After nearly a decade of appearing in supporting roles, he officially broke out in 1990 with a starring role as Vincent Mancini in The Godfather - Part III, and followed it up with several well-known roles, such as Arturo Sandoval in For Love or Country: The Arturo Sandoval Story and Terry Benedict in the Ocean's Eleven films.
Filmography:
- 8 Million Ways to Die (1986): Angel Maldonado
- The Untouchables (1987): George Stone/Giuseppe Petri
- Stand and Deliver (1988): Dr. Ramirez
- Black Rain (1989): Charlie Vincent
- Internal Affairs (1990): Raymond Avila
- The Godfather Part III (1990): Vincent Mancini
- Dead Again (1991): Gray Baker
- Accidental Hero (1992): John Bubber
- Jennifer Eight (1992): John Berlin
- When a Man Loves a Woman (1994): Michael Green
- Things to Do in Denver When You're Dead (1995): Jimmy "The Saint" Tosnia
- Hoodlum (1997): Charlie "Lucky" Luciano
- Desperate Measures (1998): Frank Conner
- Ocean's Eleven (2001), Ocean's Twelve (2004), Ocean's Thirteen (2007): Terry Benedict
- Confidence (2003): Gunther Bhutan
- Twisted (2004): Mike DelMarco
- The Lost City (2005): Fico Fellove (also executive producer/director)
- New York I Love You (2008): Garry
- Beverly Hills Chihuahua (2008): Delgado (voice role)
- The Pink Panther 2 (2009): Vicenzo Brancaleone
- City Island (2009): Vince Rizzo (also producer)
- For Greater Glory (2012): Enrique Gorostieta Velarde
- Rio 2 (2016): Eduardo (voice role)
- Ghostbusters (2016): Mayor Bradley
- Max Steel (2016): Miles Edwards
- Passengers (2016) (2016): Admiral Norris
- Geostorm (2017): President Andrew Palma
- Mamma Mia! Here We Go Again (2018): Fernando Cienfuegos
- My Dinner with Hervé (2018): Ricardo Montalbán
- 3Below (2018 - 2019): King Fialkov Tarron (voice role)
- Modern Love (2019): Michael (episode: "When Cupid is a Prying Journalist")
- Ana (2020) as Rafa
- Words On Bathroom Walls (2020): Father Patrick
- Father of the Bride (2022): Billy
- Expend4bles (2023) as Marsh
