Blip the monkey gives the audience one at the end of the episodes "The Drone", "Glasstor" and "The Sorcerer".
In "The Lizard Slavers", while Jace is telling Jan about the title creatures one of them turns its head and smiles at the camera as if it were pleased that Jan was talking about it.
The Galaxy Trio. At the end of the episode "The Eye of Time", Meteor Man looked into the camera and winked at the audience.
The Little Rascals: In "Yachtsa' Luck", Darla does this after Waldo tells her that his yacht can accommodate over 100 guests.
Mighty Mightor. Little Rok's bird pet, Ork, sometimes gives one to the audience when Little Rok did something stupid.
Wonder Dog does it on a regular basis, usually when Marvin says something stupid. He did it several times in "The Power Pirate" when Marvin made stupid puns and at the end of "The Weather Maker" when Wendy and Marvin did an "Everybody Laughs" Ending.
In "The Power Pirate", Marvin tries to impress Wendy and Wonder Dog with his fake British accent. When he fails, he turns to the camera and shrugs.
At the end of "The Planet Splitter", Wendy and Marvin take away Wonder Dog's steak bone (he's on a diet) and leave. Wonder Dog pulls out another steak bone, takes a bite out of it and winks at the audience.
In "Too Hot to Handle", the alien agent Kobar does this after Wonder Woman delivers an iceberg to Dairyland (a farm area in the heart of America). He's a little smug because he's responsible for the heat wave that required Wonder Woman to obtain the iceberg in the first place.
Reddy does this in the Ruff and Reddy story arc "The Treasure Of Skipper Kipper" when Ruff explains that the voice calling for help can help them get off the island on which they're stranded.
Series:
In the 3-2-1 Penguins! episode "Trouble on Planet Wait-Your-Turn", Jason does one after Zidgel says, "When I was your size, I was twice your size!"
Adventure Time: You have to be concentrating, but in "Vault of Bones" Flame Princess does one of these when Finn is telling a skeleton to Do the Splits.
American Dad! makes use of this in a particular episode where Roger encounters a Dumb Blonde girl named Judy Panawitz. Almost every other line she has provoked this response.
In the episode "Hello, Nice Warners", the Warner siblings pull a simultaneous aside glance after a Jerry Lewis caricature says something ridiculous. Deconstructed when the character then asks them what they were looking at, and Wakko responds, "The people watching on TV!" Dr. Director puts his face close to the TV to say "hello". But he doesn't see anyone. Of course, this was just a distraction.
Another example is with the Slappy the Squirrel being very Medium Aware in her first short.
Slappy: Oh, don't worry, kid. I've faced off against Doug the Dog before, I know all of his tricks. Haven't you watched my old cartoons? I've beaten him a thousand times. Skippy: But those were just cartoons! This is real life! Slappy: (looks dryly at camera) Don't tell him, he might crack.
Try and find an episode of Animaniacs where they didn't.
The Joker did this several times in Batman: The Animated Series. His breaking of the fourth wall was subtly treated as part of his characteristic insanity and also included such examples as occasionally whistling his own theme music.
In The Beatles cartoon "Anytime At All", the boys are at a French museum exhibit of the Three Musketeers. As the curator tells the crowd about the Musketeers' derring-do and rescuing maidens in distress, John turns to the camera and does an Eyebrow Waggle.
Classic Disney Shorts: In the old Goofy cartoons, especially the "How to" shorts, Goofy spends a great deal nodding, winking, smiling, gesturing, and staring in confusion at the viewer and/or invisible narrator. And to quote Art Babbit, "When something stupid befalls him, he mugs the camera like an amateur actor with relatives in the audience, trying to cover up his accident by making faces and signaling to them."
Odd winks once or twice directly at the "camera" while in Lyoko — notably in the episode "Nobody in Particular", after devirtualizing Ulrich's body.
The last episode of the animated series has the characters waving goodbye at the audience.
"The Pretender" had an Aside Glance combined with a Fourth Wall Psych with Aelita. She was winking at Ulrich, but she winked into the "camera" on Lyoko.
Danger Mouse has been known to do this after a bad Penfold joke.
DM: Out of the mouths of clots and half-wits...
As does Danny Phantom. Coupled with its frequent usage of Sounding It Out, at times it almost seemed as though Danny was conversing with the viewer, without any fourth wall breakage.
In My Brother's Keeper, Danny notices us after Jazz kisses his head. He then promptly becomes grossed out.
In one episode of Drawn Together, Toot unleashes an epic "A-Duh!" lasting several seconds, involving spit and protruding teeth. In the middle of it, she looks directly at the camera for a second.
Family Guy tends to do this a lot. Usually after Peter has just pointed out something using his Medium Awareness.
Peter: And since you're black and I'm white, that makes it more a-special for the audience! (aside glance)
The Fantastic Voyage cartoon series episode "Revenge of the Spy". When Lisette Clochard shows up, she and Jonathan Kidd start flirting with each other. Doctor Erica Lane (who has a crush on Kidd) turns and gives the camera an annoyed look.
Many Grizzy & the Lemmings episodes have Grizzy and/or the Lemmings give a look to the audience as they suffer a Downer Ending.
Done regularly on Johnny Bravo, usually by Johnny himself.
One episode of Johnny Test featured Johnny and Dukey stuck inside a Steve McQueen movie, or its closest in-universe equivalent. At one point, about when they learn the main character is going to drive a car off a cliff, Dukey says, "Why couldn't you just have watched cartoons like a normal kid?" Both then turn to look at the camera.
Mr. Cat does this fairly often, usually after someone around him does something idiotic.
In one episode, Pretty does this to the audience after she and Stumpy become victims of an internet scam and are sent a toilet instead of the promised reward.
In Episode 105, Mr. Cat has an Imagine Spot of himself being massaged by numerous clones of Kaeloo. The real Kaeloo, standing right next to him, looks at the camera with an annoyed expression since all she sees is Mr. Cat blushing and drooling.
Every episode of Little Bill ends with the titular kindergartner in bed discussing his experiences in both segments of the episode to the audience right before one of his family members asks him who he's talking to.
Lolita Lolita: In "Museum", when an old guy in the museum sees Lolita imitating poses of characters in various artworks, he gets an idea and looks to the audience. The second time he does this is when his latest picture doesn't get the reaction he expected from her (she blew a raspberry at it).
Turned up often in Looney Tunes cartoons and other animated shorts. Pretty much a trademark of Chuck Jones' work.
For example, in Rabbit Fire Daffy does it after one of Elmer Fudd's bullets is embedded in his scalp.
Bugs has a blink-and-you'll-miss-it one in the same cartoon just as he's about to pull the Duck Season, Rabbit Season switch on Daffy.
Elmer even does one in Rabbit Seasoning following Daffy's demand that he shoot him now.
The wild claims of the hapless protagonist of One Froggy Evening unsurprisingly inspires an incident.
In The Looney Tunes Show episode "The Shell Game," Cecil Turtle glances at the camera with a Psychotic Smirk on his face after he denies doing an Evil Laugh. This is when Bugs realizes that something is going on.
Bugs: Who are you looking at?
In the Nelvana cartoon of Martin the Warrior, the searats give a rather creeped-out look to the camera when Clogg starts gushing about how awesome his "new friend" (actually a spy for the good guys) is. May be either because they're weirded out by "Tibbar the magic rabbit" or perhaps even the characters can spot the Ho Yay.
In the dream sequence of the Bakshi Mighty Mouse episode "Mighty's Wedlock Whimsy", our hero (doing a Ralph Kramden) looks at us in silent ire as the Cow (doing Ed Norton) meticulously prepares, bakes and eats a rotten potato.
Mr. Magoo does this in "Hotsy Footsy". Magoo thinks he is at a college reunion dance, but he has walked through the exit door, through a back alley, and is in a gym where wrestler Francis the Terrible is taking on all comers! Magoo sees the long line of wrestlers being carried off after being injured, turns to the screen and whispers "loaded!"
In "Applebuck Season", after the sleep-deprived Applejack falls asleep in the middle of accepting her trophy for saving the town from a stampede, Twilight Sparkle and Pinkie Pie both look at the camera with baffled expressions on their faces.
Pinkie Pie has a somewhat exaggerated reputation for this. She gives an aside glance at the end of "Bridle Gossip" (though Word of God says it was unintentional), and one after sending off a picnic basket full of balloons in "Lesson Zero" (though she could also be said to be looking at Fluttershy).
Pinkie Pie and Rarity give a shared aside glance in "Putting Your Hoof Down", after Iron Will introduces himself like he's giving one of his motivational lectures.
Which might instead be Audience? What Audience?. Pinkie Pie and Rarity look more than a little confused as if wondering "Who are you talking to?"
Fluttershy gives one in "A Bird in the Hoof" adding "Always works." Obvious considering there is no one else in the room at the time.
In "Wonderbolts Academy", Pinkie Pie rambles on how Rainbow Dash has forgotten about her friends, to which Applejack gives the audience a "Yes, this is happening" side glance.
In "Simple Ways" Rarity complains that Spike cannot possibly understand the feeling of being in love with a pony who loves someone else. Spike disagrees.◊
Filmation's 1960s The New Adventures of Superman. Superman and Superboy turned and looked at the camera (usually winking as well) at the end of almost every episode.
P.C. Pinkerton: Pinkerton makes one of these at the end of "See You In The Morning".
Other characters pull this off from time to time, including Doofensmirtz himself in "Out of Toon". After his dancing ray hits both him and Perry the Platypus, causing the two to compulsively dance together, he glances at the camera with the remark "And to add insult to injury, the platypus is leading."
From "Cheer Up Candace":
Phineas: Candace has a great sense of humor! Remember that time she got her face stuck in the sink? Isabella: (aside glance)
Perry gave the audience one when Dr. Doofenshmirtz unveils his latest plan to flood Danville and charge people ridiculous sums of money for the only form of transportation that he himself invented: the B.O.-A.T., which looks (and functions) exactly like a boat. Perry, despite being a Silent Snarker, seems to say to the audience "Leave it to Doofenshmirtz to 'invent' something that already exists!"
In the opening sequence of Pinky, Elmyra & the Brain, as Pinky claps along with Elmyra's antics, the Brain gives a very un-amused look at the camera.
At the end of the Punky Brewster episode "The Bermuda Tangle", Punky winks to the audience.
In the Darker and Edgier (not to mention much better animated) Season 3 of ReBoot, Dot and Enzo are trapped in a graveyard in a First-Person Shooter while the player (looking exactly like Ash from Evil Dead 2) slaughters Binomes off camera playing the roles of zombies. They wince at the carnage, and Dot cries out "What kind of sick monster would want to play a game like this?" Both then turn and glare at the camera.
This happens with relative frequency in The Replacements, which loves subverting this trope (generally by having a cut reveal someone standing in the "camera" spot the characters were looking at).
In the middle of one episode, Sheldon essentially summarizes everything that had happened thus far in the episode, after which he looks directly at the fourth wall and says "What do YOOUUU think [will happen]?" Cut to Buzz, who is standing right in front of him.
Rugrats gives us a rather hilarious example during "The Trial" with this exchange between Angelica and the twins as she tries her role as prosecutor:
Angelica: Do you swear to tell ruth, all ruth, and nothing but ruth so help you Bob? (Phil and Lil look at each other confused) Angelica: (whispering) Just say you do. Phil and Lil: You do. (Angelica casts Aside Glance directly at the camera)
Samurai Jack does this a few times when he is so perplexed that a simple confused stare wouldn't be enough.
On one episode, when Smithers catches on fire he calls out, "Help me Mr. Burns, I'm flaming!" Burns looks at the viewer and shakes his head with a "My, my" expression.
In "Pygmoelian", after Carl fails at cheering Moe up, and ends up making the rest of the people at "Moe's Bar" depressed, he looks directly at the camera and says "See, this I why I don't talk much."
Made fun of in the first of the two-part episode when Burns is shot. Doctor Hibbert says "I can't figure this out! Can... you?" and points right at the "camera", holding the pose for a few seconds before the view switches and you see he was really pointing at Chief Wiggum (who could have been behind the viewers' point of view, or it would have even been Wiggum's point of view before the view-shift).
They recycled it for their The Da Vinci Code parody: We come out of a commercial with Lisa basically saying "Have you figured it out yet?" and then revealing she was talking to Milhouse.
In The Spectacular Spider-Man, after Spider-Man repeats verbatim dialogue that the Green Goblin has just heard from Tombstone, Goblin briefly turns to the camera and quips "Anyone else getting déjà vu? Oh well, let's run with it."
In "Pressure" when Sandy dares SpongeBob, Patrick, Mr. Krabs and Squidward to go on dry land and they encounter a seagull. When SpongeBob asks if it knows Sandy, it turns to the camera.
In the episode "Missing Identity", SpongeBob tells some fish in a diner the story of how he lost his identity (to be exact, his name tag, which was on his shirt the whole time, but he was wearing it backward). Over the course of the episode, he does two of these glances, except he makes them particularly drawn-out, slowly turning and staring straight at the camera. The first is in response to one of Patrick's moments of incredible ignorance, and the second comes after the waitress in the diner says she's borrowing someone else's name tag. Both are Shout Outs to Jack Benny. The hand on the cheek is a trademark of Benny's.
Another one crops up in "I'm With Stupid".
In "Clams", Squidward looks right at the camera while Mr. Krabs is yelling at Spongebob to reel his millionth dollar in.
In "A Pal For Gary", Gary gives a very annoyed one to the camera after being scolded one last time for chasing Puffy Fluffy away despite saving SpongeBob's life. He gives another one after SpongeBob brings him to work with him.
Star Wars: The Clone Wars: In "The Bad Batch", Sergeant Hunter's reaction when Tech interrupts him to explain that the Yalbec males Hunter had just been telling Commander Cody were trying to eat them were actually trying to mate with them is an aside glance coupled with an amused and exasperated facial expression.
Steven Universe: In "Buddy's Book", Rose Quartz tells Buddy Buddwick how each book is a new experience for each reader and briefly glances into the camera. Buddy looks into the direction of the audience, wondering what she's looking at.
In Young Justice (2010), the Joker looks at the camera and says, "Admit it: you can't turn away," when the Injustice League is introduced.
Later on, he does the glance after saying "Inconceivable! Unacceptable! Retributionable!" Cupping his hand around his mouth like he's whispering in the camera's ear, he adds, "That last one might not be a word. So sue me."
Keep an eye on Wally in the background of the penultimate scene of "Bloodlines." When Impulse delivers his "Gotta run" pun, Barry smiles, Jay Face Palms with his tin hat, and Wally just turns this exasperated "Look at what I have to deal with" face towards the camera.
VeggieTales: In "Where's God When I'm S-Scared?", Scallion 1 does an aside glance when Daniel reveals he and the lions spent the night eating pizza.
Specials:
How the Grinch Stole Christmas!. Both the Grinch and his dog Max both do this multiple times during the episode. (Not a surprise since this was made by the aforementioned Chuck Jones.)
Lampshaded to hell and back in Turtles Forever, where 1987 Raphael does this all the time — to the utter confusion of everyone who isn't from his reality. At one point, the 2003 Dragon Hun has had just about enough:
Raph: (to camera) Some people just can't handle change. Hun: (follows his gaze) Why do you keep doing that? Who are you talking to?! There's no-one there!
reputation for this. She gives an aside glance at the end of "Bridle Gossip" (though Word of God says it was unintentional), and one after sending off a picnic basket full of balloons in "Lesson Zero" (though she could also be said to be looking at Fluttershy).
