Anyone managing to outrun "It" for a long time has to be listed here, just for sheer tenacity.
Paul briefly subduing "It" by shooting it in the head during the climax.
The plan the group put together to try and stop "It", even if it didn't work. Well thought-out, with some good improvisation. Even the musical score wants you to know this is the moment they decided to stop running and start fighting back.
Using the ruins of post industrial Detroit is quite effective.