Night Train has the player characters stop a train full of vampires using it to travel from town to town, devouring citizens and moving on. It was such an immensely popular adventure module that people created badges that said, I SURVIVED NIGHT TRAIN, for tabletop game conventions.
Dead Presidents has the PCs assassinate Jefferson Davis' Doppelgänger and bring an end to the Civil War. After killing the President of the CSA, they have to board an iron clad that's going to destroy Richmond that is manned by undead soldiers. It's pretty much a Bond movie in the Wild West (South?).
Deadlands Reloaded
The player characters manage an epic Did You Just Punch Out Cthulhu? by destroying one of the Servitors in Brother and his thirteen Disciples with a re-enactment of the Biblical Flood in the appropriately titled "The Flood" Plot Point Campaign. It's doubly impressive because Brother Grimme's official weakness is his walking stick. He just can also be killed if you somehow killed all of his spare bodies (The Disciples) at once.
Stone has long been accused of being a Creator's Pet, given that not only is he nearly unkillable but also the world's best gunslinger. He even insults the PCs at the beginning of "Stone and a Hard Place" Plot Point Campaign by saying they're "Not worth the lead." The PCs prove this to be a very bad mistake when they ally with his past self and manage to destroy not the younger weaker Stone but his even more super-powered OP future self who had been through potentially countless timeline loops of previous heroes.
Darius Hellstromme gets one with the PCs both when the latter convince the former that he's been a puppet of the Reckoners all along. Darius has enough of a Heel Realization to turn against them long enough to prevent a literal invasion from Hell. He stumbles at making a full Heel–Face Turn but points for the effort.
The PCs manage to thwart Raven's attempts to unleash the Eater of Tribes and continue his attempts to fight the White Man by destroying the world by also making it impossible for his people to be conquered. Unleashing the thunderbirds, they render mechanized devices and industrially produced weapons impossible to use in the Sioux Nation. The primary advantage of the United States is rendered moot and a war is prevented as well as the death of countless innocents.
The Twilight Legion is informed of the Reckoners plot in Arthurian times and makes efforts to make sure that the Confederacy loses the Civil War. This dramatically changes the socio-political framework of the setting and prevents the Deadlands: Hell on Earth setting where nuclear war has destroyed the United States.
Deadlands: The Weird West (Savage Worlds Adventure Edition)
While originally a Reloaded trilogy of adventures, Blood Drive was assembled together into one epic mini-campaign about driving 1000 cattle across the Weird West to the Mazes. Along the way you have to deal with all the train companies, the US Army, a bandit gang, an insane Native shaman, and a cattle baron out to steal your posse's land. It is also an extremely realistic depiction of how actual cowboys went, ghosts and blood ticks aside.
The Horror at Headstone Hill has the player characters investigate a missing Agency agent before discovering a massive plot to take over the town by a sentient forest corrupted by Ghost Rock. There's also an evil land baron because of course there is. It has Invasion of the Body Snatchers overtones with Replicant Snatching. It is also an impressive sandbox setting with hundreds of characters.
