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* RewatchBonus: N.K. asks a cell that she saved from infection to show her where he was attacked. She also holds him in a headlock, as contrasted when Killer T asks for the cell's arm. [[spoiler:She knew it was a disguised Cancer cell and was treating him as a threat]].
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* AscendedFridgeHorror: "What would autoimmune disease look like in this setting?" has been a good question since the series started, and was addressed by BLACK in the episode/chapter where Killer T cells got so worked up by stress that they went after hair cells, and when gout caused the immune system to cause inflammation across the body. The main series manga ends with Coronavirus - the virus itself is not nearly as threatening as the cytokine storm resulting from the immune system continuously escalating.

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* ''Cells at Work! WHITE'' (''Hataraku Saibou WHITE''), which focuses on the fan favorite Neutrophils of the original manga and digs deeper into their daily lives and functions. Illustrated by Tetsuji Kanie, this manga runs in ''Sirius''.

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* ''Cells at Work! WHITE'' ''Manga/CellsAtWorkWhite'' (''Hataraku Saibou WHITE''), which focuses on the fan favorite Neutrophils of the original manga and digs deeper into their daily lives and functions. Illustrated by Tetsuji Kanie, this manga runs in ''Sirius''.




!!Tropes present in the spinoffs:

!!''Manga/CellsAtWorkBacteria'', ''Manga/CellsAtWorkBaby'', ''Manga/CellsAtWorkCodeBlack'', ''Manga/CellsAtWorkAndFriends'', ''Manga/CellsAtWorkPlatelets'', ''Manga/CellsNotAtWork'', and ''Manga/CellsAtWorkLady'' have their own articles.

[[folder:''Cells at Work! WHITE'']]
* AnthropomorphizedAnatomy: Every entry in the series personifies various cells of the human body and how they function. WHITE is no exception.
* AnthropomorphicPersonification: Cells are personified.
* CastFullOfPrettyBoys: The main cast is staffed by U-1146 and his all-male neutrophil squad, and the male Band Cell who is training to become a mature neutrophil.
* SempaiKouhai: Band Cell, training to become a mature neutrophil, calls the neutrophil squad members "senpai," and the neutrophil squad acknowledges him as their kouhai.
[[/folder]]
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* Anthropomorphic Personification: Cells are personified.

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* Anthropomorphic Personification: AnthropomorphicPersonification: Cells are personified.
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* ''Manga/CellsAtWorkCodeBlack'' (''Hataraku Saibō Black''), a much darker series about the life of cells in an unhealthy body. The human smokes, drinks too much, is under high stress, never exercises, has high cholesterol and does not practice safe sex, leading the cells inside to overexert themselves. The first spinoff not to be written by Shimizu, instead being penned by Shigemitsu Harada and illustrated by Issei Hatsuyoshi. Runs in ''Morning'', a {{Seinen}} anthology. Like the main series, the manga is licensed by Kodansha Comics in North America.

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* ''Manga/CellsAtWorkCodeBlack'' (''Hataraku Saibō Saibou; Black''), a much darker series about the life of cells in an unhealthy body. The human smokes, drinks too much, is under high stress, never exercises, has high cholesterol and does not practice safe sex, leading the cells inside to overexert themselves. The first spinoff not to be written by Shimizu, instead being penned by Shigemitsu Harada and illustrated by Issei Hatsuyoshi. Runs in ''Morning'', a {{Seinen}} anthology. Like the main series, the manga is licensed by Kodansha Comics in North America.



* ''Cells at Work! Lady'' [[/index]] (''Hataraku Saibou Lady''), having much of the same content but aimed at adult women. The second manga written by Shigemitsu Harada, though illustrated by Akari Otokawa. Runs in ''Morning two''.

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* ''Cells at Work! Lady'' ''Manga/CellsAtWorkLady'' [[/index]] (''Hataraku Saibou Lady''), having much of the same content but aimed at adult women. The second manga written by Shigemitsu Harada, though illustrated by Akari Otokawa. Runs in ''Morning two''.



!!''Manga/CellsAtWorkBacteria'', ''Manga/CellsAtWorkBaby'', ''Manga/CellsAtWorkCodeBlack'', ''Manga/CellsAtWorkAndFriends'', ''Manga/CellsAtWorkPlatelets'', and ''Manga/CellsNotAtWork'' have their own articles.

[[folder:''Cells at Work! Lady'']]
* BreakingOldTrends: This is the only spin-off with a multi-cell cast that doesn't have a type of Red Blood Cell in the main crew.
* CastFullOfPrettyBoys: The main cast is staffed by fair-faced versions of the usual cell types.
* GenderFlip: Instead of the usual {{Ninja Maid}}s, the main Macrophage in this body is portrayed as a {{Battle Butler}}.
* NoPeriodsPeriod: Averted, as one of the arcs focuses on the cells dealing with the host's Pre-Menstrual Syndrome. Time will tell if the actual event is depicted as well.

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!!''Manga/CellsAtWorkBacteria'', ''Manga/CellsAtWorkBaby'', ''Manga/CellsAtWorkCodeBlack'', ''Manga/CellsAtWorkAndFriends'', ''Manga/CellsAtWorkPlatelets'', ''Manga/CellsNotAtWork'', and ''Manga/CellsNotAtWork'' ''Manga/CellsAtWorkLady'' have their own articles.

[[folder:''Cells at Work! Lady'']]
WHITE'']]
* BreakingOldTrends: This is the only spin-off with a multi-cell cast that doesn't have a type of Red Blood Cell AnthropomorphizedAnatomy: Every entry in the main crew.
series personifies various cells of the human body and how they function. WHITE is no exception.
* Anthropomorphic Personification: Cells are personified.
* CastFullOfPrettyBoys: The main cast is staffed by fair-faced versions of U-1146 and his all-male neutrophil squad, and the usual cell types.
male Band Cell who is training to become a mature neutrophil.
* GenderFlip: Instead of SempaiKouhai: Band Cell, training to become a mature neutrophil, calls the usual {{Ninja Maid}}s, neutrophil squad members "senpai," and the main Macrophage in this body is portrayed neutrophil squad acknowledges him as a {{Battle Butler}}.
* NoPeriodsPeriod: Averted, as one of the arcs focuses on the cells dealing with the host's Pre-Menstrual Syndrome. Time will tell if the actual event is depicted as well.
their kouhai.
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* DoItYourselfThemeTune: The opening theme of the anime, "Mission! Health Comes First" is sung by Creator/KanaHanazawa (Red Blood Cell), Creator/TomoakiMaeno (Neutrophil), Creator/DaisukeOno (Killer T Cell) and Creator/KikukoInoue (Macrophage). [[https://youtu.be/50tWmqLuxvc The dub follows suit]] (a first for an Aniplex release) with Creator/CheramiLeigh (Red Blood Cell), Creator/BillyKametz (Neutrophil), Creator/RobbieDaymond (Killer T Cell), and Creator/LauraPost (Macrophage).

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* DoItYourselfThemeTune: The opening theme of the anime, "Mission! Health Comes First" is sung by Creator/KanaHanazawa (Red Blood Cell), Creator/TomoakiMaeno (Neutrophil), Creator/DaisukeOno (Killer T Cell) and Creator/KikukoInoue (Macrophage). [[https://youtu.be/50tWmqLuxvc The dub follows suit]] (a first for an Aniplex release) with Creator/CheramiLeigh (Red Blood Cell), Creator/BillyKametz (Neutrophil), Creator/RobbieDaymond (Killer T Cell), and Creator/LauraPost (Macrophage). This also applies to the second season's opening, "Go! Go! Cell Festa".
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* GravityScrew: When a bump on the head causes internal bleeding, it has the side effect of making all the blood cells float around in the air.
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''Cells at Work!'' (''Hataraku Saibou'') is a manga by Akane Shimizu about [[AnthropomorphizedAnatomy all the wonders of the human body, shown to us as humans themselves]]. The manga began with a one-shot {{pilot}} called ''The Story of Cells'' (''Saibou no Hanashi'') and began running in ''Shonen Sirius'' in 2015. The manga has been licensed for North American release by Kodansha Comics. After 6 years of on-and-off serialization, the original manga is expected to end after tackling a story related to the UsefulNotes/COVID19Pandemic.

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''Cells at Work!'' (''Hataraku Saibou'') is a manga by Akane Shimizu about [[AnthropomorphizedAnatomy all the wonders of the human body, shown to us as humans themselves]]. The manga began with a one-shot {{pilot}} called ''The Story of Cells'' (''Saibou no Hanashi'') and began running ran in ''Shonen Sirius'' in 2015.from 2015 to 2021. The manga has been licensed for North American release by Kodansha Comics. After 6 years of on-and-off serialization, the original manga is expected to end after tackling a story related to the UsefulNotes/COVID19Pandemic.\n
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* BreatherEpisode: Episode 8, coming right after the first battle with Cancer Call, is a relaxing episode that's about the circulatory system, with [=AE3803=] attempting to finish a delivery without the help of other cells.

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* BreatherEpisode: Episode 8, coming right after the first battle with Cancer Call, Cell, is a relaxing episode that's about the circulatory system, with [=AE3803=] attempting to finish a delivery without the help of other cells.
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* OhMyGods: Starting here and maintained in the spinoffs, whenever the cells are confused or disturbed by various events, they end up exclaiming "what the cell?" instead of "what the hell?", since the cells have no concept of an afterlife and it makes for a good pun.

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There's no Alternate Timeline shenanigans going on there, so this trope fits better.


* ForWantOfANail: [[spoiler:After being defeated the first time, Cancer Cell returns, tricks Regulatory T cell into protecting him, and starts absorbing toxins produced by harmful gut flora to empower himself, becoming nearly invincible. However, because Ordinary Cell picked up the stray Lactic Acid Bacteria and helped them get back to the intestines, the harmful bacteria are swiftly beaten and Cancer Cell gets weakened enough that he loses the upper hand in the battle with the immune cells and is ultimately killed.]]


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* SpannerInTheWorks: [[spoiler:After being defeated the first time, Cancer Cell returns, tricks Regulatory T cell into protecting him, and starts absorbing toxins produced by harmful gut flora to empower himself, becoming nearly invincible. However, because Ordinary Cell picked up the stray Lactic Acid Bacteria and helped them get back to the intestines, the harmful bacteria are swiftly beaten and Cancer Cell gets weakened enough that he loses the upper hand in the battle with the immune cells and is ultimately killed.]]
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* ForWantOfANail: [[spoiler:After being defeated the first time, Cancer Cell returns, tricks Regulatory T cell into protecting him, and starts absorbing toxins produced by harmful gut flora to empower himself, becoming nearly invincible. However, because Ordinary Cell picked up the stray Lactic Acid Bacteria and helped them get back to the intestines, the harmful bacteria are swiftly beaten and Cancer Cell gets weakened enough that he loses the upper hand in the battle with the immune cells and is ultimately killed.]]
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* BookEnds :The last page of the final chapter is a call back to the last page of first chapter when AE3803 says goodbye and good luck to U-1146 who is busy as usual killing bacteria https://i.imgur.com/5G1xBlj.jpg

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* BookEnds :The last page of the final chapter is a call back to the last page of first chapter when AE3803 [=AE3803=] says goodbye and good luck to U-1146 who is busy as usual killing bacteria https://i.to protect the human body [[https://i.imgur.com/5G1xBlj.jpgjpg]]
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The series has a bookend

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* BookEnds :The last page of the final chapter is a call back to the last page of first chapter when AE3803 says goodbye and good luck to U-1146 who is busy as usual killing bacteria https://i.imgur.com/5G1xBlj.jpg
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* CerebusRollercoaster: The manga follows this pattern, with lighter arcs after a darker arc. The story starts with cells being introduced, [[spoiler: after which Cancer Cell is introduced as an Arc Villain.]] followed by some more lighthearted chapters. [[spoiler: Then suddenly, the body gets into a hypovolemic shock and almost shuts down. This is followed by the lighthearted Lactic Acid Bacteria arc, which is then followed by Cancer Cell's revival.]]

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* CerebusRollercoaster: The manga follows this pattern, with lighter arcs after a darker arc. The story starts with cells being introduced, [[spoiler: after which Cancer Cell is introduced as an Arc Villain.]] followed by some more lighthearted chapters. [[spoiler: Then suddenly, the body [[spoiler: gets into a hypovolemic shock shock]] and almost shuts down. This is followed by the lighthearted Lactic [[spoiler:Lactic Acid Bacteria Bacteria]] arc, which is then followed by Cancer [[spoiler:Cancer Cell's revival.]]
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That term is referred in this wiki under Old Shame.


** In episode 5 of the anime's second season, U-2048 shouts [[Anime/TurnAGundam "UNIVERSE!" after declaring an embarrassing photo of himself from when he was younger to be Black History.]]

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** In episode 5 of the anime's second season, U-2048 shouts [[Anime/TurnAGundam "UNIVERSE!" after declaring an embarrassing photo of himself from when he was younger to be Black History.Old Shame.]]
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** In episode 5 of the anime's second season, U-2048 shouts [[Anime/TurnAGundam "UNIVERSE!" after declaring an embarrassing photo of himself from when he was younger to be Black History.]]
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* MookHorrorShow: The season 1 anime opening has an army of Neutrophils chasing down a cute pollen allergen that stumbles without care. The show proper reveals that the allergens themselves are harmless, but the body's programming sees them as a threat.
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Convention here: anthromorphized cells must be capitalized.


* AcceptableBreaksFromReality: This show has red blood cells deliver oxygen and other nutrients throughout the body and remove carbon dioxide and other waste products. In real life, red blood cells ''only'' deliver oxygen. Everything else is transported by dissolving in the blood plasma. Because the blood plasma isn't made of cells, there's no real way to portray this via AnthropomorphicPersonification, so all of these deliveries are handled by the red blood cells instead.

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* AcceptableBreaksFromReality: This show has red blood cells Red Blood Cells deliver oxygen and other nutrients throughout the body and remove carbon dioxide and other waste products. In real life, red blood cells ''only'' deliver oxygen. Everything else is transported by dissolving in the blood plasma. Because the blood plasma isn't made of cells, there's no real way to portray this via AnthropomorphicPersonification, so all of these deliveries are handled by the red blood cells instead.



* AlienAbduction: Blood transfusion is depicted as this for the hapless red blood cells involved. Similarly, a mosquito bite is depicted as a giant tube in the sky sucking out red blood cells.

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* AlienAbduction: Blood transfusion is depicted as this for the hapless red blood cells Red Blood Cells involved. Similarly, a mosquito bite is depicted as a giant tube in the sky sucking out red blood cells.Red Blood Cells.



** The pathogens are shown to be the size of the neutrophils or even bigger, when realistically, they would actually be small enough for the neutrophils to swallow whole! Of course, that would be neither [[RuleOfCreepy threatening]] nor [[RuleOfCool interesting to watch]].

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** The pathogens are shown to be the size of the neutrophils Neutrophils or even bigger, when realistically, they would actually be small enough for the neutrophils to swallow whole! Of course, that would be neither [[RuleOfCreepy threatening]] nor [[RuleOfCool interesting to watch]].



* AxCrazy: The neutrophils appear to be those nice, swell guys you could be friends with. That is, unless you are a harmful bacterium; they then become unhinged literal murderous {{Blood Knight}}s out to kill them indiscriminately. The only exception to this rule are lactic bacteria that help the body.

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* AxCrazy: The neutrophils Neutrophils appear to be those nice, swell guys you could be friends with. That is, unless you are a harmful bacterium; they then become unhinged literal murderous {{Blood Knight}}s out to kill them indiscriminately. The only exception to this rule are lactic bacteria Lactic Acid Bacteria that help the body.



** Also the platelets, who are willing to wander into battlefields and walk past hostile bacteria to do their duty, despite being little kids. Not for nothing U-1146 considers them their most trusted and reliable allies.

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** Also the platelets, Platelets, who are willing to wander into battlefields and walk past hostile bacteria to do their duty, despite being little kids. Not for nothing U-1146 considers them their most trusted and reliable allies.



* BloodKnight: Quite literally with the immune system cells, most being different white blood cells, since they're ''blood cells'' that act like knights. U-1146 is a KnightInShiningArmor example.
* BootCampEpisode: One chapter is a WholeEpisodeFlashback to when Helper T Cell and Killer T Cell were thymocytes (developing T cells), which is depicted as them being rookies going through basic training during their time in the thymus.

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* BloodKnight: Quite literally with the immune system cells, most being different white blood cells, White Blood Cells, since they're ''blood cells'' that act like knights. U-1146 is a KnightInShiningArmor example.
* BootCampEpisode: One chapter is a WholeEpisodeFlashback to when Helper T Cell and Killer T Cell were thymocytes Thymocytes (developing T cells), which is depicted as them being rookies going through basic training during their time in the thymus.



** Just as the body was about to shut down from a hypovolemic shock, the red blood cells are gone, the Ordinary Cells are dying due to lack of food and oxygen, and the bacteria are rampaging in the body... suddenly [[spoiler:comes an army of red blood cells from a blood transfusion to get it back in order.]] It's ''almost'' a played straight version of the trope, but not quite, because we see where [[spoiler:the new red blood cells come from.]]
* DidntThinkThisThrough: When the host is going through hypovolemic shock, the brain cells decide to increase blood pressure to get the red blood cells to move faster. The increased pressure ends up blowing many of the cells out of the wound, which the survivors annoyedly lampshade.

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** Just as the body was about to shut down from a hypovolemic shock, the red blood cells are gone, the Ordinary Cells are dying due to lack of food and oxygen, and the bacteria are rampaging in the body... suddenly [[spoiler:comes an army of red blood cells Red Blood Cells from a blood transfusion to get it back in order.]] It's ''almost'' a played straight version of the trope, but not quite, because we see where [[spoiler:the new red blood cells Red Blood Cells come from.]]
* DidntThinkThisThrough: When the host is going through hypovolemic shock, the brain cells Brain Cells decide to increase blood pressure to get the red blood cells Red Blood Cells to move faster. The increased pressure ends up blowing many of the cells out of the wound, which the survivors annoyedly lampshade.
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* DidntThinkThisThrough: When the host is going through hypovolemic shock, the suits running the body decide to increase blood pressure to get the red blood cells to move faster. The increased pressure ends up blowing many of the cells out of the wound, which the survivors annoyedly lampshade.

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* DidntThinkThisThrough: When the host is going through hypovolemic shock, the suits running the body brain cells decide to increase blood pressure to get the red blood cells to move faster. The increased pressure ends up blowing many of the cells out of the wound, which the survivors annoyedly lampshade.
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An anime adaptation by Creator/DavidProduction began airing on July 8, 2018. It is licensed by Creator/AniplexUSA and is streamed internationally through Website/{{Crunchyroll}}, spanning 13 episodes. The English dub of the anime was released for Blu-Ray on August 27, 2019. The anime is also noted to be the first title where Aniplex USA dubbed the opening song in English.[[note]]Generally speaking, anime titles that are generally dubbed in English will normally leave the opening and ending songs left sung in Japanese, as it's generally too tedious to find a voice actor/actress who has some singing capacity.[[/note]] A fourteenth "special episode," "Common Cold," was released months after the original run of the anime as a Christmas Day special. A second season was announced in 2019, and it will premiere in January 2021.

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An anime adaptation by Creator/DavidProduction began airing on July 8, 2018. It is licensed by Creator/AniplexUSA and is streamed internationally through Website/{{Crunchyroll}}, spanning 13 episodes. The English dub of the anime was released for Blu-Ray on August 27, 2019. The anime is also noted to be the first title where Aniplex USA dubbed the opening song in English.[[note]]Generally speaking, anime titles that are generally dubbed in English will normally leave the opening and ending songs left sung in Japanese, as it's generally too tedious to find a voice actor/actress who has some singing capacity.[[/note]] A fourteenth "special episode," "Common Cold," was released months after the original run of the anime as a Christmas Day special. A second season was announced in 2019, and it will premiere in premiered on January 9, 2021.
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moving to trivia


* AccidentallyCorrectWriting: The platelet leader refers to both [=AE3803=] and White Blood Cell as 'oneechan' and 'oniisan', respectively. While it literally means 'big sister' and 'big brother', these words are often used in real life to refer to slightly older people who you know but aren't related to you. However, Dr. Hope explained on his review of the episode that this is ''entirely correct'', as platelets, white blood cells and red blood cells are all created in the bone marrow, and they all [[StealthPun stem]] from the same [[StealthPun cells]], that act as base cells that can grow into anything.

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* MythologyGag:
** The anime's opening shows U-1146 carrying the Platelet Leader while he's about to attack, just like he does on the manga's [[https://images-na.ssl-images-amazon.com/images/I/91gAFP4GFXL.__BG0,0,0,0_FMpng_AC_UL320_SR226,320_.jpg third volume cover.]]
** Though Effector T's ''Manga/{{JoJo|s Bizarre Adventure}}''-like transformation was already in the manga, it gave David Production (the studio that produces the franchise's 2010s adaptations) a good excuse to bring out their house style for the occasion.

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* MythologyGag:
**
MythologyGag: The anime's opening shows U-1146 carrying the Platelet Leader while he's about to attack, just like he does on the manga's [[https://images-na.ssl-images-amazon.com/images/I/91gAFP4GFXL.__BG0,0,0,0_FMpng_AC_UL320_SR226,320_.jpg third volume cover.]]
** Though Effector T's ''Manga/{{JoJo|s Bizarre Adventure}}''-like transformation was already in the manga, it gave David Production (the studio that produces the franchise's 2010s adaptations) a good excuse to bring out their house style for the occasion.
]]


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* ProductionThrowback: Though Effector T's ''Manga/{{JoJo|s Bizarre Adventure}}''-like transformation was already in the manga, it gave David Production (the studio that produces the franchise's 2010s adaptations) a good excuse to bring out their house style for the occasion.
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* DarkestHour: The hypovolemic shock (extreme blood loss) episode (covered in chapters 17 and 18 respectively) is probably the darkest and most difficult moment of the whole series, probably even more than the Cancer Cell arc. Due to the loss of many red blood cells, oxygen is not distributed through the body, which causes Ordinary Cells to start dying of asphyxia, turning the dying body into a cold and desolate landscape. It gets so bad that, [[spoiler: had it not been for the transfused red blood cells]], [=AE3803=] (and the rest of the other cells) would have ended up dying.

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* DarkestHour: The hypovolemic shock (extreme blood loss) episode incident (covered in chapters 17 the manga and 18 anime as Chapters 17-18 and Episode 12 respectively) is probably the darkest and most difficult moment of the whole series, probably even more than the Cancer Cell arc. Due to the loss of many red blood cells, oxygen is not distributed through the body, which causes Ordinary Cells to start dying of asphyxia, turning the dying body into a cold and desolate landscape. It gets so bad that, [[spoiler: had it not been for the transfused red blood cells]], [=AE3803=] (and the rest of the other cells) would have ended up dying.
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* PapaWolf: In the FlashbackEpisode, the White Blood Cell instructor moved to save a younger U-1146 and AE3803 on realizing a giant germ was threatening them in the bone marrow. He then took time to check over his protege, relieved neither of them were hurt. Not too badly at least; U-1146 tried to fight the germ but was curbstomped.

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* PapaWolf: In the FlashbackEpisode, the White Blood Cell instructor moved to save a younger U-1146 and AE3803 [=AE3803=] on realizing a giant germ was threatening them in the bone marrow. He then took time to check over his protege, relieved neither of them were hurt. Not too badly at least; U-1146 tried to fight the germ but was curbstomped.
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''Cells at Work!'' (''Hataraku Saibou'') is a manga by Akane Shimizu about [[AnthropomorphizedAnatomy all the wonders of the human body, shown to us as humans themselves]]. The manga began with a one-shot {{pilot}} called ''The Story of Cells'' (''Saibou no Hanashi'') and began running in ''Shonen Sirius'' in 2015. The manga has been licensed for North American release by Kodansha Comics. After 6 years of on-and-off serialization, the original manga is expected to end after tackling a story related to the UsefulNotes/COVID19Epidemic.

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''Cells at Work!'' (''Hataraku Saibou'') is a manga by Akane Shimizu about [[AnthropomorphizedAnatomy all the wonders of the human body, shown to us as humans themselves]]. The manga began with a one-shot {{pilot}} called ''The Story of Cells'' (''Saibou no Hanashi'') and began running in ''Shonen Sirius'' in 2015. The manga has been licensed for North American release by Kodansha Comics. After 6 years of on-and-off serialization, the original manga is expected to end after tackling a story related to the UsefulNotes/COVID19Epidemic.
UsefulNotes/COVID19Pandemic.
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''Cells at Work!'' (''Hataraku Saibou'') is a manga by Akane Shimizu about [[AnthropomorphizedAnatomy all the wonders of the human body, shown to us as humans themselves]]. The manga began with a one-shot {{pilot}} called ''The Story of Cells'' (''Saibou no Hanashi'') and began running in ''Shonen Sirius'' in 2015. The manga has been licensed for North American release by Kodansha Comics.

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''Cells at Work!'' (''Hataraku Saibou'') is a manga by Akane Shimizu about [[AnthropomorphizedAnatomy all the wonders of the human body, shown to us as humans themselves]]. The manga began with a one-shot {{pilot}} called ''The Story of Cells'' (''Saibou no Hanashi'') and began running in ''Shonen Sirius'' in 2015. The manga has been licensed for North American release by Kodansha Comics.
Comics. After 6 years of on-and-off serialization, the original manga is expected to end after tackling a story related to the UsefulNotes/COVID19Epidemic.
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* DoItYourselfThemeTune: The opening theme of the anime, "Mission! Health Comes First" is sung by Creator/KanaHanazawa (Red Blood Cell), Creator/TomoakiMaeno (Neutrophil), Creator/DaisukeOno (Killer T Cell) and Creator/KikukoInoue (Macrophage). [[https://youtu.be/50tWmqLuxvc The dub follows suit]] (a first for an Aniplex release) with Creator/CheramiLeigh (Red Blood Cell), Billy Kametz (Neutrophil), Creator/RobbieDaymond (Killer T Cell), and Creator/LauraPost (Macrophage).

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* DoItYourselfThemeTune: The opening theme of the anime, "Mission! Health Comes First" is sung by Creator/KanaHanazawa (Red Blood Cell), Creator/TomoakiMaeno (Neutrophil), Creator/DaisukeOno (Killer T Cell) and Creator/KikukoInoue (Macrophage). [[https://youtu.be/50tWmqLuxvc The dub follows suit]] (a first for an Aniplex release) with Creator/CheramiLeigh (Red Blood Cell), Billy Kametz Creator/BillyKametz (Neutrophil), Creator/RobbieDaymond (Killer T Cell), and Creator/LauraPost (Macrophage).
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** The two protagonist have a RunningGag of sorts involving this, where no matter how dire the circumstances they bump into each other they still take a couple moments to greet each other.

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** The two protagonist protagonists have a RunningGag of sorts involving this, where no matter how dire the circumstances they bump into each other they still take a couple moments to greet each other.

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* BreakingOldTrends: This is the only spin-off with a multi-cell cast that doesn't have a Red Blood Cell in the main crew.
* GenderFlip: Instead of the usual {{Ninja Maid}}s, Macrophages in this body are portrayed as {{Battle Butler}}s.

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* BreakingOldTrends: This is the only spin-off with a multi-cell cast that doesn't have a type of Red Blood Cell in the main crew.
* CastFullOfPrettyBoys: The main cast is staffed by fair-faced versions of the usual cell types.
* GenderFlip: Instead of the usual {{Ninja Maid}}s, Macrophages the main Macrophage in this body are is portrayed as a {{Battle Butler}}s. Butler}}.
* NoPeriodsPeriod: Averted, as one of the arcs focuses on the cells dealing with the host's Pre-Menstrual Syndrome. Time will tell if the actual event is depicted as well.

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