Welcome back to Cvstodia, where the Miracle has returned to once again transform the land's inhabitants into horrifying monstrosities based on their manifested sins. Plenty of (body) horror ensues.
- It is made clear right from the start that the Miracle is about to give birth to a child, with a massive human heart in the sky hanging ominously above Cvstodia and acting as the child's womb. Considering how products of the Miracle tend to look this does not bode well.
- And when it's finally born and fought in the final battle, it manages to look exactly as you'd expect; an uncanny mix of holy and unholy at the same time.
- The first time you reach the chasm leading to Profundo Lamento a chilling scream can be heard out of nowhere, implying something horrifying is down there. You never actually find its source, it merely ends up being a hint for one of the game's more difficult quests.
- The Lady of the Chalices, who improves and increases your health and Bile Flasks has her flesh slowly peeled, first from her arm, her head, and eventually her entire torso. The cherubs that accompany her flay her bit by bit to allow her to bleed enough to complete the Flasks. Collect all of her associated collectables and she ends up as just a blood-red, still animate skeleton, with her limp flesh hanging off her. It doesn't help that she actively urges the Penitent One to collect the upgrades in spite of the horrific torture she suffers.
- Palace of the Embroideries is an unsettling and cursed place. It is absolutely littered with the corpses of unfortunate individuals wrapped up in thread-like material, as if wrapped up by giant spiders. It is revealed to be the handywork of the area's boss, Orospina, who delighted in the torture of her victims, before leaving them in this wrapped-up state. Some of the corpses have been there for so long their "cocoons" are empty when struck.
- A similar predicament has befallen a lot of people who entered the Severed/Inverted Tower, but their bodies have simply been covered in copious amounts of candlewax, eventually drying up.
- An NPC in the Choir of Thorns vomits and bleeds an endless tide of honey due to the massive hive of bees that have built a nest in his guts. If you break the Maiden altarpiece he gives you and return to him, he's increasingly full of holes. By the third and final time, his head is gone, revealing a hollow torso overflowing with honey. He notes with disturbing cheerfulness that he's actually dissolving completely into honey, and will soon be gone for good — leave the room and return, and there will be nothing of him but a massive puddle of honey where he was.
- Afilaor, Sentinel of the Emery is found deep in Beneath Her Sacred Grounds, below Mother of Mothers. There is little indication you're about to face a boss before encountering him. Upon entering his room there is no dialogue. This lanky figure sharpening a sword simply notices you and you're thrust into battle with an ominous score to accompany the fight. The entire ordeal is unsettling.
- Cesáreo, an NPC found in the Severed/Inverted Tower combines this with nausea fuel. He is found breastfeeding a child from a breast grafted onto his own body. His animations even show him squeezing it to produce squirts of milk.
- Ending B. The Incarnate Devotion has learned about pain and its role in Cvstodia. It matters no longer that the High Wills are dead. The Miracle must go on, with or without a purpose. And this time, by merging with the Penitent One's corpse, it all but ensures this time it will stick.
