HQ receives word that astronauts on the International Space Station orbiting Earth have been disappearing, and dispatch Gadget, Penny and Brain to get to the bottom of what's going on. Meanwhile, something lurks aboard the station...
This episode contains examples of:
- Evil Is Petty: Talon is annoyed with what Dr. Claw plans to do with the solar-focused ray they've attached to the station: use it to carve the Grand Canyon into "the Grand Claw-yon!"
- Mythology Gag: This isn't the first time that MAD has used a solar-focused ray as part of an evil scheme, though in the original show Claw did intend to use it to hold the world hostage for money, as Talon suggested here.
- Rubber-Forehead Alien: Well, more accurately rubber suit alien.
- Shout-Out: The title is one to the Alien franchise, specifically Hudson's famous line, "Game over, man! Game over!"
