History YMMV / SentinelsOfTheMultiverse

** To a lesser extent, Spite. Unlike every other villain, his buffing cards -- the drugs -- are indestructible and cannot be removed from play once they're out. He also heals with every bit of damage he does on his front side and is constantly doing damage, making it hard to make anything stick. His victim cards -- which heal him when he destroys them -- tend to extract a substantial toll to be put under the Safe House, but Spite has cards to undo the hard work of getting them under there. Deck control is of limited use because he plays two cards a round -- so even if you make sure he'll play a relatively harmless card at the middle of his turn, there's no real guarantee he won't play something like Drug Raid at the end of it. Even though he's rated at a 2, an unprepared team can have a mountain of trouble facing him. What saves him from being on The Chairman's level is the effects of his drugs include nerfed versions of normal effects -- one gives him H-2 DamageReduction, but only to the first hit a turn instead of permanent every hit; another makes the players put H-2 equipment or ongoing cards back into their hands, rather than destroying them -- the fact he's the only damage dealer in his deck, so cards like Elbow Jab and Twist the Ether can hold him back significantly and the Potential Sidekick victim card, which lets the heroes draw two cards every villain turn as long as he's out.

** Iron Legacy. He has no minions. He has the lowest HP of any villain aside from the Dreamer. He's just one target to hit. All he has is a ''non-stop'' onslaught of ongoing cards that reduce damage dealt to him, amplify damage dealt to heroes, and generally ruin your day. His damage output is so high that it's not implausible that you'll have downed heroes by the ''second turn.'' He's a terrifying example of a Legacy who [[TheUnfettered isn't holding back.]]

** Wraith's Infrared Eyepiece can make any villain deck almost trivial -- if used every round, you can tightly control what cards are played. This means the cards listed under ThatOneAttack never have to come up. And it's not Limited, so she can have -- and with the Utility Belt, use -- two at a time.

** Grand Warlord Voss has Forced Deployment, which resurrects every minion in the trash at the start of his turn -- this could easily bring a dozen damaging cards, many with global damage, back to the field if it pops up late in the game.

** The Dreamer is a combination of the nastier mook swarm-based decks with the added caveat that the most effective minion-clearing abilities are often useless, as they most often target ''all'' villain targets, including the Dreamer herself, and the objective when fighting her is to keep her alive. Not only do you have to fight off packs of minions, but once you get the Dreamer to a flip to the side that will let you start knocking out minions to save her, she'll start hitting you with board-wipes that remove all hero ongoings as well as blasting your team with continuous psychic attacks every turn.

** One of the nastier elements of Miss Information is that for the most part, her clues cause the heroes to do damage to ''themselves''. She effectively turns around damage-boosting powers and artifacts to hurt the heroes, and because a lot of the more powerful damage mitigating cards specify that they prevent damage from ''villain'' or ''environment'' targets and not heroes. Since her Clues are necessary to reveal her and get her to flip, the players have to deal with these devastating cards for some time before they can take her out. And because she's not a target until she flips, it becomes a waiting game for the clues to come out where the heroes have little option but to sit back and get hammered by her and the environment.

** Haka's Savage Mana has the potential to take a ''lot'' of bite out of minion-heavy decks; by putting them under the card instead of in the trash, Voss's minions can't come back during Forced Deployment, Citizen Dawn may never flip, Baron Blade's NonStandardGameOver is curtailed, The Chairman's Prison Break does nothing, and the Matriarch's Darken the Sky brings nothing back from her trash.

** One of the nastier elements of Miss Information is that for the most part, her clues cause the heroes to do damage to ''themselves''. She effectively turns around damage-boosting powers and artifacts to hurt the heroes, and because a lot of the more powerful damage mitigating cards specify that they prevent damage from ''villain'' or ''environment'' targets and not heroes. Since her Clues are necessary to reveal her and get her to flip, the players have to deal with these devastating cards for some time before they can take her out.

** Baron Blade and Omnitron each have a card that's this trope for set-up heavy heroes. Baron Blade's allows players to discard as many equipment and ongoing cards as they want, and afterward he does every hero target X damage, where X equals 3 plus however many equipment cards are still on the table. This means either wiping your equipment and ongoings out, or everyone taking massive damage -- it can easily become a TotalPartyKill. Omnitron's outright destroys the equipment, and does damage to each hero based on how many of their equipment cards were destroyed at a rate of 2 to 1, which can be devastating to heroes like Bunker, The Wraith or Absolute Zero.

** Spite's Agent of Gloom variant is another headache. He starts with all the Drug cards face down, and flips one face up at the start of his turn unless there are H victims in the safe house, in which case he flips instead. The variant opens the turn flipping one drug card face up (and the players don't know beforehand which is which), the Safe House puts a Victim into play and, at best, Spite plays another victim card, as the variant only plays one card per turn. The only way to flip a drug card face down again is to end Spite's turn with more victims in the safe house than there are drugs face up. Unless the players can force him to play an additional victim (i.e., if you're using one of the tiny handful of heroes who can do so, or if he plays the Good Samaritan, which can play the villain's top card to go in the safehouse), there's no way to outpace the drugs going face up before he flips and the flipped side has no mechanism to flip back or flip the drug cards. And on his flipped side? Every instance of his damage is boosted by 1 for every card under the Safe House, so if you're in a 5-hero game, he's doing obscene amounts of damage until you can get some of them back out.

** Spite's Agent of Gloom variant is another headache. He starts with all the Drug cards face down, and flips one face up at the start of his turn unless there are H victims in the safe house, in which case he flips instead. The variant opens the turn flipping one drug card face up (and the players don't know beforehand which is which), the Safe House puts a Victim into play and, at best, Spite plays another victim card, as the variant only plays one card per turn. The only way to flip a drug card face down again is to end Spite's turn with more victims in the safe house than there are drugs face up. Unless the players can force him to play an additional victim (i.e., if you're using one of the tiny handful of heroes who can do so, or if he plays the Good Samaritan, which can play the villain's top card to go in the safehouse), there's no way to outpace the drugs going face up before he flips and the flipped side has no mechanism to flip back or flip the drug cards.

** To a lesser extent, Spite. Unlike every other villain, his buffing cards -- the drugs -- are indestructible and cannot be removed from play once they're out. He also heals with every bit of damage he does on his front side and is constantly doing damage, making it hard to make anything stick. His victim cards -- which heal him when he destroys them -- tend to extract a substantial toll to be put under the Safe House, but Spite has cards to undo the hard work of getting them under there. Deck control is of limited use because he plays two cards a hand -- so even if you make sure he'll play a relatively harmless card at the middle of his turn, there's no real guarantee he won't play something like Drug Raid at the end of it. Even though he's rated at a 2, an unprepared team can have a mountain of trouble facing him. What saves him from being on The Chairman's level is the effects of his drugs include nerfed versions of normal effects -- one gives him H-2 DamageReduction, but only to the first hit a turn instead of permanent every hit; another makes the players put H-2 equipment or ongoing cards back into their hands, rather than destroying them -- the fact he's the only damage dealer in his deck, so cards like Elbow Jab and Twist the Ether can hold him back significantly and the Potential Sidekick victim card, which lets the heroes draw two cards every villain turn as long as he's out.

** To a lesser extent, Spite. Unlike every other villain, his buffing cards -- the drugs -- are indestructible and cannot be removed from play once they're out. He also heals with every bit of damage he does on his front side and is constantly doing damage, making it hard to make anything stick. His victim cards -- which heal him when he destroys them -- tend to extract a substantial toll to be put under the Safe House, but Spite has cards to undo the hard work of getting them under there. Deck control is of limited use because he plays two cards a hand -- so even if you make sure he'll play a relatively harmless card at the middle of his turn, there's no real guarantee he won't play something like Drug Raid at the end of it. Even though he's rated at a 2, an unprepared team can have a mountain of trouble facing him. What saves him from being on The Chairman's level is the effects of his drugs include nerfed versions of normal effects -- one gives him H-2 DamageReduction, but only to the first hit a turn instead of permanent every hit; another makes the players put H-2 equipment or ongoing cards back into their hands, rather than destroying them -- the fact he's the only damage dealer in his deck, so cards like Elbow Jab and Twist the Ether can hold him back significantly and the Potential Sidekick victim card, which lets the heroes draw two cards every villain turn as long as he's out.

* ThatOneBoss: The Chairman stands above several of the other villains -- even others rated at the highest difficulty, like he is -- and can easily overwhelm players who don't know exactly how to handle him. Of his 25 cards, 10 are "Thug" cards, who do damage, destroy hero ongoing or equipment cards, protect the higher level minions, or play a villain card every time a hero card is played. Five of the other cards are "Underbosses," who buff the villains' damage, heal them, and revive the Thug cards at the end of each Villain turn. Players must keep the minions in check, because they ''will'' overwhelm your team if you don't...but each minion you destroy has [[TheDragon The Operative]] attack one of the heroes for heavy damage. Each turn guarantees at least one Underboss play, and when you do start making real headway, Jailbreak can revive all the minions you've put down, and Undivided Attention will do severe damage to someone on your team. Oh, and The Chairman is invincible for most of the fight, and when you do get to hit him, he retaliates against the damage dealer for heavy damage, ''and'' buffs his Thugs' damage by up to +3, doubling most of their damage. Other villain decks have similar mechanics -- Citizen Dawn's minions are just as much trouble and boost one another, while The Matriarch does similar retaliatory damage -- but The Chairman does it with a consistency and scale that is above and beyond the others.

** Wraith's Infrared Eyepiece can make any villain deck almost trivial -- if used every round, you can tightly control what cards are played. This means the cards listed under ThatOneAttack never have to come up.

** The Chairman has Prison Break, which brings every Underboss in the trash back into play.

** The Matriarch has Darken the Sky, which brings out ''all'' of the Fowl cards in her trash. When considering the [[ZergRush number of fowl]] she has and how fast you'll likely be burning through them, you could go form dealing with a few ach turn to fight a dozen at a time.

* ThatOneBoss: The Chairman stands above several of the other villains -- even others rated at the highest difficulty, like he is -- and can easily overwhelm players who don't know exactly what to do right. Of his 25 cards, 10 are "Thug" cards, who do damage, destroy hero ongoing or equipment cards, protect the higher level minions, or play a villain card every time a hero card is played. Five of the other cards are "Underbosses," who buff the villains' damage, heal them, and revive the Thug cards at the end of each Villain turn. Players must keep the others in check, because they ''will'' overwhelm your team if you don't...but each minion you destroy has [[TheDragon The Operative]] attack one of the heroes for heavy damage. Each turn guarantees at least one Underboss play, and when you do start making real headway, Jailbreak can revive all the minions you've put down, and Undivided Attention will do severe damage to someone on your team. Oh, and The Chairman is invincible for most of the fight, and when you do get to hit him, he retaliates against the damage dealer for heavy damage, ''and'' buffs his Thugs' damage by up to +3, doubling most of their damage. Other villain decks have similar mechanics -- Citizen Dawn's minions are just as much trouble and boost one another, while The Matriarch does similar retaliatory damage -- but The Chairman does it with a consistency and scale that is bordering on unfair.

** The Matriarch has Darken the Sky, which brings out ''all'' of the Fowl cards in her trash. When considering the [[ZergRush number of fowl]] she has and how fast you'll likely be burning through them, you could go form dealing with a few ach turn to fight a dozen at a time.

** Baron Blade and Omnitron each have a card that's this trope for equipment heavy heroes -- Baron Blade's allows players to discard as much equipment as they want, and afterward he does X damage, where X equals 3 plus however many equipment cards are still on the table -- potentially a TPK if enough people didn't give up equipment. Omnitron's outright destroys the equipment, and does damage to each hero based on how many of their equipment cards were destroyed, which can be devastating to heroes like Bunker, The Wraith or Absolute Zero.

** Wraith's Infrared Eyepiece can make any villain deck almost trivial -- if used every round, you can tightly control what cards are played. This means ongoings and one-shots that would devastate your team never have to come up.

** Unity's Stealth Bot + Fanatic's Chastise. Chastise makes its target both unable to do damage and invincible to damage. Stealth Bot can redirect any damage to hero targets to itself. This ends as soon as a villain or environment knocks out Ongoing cards, but several other heroes have ways of preventing that.

** Haka's Savage Mana has the potential to take a ''lot'' of bite out of minion-heavy decks; by putting them under the card instead of in the trash, Voss's minions can't come back during Forced Deployment, Citizen Dawn may never flip, Baron Blade's NonStandardGameOver is curtailed, and The Chairman's Prison Break does nothing.

*** Look, let's be honest... when they ''least'' damaging cards Citizen Dawn can throw out are ones that let her draw more villain cards or damage the entire party and force them to discard cards, you know you've got a deck loaded with this trope.

* GameBreaker: No one character is capable of it on his own, but certain combinations can be ''incredibly'' potent:

*** Citzens Blood, Sweat, and Tears, if they're out together. You'll be shedding ongoing cards like water, discarding multiple cards from hands, and taking heavy damage the entire time.