The first villain alongside John Dee the protagonists faced in Urban Legends.
- One-Winged Angel: This time, he stole Yumeko's Nine Tails to become the Nine-Tailed Fox at the climax against the Phantom Thieves and allies.
- Starter Villain: Alongside John Dee in Urban Legends.
The first villain alongside Kelley the protagonists faced in Urban Legends.
- One-Winged Angel: As always, his Hundred Eyes form.
- Starter Villain: Alongside Edward Kelley in Urban Legends.
The most feared and strongest Yokai in Japan. Orochi was once revived in the past by Edward Kelley (and merged with the serpent) before slain by William. In Ch. 5 of Persona Vein, the serpent is revived by Saklas to fight the Phantom Thieves (except Joker), but he is slain again by them with Makoto specifically finished off Orochi.
- Orochi: As obviously part of his nature.
A hideous female Oni armed with long sharp claws. This is a separate being and not the same Yokai that was originally Senahime.
- Foil: To the Onryoki as both are the starting monsters for the protagonists (William for the Onryoki in the past, and Hifumi for the Ogress in modern times).
- Starter Villain: The first major Yokai that Hifumi fought alongside Sion.
A vampire demoness that suck the blood out of men.
A large brutish Oni who is known as one of the most commonly seen bosses back in Nioh.
A spider-woman with sickled like blades in her arms.
A chimeric beast who wielded electrical powers.
- Starter Villain: The first major Yokai that Yumeko and her friends fought in Book I.
A large flying bird with traits of corpses. It is fought in Ch. 3 of Persona Vein at Osaka, and is obliterated by the combine efforts of Sion, Joker, and Queen.
Shadow versions of Otani Yoshitsugu and Ishida Mitsunari as Yokai that the Phantom Thieves and allies fought in the Distorted Osaka realm.
A demonic centipede.
The executioner with a huge axe that serves as Kelly and John's attack dog.
Two specialized Magatsu Warriors that assist Kelley during the first Yami Matter event.
