Nightmare Fuel / Dragon Quest IV

• In a mixture of this and Tear Jerker, Mamon and its Mines, allegedly based on the infamous mining town of Centralia, Pennsylvania, starts off as a mining town where people are sick from the poison gas that's emitting from the mines. Then when you come back later in Chapter 5, after learning about Estark's whereabouts, the town is literally empty. It was not helped that the people dug too deep into the mines, worsening the poison gas situation. You can actually see it in the remakes...brrr...
• Psaro the Manslayer's grotesque transformation during the final battle. When you finally track him down, he's used the Secret of Evolution to transform himself into a being like Estark in hopes of defeating you. However, the method had warped his mind so severely that he can hardly remember who he was, nor what he had originally set out to do. He still manages to slowly transform into something even more monstrous than Estark was over the course of the battle, which takes up to seven phases to finally complete.