Fiend Folio is filled to the brim with fiendish friends and foes.
Playable Characters
Normal Characters
Fiend
Fiend
Fiend begins each run with an innate Pyromancy item, which allows him to launch a fireball at his enemies by double tapping the fire keys.
Fiend's Birthright grants his Pyromancy fireballs a homing effect and gives them a chance to spawn a heart minion.
- Amazing Technicolor Population: For whatever reason, Fiend is purple.
- Flipping the Bird: This may as well be Fiend's trademark; it's his signature pose, what he does for "positive" actions in place of Isaac's thumbs-up, and official artwork usually has him giving the middle finger if his hands are visible.
- Genius Bruiser: Fiend wrote the eponymous folio that the mod is named for, and is more than capable of obliterating everything it adds to the basement.
- Glass Cannon: Whenever Fiend takes damage, his health bar turns into familiars. More familiars means more damage dealt, but can potentially leave Fiend with only half a heart for defense.
- Life Drain: Enemies killed by Pyromancy's fireballs have a chance of dropping half Immoral Hearts.
- Lovable Rogue: Fiend's an asshole, but it's hard to not root for him.
- The Minion Master
- Playing with Fire: Can be configured, but Fiend has the ability to conjure up fireballs and fling them at his foes.
- Ruder and Cruder: Fiend's equivalent to Isaac's thumbs up pose has him flip the bird instead. Fiend also swears up a storm when he takes damage, as seen when he picks up the Mime Degree.
Golem
Golem
Golem starts every run with an inherent Mom's Purse effect, allowing him to carry two trinkets at once. He also begins with the Dirt Clump and Rolling Rock trinkets.
Golem's Birthright effect gives him +2 Luck and causes tinted rocks to drop rock trinkets instead of Soul Hearts.
- Diminishing Returns for Balance: Smelted rock trinkets grant less of an effect than if they were held in one of his trinket slots. Smelted geodes also don't grant their bonus effect unless both of Golem's trinket slots contain geodes.
- Golem: Obviously.
- Hub Level: Golem's Subway has doors that lead to the Treasure Room, Boss Room, Secret Room, and Shop, but they only function once Golem has already entered the room in question.
- Living Statue
- Unique Protagonist Asset: Golem's Subway is entirely unique to him and contains several NPCs that perform services relevant to Golem's Trinket-heavy playstyle.
- Sourpuss the pig will smelt one of Golem's rocks in exchange for 1.5 Soul Hearts, but only appears on even-numbered floors.
- Sweetpuss the pig will take a rock and reroll it into a fossil. If the rock he's given is already a fossil, he instead crushes it and activates its crush effect three times.
- Babi the demon sells rare-quality rocks in exchange for heart containers, similar to a devil deal.
- The Unfinished Golem only appears on odd-numbered floors, but drops a rock trinket when bombed.
- The Bismuth Golem will crush one of Golem's rocks, spawning 1-1.5 Soul Hearts, plus a bonus effect if the rock was a fossil.
- The Mining Machine costs 3 cents to use and will grind one of Golem's rocks, rerolling it into another, different rock.
- The Geode Golem will take a rock and reroll it into a geode. If the rock Golem gives it is already a geode, it will duplicate it instead.
- The Midarizer costs 10 cents to use, and will turn one of Golem's rocks into its golden version.
- Visual Pun: Golem's equivalent to Isaac's thumbs-up pose is a devil horn hand gesture. He's telling you to rock on.
Tainted Characters
Fiend, the Bastard
Fiend
Using Malice a second time while split will cause all of the Bastard's duplicates to fuse back into one.
The Bastard's Birthright effect grants a greatly increased chance for enemies to drop Black Hearts when killed by Malice, and gives each of his copies a hat that alters their stats in various ways.
- Anti-Frustration Features: While split up, each of his copies has only one health. But when one dies, the rest gain Mercy Invincibility.
- Additionally, unlike Jacob & Esau, or any of the items that give a temporary extra character, the player only controls one of the Bastard's copies while split up, with the other copies automatically clustering around the player-controlled copy. This, plus their small size, makes it less likely for the other copies to get caught on objects.
- Blob Monster: The Bastard's body is made up of nothing more than black sludge.
- Doppelgänger Attack: His main gameplay mechanic.
- Pulling Themselves Together: Using Malice while split causes the Bastard's copies to fuse back together.
- Shout-Out: Some of the hats given by Birthright include Captain Olimar's helmet, a flower, Mario's hat (but with an "F" in place of the "M"), the Ghastly Gibus, the Tyrant's Helm, and a pair of googly-eyed goggles.
- Weak, but Skilled: The Bastard has an inherent 20% damage penalty, which is further decreased to about 50% while split up, but makes up for it by having up to six bodies to shoot with.
Challenge Characters
China
China
China has a 15% chance to find a Horse Push-Pop after clearing a room, which will remove one of her broken hearts. Additionally, she has a 20% smaller hitbox and an innate 25% faster fire rate.
China's Birthright grants her the Horse Paste item in her pocket slot, which allows her to remove a broken heart once every eight rooms.
- Blessed with Suck: The design document for Fiend's gang describes her fragility as being her "special ability".
- Edge Gravity: Averted. China can fall into the pits that other characters treat as walls, damaging her.
- Fragile Speedster: She has an inherently faster firing speed than other characters, but takes damage very, very easily.
- Literally Shattered Lives: Dying causes China to shatter into pieces.
- Meaningful Name: China as in "fine china", another term for porcelain.
- Obvious Rule Patch: To accommodate China not being able to press up against objects without taking damage, she's able to interact with doors and key blocks from a short distance away.
- Trademark Favorite Food: Horses. Horse glue heals her, and if Fiend Folio's joke "Stable Mode" is activated, China will eat any horse enemy that touches her.
Slippy
Slippy
Slippy has an inherent triple shot much like the Keeper, and begins play with the aforementioned Golden Frog Head in her active slot. By holding the active item button, Slippy is forced to stand still and begins to charge up a fart that grows in strength the longer the charge is held.
Slippy's Birthright causes her Golden Frog Head farts to leave behind clouds of gas that poison enemies.
- Obvious Rule Patch: Slippy is the only character who can't make an immediate 180 degree turn, to prevent players from circumventing her gimmick by pressing opposing movement keys. If the player wants to hold still, they'll need to either use the Golden Frog Head, or do fancy footwork with all four of the movement keys.
- Wing Ding Eyes: "X"es.
Hidden Characters
Fend
A yellow imp who is Fiend's janitor and best friend. He can't normally be selected, but the player may "unlock" him by editing the 'players.xml' file
- Almighty Janitor: Averted. He's literally a janitor, but he's not good at anything else.
- Joke Character: Fend starts with the Spirit Sword (reskinned to look like a mop) and Lost Contact, but has an inherent .20x damage multiplier. He won't take much damage, but neither will his enemies.
Fient
An orange imp who is Fiend's weed supplier. Like Fend, he can only be played as by editing the 'players.xml' file
- Mighty Glacier: Played with. His speed is quite average. But he might as well start with Polyphemus, as his damage and tears stats start at 14.20 and 0.97 respectively. The latter can be rectified by using Wavy Cap at a cost. He also starts with two Black Hearts and one of Fiend Folio's Morbid Hearts, which take 3 hits to deplete and spawn a tumor familiar upon doing so.
- Numerological Motif: Fient is associated with the number 420. He starts with 14.20 damage, 4.20 range, a 0.420x shot speed multiplier, as well as 4 coins, 2 bombs, and 0 keys. Fitting, since he's...
- The Stoner: He is heavily associated with weed, is Fiend's weed supplier, and starts with the Wavy Cap item in his pocket slot.
Peat
A character made from low-res images of Peter Griffin from Family Guy. Like Fend and Fient, he too can only be played by editing the game files.
- Joke Character: Even moreso than Fend. No attempt is made to make him fit the art style of The Binding of Isaac, and he's completely unable to pick up items of any kind aside from hearts. Meaning he can't increase his stats except his health, and he's unable to fight ???, The Lamb, the Boss Rush, Mega Satan, Mother, or Dogma and the Beast since he can't pick up their associated quest items.
Bosses
Chapter 1
Buck
Buck
Debut: Fiend Folio
Floor(s): Basement
A large beggar wearing a burlap sack over his head.
- Angry Eyebrows: The first thing Buck does after entering his boss room is draw a pair of eyebrows on his bag.
- Bag of Holding: Buck's bag contains blood, bombs, and smaller bags (that turn into Mooks).
- The Dividual: A close look at Buck reveals that he's actually two separate beings: A fat, headless corpse, and a shadow monster hiding inside the bag.
- Easter Egg: Landing the killing blow on Buck using the Crafting Bag causes him to drop the Mystery Badge.
- King Mook: To the Snagger enemies.
- Off with His Head!: Defeating him makes his bag mask fall off, revealing that he has no head.
The Whispers
The Whispers
Debut: Reheated
Floor(s): Cellar
A trio of ghosts found haunting the Cellar.
- The Dividual: All three ghosts share the same health pool. When one of them dies, they all die.
- Easter Egg: Taking a photo of them with the Toy Camera item shows a fourth ghost that the other three orbit around.
- Shout-Out: Their movement pattern is based on the Boo Buddies in Super Mario World. Also, their laugh is a sped up version of Satan's laugh, similar to how Boos use a sped up Bowser laugh in Super Mario 64
Honeydrop
Honeydrop
Debut: The Devil's Harvest
Floor(s): Cellar
A colossal bee found in the Cellar.
- Bee Afraid: Honeydrop is relentless. After losing half of her health, she launches her stinger and continues fighting anyway.
- Flunky Boss: Honeydrop constantly summons other bee enemies.
- King Mook: Of the various bee enemies Fiend Folio added to the Cellar.
Griddle Horn
Griddle Horn
Debut: Fiend Folio
Floor(s): Burning Basement
A thoroughly-scorched Little Horn variant whose attacks are now more incendiary than explosive.
- Easter Egg: Using the White Pepper on Griddle Horn instantly kills him and drops the Spatula Badge.
- Eye Scream: Compared to his living counterpart, Griddle Horn's eyes have melted away leaving just the sockets.
- Finger-Snap Lighter: If there's any gunpowder in the room when Griddle Horn snaps his fingers, it'll catch fire. Otherwise, it creates gunpowder creep under Isaac.
- Playing with Fire: Griddle Horn coughs up clumps of burning coal, which can ignite the gunpowder his other attacks leave behind.
- Powder Trail: A variation without explosives. The gunpowder catching fire serves as the hazard instead.
Buster
Buster & His Commission
Debut: Fiend Folio
Floor(s): Burning Basement
A large fly with burnt skin who attacks alongside his minions known as "Commissions".
- Bad Boss: Some of Buster's attacks involve setting his Commissions on fire, and chewing them up to spit at Isaac.
- Easter Egg: Using the Defuse card after defeating Buster (but before he explodes) stops him from exploding and drops the Commissioned Badge.
- Eyeless Face: Buster lacks eyes, unlike most of the fly enemies.
- King Mook: To the Boom Flies.
- Made of Explodium: When defeated, Buster begins ticking and eventually explodes, which can damage Isaac if he's too close.
- Playing with Fire: Leaves behind a trail of fire when he charges.
- Wild Take: Nearby Commissions' understandable reaction once Buster starts ticking.
Meltdown
Meltdown
Debut: Reheated
Floor(s): Burning Basement
One of the Modern Horsemen of the Apocalypse, representing nuclear winter.
- Bad Boss: Meltdown punches his horse mount to attack, and when going into phase two, he tosses it to the ground in anger.
- Body Horror: Meltdown's body looks as though it's melting, so much that he's effectively fused to his horse mount, and his flesh sloughs off into Falafel minions as he takes damage. His skeleton reveals that he doesn't have legs.
- Dem Bones: Reduced to a skeleton in phase two.
- Didn't Think This Through: After losing half his health, Meltdown blames his horse and throws it on the ground in frustration, not realizing that throwing around something that's carrying a nuclear bomb in its mouth isn't a good idea until it starts beeping.
- Early-Bird Cameo: Defeating Meltdown three times in a file unlocks two Flea trinkets, revealing the existence of Deluge, chapter 2's as-of-yet unreleased Modern Horseman.
- Sickly Green Glow: In phase two, Meltdown's head is engulfed in green fire.
Chapter 1.5
Ghostbuster
Ghostbuster & His Emissions
Debut: Reheated
Floor(s): Downpour
A posthumous Buster, now a ghost who attacks with his ghostly minions known as "Emissions".- Fire/Water Juxtaposition: In contrast to the living Buster's fire attacks, Ghostbuster instead uses water.
- Non-Human Undead: Ghostbuster is the ghost of a fly.
- Shout-Out: To Ghostbusters.
- Vacuum Mouth: Uses this to suck in his Emission minions, as well as Isaac. He also does it when defeated before exploding.
Cacamancer
Cacamancer
some caption text
Debut: Reheated, returning from Devil's Harvest
Floor(s): Dross
A large mage made of pure poop.- Last Ditch Move: Upon death, he fires out multiple projectile patterns, ending with an explosive shot that detonates the gas clouds he leaves behind.
- Toilet Humor: He's made out of poop.
- Whatevermancy: Cacamancy.
Chapter 2
Battie
Battie
Debut: Fiend Folio
Floor(s): Caves
A large bat with an ill temper.- Easter Egg: Using the Fiend Folio active item against Battie always creates a friendly Battie that defeats the boss instantly, which also rewards the player with the Baby Badge.
- Ground Pound: She flies into the air and slams down, creating shockwaves of stone.
- King Mook: To the various bat enemies.
- Wraparound: One of Battie's attacks has her charge across the room several times in this manner, leaving behind a trail of blood shots.
Kingpin
Kingpin
Debut: Fiend Folio
Floor(s): Caves
A large worm who burrows in and out of the ground while chasing Isaac.- Bullet Hell: Every time Kingpin leaps out of the ground, he leaves behind trails of stationary bullets that can quickly fill the room.
- King Mook: To the Weavers.
- Non-Indicative Name: Despite having "Pin" in his name, Kingpin acts more like a cross between Larry Jr. and one of Fiend Folio's Weaver enemies.
- Segmented Serpent: Just like Larry Jr., killing one of Kingpin's center pieces causes him to split into two.
Slinger
Slinger
Debut: Reheated
Floor(s): Catacombs
A skinless humanoid creature with a spider egg sack for a head.- Teeth Flying: When Slinger first enters the room, he faceplants and leaves a tooth on the floor that generates red creep until it's destroyed.
- Use Your Head: Slinger can spawn spiders by lobbing his head, which naturally grows back.
Monsoon
Monsoon
Debut: Fiend Folio
Floor(s): Flooded Caves
A Blob Monster made entirely of water based on Monstro.- Easter Egg: Using Flush against Monsoon's smaller form instantly kills him and drops the Dripping Badge.
- I Have Many Names: While "Monsoon" is the default, there are options to change his name to "Moistro", "Jack the Dripper", or "Jack Moistro the Monsoon Dripper".
- Kill It with Water: A water drop monster who sprays water and bubbles to attack.
- King Mook: To the Drop enemies.
- Mythology Gag: Monsoon reuses Monstro's sound effects from the original Flash Binding of Isaac.
Aquagob
Aquagob
Debut: Reheated
Floor(s): Flooded Caves
A large blue severed head who spits water and bubbles at Isaac.- King Mook: To the Horf enemies.
- Mook Maker: He can summon Horf variants called Aquababs, and some of his bubbles contain flies.
Chapter 3
The Organization
The Organization (Chaser, Speedy, Bashful, and Pokey)
Debut: Fiend Folio
Floor(s): Depths
A quartet of ghosts, each possessing a single organ. They consist of Chaser (brain), Speedy (heart), Bashful (eye), and Pokey (intestines).- Attack Its Weak Point: Only Chaser's brain is vulnerable to damage. All of the other ghosts are invincible, including Chaser's brainless body when he throws it, and block Isaac's shots.
- Easter Egg: They die in one hit to the Gamekid or Power Pill effect and drop the Haunted Badge. Which is appropriate, considering...
- Expy: They're basically the ghosts from Pac-Man, with their names and movement patterns taken from the original game: Chaser is Blinky's Japanese title, while Speedy, Bashful and Pokey are the English titles for Pinky, Inky, and Clyde.
- Irony: Despite containing the quartet's guts, Pokey himself is gutless.
- Meaningful Name: Chaser chases, Speedy is fast, Bashful is bashful, and Pokey is slow.
- Punny Name: "Organization" is a play on how there's not only four ghosts, but that each of them contain an organ.
Gutso the Great
Gutso the Great
Debut: Reheated
Floor(s): Depths
A massive, overbloated humanoid figure the size of Gurdy, whose eponymous gut hides a nasty secret...- Body Horror: After taking enough damage, Gutso's stomach tears open and his innards begin attacking.
- Fat Bastard: Gutso's so fat he can't even move.
- Mythology Gag: Gutso bears a resemblance to this
◊ unused sprite for Mega Fatty.
Luncheon
Luncheon and the Tapeworms (Petunia, Minkus, Greg, and Boris)
Debut: Fiend Folio
Floor(s): Necropolis
A massive, sock puppet-like worm creature, from whose maw spill other, smaller worms.- Flunky Boss: Luncheon spits up tapeworms to fight on its behalf. After killing enough worms, Luncheon is defeated.
- Mix-and-Match Critters: The tapeworms Luncheon spawns have three segments that influence the worm's abilities: A head, a torso, and a tail. Each segment is taken from one of four possible tapeworms: The cheerful Petunia, the fearful Minkus, the aggressive Greg, and the spacey Boris.
- Mythology Gag: The tapeworms are based on Tapeworm, a board game made by Edmund McMillen.
Pollution
Pollution
Debut: Fiend Folio
Floor(s): Dank Depths
One of Meltdown's colleagues among the Modern Horsemen, though HIS gimmick is evident from his name.- Badass Biker: Pollution's horse is also a motorcycle.
- Breath Weapon: His horse can breathe fire, which carries over into phase 2 when Pollution wears its head in place of his own.
- Car Fu: Pollution will run Isaac down on his horse-cycle, and when phase 2 of the fight begins, he kicks the horse's remains at Isaac.
- Defeat Equals Explosion: Pollution explodes when defeated. Unlike Buster, however, this can't damage Isaac.
- Early-Bird Cameo: Defeating Pollution three times in a file unlocks two Flea trinkets, revealing the existence of Propaganda, chapter 4's as-of-yet unreleased Modern Horseman.
- Off with His Head!: The transition into phase 2 begins with Pollution losing his head and replacing it with his horse's.
Tsar
Tsar
Debut: Reheated
Floor(s): Dank Depths
The foulest-smelling entity in all of Fiend Folio, Tsar is a blob-like creature who can alter its bodily composition by absorbing a number of foul substances.- "Get Back Here!" Boss: Between hiding inside grates and bouncing out of range of Isaac's tears, there are few opportunities to deal damage to Tsar.
- Ground Pound: He can hover in the air and slam down, not only trying to smash Isaac, but also causing the pipes in his room to spread creep on the floor.
- Muck Monster: Tsar's body is made up of not only tar, but sewage and corrosive sludge as well.
- Punny Name: Normally tsar is pronounced with a silent T, but in this case the S is silent to make the word tar.
- Vomit Indiscretion Shot: Upon his death Tsar vomits up his whole body, leaving him as just a withered skeleton.
Junkstrap
Junkstrap
Debut: Monthiversary Update
Floor(s): Dank Depths
A massive skull armed with and protected by tar, trash and a massive football helmet.- Expy: Visually, he resembles The Gate from base Isaac, but made of garbage and wearing a football helmet.
- King Mook: To Fiend Folio's Dope's Head enemies.
- Punny Name: Junk + jock strap.
- Spikes of Doom: Junkstrap can line the edges of his boss room with spikes, which he'll try to push Isaac onto.
Chapter 3.5
Warp Zone
WARP ZOOOOOOOOOONE!
Debut: The Devil's Harvest (as Mega Portal)
Floor(s): Mausoleum
A sentient portal with an ill will and a propensity for tricks. Who knows what lurks on the other side...?- Boss Rush: Part of Warp Zone's boss fight is dedicated to fighting warped versions of earlier bosses: Monstro, Larry Jr., and Gemini.
- I Have Many Names: Warp Zone's name can be changed to "Warp Zooooooooone" or "Mega Portal".
- King Mook: To the Portal and Mini-Portal "enemies" from the base game.
- Kung Fu-Proof Mook: Warp Zone is one of the few bosses immune to the Chaos Card. Throwing it at him has him Catch and Return it, turning Isaac into The Lost if it hits.
- Shout-Out: To Super Meat Boy. The "Warp Zooooooooone!" sound clip even plays during the Versus Character Splash.
Dusk
Dusk
Debut: Reheated
Floor(s): Mausoleum
A strange, bony, long-armed shadow creature with tricky effect tears and a mean streak a mile wide.- Creepily Long Arms: Skeletal ones, at that. At least in his first phase.
- Doppelgänger Spin: Dusk has two variants on this. One where he spawns a bunch of spectral versions of himself before lunging at Isaac, and one where he orbits Isaac alongside three copies that are colored differently than the true one.
- Flying Face: In phase two, Dusk is reduced to just his skull.
- Shout-Out: To the boss of the same name from The Legend of Bum-bo.
- Wing Ding Eyes: Violet spirals.
Madomme
Madomme
Debut: Spitshine Update
Floor(s): Gehenna
A fiendish dominatrix suit with a queenly taste for inflicting pain. Leads her loyal army of bitches into battle.- Bondage Is Bad: Kinda goes with Gehenna as a whole, but Madomme refuses to be subtle about it.
- Chess Motifs: Madomme and her bitches have this sort of motif going. G-Imps are Pawns, Horses are Knights, Castles are Rooks, Glorias are Bishops, Champ is the King, and Madomme herself the Queen.
- Dominatrix: Madomme herself, who rules over her bitches with a leather-clad iron fist, and is a living leather suit. Even Champ, the "king", is kept locked in a cage for no reason other than Madomme's amusement (Champ at least seems okay with this arrangement).
- Evil Counterpart: Madomme is the eviler counterpart to the Mausoleum's Siren, both being demonic women with large, curved horns and an emphasis on controlling minions.
- Hell-Bent for Leather: Exaggerated; Madomme is a sentient, demonic dom suit. Played straight with all of her bitches, who only wear leather gear instead of being leather gear.
- Red and Black and Evil All Over: She's a Gehenna boss, did you expect anything different?
- Slasher Smile: Half of Madomme's face is taken up by her ridiculously pointy teeth.
- Video Game Cruelty Punishment: Champ is normally harmless and invincible, but killing her using a Chaos Card or other instant death effect causes several G-Imps to spawn in retaliation.
Chapter 4
Basco
Basco
Debut: Reheated
Floor(s): Womb
A large, spiced-up poop monster with a penchant for rolling and a rather heated reaction to spicy food.- Fire-Breathing Diner: Eating spicy food will cause Basco to speed up and spray fire for a short time.
- I Ate WHAT?!: Basco's "food" only superficially resembles actual food: Cherries are a pair of eyeballs on a stem, and the strawberry is a heart. Only the drumstick seems to be exactly what it looks like, but is probably made of human meat.
- Power-Up Food: Basco will spawn several pieces of food every so often, which will either heal him or power him up depending on if they're "spicy" or not. Dealing enough damage to a healing food will cause it to rot and poison Basco when he eats it.
The Sun
The Sun
Debut: Fiend Folio
Floor(s): Utero
A gilded cauldron filled with viscera who commands a solar system of organs to defend itself: Venus (brain), Earth (kidney), and Neptune (heart).- Black Speech: Its voice is the same as Satan'snote , complete with constantly shouting Isaac's name in reverse.
- Easter Egg: Similarly to Great Gideon, killing the Sun's body with the Chaos Card will both instantly end the fight and grant the player the Planet Badge.
- Kill One, Others Get Stronger: When one of the organs is destroyed, the other two gain enhanced attacks.
- Orbiting Particle Shield: Earth is orbited by a pair of kidney stones that can block shots and will fire back if hit.
Peeping
Peeping
Debut: Fiend Folio
Floor(s): Utero
A mobile eyelike creature with a nasty glare and its sights set on conflict.- Eye Scream: Peeping tears itself out of the floor to start the fight alongside its ocular nerves. In phase three, it tears itself from the nerves and begins rolling around as just an eyeball.
- Eyes Do Not Belong There: In the first phase, Peeping has a mouth filled with other, smaller eyeballs. In phase two, he spits four of them onto stalks to aid him.
Cacophobia
Cacophobia
Debut: Monthiversary Update
Floor(s): Scarred Womb
A strange collective consisting of Venus, a bandage-wrapped creature who acts as Cacophobia's avatar, but neither moves nor attacks; and Cacophobia's many, many eyes.- Arc Symbol: Rorschach tests. They appear as her boss icon, her bestiary icon, and if you die to it, Isaac's Last Will gets replaced with one.
- Body Horror: Venus goes through a lot of it. From having her jaw broken, to her limbs cut off, to being bisected horizontally or vertically, and even reduced to Ludicrous Gibs.
- Drone of Dread: Cacophobia's fight replaces the normal boss theme with various droning sounds that change as the room does.
- Interface Screw: If the player dies to Cacophobia, Isaac's last will is replaced with a Rorshach test.
- Jump Cut: Cacophobia's main gimmick. Every few seconds, the entire boss room is rearranged. As Cacophobia's health lowers, the more frequently the jump cuts happen.
- The Little Shop That Wasn't There Yesterday: After Cacophobia is defeated, the game jump cuts to a red field, then back to the boss room, with no evidence of Cacophobia ever having been there at all.
- Shout-Out: Cacophobia as a whole is based on the works of Francis Bacon. Venus's design is based on Carsoro from Hylics 2, while the mechanics of the fight itself are reminiscent of Sans in Undertale.
- Surprisingly Creepy Moment: In a game full of Bloody Hilarious Black Comedy, Cacophobia stands out by being a genuine horror monster with very little humor.
Chapter 4.5
Mr. Dead
Mr. Dead
Debut: Fiend Folio
Floor(s): Corpse
A sentient Teratoma-like entity piloting the remains of Mr. Fred, in whose busted-open head it reclines.- Eye Scream: As a last resort, the tumor tears Mr. Dead's eyes from their sockets to act as minions.
- Mook Maker: He can spit up Bonies, as well as Tinytoma chunks that spawn Spiders or Small Maggots when destroyed.
- Orbiting Particle Shield: He often shields himself using Tinytomas.
- Puppeteer Parasite: The tumor on Mr. Dead's head appears to be in complete control of the body.
