin, has Supernatural Gold Eyes in contrast, when she uses her powers.
The Japanese stranger from The Wailing usually looks like a normal old man, but when hunting in the wild he is pictured with red eyes (and also almost completely naked).
. In fact it's the red eyes that is first real indication to Happy Hogan that Savin is up to no good.
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