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* [[http://en.wikipedia.org/wiki/Plague_of_Justinian Justinian's Plague]] absolutely devastated the Roman and Persian empires, and was probably one of the reasons Islam spread as far as it did.
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->"You have to admire its simplicity. It's one billionth our size, and it's beating us."
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* Throughout history, disease epidemics killed far more people than wars ever did. It was a source of HighOctaneNightmareFuel for people, as a plague could strike without much warning and kill a ''majority'' of the people in the village. The phrase "a pox on your house" may seem quaint to us now, but it was essentially wishing that a person and his entire family would be killed by a plague, which was a very real possibility.
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* Hronmeer's Curse, AKA the reason the Martian Manhunter is the {{Last Of His Kind}}.
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* Hronmeer's Curse, AKA the reason the Martian Manhunter is the {{Last Of His Kind}}.LastOfHisKind.
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* The [[{{Comicbook/X-Men}} Legacy Virus]] killed off a few {{mutants}}.
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[[folder: Webcomics ]]
* A plague wiped out 90% of all males in the universe of ''{{Angels 2200}}'' [[supersecretspoiler: A plague we find out was created by Earth's central government as a way to pacify the off-world colonies.]]
[[/folder]]
[[folder: Web Original ]]
* A big part of ''LandsOfRedAndGold'' concerns the fact that the AlternateHistory Australian civilisation has its own pandemic diseases which make their way back to the Old World after contact is made in the early 1600s, basically decapitating half the political leadership of Europe among other things.
* The ChaosTimeline has the Black Death, happening somewhat later and spread through longer time than in our world.
[[/folder]]
[[folder: Western Animation ]]
* ''TheMarvelousMisadventuresOfFlapjack'', a ''children's'' cartoon had an episode that dealt with this very disease.
** [[GrotesqueGallery And good God,]] [[HighOctaneNightmareFuel it was horrific.]]
[[/folder]]
* A plague wiped out 90% of all males in the universe of ''{{Angels 2200}}'' [[supersecretspoiler: A plague we find out was created by Earth's central government as a way to pacify the off-world colonies.]]
[[/folder]]
[[folder: Web Original ]]
* A big part of ''LandsOfRedAndGold'' concerns the fact that the AlternateHistory Australian civilisation has its own pandemic diseases which make their way back to the Old World after contact is made in the early 1600s, basically decapitating half the political leadership of Europe among other things.
* The ChaosTimeline has the Black Death, happening somewhat later and spread through longer time than in our world.
[[/folder]]
[[folder: Western Animation ]]
* ''TheMarvelousMisadventuresOfFlapjack'', a ''children's'' cartoon had an episode that dealt with this very disease.
** [[GrotesqueGallery And good God,]] [[HighOctaneNightmareFuel it was horrific.]]
[[/folder]]
[[folder: Webcomics ]]
* A plague wiped out 90% of all males in the universe of ''{{Angels 2200}}'' [[supersecretspoiler: A plague we find out was created by Earth's central government as a way to pacify the off-world colonies.]]
[[/folder]]
[[folder: Web Original ]]
* A big part of ''LandsOfRedAndGold'' concerns the fact that the AlternateHistory Australian civilisation has its own pandemic diseases which make their way back to the Old World after contact is made in the early 1600s, basically decapitating half the political leadership of Europe among other things.
* The ChaosTimeline has the Black Death, happening somewhat later and spread through longer time than in our world.
[[/folder]]
[[folder: Western Animation ]]
* ''TheMarvelousMisadventuresOfFlapjack'', a ''children's'' cartoon had an episode that dealt with this very disease.
** [[GrotesqueGallery And good God,]] [[HighOctaneNightmareFuel it was horrific.]]
[[/folder]]
* A plague wiped out 90% of all males in the universe of ''{{Angels 2200}}'' [[supersecretspoiler: A plague we find out was created by Earth's central government as a way to pacify the off-world colonies.]]
[[/folder]]
[[folder: Web Original ]]
* A big part of ''LandsOfRedAndGold'' concerns the fact that the AlternateHistory Australian civilisation has its own pandemic diseases which make their way back to the Old World after contact is made in the early 1600s, basically decapitating half the political leadership of Europe among other things.
* The ChaosTimeline has the Black Death, happening somewhat later and spread through longer time than in our world.
[[/folder]]
[[folder: Western Animation ]]
* ''TheMarvelousMisadventuresOfFlapjack'', a ''children's'' cartoon had an episode that dealt with this very disease.
** [[GrotesqueGallery And good God,]] [[HighOctaneNightmareFuel it was horrific.]]
[[/folder]]
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*** Actually it isn't really completely wiped out. All you have to do is go to Alaska/Siberia/north Finland or Norway and dig up the ground a bit. You're bound to find some smallpox bacteria preserved in the frozen soil. Plagues, like EldritchAbominations, are not dead if they can eternal lie.
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*** Actually it isn't really completely wiped out. All you have to do is go to Alaska/Siberia/north Finland or Norway and dig up the ground a bit. You're bound to find some smallpox bacteria preserved in the frozen soil. Plagues, like EldritchAbominations, {{Eldritch Abomination}}s, are not dead if they can eternal lie.
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* The ChaosTimeline has the Black Death, happening somewhat later and spread through longer time than in our world.
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* ''DoomsdayBook'' has two plagues. Influenza ravages Oxford, while a {{time travel}}ling historian gets stuck in the Black Death.
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* ConnieWillis's ''DoomsdayBook'' has two plagues. Influenza ravages Oxford, while a {{time travel}}ling historian gets stuck in the Black Death.
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* In RobertEHoward's ConanTheBarbarian novel ''The Hour of the Dragon'', a plague is used to eliminate a king and his immediate heirs, to allow his young brother Tarascus to ascend the throne. Since the plague stops with the king's death, Tarascus is acclaimed as the chosen of the gods.
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* The Ebola Gulf-A from ''{{Batman}}'' ''Contagion'', originally unleashed in Gotham City by the Saint Duma's Order [[spoiler:but later revealed to have been created by Ra's al Ghul]]
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*** Indeed WorldWarI was partly responsible for how far and how fast it spread: troops were being shipped all over the world, and while many of the military were told how dangerous it was, they [[TooDumbToLive ignored]] those warnings and turned the troopships into floating morgues.
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*** Later a CrowningMomentOfAwesome for humanity as smallpox is to date the only plague to be ''defeated''. [[SealedEvilInACan Apart from a few samples in laboratories in countries with a rather record of weapons of mass destruction.]]
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*** Later a CrowningMomentOfAwesome for humanity as smallpox is to date the only plague human plague[[hottip:*:We've just recently destroyed [[http://en.wikipedia.org/wiki/Rinderpest the cattle plague]] too, but that's it so far.]] to be ''defeated''. [[SealedEvilInACan Apart from a few samples in laboratories in countries with a rather record of weapons of mass destruction.]]
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** Also, the Drakh plague.
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** Well, it's suggested that the First and Forsaken Lion, the Deathlord who helped unleash the Contagion, got hasty and decided to let TheFairFolk come in to tear down whatever remained. However, although the Fair Folk ''literally'' erased large chunks from Creation, [[RealityIsOutToLunch the energies of the Wyld]] also began to suffuse the world, which [[NiceJobFixingItVillain are suggested to have boosted everyone else's immune system]].
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*{{Carriers}}
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*** Other European diseases, including some that are generally considered 'childhood diseases' like measles, also contributed to the disaster. It wasn't ''all'' smallpox.
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Compare DepopulationBomb.
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Compare DepopulationBomb.
DepopulationBomb. TheBlackDeath is a particularly famous case.
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----
<<|ApocalypticIndex|>>
<<|ApocalypticIndex|>>
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<<|ApocalypticIndex|>>
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* It's small potatoes compared to the rest of the plot, but there's a plague on Omega in {{Mass Effect 2}} which is rapidly lethal towards everyone but vorcha and humans, the latter of which are accused of creating and spreading it. Vorcha are seen as too short-lived and unintelligent to do anything of the sort. Professor Mordin Solus, who develops a cure, believes it was created by the Collectors.
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* TruthInTelevision far, far more often than we'd like it to be. The most infamous case is the Black Death, or bubonic plague, which killed approximately 75 million people (30-60% of Europe's population) in the 1300s.
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* TruthInTelevision far, far more often than we'd like it to be. The most infamous case is the Black Death, TheBlackDeath, or bubonic plague, which killed approximately 75 million people (30-60% of Europe's population) in the 1300s.
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* ''The Plague'', a novel by Albert Camus.
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* ''The Plague'', a novel by Albert Camus.Camus, is about a plague outbreak of the Algerian city of Oran.
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* Gray Death from ''DeusEx''. [[spoiler: Later revealed to be a man-made disease formed by [[AncientConspiracy MJ12]] to take control of the world. ]]
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* Gray Death from ''DeusEx''. [[spoiler: Later revealed to be a man-made disease nano-mechanical virus formed by [[AncientConspiracy MJ12]] to take control of the world. world.]]
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* In ''Pandemic'' [[hottip:*:where you ''fight'' disease, not like in [[{{Pandemic}} the flash game of the same name]], where you ''are'' the disease]] you have not only one, but four (or even five with the expansion) plagues.
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*** Actually it isn't really completely wiped out. All you have to do is go to Alaska/Siberia/north Finland or Norway and dig up the ground a bit. You're bound to find some smallpox bacteria preserved in the frozen soil. Plagues, like EldritchAbominations, are not dead if they can eternal lie.
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* {{Persona3}} had the [[{{Muggles}} city]] believe that Apathy Syndrome was caused by a plague.
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* {{Persona3}} ''{{Persona 3}}'' had the [[{{Muggles}} city]] believe that Apathy Syndrome was caused by a plague.plague.
** In ''{{Persona 4}}'', the fog that [[spoiler:envelops Inaba by the end of the year and causes every last (non-named) inhabitant to slowly go insane with nihilism at best, or collapse in inexplicable, incurable illness at worst]].
** In ''{{Persona 4}}'', the fog that [[spoiler:envelops Inaba by the end of the year and causes every last (non-named) inhabitant to slowly go insane with nihilism at best, or collapse in inexplicable, incurable illness at worst]].
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** Also featured in King's early short story "Night Surf".
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** Also featured in King's early short story "Night Surf".Surf" (appears in the collection ''NightShift'').
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psychosis is not the same as pyschotic.
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* The Omega virus from ''TheOmegaMan''. It kills most of the human race, and turns most of the rest into psychotic albinos.
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* The Omega virus from ''TheOmegaMan''. It kills most of the human race, and turns most of the rest into psychotic psychopathic albinos.
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* A plague wiped out 90% of all males in the universe of {{Angels 2200}}
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* A plague wiped out 90% of all males in the universe of {{Angels 2200}}''{{Angels 2200}}'' [[supersecretspoiler: A plague we find out was created by Earth's central government as a way to pacify the off-world colonies.]]
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[[folder: Webcomics ]]
* A plague wiped out 90% of all males in the universe of {{Angels 2200}}
[[/folder]]
* A plague wiped out 90% of all males in the universe of {{Angels 2200}}
[[/folder]]
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* The disease that killed all the adults in O.T. Nelson's ''The Girl Who Owned a City''.
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* The disease that killed all the adults in O.T. Nelson's ''The Girl Who Owned a City''.''TheGirlWhoOwnedACity''.
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* [[MadScientist|Vul Isen]] in ''StarWarsLegacy'' [[spoiler: creates one to be unleashed against the galaxy]]
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* [[MadScientist|Vul [[MadScientist Vul Isen]] in ''StarWarsLegacy'' [[spoiler: creates one to be unleashed against the galaxy]]
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* {{Persona3}} had the [[{{Muggles}} city]] believe that Apathy Syndrome was caused by a plague.
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** The Black Death's actual death toll was closer to 1/5 - 1/6 of Europe's population. Still a rather large number, and an even that left a visible mark on European society.
