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Missing a couple Doctor Who episodes that are good examples.
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[[AC:Live-ActionTV]]
* The "Series/DoctorWho" episode "Mawdryn Undead" is a brilliant example. Stealing Time Lord regeneration technology to extend their lives leads to them constantly regenerating and mutating horribly, so they beg the Fifth Doctor to release them from their karmic hell.
* The "Series/DoctorWho" episode "Mawdryn Undead" is a brilliant example. Stealing Time Lord regeneration technology to extend their lives leads to them constantly regenerating and mutating horribly, so they beg the Fifth Doctor to release them from their karmic hell.
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* On ''StarTrek'', taking organic oversight out of the command decision loop is almost invariably a catastrophic mistake (except when it's Data). [[WeWillUseManualLabourInTheFuture Humans in the Federation almost do more manual labor than we do.]]
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* On ''StarTrek'', ''Franchise/StarTrek'', taking organic oversight out of the command decision loop is almost invariably a catastrophic mistake (except when it's Data). [[WeWillUseManualLabourInTheFuture Humans in the Federation almost do more manual labor than we do.]]
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* On ''StarTrek'', human genetic engineering is banned, and most of the products of it are dangerously deranged.
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* On ''StarTrek'', ''Franchise/StarTrek'', human genetic engineering is banned, and most of the products of it are dangerously deranged.
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* The Genesis Planet from ''StarTrekIITheWrathOfKhan'' didn't exactly turn out well in the end.
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* The Genesis Planet from ''StarTrekIITheWrathOfKhan'' ''Film/StarTrekIITheWrathOfKhan'' didn't exactly turn out well in the end.
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* ''StarTrek'' , while future medical science is sophisticated enough that characters almost routinely come back from clinical death. However, some extreme attempts have fallen into this trope, such as Kira wanting her boyfriend, Vedek Bareil, to be rejuvenated by using artificial parts to replace decaying brain tissue. This is progressive and further replacements leave him less and less Bajoran till he asks to be allowed to die.
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* ''StarTrek'' ''Franchise/StarTrek'' , while future medical science is sophisticated enough that characters almost routinely come back from clinical death. However, some extreme attempts have fallen into this trope, such as Kira wanting her boyfriend, Vedek Bareil, to be rejuvenated by using artificial parts to replace decaying brain tissue. This is progressive and further replacements leave him less and less Bajoran till he asks to be allowed to die.
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* StarTrekDeepSpaceNine : Jem'Haddar and Vorta are genetically bred (see above) to regard Founders as gods.
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* StarTrekDeepSpaceNine : ''Series/StarTrekDeepSpaceNine'': Jem'Haddar and Vorta are genetically bred (see above) to regard Founders as gods.
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* Surprise, surprise, ''{{Warhammer 40000}}'', albeit in an unconventional fashion: the Immortal God-Emperor of Man. The fallen Primarchs may also think of themselves this way, though they didn't elevate ''themselves'' to levels just shy of a PhysicalGod.
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* Surprise, surprise, ''{{Warhammer ''TabletopGame/{{Warhammer 40000}}'', albeit in an unconventional fashion: the Immortal God-Emperor of Man. The fallen Primarchs may also think of themselves this way, though they didn't elevate ''themselves'' to levels just shy of a PhysicalGod.
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* ''[=~Frankenstein's Monster~=]'' - though debatable, since the Monster was created as a blank slate in the book.
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* ''[=~Frankenstein's Monster~=]'' ''FrankensteinsMonster'' - though debatable, since the Monster was created as a blank slate in the book.
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** It all depends on how close they where to death. Those who suffered brain damage, tend to mistake people for others, suffer memory loss and in general act like hollow imitations of the original person. Those who didn't have their brains affected are almost as normal as any other Space Marine (even if they are kind of slow on the uptake) Davian Thule for example.
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** It all depends on how close they where were to death. Those who suffered brain damage, damage tend to mistake people for others, suffer memory loss loss, and in general act like hollow imitations of the original person. Those who didn't have their brains affected are almost as normal as any other Space Marine (even if they are kind of slow on the uptake) Davian Thule for example.
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easier to read.
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** It all depends on how close they where to death those who suffered brain damage tend to mistake people for others suffer memory loss and in general acting like hollow imitations of the original person. Those who didn't have their brains affected are almost as normal as any other Space Marine even if they are kind of slow on the uptake they tend to be almost exactly the same e.g Davian Thule.
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** It all depends on how close they where to death those death. Those who suffered brain damage damage, tend to mistake people for others others, suffer memory loss and in general acting act like hollow imitations of the original person. Those who didn't have their brains affected are almost as normal as any other Space Marine even (even if they are kind of slow on the uptake they tend to be almost exactly the same e.g uptake) Davian Thule.Thule for example.
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Updated to meet new Nightmare Fuel criteria.
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* NeonGenesisEvangelion gives us the [[spoiler: [[HighOctaneNightmareFuel Mass Production Evangelions]].]]
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* NeonGenesisEvangelion gives us the [[spoiler: [[HighOctaneNightmareFuel Mass Production Evangelions]].Evangelions.]]
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* The ''ElGoonishShive'' universe makes some sort of GeneticEngineering easy, given some of its non-human (but not alien) residents. Still, Project Lycanthrope starts up to make weird hybrids to go on missions and assassinate. Before AmericaSavesTheDay, though, the intended target (Damien) shows up, 'liberates' (read: enslaves) the results, and kills everyone else save one. Note that in an alternate universe, one of the Project Lycanthrope products is hinted to be the reason it's now ruled by an EvilOverlord.
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* The ''ElGoonishShive'' ''Webcomic/ElGoonishShive'' universe makes some sort of GeneticEngineering easy, given some of its non-human (but not alien) residents. Still, Project Lycanthrope starts up to make weird hybrids to go on missions and assassinate. Before AmericaSavesTheDay, though, the intended target (Damien) shows up, 'liberates' (read: enslaves) the results, and kills everyone else save one. Note that in an alternate universe, one of the Project Lycanthrope products is hinted to be the reason it's now ruled by an EvilOverlord.
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IGB cleanup
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* Also on ''Series/DoctorWho'', the Daleks were a GeneticEngineering horror story. The Kaled people were being mutated by a millennium-long nuclear/biological/chemical war. One of their scientists, Davros, came up with (or stole) the brilliant idea of accelerating the mutations to see where they would finally end up. And, while at it, he couldn't pass up the opportunity to improve on his creations, making them stronger and more determined. In one version of the story, he was explicitly trying to turn the Kaled race into gods, based on a prophecy he'd read. In all versions, the result was the Daleks, whose sole motivation was to exterminate any lesser (i.e., non-Dalek) forms of life. Starting with Davros himself. (Although of course [[IGotBetter he got better]].)
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* Also on ''Series/DoctorWho'', the Daleks were a GeneticEngineering horror story. The Kaled people were being mutated by a millennium-long nuclear/biological/chemical war. One of their scientists, Davros, came up with (or stole) the brilliant idea of accelerating the mutations to see where they would finally end up. And, while at it, he couldn't pass up the opportunity to improve on his creations, making them stronger and more determined. In one version of the story, he was explicitly trying to turn the Kaled race into gods, based on a prophecy he'd read. In all versions, the result was the Daleks, whose sole motivation was to exterminate any lesser (i.e., non-Dalek) forms of life. Starting with Davros himself. (Although of course [[IGotBetter he got better]].)
himself.
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** Interestingly, [[TheFederation the TSB]] only comes down hard on the people that built and commissioned artificial mages/cyborgs. The creations themselves are only punished if they're found to have been gleefully kicking dogs or something. Otherwise, they're treated same as any other person, with no limits on what they're allowed to do. Also interestingly, the majority of these created beings seem to turn out to ultimately be pretty nice people; turning out as well as they do when built and raised by insane women and/or mad scientists, one has to wonder how well off they'd be if the process WASN'T illegal and thusly only used by madsci types.
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** Interestingly, [[TheFederation the TSB]] only comes down hard on the people that built and commissioned artificial mages/cyborgs. The creations themselves are only punished if they're found to have been gleefully kicking dogs or something. Otherwise, they're treated same as any other person, with no limits on what they're allowed to do. Also interestingly, the majority of these created beings seem to turn out to ultimately be pretty nice people; turning out as well as they do when built and raised by insane women and/or mad scientists, one has to wonder how well off they'd be if the process WASN'T illegal and thusly thus only used by madsci MadScientist types.
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* This is ultimately the goal of the Human Instrumentality Project in ''NeonGenesisEvangelion'', and it is most certainly portrayed in a fairly negative light. [[ScienceFictionVersusFantasy Of course, the scientificity of this sin is somewhat questionable.]]
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* This is ultimately the goal of the Human Instrumentality Project in ''NeonGenesisEvangelion'', and it is most certainly portrayed in a fairly negative light. [[ScienceFictionVersusFantasy [[ScienceFantasy Of course, the scientificity of this sin is somewhat questionable.]]
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* This trope is extensively played with in ''GhostInTheShell'' - the empact of extensive technical progress in the area of AI and cybernetics on society forms the premise of the series.
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* This trope is extensively played with in ''GhostInTheShell'' - the empact impact of extensive technical progress in the area of AI and cybernetics on society forms the premise of the series.
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** Faking the death triggered signal nets you a body in the "vegetable state". If the original dies afterwards, the previously "vegetable" body will nigh-instantly come to sentience. As Arthur, the A-Than MegaCorp heir notes, the Church gave A-Than their blessing because they had "scientifically proven the existance of immortal souls".
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** Faking the death triggered signal nets you a body in the "vegetable state". If the original dies afterwards, the previously "vegetable" body will nigh-instantly come to sentience. As Arthur, the A-Than MegaCorp heir notes, the Church gave A-Than their blessing because they had "scientifically proven the existance existence of immortal souls".
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* ''[=~Frankenstein's Monster~=]'' - though debateable, since the Monster was created as a blank slate in the book.
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* ''[=~Frankenstein's Monster~=]'' - though debateable, debatable, since the Monster was created as a blank slate in the book.
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** It all depends on how close they where to death those who suffered brain damage tend to mistake people for others suffer memory loss and in general acting like hollow imitations of the original person. Those who didnt have their brains affected are almost as normal as any other Space Marine even if they are kind of slow on the uptake they tend to be almost exactly the same e.g Davian Thule.
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** It all depends on how close they where to death those who suffered brain damage tend to mistake people for others suffer memory loss and in general acting like hollow imitations of the original person. Those who didnt didn't have their brains affected are almost as normal as any other Space Marine even if they are kind of slow on the uptake they tend to be almost exactly the same e.g Davian Thule.
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* ''TalesOfTheAbyss'' hits about a 5.5 here. Fomicry - the replication of any physical form - is all well and good until you start using it on biologicals and creating clones. Often [[CloneDegeneration imperfect clones]]. The first human replica ever created was flawed enough to be psychopathically insane and hugely powerful. Others fared less well, living short and torturous lives due to their "birth defects", or even being killed shortly after creation due to their imperfections.
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* ''TalesOfTheAbyss'' again, under the same concept. Fomicry as used to create human clones was originally an attempt to bring back the dead. It [[CameBackWrong never worked]] right, though - not only were many replicas physically imperfect, [[BodyHorror often in horrifying ways]], but not a single one of them ever had the original's memories.
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* ''StarTrek'' , while future medical science is sophisticated enough that characters almost routinely come back from clinical death. However, some extreme attempts have fallen into this trope, such as Kira wanting her boyfriend, the Kai, to be rejuvenated by using artificial parts to replace decaying brain tissue. This is progressive and further replacements leave him less and less Bajoran till he asks to be allowed to die.
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* ''StarTrek'' , while future medical science is sophisticated enough that characters almost routinely come back from clinical death. However, some extreme attempts have fallen into this trope, such as Kira wanting her boyfriend, the Kai, Vedek Bareil, to be rejuvenated by using artificial parts to replace decaying brain tissue. This is progressive and further replacements leave him less and less Bajoran till he asks to be allowed to die.
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* Averted and played straight in BuffyTheVampireSlayer. When Dawn revives their recently deceased mother while it is never seen it is implied it would have [[GoneHorriblyWrong gone poorly]]. Buffy's resurrection on the other hand didn't have any major consequences.
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* Averted and played straight in BuffyTheVampireSlayer. When Dawn revives their recently deceased mother while it is never seen it is implied it would have [[GoneHorriblyWrong gone poorly]]. Buffy's resurrection on the other hand didn't have any major consequences.consequences [[spoiler: except for the whole opening up the opportunity that The First needed to destroy the Slayer line, and take over the world thing.]]
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And by \"hero\" I include anyone who was involved in the \"cure.\"
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* ''IAmLegend'', the movie: we cured cancer and everybody died. And turned into an evil horde of zombie-vampires.
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* ''IAmLegend'', the movie: we cured cancer and everybody died. [[NiceJobBreakingItHero And turned into an evil horde of zombie-vampires.
zombie-vampires.]]
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* ''FrankenFran'': No explanation needed here.
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* Aside from the ghouls, ''{{Hellsing}}'' has [[spoiler: The Major's Body. Schrödinger (Schroedinger) may or may not count]]
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* Aside from the ghouls, ''{{Hellsing}}'' has [[spoiler: The Major's Body. Schrödinger (Schroedinger) may or and/or may not count]]
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* ''FullmetalAlchemist'' The BigBad accomplishes just about everything this list and even some of the good guys try a few.
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* The resurrection gauntlets (the second, Weevil related one moreso than the original Risen Mitten) of ''{{Torchwood}}''.
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* The resurrection gauntlets (the second, Weevil related one moreso than the original Risen Mitten) of ''{{Torchwood}}''.''Series/{{Torchwood}}''.
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* ''DoctorFaustus'' set out to "gain a deity" through the study of [[ThingsManWasNotMeantToKnow forbidden magic]] and the consequently-named [[DealWithTheDevil Faustian Pact]]. To say it [[GoneHorriblyWrong went horribly wrong]] would be an understatement, but then the terms of his bargain were [[TooDumbToLive pretty stupid to begin with]].
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* ''DoctorFaustus'' ''Theatre/DoctorFaustus'' set out to "gain a deity" through the study of [[ThingsManWasNotMeantToKnow forbidden magic]] and the consequently-named [[DealWithTheDevil Faustian Pact]]. To say it [[GoneHorriblyWrong went horribly wrong]] would be an understatement, but then the terms of his bargain were [[TooDumbToLive pretty stupid to begin with]].
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** This concept was addressed in-universe when Willow tried to get [[spoiler: Tara]] back after her death and was told that the reason why getting Buffy back was possible was that she died due to supernatural causes, where [[spoiler: Tara]] (and Joyce) had both died normally.
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* DeusExHumanRevolution focuses on this as its primary setting. Whether or not human augmentation is evil is up for the player to decide, but it does make the world worse to a degree.
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* DeusExHumanRevolution VideoGame/DeusExHumanRevolution focuses on this as its primary setting. Whether or not human augmentation is evil is up for the player to decide, but it does make the world worse to a degree.
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[[AC:WebOriginal]]
* Pretty much Jobe Wilkins' ''raison d'etre'' in the WhateleyUniverse. He has genetically engineered a synthetic [[TheFairFolk Sidhe]] that is essentially a dark elf hottie. He has invented serums that can turn people into transhuman monsters... and he ''has used them on people who annoyed him''. He has invented a serum that gives people strength, endurance, and healing abilities... by turning them into what amounts to feral orcs who are put to work in his father's mines.
* Pretty much Jobe Wilkins' ''raison d'etre'' in the WhateleyUniverse. He has genetically engineered a synthetic [[TheFairFolk Sidhe]] that is essentially a dark elf hottie. He has invented serums that can turn people into transhuman monsters... and he ''has used them on people who annoyed him''. He has invented a serum that gives people strength, endurance, and healing abilities... by turning them into what amounts to feral orcs who are put to work in his father's mines.
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* Marquis [=DeSinge=] in ''[[MonkeyIsland Tales of Monkey Island]]''.
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* Marquis [=DeSinge=] in ''[[MonkeyIsland Tales ''{{Tales of Monkey Island]]''.Island}}''.
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* Many of the mooks (and some of the bosses) you face in ''{{Mother 3}}'' are either unnatural crosses of animal species (eg., Cattlesnake, Batangutan, Kangashark) or mechanised animals (eg., Steel Mecharilla). They only exist because [[spoiler:Porky ]] deemed regular animals as uncool, and so had his Pigmask army to alter them genetically.
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* Many of the mooks (and some of the bosses) you face in ''{{Mother ''VideoGame/{{Mother 3}}'' are either unnatural crosses of animal species (eg., Cattlesnake, Batangutan, Kangashark) or mechanised animals (eg., Steel Mecharilla). They only exist because [[spoiler:Porky ]] deemed regular animals as uncool, and so had his Pigmask army to alter them genetically.
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* ''EclipsePhase'' has checked off each of them, although number 7 was carried out by superintelligent AI's, the [=TITANs=], who proceeded to forcibly upload many humans, reduce Earth to a blasted hellscape, and vanish through hyper-advanced wormhole gates. Most of them are considered routine everywhere except the Jovian Junta, although attempting to create another TITAN-style "seed AI" with unlimited potential is so illegal that if you attempt it you will be killed and of your backups will be wiped, and if your habitat doesn't take you down, Firewall will.
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* ''{{Dune}}'' - where humanity was enslaved by its own machines and who outlawed anything approaching sentient machines on pain of death.In the Duneverse's religion, this is an actual sin."Thou shall not create a machine to the likeness of Man" is their main commandement
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* ''{{Dune}}'' - where humanity was enslaved by its own machines and who outlawed anything approaching sentient machines on pain of death. In the Duneverse's religion, this is an actual sin.sin. "Thou shall not create a machine to the likeness of Man" is their main commandement
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* ''{{Dune}}'' - where humanity was enslaved by its own machines and who outlawed anything approaching sentient machines on pain of death.In the Duneverse's religion ,this is an actual sin."Thou shall not create a machine to the likeness of Man" is their main commandement
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* ''{{Dune}}'' - where humanity was enslaved by its own machines and who outlawed anything approaching sentient machines on pain of death.In the Duneverse's religion ,this religion, this is an actual sin."Thou shall not create a machine to the likeness of Man" is their main commandement
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* ''{{Dune}}'' - where humanity was enslaved by its own machines and who outlawed anything approaching sentient machines on pain of death.
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* ''{{Dune}}'' - where humanity was enslaved by its own machines and who outlawed anything approaching sentient machines on pain of death.In the Duneverse's religion ,this is an actual sin."Thou shall not create a machine to the likeness of Man" is their main commandement