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** On a rare occasion, the Warners themselves, who usually FeignInsanity, will ''genuinely'' go insane when even they can't cope with the madness.
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** In ''[[Recap/MyLittlePonyFriendshipIsMagicS4E23InspirationManifestation Inspiration Manifestation]]'', the more Rarity uses the book's power, the more deranged she becomes.
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** Randy in "A Nightmare on FaceTime". Complete with a shot-for-shot, line-for-line {{homage}} to Creator/JackNicholson and ''Film/TheShining''.
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** Randy in "A Nightmare on FaceTime".Face Time". Complete with a shot-for-shot, line-for-line {{homage}} to Creator/JackNicholson and ''Film/TheShining''.
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* The Christmas episode of ''WesternAnimation/AdventureTime'' shows that, centuries ago, before TheEndOfTheWorldAsWeKnowIt this happened to an antique collector by the name of Simon Petrikov after he made the mistake of wearing a cursed artifact. A thousand years of sanity slippage later, the man he was is completely gone, and what remains only knows himself as [[spoiler: The Ice King]].
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* The Christmas episode of ''WesternAnimation/AdventureTime'' shows that, centuries ago, before TheEndOfTheWorldAsWeKnowIt TheEndOfTheWorldAsWeKnowIt, this happened to an antique collector by the name of Simon Petrikov after he made the mistake of wearing a cursed artifact. A thousand years of sanity slippage later, the man he was is completely gone, and what remains only knows himself as [[spoiler: The Ice King]].
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** In "Rarity Takes Manehattan", it's the title pony who ends up doing some hyperventilating during another of her epic freakouts.
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** [[{{Adorkable}} Twilight Sparkle]] goes through a complete psychotic break in [[Recap/MyLittlePonyFriendshipIsMagicS2E3LessonZero "Lesson Zero"]]. Convinced that she's about to fail her duty to Princess Celestia, [[MadnessMakeover her mane goes disheveled, her teeth grind, her eyes becoming unfocused]], she [[TalkingToThemself talks to herself]], and she starts [[TeleportSpam teleporting at random]] while undergoing a complete nervous breakdown. It culminates in an (unintended) mass hypnosis of Ponyville that requires the Princess herself to intervene, furious at her student for abusing her powers.
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** [[{{Adorkable}} Twilight Sparkle]] goes through a complete psychotic break in [[Recap/MyLittlePonyFriendshipIsMagicS2E3LessonZero "Lesson Zero"]]. Convinced that she's about to fail her duty to Princess Celestia, [[MadnessMakeover her mane goes disheveled, her teeth grind, her eyes becoming become unfocused]], she [[TalkingToThemself talks to herself]], and she starts [[TeleportSpam teleporting at random]] while undergoing a complete nervous breakdown. It culminates in an (unintended) mass hypnosis of Ponyville that requires the Princess herself to intervene, furious at her student for abusing her powers.
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** [[{{Adorkable}} Twilight Sparkle]] goes through a complete psychotic break in [[Recap/MyLittlePonyFriendshipIsMagicS2E3LessonZero "Lesson Zero"]]. Convinced that she's about to fail her duty to Princess Celestia, her mane goes disheveled, her teeth grind, her eyes becoming unfocused, she [[TalkingToThemself talks to herself]], and she starts [[TeleportSpam teleporting at random]] while undergoing a complete nervous breakdown. It culminates in an (unintended) mass hypnosis of Ponyville that requires the Princess herself to intervene, furious at her student for abusing her powers.
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** [[{{Adorkable}} Twilight Sparkle]] goes through a complete psychotic break in [[Recap/MyLittlePonyFriendshipIsMagicS2E3LessonZero "Lesson Zero"]]. Convinced that she's about to fail her duty to Princess Celestia, [[MadnessMakeover her mane goes disheveled, her teeth grind, her eyes becoming unfocused, unfocused]], she [[TalkingToThemself talks to herself]], and she starts [[TeleportSpam teleporting at random]] while undergoing a complete nervous breakdown. It culminates in an (unintended) mass hypnosis of Ponyville that requires the Princess herself to intervene, furious at her student for abusing her powers.
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She definitely is going through Sanity Slippage, but this is selective memory. She was nice to LSP at the end of Bad Timing and took her abuse, hasn\'t tortured anyone (game isn\'t canon) and let everyone go in Apple Wedding.
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** Recent episodes have implied that Princess Bubblegum is undergoing sanity slippage, seeing as she has no qualms with torturing and hurting others, locked up every wedding guest in "Apple Wedding" without trial, and in "Bad Timing", she threatened a military invasion on Lumpy Space if Lumpy Space Princess didn't apologize for assaulting her.
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** Recent episodes have implied that Princess Bubblegum is undergoing sanity slippage, seeing as she has no qualms with torturing and hurting others, locked up every wedding guest in "Apple Wedding" without trial, and in "Bad Timing", she threatened a military invasion on Lumpy Space if Lumpy Space Princess didn't apologize for assaulting her.
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** Twilight goes crazy again in [[Recap/MyLittlePonyFriendshipIsMagicS2E20ItsAboutTime "It's About Time"]] due to a warning from her future self that got cut off before the important bit could be delivered, leading to a spiral down into the depths of paranoia.
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* ''PinkyAndTheBrain'': Snowball in "Welcome to the Jungle", where he's the leader of makeshift jungle tribe made up of tourists and it's implied he's been hallucinating.
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** Randy in "A Nightmare on FaceTime". Complete with a shot-for-shot, line-for-line {{homage}} to JackNicholson and TheShining.
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** Randy in "A Nightmare on FaceTime". Complete with a shot-for-shot, line-for-line {{homage}} to JackNicholson Creator/JackNicholson and TheShining.''Film/TheShining''.
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* Happens to Dog in one episode of ''{{CatDog}}'', when he learns that meat comes from animals and becomes convinced that food are his friends.
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* Kowalski gets this ''a lot'' in ''ThePenguinsofMadagascar''.
* ''WesternAnimation/Futurama'': Fry suffers this in "Insane in the Mainframe" as a result of being a human confined to a robot asylum.
* ''WesternAnimation/Futurama'': Fry suffers this in "Insane in the Mainframe" as a result of being a human confined to a robot asylum.
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* Kowalski gets this ''a lot'' in ''ThePenguinsofMadagascar''.
''ThePenguinsOfMadagascar''.
*''WesternAnimation/Futurama'': ''{{Futurama}}'': Fry suffers this in "Insane in the Mainframe" as a result of being a human confined to a robot asylum.
*
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* ''WesternAnimation/Futurama'': Fry suffers this in "Insane in the Mainframe" as a result of being a human confined to a robot asylum.
** In "Mobius Dick", Leela went insane when she became obsessed with trying to kill a space whale as revenge.
** In "Mobius Dick", Leela went insane when she became obsessed with trying to kill a space whale as revenge.
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* MickeyMouse in the short "New York Weenie".
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* MickeyMouse in the short "New York Weenie".Weenie" and "Dog Show".
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*** But if her hyperventilating near the climax of the episode is anything to judge by, it was a pretty near miss.
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** Homer himself does so in ''The Shinning'' segment of "[[Recap/TheSimpsonsS6E6TreehouseOfHorrorV Treehouse of Horror V]]" when the cable stops working and they run out of beer.
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** Homer himself does so in ''The Shinning'' segment of "[[Recap/TheSimpsonsS6E6TreehouseOfHorrorV Treehouse of Horror V]]" when the cable stops working and they run out of beer.beer, all thanks to Mr. Burns.
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-> "''But I'm losing myself and I'm afraid you're going to lose me too.''"
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** It gets worse. Later episodes document Simon's attempts at surviving and [[spoiler: raising Marceline]] after the nuclear holocaust, and his desperation at remaining himself.
-> "''But I'm losing myself and I'm afraid you're going to lose me too.''"
-> "''But I'm losing myself and I'm afraid you're going to lose me too.''"
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* Kowalski gets this ''a lot'' in ''ThePenguinsofMadagascar''.
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** In [[Recap/MyLittlePonyFriendshipIsMagicS2E19PuttingYourHoofDown "Putting Your Hoof Down"]], Fluttershy's takes some [[TeahHimAnger assertiveness training]] which [[GoneHorriblyRight works a little too well]], resulting in her [[TookALevelInJerkass taking multiple levels in Jerkass]] and becoming increasingly violent, paranoid and aggressive to the point that she reduces Pinkie and Rarity to ''tears''.
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** In [[Recap/MyLittlePonyFriendshipIsMagicS2E19PuttingYourHoofDown "Putting Your Hoof Down"]], Fluttershy's takes some [[TeahHimAnger [[TeachHimAnger assertiveness training]] which [[GoneHorriblyRight works a little too well]], resulting in her [[TookALevelInJerkass taking multiple levels in Jerkass]] and becoming increasingly violent, paranoid and aggressive to the point that she reduces Pinkie and Rarity to ''tears''.
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** In [[Recap/MyLittlePonyFriendshipIsMagicS2E19PuttingYourHoofDown "Putting Your Hoof Down"]], Fluttershy's takes some assertiveness training which [[GoneHorriblyRight works a little too well]], resulting in her [[TookALevelInJerkass taking multiple levels in Jerkass]] and becoming increasingly violent, paranoid and aggressive to the point that she reduces Pinkie and Rarity to ''tears''.
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** In [[Recap/MyLittlePonyFriendshipIsMagicS2E19PuttingYourHoofDown "Putting Your Hoof Down"]], Fluttershy's takes some [[TeahHimAnger assertiveness training training]] which [[GoneHorriblyRight works a little too well]], resulting in her [[TookALevelInJerkass taking multiple levels in Jerkass]] and becoming increasingly violent, paranoid and aggressive to the point that she reduces Pinkie and Rarity to ''tears''.
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-->'''Red''': AAAAAHHHH!!!!! I CAN'T TAKE IT ANYMORE!!!! I don't have any ice cream! Not one, so! EVER! I don't even like ice cream, OR KIDS! It says "Eye Screem" on my truck, not "Ice Cream"! Get it? 'cause I SCREAM!!! Look at me. (screams while spinning in circles) SCREAMING IS MY HOBBYYYYYY!!!!!! (gets hit on the head by a policeman).
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-->'''Red''': AAAAAHHHH!!!!! I CAN'T TAKE IT ANYMORE!!!! I don't have any ice cream! Not one, so! EVER! (Hangs near the side of the cop, then switches to a calm, quiet voice) I don't even like ice cream, (switches back to LargeHam mode) OR KIDS! It says "Eye Screem" on my truck, not "Ice Cream"! Get it? 'cause I SCREAM!!! Look at me. (screams while spinning in circles) SCREAMING IS MY HOBBYYYYYY!!!!!! (gets hit on HOBBYYYYYY!!!!!!.
-->'''Policeman''': (hits Red with a sausage) It's thehead by a policeman).padded cell for you, scream man!
-->'''Policeman''': (hits Red with a sausage) It's the
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* ''WesternAnimation/SouthPark'':
** "%1" ends with the implication that Cartman's sociopathic tendencies are growing into a full blown psychosis.
*** Even without any greater implications, you can see his sanity suffer with each stuffed animal destroyed.
** Randy in "A Nightmare on FaceTime". Complete with a shot-for-shot, line-for-line {{homage}} to JackNicholson and TheShining.
** "%1" ends with the implication that Cartman's sociopathic tendencies are growing into a full blown psychosis.
*** Even without any greater implications, you can see his sanity suffer with each stuffed animal destroyed.
** Randy in "A Nightmare on FaceTime". Complete with a shot-for-shot, line-for-line {{homage}} to JackNicholson and TheShining.
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* MickeyMouse in the short "New York Weenie".
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** In [[Recap/MyLittlePonyFriendshipIsMagicS2E19PuttingYourHoofDown "Putting Your Hoof Down"]], Fluttershy's assertiveness [[GoneHorriblyRight works a little too well]], resulting in her [[TookALevelInJerkass taking multiple levels in Jerkass]] and becoming increasingly violent, paranoid and aggressive to the point that she reduces Pinkie and Rarity to ''tears''.
to:
** In [[Recap/MyLittlePonyFriendshipIsMagicS2E19PuttingYourHoofDown "Putting Your Hoof Down"]], Fluttershy's takes some assertiveness training which [[GoneHorriblyRight works a little too well]], resulting in her [[TookALevelInJerkass taking multiple levels in Jerkass]] and becoming increasingly violent, paranoid and aggressive to the point that she reduces Pinkie and Rarity to ''tears''.
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** Before [[Recap/MyLittlePonyFriendshipIsMagicS3E12GamesPoniesPlay "Games Ponies Play"]] aired, people were expecting another "Twilight goes crazy" episode. They were likely surprised when this trope was {{averted|Trope}} for that episode.
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** Before [[Recap/MyLittlePonyFriendshipIsMagicS3E12GamesPoniesPlay "Games Ponies Play"]] aired, people were expecting another "Twilight goes crazy" episode. They were likely surprised when this trope was {{averted|Trope}} for that episode.episode because Cadance taught her a controlled breathing excercise to relieve stress.
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* Rigby of ''WesternAnimation/RegularShow'' goes cuckoo when he learns the "Death Punch of Death", to the point where he's willing to drown in lava if it means beating Mordecai at Punchie's.
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----
* [[MagnificentBastard Azula]] in the finale of ''WesternAnimation/AvatarTheLastAirbender''. Her slippage began with [[spoiler:Mai and Ty Lee's [[HeelFaceTurn betrayals]] a couple episodes]] earlier. When Ozai told her to remain in the Fire Nation as Fire Lord, she became increasingly more paranoid. She acted on the paranoia, then began hallucinating, and eventually had a VillainousBreakdown.
* ''WesternAnimation/TheSimpsons'' episode "Springfield Up" contains a very swift summary of how doctor/lawyer Eleanor Abernathy went off her rocker and became the town's yowling cat lady.
** Frank Grimes learns the hard way in "[[Recap/TheSimpsonsS8E23HomersEnemy Homer's Enemy]]" that being the OnlySaneMan in a CrapsackWorld is not conducive to one's long term health.
** Homer himself does so in ''The Shinning'' segment of "[[Recap/TheSimpsonsS6E6TreehouseOfHorrorV Treehouse of Horror V]]" when the cable stops working and they run out of beer.
--->'''Homer''': No TV and no beer make Homer something something...\\
'''Marge''': "Go crazy?"\\
'''Homer''': '''''Don't mind if I do!!''''' (''proceeds to go crazy'')
* ''WesternAnimation/ToyStory''. Buzz ''really'' doesn't take realizing he's a toy well.
-->'''Buzz Lightyear:''' YOU SEE THE HAT?! I AM MRS... ''NESBITT''! ''(laughs maniacally)''
* PlayedForLaughs on ''WesternAnimation/JimmyTwoShoes'', when Jimmy is left the only person in Miseryville awake while everyone else is in hibernation. He slowly begins to go crazy.
* WesternAnimation/SpongeBobSquarePants and Mr. Krabs try to keep their sanity when they believed they killed the health inspector. [[spoiler:Turns out that the inspector is still alive, and the Krusty Krab passes inspection.]]
** In "Pickles", [=SpongeBob=]'s life takes a turn for the chaotic after a JerkAss customer claims that he forgot the titular condiment. By which we mean he tries to cook his bicycle and hangs the toaster on his front door.
** Poor Squidward. In between being the entire ocean's ButtMonkey and victim to the constant shenanigans of his next door neighbors, [=SpongeBob=] and Patrick, it's no wonder he's been shown to break down into a sobbing wreck or fits of maniacal laughter when the AmusingInjuries and ever-present failures prove too much to handle. In "Squid's Day Off" Squidward tricks [=SpongeBob=] into running the Krusty Krab all by himself while he takes a day off, but he keeps imagining [=SpongeBob=] destroying the Krusty Krab and repeatedly goes back and forth to and from his house. While taking a bath he hallucinates [=SpongeBob=] is watching him and runs off to the Krusty Krab wearing only bubbles.
** [=SpongeBob=] frequently has Sanity Slippage to the point that you wonder whether he's exactly sane to begin with...
--->''(from "Stuck in the Wringer")''\\
'''Patrick:''' Hey, whatcha watchin'?\\
'''[=SpongeBob=]:''' ''(watching static on TV)'' My favorite show. ''(the TV dies)'' Ha, ha, I love that part!
** Mr. Krabs goes crazy when the squeaky noise of the rubber boots he gave Spongebob becomes too much to bear.
** In "Clams" after Mr. Krabs loses his millionth dollar we see him slowly go completely insane. The cut back to Mr. Krabs, who begins giggling maniacally [[EyeScream and tears his two eyes out, using them as a jumprope]] is genuinely disturbing.
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic'': The FanNickname for this is "Cutie Mark Failure Insanity Syndrome", given that a pony failing to live up to their special talent (symbolized by their cutie mark) is the most common cause of ponies going nuts. (It's worth pointing out that in all of these cases, the insanity was cleared up by the end of the episode with ThePowerOfFriendship.)%% NOTE TO EDITORS: Please leave the mention of the fandom term for searchability.
** In [[Recap/MyLittlePonyFriendshipIsMagicS1E25PartyOfOne "Party of One"]], [[GenkiGirl Pinkie Pie]] thinks her friends are avoiding her because they're sick of her parties. Her normally curly hair goes straight, she [[CompanionCube makes her own party guests]] out of things like a sack of flour and a pile of rocks (whom she holds conversations with), her colourful persona becomes noticeably darker, as if it's under a shadow, and the normally insufferably cheerful pony becomes cranky, miserable, and borderline paranoid schizophrenic, all the while sporting a SlasherSmile. Her slippage even comes complete with {{Creepy Circus|Music}} [[http://www.youtube.com/watch?v=_cy9gNE_vIE Music]] (which has a disturbing resemblance to the {{leitmotif}} of a certain personification of chaos).
** In [[Recap/MyLittlePonyFriendshipIsMagicS1E26TheBestNightEver "The Best Night Ever"]], [[ShrinkingViolet Fluttershy]] snaps at the Grand Galloping Gala due to all of the animals running in fear from her. After her increasingly desperate methods fail, she goes into full blown {{Yandere}} mode, unleashing animal-based chaos with the line [[http://www.youtube.com/watch?v=rwp60eYuie0 "You're... going to LOVE MEEEE!"]].
** In [[Recap/MyLittlePonyFriendshipIsMagicS2E1TheReturnOfHarmonyPart1 "The Return Of Harmony Part 1"]] and [[Recap/MyLittlePonyFriendshipIsMagicS2E2TheReturnOfHarmonyPart2 "Part 2"]], the [[CorruptTheCutie discorded mane ponies']] misbehavior becomes worse as the episode progresses.
** [[{{Adorkable}} Twilight Sparkle]] goes through a complete psychotic break in [[Recap/MyLittlePonyFriendshipIsMagicS2E3LessonZero "Lesson Zero"]]. Convinced that she's about to fail her duty to Princess Celestia, her mane goes disheveled, her teeth grind, her eyes becoming unfocused, she [[TalkingToThemself talks to herself]], and she starts [[TeleportSpam teleporting at random]] while undergoing a complete nervous breakdown. It culminates in an (unintended) mass hypnosis of Ponyville that requires the Princess herself to intervene, furious at her student for abusing her powers.
*** Keep in mind that all those examples happened in ''five consecutive episodes''.
** In [[Recap/MyLittlePonyFriendshipIsMagicS2E19PuttingYourHoofDown "Putting Your Hoof Down"]], Fluttershy's assertiveness [[GoneHorriblyRight works a little too well]], resulting in her [[TookALevelInJerkass taking multiple levels in Jerkass]] and becoming increasingly violent, paranoid and aggressive to the point that she reduces Pinkie and Rarity to ''tears''.
** Princess Luna experiences this a thousand years before the time of the series. Literally consumed with [[GreenEyedMonster jealousy and anger]] towards the ponies rejecting [[TheSacredDarkness her beautiful night]] in favour of Celestia's day, she [[FaceHeelTurn transforms into]] [[SuperpoweredEvilSide Nightmare Moon]] and tries to enact [[TheNightThatNeverEnds eternal night]] in a stubborn attempt to ''force'' the ponies to love her, showing that even a [[PhysicalGod Physical Goddess]] isn't immune to CMFIS. In [[Recap/MyLittlePonyFriendshipIsMagicS2E4LunaEclipsed "Luna Eclipsed"]] she runs the risk of having to bear these insecurities all over again when the ponies begin to reject her once more, but fortunately Twilight is there to help.
** Before [[Recap/MyLittlePonyFriendshipIsMagicS3E12GamesPoniesPlay "Games Ponies Play"]] aired, people were expecting another "Twilight goes crazy" episode. They were likely surprised when this trope was {{averted|Trope}} for that episode.
* In the ''WesternAnimation/KingOfTheHill'' episode "Pretty, Pretty Dresses" Bill is very lonely and depressed, and finally loses it when Hank destroys the gifts he'd been saving for his ex-wife Lenore in case she ever came back. He starts wearing her old clothes she'd left behind and talks in a falsetto voice, believing that he himself is Lenore; eventually Hank is able to break him out of it and gets him to get over Lenore.
* In ''Disney/TheLionKing 1 1/2'', during a scene approximately taking place during Scar's VillainSong in the original movie, Timon is on the verge of cracking in his "dream home" quest...
-->'''Timon:''' ''(comes across a steam vent)'' Hey! This is home sweet home, baby! Home-- ''(gets sent into the air a bit by the eruption)'' Ha ha! Steam! Ha ha! Steam is good. Steam is--is--is water. Whoo! Gotta have water. You know, for the dream home. Steam home, dream home! Steam, steam, steam.
* More or less the plot of ''WesternAnimation/{{Wakfu}}'''s StartOfDarkness prequel episode.
* The Christmas episode of ''WesternAnimation/AdventureTime'' shows that, centuries ago, before TheEndOfTheWorldAsWeKnowIt this happened to an antique collector by the name of Simon Petrikov after he made the mistake of wearing a cursed artifact. A thousand years of sanity slippage later, the man he was is completely gone, and what remains only knows himself as [[spoiler: The Ice King]].
* Ren of ''WesternAnimation/TheRenAndStimpyShow'' frequently falls into this. Stimpy sometimes does too. And boy is it [[NightmareFuel/TheRenAndStimpyShow creepy]].
* ''WesternAnimation/LooneyTunes'': DaffyDuck seems to fall victim to this a lot. A perfect example occurs in ''Duck! Rabbit! Duck!'' after he gets shot by Elmer Fudd one too many times:
-->'''Daffy:''' ''(hysterical)'' Shoot me again! I enjoy it! I love the smell of burnt feathers! And gunpowder! And cordite! I'm an elk -- shoot me! Go on, it's elk season! I'm a fiddler crab -- why don't you shoot me?! It's fiddler crab season!
** In ''WesternAnimation/TheLooneyTunesShow'' not only Daffy, but everybody is liable to get bonkers (after all, it's a mostly CrapsaccharineWorld/ StepfordSuburbia full of {{Cloudcuckoolander}}s). As an example, Porky has turned from an apparently wealthy JerkJock in high school to a middle-class burn-out prone to suffer this [[spoiler:so frequently that it gets in BlackComedy and even "DudeNotFunny" territory]]; and Bugs didn't act like himself after he started consuming "Spargle" (being PlayedForLaughs).
* ''WesternAnimation/{{Animaniacs}}'' has this happen almost OncePerEpisode to the unfortunate soul the Warners decide to be their "special friend". Most of the time [[AssholeVictim they deserve it]], though.
** Slappy Squirrel suffers this in "One Flew Over the Cuckoo Clock" after being forced to watch talk shows.
* Candace from ''WesternAnimation/PhineasAndFerb'' quite often suffers this. Though it's not [[CloudCuckooLander like she's all there to begin with]].
* Meg Griffin from ''WesternAnimation/FamilyGuy'' quite frequently out of a desperation for love and affection.
* ''WesternAnimation/{{Rugrats}}'': From [[WesternAnimation/TheRugratsMovie the movie]], Tommy totally snaps and almost pours mashed bananas on Dil, knowing the monkeys will be attracted to it. It's thundering and raining the whole time, and Tommy just starts acting more and more crazy as he starts ranting about how much Dil has ruined his life.
** In ''[[ItsAWonderfulPlot Chuckie's Wonderful Life]]", Chaz goes insane in a world without his son.
** Stu also loses it when he's forced to take care of Angelica after she pretends to have broken her leg.
* Harleen Quinzel, who would later become Harley Quinn, in the ''WesternAnimation/BatmanTheAnimatedSeries'' episode "Mad Love".
* Dib of ''WesternAnimation/InvaderZim'' isn't that stable to begin with (being one of the handful of reasonably intelligent people in a CrapsackWorld [[SurroundedByIdiots full of idiots]] will do that), but over the course of the series becomes increasingly desperate, paranoid, and manic, and [[TalkingToThemself talks to himself]] with greater frequency.
* Though Justin Hammer already was a RichInDollarsPoorInSense PsychoticManchild from the start in ''WesternAnimation/IronManArmoredAdventures'', he gradually loses the little sanity he has left over the course of the series.
* While the Red Guy from ''WesternAnimation/CowAndChicken'' isn't exactly sane to begin with, he ends up having a complete mental breakdown in the episode "I Scream, Man" as a result of taking a job that he despises: as an ice cream man. Predictably, he ends up in a mental clinic.
-->'''Red''': AAAAAHHHH!!!!! I CAN'T TAKE IT ANYMORE!!!! I don't have any ice cream! Not one, so! EVER! I don't even like ice cream, OR KIDS! It says "Eye Screem" on my truck, not "Ice Cream"! Get it? 'cause I SCREAM!!! Look at me. (screams while spinning in circles) SCREAMING IS MY HOBBYYYYYY!!!!!! (gets hit on the head by a policeman).
* Louise on ''WesternAnimation/BobsBurgers'' [[CloudCuckoolander was never exactly the sanest kid around]], but in "Earsy Rider" she has a mental breakdown after her bunny ears are stolen. [[spoiler:It gets even worse when she thinks they've been destroyed.]]
* ''WesternAnimation/TransformersPrime'' showcases [[BigBad Megatron]]'s slow descent into (further) homicidal madness. Doping using the blood of [[{{Satan}} Unicron]] certainly hasn't helped, but he's clearly slipping even without it. It becomes most clear when he get the Dark Star Saber, whereupon he starts shouting about how he'll tear this world apart (despite the fact that doing that dooms the entire universe).
----
* [[MagnificentBastard Azula]] in the finale of ''WesternAnimation/AvatarTheLastAirbender''. Her slippage began with [[spoiler:Mai and Ty Lee's [[HeelFaceTurn betrayals]] a couple episodes]] earlier. When Ozai told her to remain in the Fire Nation as Fire Lord, she became increasingly more paranoid. She acted on the paranoia, then began hallucinating, and eventually had a VillainousBreakdown.
* ''WesternAnimation/TheSimpsons'' episode "Springfield Up" contains a very swift summary of how doctor/lawyer Eleanor Abernathy went off her rocker and became the town's yowling cat lady.
** Frank Grimes learns the hard way in "[[Recap/TheSimpsonsS8E23HomersEnemy Homer's Enemy]]" that being the OnlySaneMan in a CrapsackWorld is not conducive to one's long term health.
** Homer himself does so in ''The Shinning'' segment of "[[Recap/TheSimpsonsS6E6TreehouseOfHorrorV Treehouse of Horror V]]" when the cable stops working and they run out of beer.
--->'''Homer''': No TV and no beer make Homer something something...\\
'''Marge''': "Go crazy?"\\
'''Homer''': '''''Don't mind if I do!!''''' (''proceeds to go crazy'')
* ''WesternAnimation/ToyStory''. Buzz ''really'' doesn't take realizing he's a toy well.
-->'''Buzz Lightyear:''' YOU SEE THE HAT?! I AM MRS... ''NESBITT''! ''(laughs maniacally)''
* PlayedForLaughs on ''WesternAnimation/JimmyTwoShoes'', when Jimmy is left the only person in Miseryville awake while everyone else is in hibernation. He slowly begins to go crazy.
* WesternAnimation/SpongeBobSquarePants and Mr. Krabs try to keep their sanity when they believed they killed the health inspector. [[spoiler:Turns out that the inspector is still alive, and the Krusty Krab passes inspection.]]
** In "Pickles", [=SpongeBob=]'s life takes a turn for the chaotic after a JerkAss customer claims that he forgot the titular condiment. By which we mean he tries to cook his bicycle and hangs the toaster on his front door.
** Poor Squidward. In between being the entire ocean's ButtMonkey and victim to the constant shenanigans of his next door neighbors, [=SpongeBob=] and Patrick, it's no wonder he's been shown to break down into a sobbing wreck or fits of maniacal laughter when the AmusingInjuries and ever-present failures prove too much to handle. In "Squid's Day Off" Squidward tricks [=SpongeBob=] into running the Krusty Krab all by himself while he takes a day off, but he keeps imagining [=SpongeBob=] destroying the Krusty Krab and repeatedly goes back and forth to and from his house. While taking a bath he hallucinates [=SpongeBob=] is watching him and runs off to the Krusty Krab wearing only bubbles.
** [=SpongeBob=] frequently has Sanity Slippage to the point that you wonder whether he's exactly sane to begin with...
--->''(from "Stuck in the Wringer")''\\
'''Patrick:''' Hey, whatcha watchin'?\\
'''[=SpongeBob=]:''' ''(watching static on TV)'' My favorite show. ''(the TV dies)'' Ha, ha, I love that part!
** Mr. Krabs goes crazy when the squeaky noise of the rubber boots he gave Spongebob becomes too much to bear.
** In "Clams" after Mr. Krabs loses his millionth dollar we see him slowly go completely insane. The cut back to Mr. Krabs, who begins giggling maniacally [[EyeScream and tears his two eyes out, using them as a jumprope]] is genuinely disturbing.
* ''WesternAnimation/MyLittlePonyFriendshipIsMagic'': The FanNickname for this is "Cutie Mark Failure Insanity Syndrome", given that a pony failing to live up to their special talent (symbolized by their cutie mark) is the most common cause of ponies going nuts. (It's worth pointing out that in all of these cases, the insanity was cleared up by the end of the episode with ThePowerOfFriendship.)%% NOTE TO EDITORS: Please leave the mention of the fandom term for searchability.
** In [[Recap/MyLittlePonyFriendshipIsMagicS1E25PartyOfOne "Party of One"]], [[GenkiGirl Pinkie Pie]] thinks her friends are avoiding her because they're sick of her parties. Her normally curly hair goes straight, she [[CompanionCube makes her own party guests]] out of things like a sack of flour and a pile of rocks (whom she holds conversations with), her colourful persona becomes noticeably darker, as if it's under a shadow, and the normally insufferably cheerful pony becomes cranky, miserable, and borderline paranoid schizophrenic, all the while sporting a SlasherSmile. Her slippage even comes complete with {{Creepy Circus|Music}} [[http://www.youtube.com/watch?v=_cy9gNE_vIE Music]] (which has a disturbing resemblance to the {{leitmotif}} of a certain personification of chaos).
** In [[Recap/MyLittlePonyFriendshipIsMagicS1E26TheBestNightEver "The Best Night Ever"]], [[ShrinkingViolet Fluttershy]] snaps at the Grand Galloping Gala due to all of the animals running in fear from her. After her increasingly desperate methods fail, she goes into full blown {{Yandere}} mode, unleashing animal-based chaos with the line [[http://www.youtube.com/watch?v=rwp60eYuie0 "You're... going to LOVE MEEEE!"]].
** In [[Recap/MyLittlePonyFriendshipIsMagicS2E1TheReturnOfHarmonyPart1 "The Return Of Harmony Part 1"]] and [[Recap/MyLittlePonyFriendshipIsMagicS2E2TheReturnOfHarmonyPart2 "Part 2"]], the [[CorruptTheCutie discorded mane ponies']] misbehavior becomes worse as the episode progresses.
** [[{{Adorkable}} Twilight Sparkle]] goes through a complete psychotic break in [[Recap/MyLittlePonyFriendshipIsMagicS2E3LessonZero "Lesson Zero"]]. Convinced that she's about to fail her duty to Princess Celestia, her mane goes disheveled, her teeth grind, her eyes becoming unfocused, she [[TalkingToThemself talks to herself]], and she starts [[TeleportSpam teleporting at random]] while undergoing a complete nervous breakdown. It culminates in an (unintended) mass hypnosis of Ponyville that requires the Princess herself to intervene, furious at her student for abusing her powers.
*** Keep in mind that all those examples happened in ''five consecutive episodes''.
** In [[Recap/MyLittlePonyFriendshipIsMagicS2E19PuttingYourHoofDown "Putting Your Hoof Down"]], Fluttershy's assertiveness [[GoneHorriblyRight works a little too well]], resulting in her [[TookALevelInJerkass taking multiple levels in Jerkass]] and becoming increasingly violent, paranoid and aggressive to the point that she reduces Pinkie and Rarity to ''tears''.
** Princess Luna experiences this a thousand years before the time of the series. Literally consumed with [[GreenEyedMonster jealousy and anger]] towards the ponies rejecting [[TheSacredDarkness her beautiful night]] in favour of Celestia's day, she [[FaceHeelTurn transforms into]] [[SuperpoweredEvilSide Nightmare Moon]] and tries to enact [[TheNightThatNeverEnds eternal night]] in a stubborn attempt to ''force'' the ponies to love her, showing that even a [[PhysicalGod Physical Goddess]] isn't immune to CMFIS. In [[Recap/MyLittlePonyFriendshipIsMagicS2E4LunaEclipsed "Luna Eclipsed"]] she runs the risk of having to bear these insecurities all over again when the ponies begin to reject her once more, but fortunately Twilight is there to help.
** Before [[Recap/MyLittlePonyFriendshipIsMagicS3E12GamesPoniesPlay "Games Ponies Play"]] aired, people were expecting another "Twilight goes crazy" episode. They were likely surprised when this trope was {{averted|Trope}} for that episode.
* In the ''WesternAnimation/KingOfTheHill'' episode "Pretty, Pretty Dresses" Bill is very lonely and depressed, and finally loses it when Hank destroys the gifts he'd been saving for his ex-wife Lenore in case she ever came back. He starts wearing her old clothes she'd left behind and talks in a falsetto voice, believing that he himself is Lenore; eventually Hank is able to break him out of it and gets him to get over Lenore.
* In ''Disney/TheLionKing 1 1/2'', during a scene approximately taking place during Scar's VillainSong in the original movie, Timon is on the verge of cracking in his "dream home" quest...
-->'''Timon:''' ''(comes across a steam vent)'' Hey! This is home sweet home, baby! Home-- ''(gets sent into the air a bit by the eruption)'' Ha ha! Steam! Ha ha! Steam is good. Steam is--is--is water. Whoo! Gotta have water. You know, for the dream home. Steam home, dream home! Steam, steam, steam.
* More or less the plot of ''WesternAnimation/{{Wakfu}}'''s StartOfDarkness prequel episode.
* The Christmas episode of ''WesternAnimation/AdventureTime'' shows that, centuries ago, before TheEndOfTheWorldAsWeKnowIt this happened to an antique collector by the name of Simon Petrikov after he made the mistake of wearing a cursed artifact. A thousand years of sanity slippage later, the man he was is completely gone, and what remains only knows himself as [[spoiler: The Ice King]].
* Ren of ''WesternAnimation/TheRenAndStimpyShow'' frequently falls into this. Stimpy sometimes does too. And boy is it [[NightmareFuel/TheRenAndStimpyShow creepy]].
* ''WesternAnimation/LooneyTunes'': DaffyDuck seems to fall victim to this a lot. A perfect example occurs in ''Duck! Rabbit! Duck!'' after he gets shot by Elmer Fudd one too many times:
-->'''Daffy:''' ''(hysterical)'' Shoot me again! I enjoy it! I love the smell of burnt feathers! And gunpowder! And cordite! I'm an elk -- shoot me! Go on, it's elk season! I'm a fiddler crab -- why don't you shoot me?! It's fiddler crab season!
** In ''WesternAnimation/TheLooneyTunesShow'' not only Daffy, but everybody is liable to get bonkers (after all, it's a mostly CrapsaccharineWorld/ StepfordSuburbia full of {{Cloudcuckoolander}}s). As an example, Porky has turned from an apparently wealthy JerkJock in high school to a middle-class burn-out prone to suffer this [[spoiler:so frequently that it gets in BlackComedy and even "DudeNotFunny" territory]]; and Bugs didn't act like himself after he started consuming "Spargle" (being PlayedForLaughs).
* ''WesternAnimation/{{Animaniacs}}'' has this happen almost OncePerEpisode to the unfortunate soul the Warners decide to be their "special friend". Most of the time [[AssholeVictim they deserve it]], though.
** Slappy Squirrel suffers this in "One Flew Over the Cuckoo Clock" after being forced to watch talk shows.
* Candace from ''WesternAnimation/PhineasAndFerb'' quite often suffers this. Though it's not [[CloudCuckooLander like she's all there to begin with]].
* Meg Griffin from ''WesternAnimation/FamilyGuy'' quite frequently out of a desperation for love and affection.
* ''WesternAnimation/{{Rugrats}}'': From [[WesternAnimation/TheRugratsMovie the movie]], Tommy totally snaps and almost pours mashed bananas on Dil, knowing the monkeys will be attracted to it. It's thundering and raining the whole time, and Tommy just starts acting more and more crazy as he starts ranting about how much Dil has ruined his life.
** In ''[[ItsAWonderfulPlot Chuckie's Wonderful Life]]", Chaz goes insane in a world without his son.
** Stu also loses it when he's forced to take care of Angelica after she pretends to have broken her leg.
* Harleen Quinzel, who would later become Harley Quinn, in the ''WesternAnimation/BatmanTheAnimatedSeries'' episode "Mad Love".
* Dib of ''WesternAnimation/InvaderZim'' isn't that stable to begin with (being one of the handful of reasonably intelligent people in a CrapsackWorld [[SurroundedByIdiots full of idiots]] will do that), but over the course of the series becomes increasingly desperate, paranoid, and manic, and [[TalkingToThemself talks to himself]] with greater frequency.
* Though Justin Hammer already was a RichInDollarsPoorInSense PsychoticManchild from the start in ''WesternAnimation/IronManArmoredAdventures'', he gradually loses the little sanity he has left over the course of the series.
* While the Red Guy from ''WesternAnimation/CowAndChicken'' isn't exactly sane to begin with, he ends up having a complete mental breakdown in the episode "I Scream, Man" as a result of taking a job that he despises: as an ice cream man. Predictably, he ends up in a mental clinic.
-->'''Red''': AAAAAHHHH!!!!! I CAN'T TAKE IT ANYMORE!!!! I don't have any ice cream! Not one, so! EVER! I don't even like ice cream, OR KIDS! It says "Eye Screem" on my truck, not "Ice Cream"! Get it? 'cause I SCREAM!!! Look at me. (screams while spinning in circles) SCREAMING IS MY HOBBYYYYYY!!!!!! (gets hit on the head by a policeman).
* Louise on ''WesternAnimation/BobsBurgers'' [[CloudCuckoolander was never exactly the sanest kid around]], but in "Earsy Rider" she has a mental breakdown after her bunny ears are stolen. [[spoiler:It gets even worse when she thinks they've been destroyed.]]
* ''WesternAnimation/TransformersPrime'' showcases [[BigBad Megatron]]'s slow descent into (further) homicidal madness. Doping using the blood of [[{{Satan}} Unicron]] certainly hasn't helped, but he's clearly slipping even without it. It becomes most clear when he get the Dark Star Saber, whereupon he starts shouting about how he'll tear this world apart (despite the fact that doing that dooms the entire universe).
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