This episode, which sees footage of Mr. Herriman's dancing for Madame Foster being uploaded to the internet, seems to be a spoof of any online videos going viral and becoming famous by the public for it, and there are different versions of the footage uploaded that seem to be a spoof of YouTube Poops... until you realize that the episode premiered less than five months before YouTube existed and seven months before the first YouTube video was posted. This did not go unnoticed by the show's staff, as a later episode, "Bloo Tube" features a spoof of YouTube called ViewTube, where the "Funny Bunny" video is shown to have over twelve million views.
In the episode "Bye Bye Nerdy", Bloo is shown playing a Space Invaders-esque game with a power-up that shoots a giant vertical laser. A few years later a game title Space Invaders Extreme 2 has that exact same power-up.
In the episode "Seeing Red", Terrence imagines a pizza friend whom he eats, right after it says that it loves him, much to its horror. Twelve years later, Sausage Party gets released, which is a film about anthropomorphic foods who revere humans at first but eventually learn that the humans they look up to use them for eating and not for friendship, once they get purchased.
The much-hated Bendy now shares his name with a horror game character, and this Bendy even gets covered in ink in his episode. The other Bendy is actually very well-received, unlike Foster's Bendy.
The season 4 premiere "Challenge of the Super Friends", is the show's main Superhero Episode, the season 5 premiere airs the same day Spider-Man 3 was released in theaters. Also in the same episode there are many Star Wars references such as Revenge of the Sith and The Empire Strikes Back, what also becomes funny is that the season 5 premiere aired on what will later be National Star Wars Day.
In "My So Called Wife", Mac and Bloo make a fake charity, Jet Cars For Tots, so they can compete in the charity games. While intended as a parody of Toys For Tots, a different charity has sprung up and become rather infamous in the years since: Kars4Kids.