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* EasyLevelTrick: There are many tricks to make your runs much easier:
** Holding R: This involves resetting over and over until you get a GameBreaker on the first floor, pretty much guaranteeing that every run will be a win. The only downside is that resetting breaks your streak.
** Gamebreaks: These usually involve getting a combination of items that gives you infinite money as well as Restock, which replaces items in the shop with new ones after you buy them. This allows you to easily get all the items in the game and become absurdly powerful. Other breaks involve combinations that prevent you from dying. Not every run is possible to break, but you can easily just reset for the right items to lead to one.
** Character changing: Playing a run as an easy character, then using an item such as Clicker to change your character to a hard one. This means that you only have to beat the final boss as the hard character to get their completion mark, rather than having to use them for the whole run.
** The Tainted Cain Strategy: A more specific version of character changing which involves using Tainted Cain, who can easily make specific items out of pickups. First you craft some {{Game Breaker}}s, then you craft R Key and Clicker. Use Clicker to change character, then use R Key to restart the run while keeping all your current items. This results in an very easy completion mark for a difficult character.
** PauseScumming: A couple of different things can be achieved with this. By pausing at the right time you can kill Delirium with Plan C before Plan C kills you, which is normally impossible and saves you from doing a difficult boss fight. And as Tainted Jacob, pausing during Dark Esau's death prevents T. Jacob from turning into a OneHitPointWonder.
** Erasing Dark Esau: Using Eraser to kill Dark Esau on one floor prevents him from appearing for the rest of the run. T. Jacob is one of the hardest characters in the game, so this strategy is incredibly useful if you're going for OneHundredPercentCompletion.
** Multiplayer: ''Repentance'' introduces a "true" co-op mode, where up to four players can join the game with one of the 34 characters. When a player dies, they're reduced to a weak but invincible ghost, and the run isn't over until all players are ghosts. Defeating a final boss makes all present characters gain the respective completion mark, including those who are in ghost form. This means that if you're having trouble completing one or more characters' marks pages, you can connect more controllers, assign the "troublesome" characters to them and let them idle while you waltz through the run with your main. Oh, and you get extra items from bosses too!
*** If someone is playing as Tainted Jacob, any other co-op player (who aren't Jacob & Esau or other Tainted Jacobs) will be completely immune to Dark Esau's charges. So, get a friend, let them choose Tainted Jacob, and [[ViolationOfCommonSense let them die]]. This way, Ghost!T. Jacob can freely aim Dark Esau against enemies and bosses, giving the main player powerful support with little drawbacks, and still getting both characters completion marks.
** Holding R: This involves resetting over and over until you get a GameBreaker on the first floor, pretty much guaranteeing that every run will be a win. The only downside is that resetting breaks your streak.
** Gamebreaks: These usually involve getting a combination of items that gives you infinite money as well as Restock, which replaces items in the shop with new ones after you buy them. This allows you to easily get all the items in the game and become absurdly powerful. Other breaks involve combinations that prevent you from dying. Not every run is possible to break, but you can easily just reset for the right items to lead to one.
** Character changing: Playing a run as an easy character, then using an item such as Clicker to change your character to a hard one. This means that you only have to beat the final boss as the hard character to get their completion mark, rather than having to use them for the whole run.
** The Tainted Cain Strategy: A more specific version of character changing which involves using Tainted Cain, who can easily make specific items out of pickups. First you craft some {{Game Breaker}}s, then you craft R Key and Clicker. Use Clicker to change character, then use R Key to restart the run while keeping all your current items. This results in an very easy completion mark for a difficult character.
** PauseScumming: A couple of different things can be achieved with this. By pausing at the right time you can kill Delirium with Plan C before Plan C kills you, which is normally impossible and saves you from doing a difficult boss fight. And as Tainted Jacob, pausing during Dark Esau's death prevents T. Jacob from turning into a OneHitPointWonder.
** Erasing Dark Esau: Using Eraser to kill Dark Esau on one floor prevents him from appearing for the rest of the run. T. Jacob is one of the hardest characters in the game, so this strategy is incredibly useful if you're going for OneHundredPercentCompletion.
** Multiplayer: ''Repentance'' introduces a "true" co-op mode, where up to four players can join the game with one of the 34 characters. When a player dies, they're reduced to a weak but invincible ghost, and the run isn't over until all players are ghosts. Defeating a final boss makes all present characters gain the respective completion mark, including those who are in ghost form. This means that if you're having trouble completing one or more characters' marks pages, you can connect more controllers, assign the "troublesome" characters to them and let them idle while you waltz through the run with your main. Oh, and you get extra items from bosses too!
*** If someone is playing as Tainted Jacob, any other co-op player (who aren't Jacob & Esau or other Tainted Jacobs) will be completely immune to Dark Esau's charges. So, get a friend, let them choose Tainted Jacob, and [[ViolationOfCommonSense let them die]]. This way, Ghost!T. Jacob can freely aim Dark Esau against enemies and bosses, giving the main player powerful support with little drawbacks, and still getting both characters completion marks.
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* TheInfested:
** The Duke of Flies is a bloated corpse filled with flies that bounces around, spitting out flies to attack you. You can also encounter its UndeadCounterpart on a later chapter, The Husk, which is even more degraded and is filled with spiders as well as flies. ''Repentance'' added another alternate version, Lil' Blub, which is filled with leeches.
** Mulligans are MookMaker enemies. They're bloated humanoids infested with flies, which run from you and cough up flies. They become progressively more infested as you advance into the game, culminating in Swarmers which are nothing but mobile fly nests built into the rotted face of a Mulligan. Some alternative versions of them are infested with other things, like spiders, grubs, and fetuses.
** Several items can turn Isaac himself into a walking hive. Infestation and The Mulligan fill Isaac with flies which he releases when he takes damage or hits an enemy respectively. Spider Baby does the same with spiders instead of flies, and Infestation 2 fills every enemy with friendly spiders.
** The Duke of Flies is a bloated corpse filled with flies that bounces around, spitting out flies to attack you. You can also encounter its UndeadCounterpart on a later chapter, The Husk, which is even more degraded and is filled with spiders as well as flies. ''Repentance'' added another alternate version, Lil' Blub, which is filled with leeches.
** Mulligans are MookMaker enemies. They're bloated humanoids infested with flies, which run from you and cough up flies. They become progressively more infested as you advance into the game, culminating in Swarmers which are nothing but mobile fly nests built into the rotted face of a Mulligan. Some alternative versions of them are infested with other things, like spiders, grubs, and fetuses.
** Several items can turn Isaac himself into a walking hive. Infestation and The Mulligan fill Isaac with flies which he releases when he takes damage or hits an enemy respectively. Spider Baby does the same with spiders instead of flies, and Infestation 2 fills every enemy with friendly spiders.
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Cross-wicking an earlier edit I did.
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* HarmlessFreezing: Averted. The freeze status introduced in ''Repentance'' sees enemies being coated in ice. This is always lethal, with frozen enemies never thawing out and being counted as dead in regards to room clears and effects that activate on enemy kills. In fact, an enemy is only frozen in the first place if it runs out of health.
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* PickupHierarchy:
** '''Primary:''' None in the original game, the Polaroid starting with the ''Wrath of the Lamb'' DLC, the Negative and the Key Pieces in ''Rebirth'', and the Knife Pieces and Dad's Note in the ''Repentance'' DLC. For the {{Macrogame}}, it's the various items unlocked by clearing the Womb and, starting with ''Wrath of the Lamb'', the Cathedral. ''Rebirth'' turns the items from clearing Sheol into this, due to the addition of the Dark Room.
** '''Secondary:''' Treasure room, shop, and Devil Room items in individual runs. Angel Room items starting with the ''Wrath of the Lamb'' DLC. For the macrogame, it's any unlockables not required for new endings.
** '''Tertiary:''' Hearts, coins, keys, bombs, and in ''Rebirth'', batteries
** '''Extra:''' Library tomes starting with the ''Wrath of the Lamb'' DLC, Black Market items in ''Rebirth'', and Planetarium items in the ''Repentance'' DLC.
** '''Primary:''' None in the original game, the Polaroid starting with the ''Wrath of the Lamb'' DLC, the Negative and the Key Pieces in ''Rebirth'', and the Knife Pieces and Dad's Note in the ''Repentance'' DLC. For the {{Macrogame}}, it's the various items unlocked by clearing the Womb and, starting with ''Wrath of the Lamb'', the Cathedral. ''Rebirth'' turns the items from clearing Sheol into this, due to the addition of the Dark Room.
** '''Secondary:''' Treasure room, shop, and Devil Room items in individual runs. Angel Room items starting with the ''Wrath of the Lamb'' DLC. For the macrogame, it's any unlockables not required for new endings.
** '''Tertiary:''' Hearts, coins, keys, bombs, and in ''Rebirth'', batteries
** '''Extra:''' Library tomes starting with the ''Wrath of the Lamb'' DLC, Black Market items in ''Rebirth'', and Planetarium items in the ''Repentance'' DLC.
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* ExactlyWhatItSaysOnTheTin: The pickup quote for the Box of Spiders item reads “It’s a box of spiders.”
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Spelling/grammar fix(es)
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* AndThereWasMuchRejoicing: [[spoiler:In the epilogue, Isaac rejoices after his AbusiveMom experiences a DeathByIrony]].
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* AndThereWasMuchRejoicing: [[spoiler:In the epilogue, Isaac rejoices after his AbusiveMom experiences a DeathByIrony]].DeathByIrony.]]
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** Mods will disable unlocking features and endings... only if you haven't beat the game (as in defeating Mom for the first time) for the first time yet. After that, feel free to enjoy the rest of the game with mods, even gameplay modifiers.
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** Mods will disable unlocking features and endings... endings… only if you haven't beat the game (as in defeating Mom for the first time) for the first time yet. After that, feel free to enjoy the rest of the game with mods, even gameplay modifiers.
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* BeliefMakesYouStupid: Isaac's Mom emotionally abuses Isaac, and then tries to make him into a HumanSacrifice, because of her religious faith and belief God is telling her to do so. It's hard to put a positive reading on that display of "faith".
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* BeliefMakesYouStupid: Isaac's Mom emotionally abuses Isaac, and then tries to make him into a HumanSacrifice, because of her religious faith and belief that God is telling her to do so. It's hard to put a positive reading on that display of "faith".
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** The Bloody Penny trinket sometimes gives you a half-heart whenever you pick up a penny or other coin. While not as useful/awesome as Maggy's Faith (free [[HeartContainer eternal heart]] at the start of each floor) or The Polaroid (gives you an emergency protective forcefield as well as letting you into TheVeryDefinitelyFinalDungeon), those dropped hearts add up, allowing you partially farm for keys, bombs, and money in the Arcade (Blood Bank trades hearts for money, Bloody Penny gives you hearts when you get money, and Slot Machines sometimes give out bombs, keys, money, and hearts in exchange for money).
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** The Bloody Penny trinket sometimes gives you a half-heart whenever you pick up a penny or other coin. While not as useful/awesome as Maggy's Faith (free [[HeartContainer eternal heart]] at the start of each floor) or The Polaroid (gives you an emergency protective forcefield as well as letting you into TheVeryDefinitelyFinalDungeon), those dropped hearts add up, allowing you to partially farm for keys, bombs, and money in the Arcade (Blood Bank trades hearts for money, Bloody Penny gives you hearts when you get money, and Slot Machines sometimes give out bombs, keys, money, and hearts in exchange for money).
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** The Bible usually just gives you wings and allows you to fly for one room. However, when used against Mom or Mom's Heart/It Lives, [[OneHitKill it will kill them instantly]]. [[spoiler: Using it against Satan will kill [[PressXToDie you instead]]]].
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** The Bible usually just gives you wings and allows you to fly for one room. However, when used against Mom or Mom's Heart/It Lives, [[OneHitKill it will kill them instantly]]. [[spoiler: Using [[spoiler:Using it against Satan will kill [[PressXToDie you instead]]]].instead]].]]
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* BossBonanza: The [[TheVeryDefinitelyFinalDungeon Womb]] randomly has previous end-of-level bosses spawn in normal rooms. [[PlanetHeck Sheol]] and the [[BonusLevelOfHeaven Cathedral]] have a much higher chance of these encounters. The [[BrutalBonusLevel Chest]] has a boss in almost every single room, and the same is true of its ''Rebirth''-exclusive counterpart, the Dark Room. The Void, meanwhile, has several full-fledged boss rooms.
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* BossBonanza: The [[TheVeryDefinitelyFinalDungeon Womb]] randomly has previous end-of-level bosses spawn in normal rooms. [[PlanetHeck Sheol]] and the [[BonusLevelOfHeaven Cathedral]] have a much higher chance of these encounters. The [[BrutalBonusLevel Chest]] has a boss in almost every single room, and the same is true of its ''Rebirth''-exclusive counterpart, the Dark Room. The Void, meanwhile, has several full-fledged boss rooms. ''Repentance'' [[spoiler:ends with a more conventional example, starting with Dogma, followed up by the Ultra Horsemen one at a time before ending with The Beast]].
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** ''Rebirth'' adds a proper boss rush: [[spoiler:if you beat Mom inside of 20 minutes a secret room will open up in the wall leading to a giant room with four item pickups. Pick up one and you have to fight almost every boss in the game coming in pairs with no escape but victory, death, or [[TakeAThirdOption teleporting out]]. Succeed and you get another item.]]
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** ''Rebirth'' adds a proper boss rush: [[spoiler:if you beat Mom inside of 20 minutes minutes, a secret room will open up in the wall leading to a giant room with four item pickups. Pick up one and you have to fight almost every boss in the game coming in pairs with no escape but victory, death, or [[TakeAThirdOption teleporting out]]. Succeed and you get another item.]]
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** Repentance [[spoiler: ends with a rush, starting with Dogma, followed up by the Ultra Horsemen one at a time before ending with The Harlot.]]
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* CaptureBalls: Afterbirth adds an item called the "Friendly Ball," It's a blatant Pokéball expy. You can throw it at an enemy and release it later on as a charmed enemy. There's even a challenge in Afterbirth+ where you get a Friendly Ball that always has an enemy inside it.
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* CaptureBalls: Afterbirth adds an item called the "Friendly Ball," It's Ball" which is a blatant Pokéball [[Franchise/{{Pokemon}} Pokéball]] expy. You can throw it at an enemy and release it later on as a charmed enemy. There's even a challenge in Afterbirth+ where you get a Friendly Ball that always has an enemy inside it.
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** [[{{Denouement}} While needing to be pieced together from multiple different endings]], the endings added by the expansions [[spoiler: (as well as an ending in ''The Legend of Bum-bo'' and [[https://twitter.com/edmundmcmillen/status/1385112195772473348 Word of God]])]] make it clear. [[spoiler:[[TheHeroDies Isaac suffocates to death]] inside the chest trying to hide from his abusive mother. He is [[DyingDream hallucinating the entire game]] due to asphyxiation fueled delirium and his father encouraging him to use his imagination as a coping mechanism. His mother believes him to be missing and after an indeterminate period of time she finds his remains and mourns his death. Isaac's fate in the afterlife, however, is ultimately unknown and is left up to interpretation]].
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** [[{{Denouement}} While needing to be pieced together from multiple different endings]], the endings added by the expansions [[spoiler: (as well as an ending in ''The Legend of Bum-bo'' and [[https://twitter.com/edmundmcmillen/status/1385112195772473348 Word of God]])]] make it clear. [[spoiler:[[TheHeroDies Isaac suffocates to death]] inside the chest trying to hide from his abusive mother. He is [[DyingDream hallucinating the entire game]] due to asphyxiation fueled delirium and his father encouraging him to use his imagination as a coping mechanism. His mother believes him to be missing and after an indeterminate period of time she finds his remains and mourns his death. Isaac's fate in the afterlife, however, is ultimately unknown and is left up to interpretation]].interpretation.]]
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ymmv on non ymmv page
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* ''Eternal Edition'' is a free update to the original game, released by Florian Himsl on May 2015. The expansion features its own hard mode where almost every enemy and boss receives an EliteMook variant known as an "Eternal Champion". [[NintendoHard It's definitely as tough as it sounds]].
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* ''Eternal Edition'' is a free update to the original game, released by Florian Himsl on May 2015. The expansion features its own hard mode where almost every enemy and boss receives an EliteMook variant known as an "Eternal Champion". [[NintendoHard It's definitely as tough as it sounds]].sounds.
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* EarnYourFun: More harder levels and gimmicky characters become unlocked and many of the stronger items in the game become available in the item pool once you beat the game in several ways, most ways being [[NintendoHard stupidly hard]], such as beating all the bosses on hard mode with only [[OneHitPointWonder one hit point]].
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* EarnYourFun: More harder levels and gimmicky characters become unlocked and many of the stronger items in the game become available in the item pool once you beat the game in several ways, most ways being [[NintendoHard stupidly hard]], hard, such as beating all the bosses on hard mode with only [[OneHitPointWonder one hit point]].
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* NintendoHard: Much like the {{Roguelike}}s it's based on, ''The Binding of Isaac'' has no continues. You start with one life and additional lives are very, very unlikely to show up once along multiple playthroughs, much less a single one. If you die, you start all over again. The configurations of rooms and upgrades are randomized, and in some situations, damage will be nearly unavoidable. Survival depends on reflexes and calculated risk. Each expansion to either the Flash original or ''Rebirth'' tends to turn the difficulty up a few notches.
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* NintendoHard: A "hard" difficulty level has been added, which significantly dials up the number of enemies and [[EliteMook champions]] while giving you less powerful items, and in ''Repentance'' it allows low-tier shops to spawn regardless of the Donation Machine's coin count. ''Afterbirth+'' does this for Greed Mode, which is called Greedier Mode.
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Crosswicking
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* CaptureBalls: Afterbirth adds an item called the "Friendly Ball," It's a blatant Pokéball expy. You can throw it at an enemy and release it later on as a charmed enemy. There's even a challenge in Afterbirth+ where you get a Friendly Ball that always has an enemy inside it.
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* CastFromMoney: The Magic Fingers is an item that instantly deals a small amount of damage to every enemy in the room every time you put a penny into it. It has no cooldown time, so if you have lots of money (or are lucky enough to find the Dollar), you can spam it until your money runs out.
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* CastFromMoney: The Magic Fingers is an item that instantly deals a small amount of damage to every enemy in the room every time you put a penny into it. It has no cooldown time, so if you have lots of money (or are lucky enough to find the Dollar), you can spam it until your money runs out. ''Repentance'' also added the Golden Razor, which lets you pay 5 coins for a temporary damage boost.
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* StatOverflow: Afterbirth+, the 2nd DLC expansion, eventually added Bone Hearts. They function similarly to soul hearts in that they appear at the end of your health bar and protect deal chances. The difference is that Bone Hearts also function as disposable heart containers, so they can be filled with red hearts.
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Crosswicking new trope.
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* StatOverflow:
** Soul Hearts have been around since the original flash release. They're blue hearts that you can pick up even at full red health, and they protect you from losing your deal chances upon getting hit.
** Introduced in ''Wrath of the Lamb'', Eternal Hearts function similarly to soul hearts at first, appearing at the end of your health bar and giving you an extra hit. However, if you find a second eternal heart or protect it until the next floor, [[CapRaiser it will permanently turn into a red heart container]].
** Soul Hearts have been around since the original flash release. They're blue hearts that you can pick up even at full red health, and they protect you from losing your deal chances upon getting hit.
** Introduced in ''Wrath of the Lamb'', Eternal Hearts function similarly to soul hearts at first, appearing at the end of your health bar and giving you an extra hit. However, if you find a second eternal heart or protect it until the next floor, [[CapRaiser it will permanently turn into a red heart container]].
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Misplaced, moving to the correct tab
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* ObviousBeta:
** ''Wrath of the Lamb'' [[http://bindingofisaac.wikia.com/wiki/Wrath_of_the_Lamb_Bugs was glitchy as hell on release.]] Even the patches created further bugs temporarily; version 1.15 prevented several players from unlocking Challenge 10 or Ending 12.
** The original game [[http://www.gamasutra.com/view/feature/182380/postmortem_mcmillen_and_himsls_.php?page=3 was admitted to be very buggy on release]], due to its complexity and the difficulties of working with Flash.
** ''Wrath of the Lamb'' [[http://bindingofisaac.wikia.com/wiki/Wrath_of_the_Lamb_Bugs was glitchy as hell on release.]] Even the patches created further bugs temporarily; version 1.15 prevented several players from unlocking Challenge 10 or Ending 12.
** The original game [[http://www.gamasutra.com/view/feature/182380/postmortem_mcmillen_and_himsls_.php?page=3 was admitted to be very buggy on release]], due to its complexity and the difficulties of working with Flash.
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** Using [[spoiler:Literature/TheBible]] on [[spoiler:[[OptionalBoss Satan]]]] kills you regardless of health. Particularly mean as using it on [[spoiler:Mom or Mom's Heart]] kills them instantly.
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** Using [[spoiler:Literature/TheBible]] on [[spoiler:[[OptionalBoss Satan]]]] [[spoiler:Satan]] kills you regardless of health. Particularly mean as using it on [[spoiler:Mom or Mom's Heart]] kills them instantly.
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Trope was cut/disambiguated due to cleanup
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** ''Rebirth'' adds the "Real Platinum God" achievement. [[spoiler:This requires beating every path and BonusBoss of the game with [[OneHitPointWonder The Lost]], who cannot gain HP in any way.]]
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** ''Rebirth'' adds the "Real Platinum God" achievement. [[spoiler:This requires beating every path and BonusBoss OptionalBoss of the game with [[OneHitPointWonder The Lost]], who cannot gain HP in any way.]]
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** Using [[spoiler:Literature/TheBible]] on [[spoiler:[[BonusBoss Satan]]]] kills you regardless of health. Particularly mean as using it on [[spoiler:Mom or Mom's Heart]] kills them instantly.
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** Using [[spoiler:Literature/TheBible]] on [[spoiler:[[BonusBoss [[spoiler:[[OptionalBoss Satan]]]] kills you regardless of health. Particularly mean as using it on [[spoiler:Mom or Mom's Heart]] kills them instantly.
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* AndYourRewardIsClothes: The reward for beating Mom's Heart/It Lives! on hard mode, [[spoiler:[[BonusBoss Mega Satan]]]], and/or completing all marks (defeat every major boss plus the Boss Rush) on Hard Mode on a character? A different selectable skin for co-op babies. Slightly downplayed in that these babies have special abilities, though these are generally minor, such as dealing contact damage and dropping pickups upon death. [[spoiler:Except for [[OneHitPointWonder The Lost]], who unlocks a special baby that doesn't take damage for killing Mom's Heart/It Lives! on hard mode, and unlocking the extremely powerful Godhead if you manage to clear all Hard Mode marks with him]].
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* AndYourRewardIsClothes: The reward for beating Mom's Heart/It Lives! on hard mode, [[spoiler:[[BonusBoss [[spoiler:[[OptionalBoss Mega Satan]]]], and/or completing all marks (defeat every major boss plus the Boss Rush) on Hard Mode on a character? A different selectable skin for co-op babies. Slightly downplayed in that these babies have special abilities, though these are generally minor, such as dealing contact damage and dropping pickups upon death. [[spoiler:Except for [[OneHitPointWonder The Lost]], who unlocks a special baby that doesn't take damage for killing Mom's Heart/It Lives! on hard mode, and unlocking the extremely powerful Godhead if you manage to clear all Hard Mode marks with him]].
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* BonusBoss: ''Afterbirth'' plays with this in regards to [[spoiler:Hush]]. You do have to beat it at least once with every character, but unlike [[spoiler:Mega Satan]], this boss does not end the run. Rather, it is an optional diversion that can net you some extra items at the cost of fighting an extra boss, and once you beat it, you go right to [[spoiler:Sheol or the Cathedral]]. Averted in ''Afterbirth+'', where you have to beat this boss to unlock its FinalBoss, and averted further in ''Repentance'', which requires you to beat [[spoiler:Hush]] 3 times to unlock the Alternate Route.
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** ''Afterbirth'' adds a true example of this, [[spoiler:Hush, an [[BonusBoss extra boss]] that spawns hundreds of enemies, has very dense shot patterns with unique effects, and normalizes the damage it takes, meaning even an overpowered build can't just cheese it]].
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** ''Afterbirth'' adds a true example of this, [[spoiler:Hush, an [[BonusBoss [[OptionalBoss extra boss]] that spawns hundreds of enemies, has very dense shot patterns with unique effects, and normalizes the damage it takes, meaning even an overpowered build can't just cheese it]].
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* EarnYourBadEnding: A retroactive example in ''Repentance''. While the GoldenEnding is only a slight detour from normal gameplay progression, the previous two "final" endings are much more difficult and/or convoluted to unlock. The [[spoiler:Mega Satan]] ending, in which [[spoiler:Isaac comes to embrace his inner evil]], is largely luck-based, requiring you to either encounter the Angel Room twice in one playthrough and perform a specific action within it, or take at least 12 full hearts of damage in a Sacrifice Room. Meanwhile, the [[spoiler:Delirium]] ending, in which [[spoiler:Isaac kills himself and goes to Purgatory]], requires you to clear a BrutalBonusLevel that opens at random, the only guaranteed way to access it being to speedrun the first four chapters of the game within 30 minutes and defeat ''another'' BonusBoss, and both of these bosses are often considered even harder than the TrueFinalBoss.
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* EarnYourBadEnding: A retroactive example in ''Repentance''. While the GoldenEnding is only a slight detour from normal gameplay progression, the previous two "final" endings are much more difficult and/or convoluted to unlock. The [[spoiler:Mega Satan]] ending, in which [[spoiler:Isaac comes to embrace his inner evil]], is largely luck-based, requiring you to either encounter the Angel Room twice in one playthrough and perform a specific action within it, or take at least 12 full hearts of damage in a Sacrifice Room. Meanwhile, the [[spoiler:Delirium]] ending, in which [[spoiler:Isaac kills himself and goes to Purgatory]], requires you to clear a BrutalBonusLevel that opens at random, the only guaranteed way to access it being to speedrun the first four chapters of the game within 30 minutes and defeat ''another'' BonusBoss, {{Superboss}}, and both of these bosses are often considered even harder than the TrueFinalBoss.
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** Getting to the BossRush and [[spoiler:the ??? area/Hush fight]] are not elaborated upon aside from one vague hint from the Rules Card ("[[spoiler:THE WALLS WILL HARDEN OVER TIME. TIME IS THE ESSENCE]]") and a clock appearing on the "progress bar" -- and the clock only applies for the former. [[spoiler:Mom needs to be beaten before 20 in-game minutes, and It Lives! (the ??? area is locked prior to Mom's Heart transforming into It Lives!) needs to be beaten before 30]]. Players going in blind are likely to stumble upon the game's BonusBoss by accident after a good run.
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** Getting to the BossRush and [[spoiler:the ??? area/Hush fight]] are not elaborated upon aside from one vague hint from the Rules Card ("[[spoiler:THE WALLS WILL HARDEN OVER TIME. TIME IS THE ESSENCE]]") and a clock appearing on the "progress bar" -- and the clock only applies for the former. [[spoiler:Mom needs to be beaten before 20 in-game minutes, and It Lives! (the ??? area is locked prior to Mom's Heart transforming into It Lives!) needs to be beaten before 30]]. Players going in blind are likely to stumble upon the game's BonusBoss OptionalBoss by accident after a good run.
* OptionalBoss: ''Afterbirth'' plays with this in regards to [[spoiler:Hush]]. You do have to beat it at least once with every character, but unlike [[spoiler:Mega Satan]], this boss does not end the run. Rather, it is an optional diversion that can net you some extra items at the cost of fighting an extra boss, and once you beat it, you go right to [[spoiler:Sheol or the Cathedral]]. Averted in ''Afterbirth+'', where you have to beat this boss to unlock its FinalBoss, and averted further in ''Repentance'', which requires you to beat [[spoiler:Hush]] 3 times to unlock the Alternate Route.
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** In ''Afterbirth'', defeating Mom's Heart/It Lives in under 30 minutes grants access to [[spoiler:the ???/Blue Womb area and the BonusBoss Hush]].
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** In ''Afterbirth'', defeating Mom's Heart/It Lives in under 30 minutes grants access to [[spoiler:the ???/Blue Womb area and the BonusBoss OptionalBoss Hush]].
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** Mega Blast is an activated item which fires a massive Brimstone laser which does insane damage and persists between rooms and floors, lasting for fifteen seconds. However, not only does it have a 12-room recharge (one of very few items in the game to require that many rooms, alongside the similarly powerful Eden's Soul and Mega Mush), but normal battery pickups will not fully recharge the item for another go. Because of this, Mega Blast tends to be saved for endgame floors/bosses that players want to wipe out quickly, such as the [[DamageSpongeBoss insanely tanky]] BonusBoss.
** The Chaos Card can OneHitKill almost anything in the game. The catch, of course, is that it's a card and can therefore only be used once. Like Mega Blast above, the Chaos Card tends to be saved for endgame bosses such as said insanely tanky BonusBoss. Unless, of course, the player gets a Blank Card.
** The Chaos Card can OneHitKill almost anything in the game. The catch, of course, is that it's a card and can therefore only be used once. Like Mega Blast above, the Chaos Card tends to be saved for endgame bosses such as said insanely tanky BonusBoss. Unless, of course, the player gets a Blank Card.
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** Mega Blast is an activated item which fires a massive Brimstone laser which does insane damage and persists between rooms and floors, lasting for fifteen seconds. However, not only does it have a 12-room recharge (one of very few items in the game to require that many rooms, alongside the similarly powerful Eden's Soul and Mega Mush), but normal battery pickups will not fully recharge the item for another go. Because of this, Mega Blast tends to be saved for endgame floors/bosses that players want to wipe out quickly, such as the [[DamageSpongeBoss insanely tanky]] BonusBoss.
optional boss.
** The Chaos Card can OneHitKill almost anything in the game. The catch, of course, is that it's a card and can therefore only be used once. Like Mega Blast above, the Chaos Card tends to be saved for endgame bosses such as said insanely tankyBonusBoss.OptionalBoss. Unless, of course, the player gets a Blank Card.
** The Chaos Card can OneHitKill almost anything in the game. The catch, of course, is that it's a card and can therefore only be used once. Like Mega Blast above, the Chaos Card tends to be saved for endgame bosses such as said insanely tanky
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* CapRaiser:
** Your Tears stat (fire rate) is normally capped at 5 tears per second. However, certain items don't increase ''Tears'' but actually raise your fire rate directly, which will exceed the normal cap all the way until the nearly-impossible-to-reach hard cap of 120 tears per second.
** Normally you can only carry a maximum of 99 pennies at a time. As of ''Repentance'', the item Deep Pockets lets you carry up to 999 instead.
** Birthright is an item that has a different, unique effect for each character. A few characters have a Birthright effect that breaks certain caps.
*** Magdalene's Birthright effect increases her heart limit from the normal 12 all the way up to 18.
*** Keeper is normally limited to only 3 Coin Hearts (a special heart type that's restored by money instead of health pickups), but Birthright will increase it to 4.
*** Samson gains damage for the rest of the floor each time he takes damage, up to 10 times. With Birthright, he can get the bonus an additional 4 times each floor.
*** Tainted Magdalene slowly loses her health over time, eventually bleeding down to only two hearts. Birthright gives her a third permanent heart that doesn't bleed away.
** Your Tears stat (fire rate) is normally capped at 5 tears per second. However, certain items don't increase ''Tears'' but actually raise your fire rate directly, which will exceed the normal cap all the way until the nearly-impossible-to-reach hard cap of 120 tears per second.
** Normally you can only carry a maximum of 99 pennies at a time. As of ''Repentance'', the item Deep Pockets lets you carry up to 999 instead.
** Birthright is an item that has a different, unique effect for each character. A few characters have a Birthright effect that breaks certain caps.
*** Magdalene's Birthright effect increases her heart limit from the normal 12 all the way up to 18.
*** Keeper is normally limited to only 3 Coin Hearts (a special heart type that's restored by money instead of health pickups), but Birthright will increase it to 4.
*** Samson gains damage for the rest of the floor each time he takes damage, up to 10 times. With Birthright, he can get the bonus an additional 4 times each floor.
*** Tainted Magdalene slowly loses her health over time, eventually bleeding down to only two hearts. Birthright gives her a third permanent heart that doesn't bleed away.
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On June 27, 2018, a Kickstarter page for [[https://foursouls.com/ The Binding of Isaac: Four Souls]], a card game published by [=Studio71=], was launched, and was successfully funded. Another successful Kickstarter page was launched in June 2021 for a massive expansion with the subtitle ''Requiem,'' bringing with it the new content from ''Repentance'' as well as a plethora of crossovers with other franchises, from games like ''VideoGame/CaveStory'' and ''VideoGame/AmongUs'' to even non-video-game works such as ''Film/PGPsychoGoreman'' and ''Film/TheRoom2003''. The expansion is currently planned to be released at some point in early 2023. A digital version of ''Four Souls'' is also officially available as a [[https://steamcommunity.com/sharedfiles/filedetails/?id=2501791757 Workshop item]] for ''Tabletop Simulator''.
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On June 27, 2018, a Kickstarter page for [[https://foursouls.com/ The Binding of Isaac: Four Souls]], a card game published by [=Studio71=], was launched, and was successfully funded. Another successful Kickstarter page was launched in June 2021 for a massive expansion with the subtitle ''Requiem,'' bringing with it the new content from ''Repentance'' as well as a plethora of crossovers with other franchises, from games like ''VideoGame/CaveStory'' and ''VideoGame/AmongUs'' to even non-video-game works such as ''Film/PGPsychoGoreman'' and ''Film/TheRoom2003''. The expansion is currently planned to be was eventually released at some point in early March and April 2023. A digital version of ''Four Souls'' is also officially available as a [[https://steamcommunity.com/sharedfiles/filedetails/?id=2501791757 Workshop item]] for ''Tabletop Simulator''.
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* NoticeThis: The Shiny Rock Trinket makes tinted rocks (rocks which may contain useful items) briefly flash when Isaac enters the room (as well as every 10 seconds afterwards).
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* ShinySense: The Shiny Rock Trinket makes tinted rocks (rocks which may contain useful items) briefly flash when Isaac enters the room (as well as every 10 seconds afterwards).
