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* In ''Series/Runaways2017'', as seen in ''Film/{{Doctor Strange|2016}}'', tapping into the power Dark Dimension causes the skin around the wielder's eyes to blister and decay. Nico Minoru accidentally finds this out the hard way, without realizing what she is doing.

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* In ''Series/Runaways2017'', as seen in ''Film/{{Doctor Strange|2016}}'', tapping into the power of the Dark Dimension causes the skin around the wielder's eyes to blister and decay. Nico Minoru accidentally finds this out the hard way, without realizing what she is doing.
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* Similar to the ''Claymore'' example, if the [[spoiler:Magical Girls]] of ''Anime/PuellaMagiMadokaMagica'' falls into DespairEventHorizon, they will turn into [[spoiler:[[EldritchAbomination Witches]]]]. This is actually a {{subver|tedTrope}}sion, since [[spoiler:Witches]] lose their sanity and acts purely on instinct, making them less effective in actual combat.

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* Similar to the ''Claymore'' example, if the [[spoiler:Magical Girls]] of ''Anime/PuellaMagiMadokaMagica'' falls fall into DespairEventHorizon, they will turn into [[spoiler:[[EldritchAbomination Witches]]]]. This is actually a {{subver|tedTrope}}sion, since [[spoiler:Witches]] lose their sanity and acts purely on instinct, making them less effective in actual combat.
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** The Cursed Seal Transformations (courtesy of Orochimaru). It grants the likes The Sound Four, Kimimaro and Sasuke an immense power boost, but it also changes users into [[https://vignette.wikia.nocookie.net/naruto/images/7/72/Curse_Seal.png/revision/latest?cb=20140421150228 fleshy horned dark-skinned monstrosities]]. Only Tayuya somewhat {{avert|edTrope}}s this, looking like a CuteMonsterGirl compared to the males.

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** The Cursed Seal Transformations (courtesy of Orochimaru). It grants the likes of The Sound Four, Kimimaro and Sasuke an immense power boost, but it also changes users into [[https://vignette.wikia.nocookie.net/naruto/images/7/72/Curse_Seal.png/revision/latest?cb=20140421150228 fleshy horned dark-skinned monstrosities]]. Only Tayuya somewhat {{avert|edTrope}}s this, looking like a CuteMonsterGirl compared to the males.
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* ''Manga/{{Jagaaaaaan}}'': The [[HumanoidAbomination Fractured Humans]] gain [[LovecraftianSuperpower lovecraftian superpowers]] from the [[UncannyValley Frenzied Frogs]] which has to merge with them in order to happen. The power-up comes with a disturbing [[OneWingedAngel physical change]] that they can't control and makes them stand out like a sore thumb when among ordinary humans. That the change is permanent tends not to bother them, as they're [[UnstoppableRage far too out of their minds]] to care.

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* ''Manga/{{Jagaaaaaan}}'': The [[HumanoidAbomination Fractured Humans]] gain [[LovecraftianSuperpower lovecraftian superpowers]] from the [[UncannyValley Frenzied Frogs]] which has have to merge with them in order to happen. The power-up comes with a disturbing [[OneWingedAngel physical change]] that they can't control and makes them stand out like a sore thumb when among ordinary humans. That the change is permanent tends not to bother them, as they're [[UnstoppableRage far too out of their minds]] to care.
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* ''LightNovel/HighSchoolDXD'': After Issei he sacrifices an arm to temporarily gain [[SuperMode Balance Breaker]]. This sacrifice is not actually losing the arm, its that whenever the energy in the arm builds up too much it begins to look like a dragon's rather than human. Played even straighter later on. After being [[spoiler: being resurrected using the power of Ophis and Great Red]] Issei's true form is that of a [[spoiler:humanoid dragon]]. Normally Issei subconsciously uses his devil powers to shapeshift so that his appearance seems unaltered but on the rare occasions that this is blocked or dispelled the results are startling.

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* ''LightNovel/HighSchoolDXD'': After Issei he sacrifices an arm to temporarily gain [[SuperMode Balance Breaker]]. This sacrifice is not actually losing the arm, its it's that whenever the energy in the arm builds up too much it begins to look like a dragon's rather than human. Played even straighter later on. After being [[spoiler: being resurrected using the power of Ophis and Great Red]] Issei's true form is that of a [[spoiler:humanoid dragon]]. Normally Issei subconsciously uses his devil powers to shapeshift so that his appearance seems unaltered but on the rare occasions that this is blocked or dispelled the results are startling.
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* ''WesternAnimation/TheTransformers'': In "The Burden Hardest to Bear", Scourge forcibly inserts [[OnlyTheChosenMayWield the Matrix]] into his chest, which ravages his body [[WithGreatPowerComesGreatInsanity and mind]], turning him into a grotesque lumpy freak. Still, a freak powerful enough to defeat [[BigBad Galvatron]], taking leadership of the Decepticons for himself.
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*** With Paramecia types, while some Fruits in this category don't affect the body, at all others like Luffy's [[RubberMan Gomu Gomu No mi]] allows him to transform into bloated or even monstrous (e.g Gear 4) shapes. We've seen some Paramecia Fruits that transform the user's bodies into blades, spikes, springs, extra limbs, gooey substances and much more.

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*** With Paramecia types, while some Fruits in this category don't affect the body, body at all all, others like Luffy's [[RubberMan Gomu Gomu No mi]] allows him to transform into bloated or even monstrous (e.g Gear 4) shapes. We've seen some Paramecia Fruits that transform the user's bodies into blades, spikes, springs, extra limbs, gooey substances and much more.
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* ''TabletopGame/SystemsFailure'': One of the experiments NORAD has taken to try to win the BugWar is splice Bug DNA in volunteers to grant them powers. NORAD Splicers end up getting random insectile features as a side-effect, which tend to freak out the common human more often than not (and considering how much on the brink humanity is, it's an understandable reason).
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** [[Anime/DragonBallSuperBroly Broly]] and [[AmazonianBeauty Kale]] become more monstrous the more they enter their "Legendary" aka [[TheBerserker berserker]] state.

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** [[Anime/DragonBallSuperBroly Broly]] and [[AmazonianBeauty Kale]] Kale become more monstrous the more they enter their "Legendary" aka [[TheBerserker berserker]] state.

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* The Transmetals of the ''[[WesternAnimation/TransformersBeastWars Beast Wars]]'' toyline gain organic aspects in their robot modes (e.g. [[TheCaptain Optimus Primal]] and [[KidHero Cheetor]] sport fur on their chests) and mechanical aspects in their beast modes. They're much more powerful than regular Maximals and Predacons as a result, and even gain a tertiary "transport" mode that allows them to travel faster (e.g. [[BigBad Megatron]] gains hoverjets, allowing him to fly in his T-rex mode, while Rattrap can fold up his legs in rat mode, turning him into an approximation of a hot rod racer).

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* The Transmetals of the ''[[WesternAnimation/TransformersBeastWars Beast Wars]]'' ''WesternAnimation/BeastWars'' toyline gain organic aspects in their robot modes (e.g. [[TheCaptain Optimus Primal]] and [[KidHero Cheetor]] sport fur on their chests) and mechanical aspects in their beast modes. They're much more powerful than regular Maximals and Predacons as a result, and even gain a tertiary "transport" mode that allows them to travel faster (e.g. [[BigBad Megatron]] gains hoverjets, allowing him to fly in his T-rex mode, while Rattrap can fold up his legs in rat mode, turning him into an approximation of a hot rod racer).


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* Becoming a ghoul in the ''VideoGame/{{Fallout}}'' universe. The main perks are immortality and [[RadiationImmuneMutants radiation immunity]], at the cost of [[TechnicallyLivingZombie looking like a rotting corpse]] due to radiation exposure. Though the upgrade only applies for the lucky ghouls that retain their memories and sentience.
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** Whenever Dante and Vergil tap into their demon blood aka activate [[SuperMode Devil Tigger]] they turn into [[https://i.pinimg.com/originals/a3/2e/ea/a32eeae70b596f607535627ba0313270.jpg armored insectoid humanoid demons]]. Dante, in particular, gets more a variety of monstrous Devil Triggers in the later titles. Even Lucia from the [[VideoGame/DevilMayCry2 second game]] becomes much less attractive in her DT.
** Arkham got this twice over, [[spoiler:first when he sacrificed his wife to become a demon but messed the ritual up and became a MonsterClown instead, then in the FinalBattle he gets the power of Sparda through [[CoolSword Force Edge]] but soon dissolves into a hideous, amorphous blob. Dante lampshades it saying Arkham looks nothing like his father Sparda, [[ProudBeauty using himself]] as proof]].
** Averted with Trish and to a lesser extent [[spoiler: Nero from ''VideoGame/DevilMayCry5'' as the former just gets a BattleAura and latter whose Devil Trigger is much more handsome than his father and uncle's transformations]].

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** Whenever Dante and Vergil tap into their demon blood aka activate [[SuperMode Devil Tigger]] they turn into [[https://i.pinimg.com/originals/a3/2e/ea/a32eeae70b596f607535627ba0313270.jpg armored insectoid humanoid demons]]. Dante, in particular, gets more a variety of monstrous Devil Triggers in the later titles. Even Lucia from the [[VideoGame/DevilMayCry2 second game]] becomes much less attractive in her DT.
** Arkham got this twice over, [[spoiler:first when he sacrificed his wife
DT. Averted with Trish and to become a demon but messed lesser extent [[spoiler: Nero from ''VideoGame/DevilMayCry5'' as the ritual up and became a MonsterClown instead, then in the FinalBattle he former just gets the power of Sparda through [[CoolSword Force Edge]] but soon dissolves into a hideous, amorphous blob. Dante lampshades it saying Arkham looks nothing like BattleAura and latter whose Devil Trigger is much more handsome than his father Sparda, [[ProudBeauty using himself]] as proof]].and uncle's transformations]].
** Averted Arkham got this twice over, [[spoiler:first when he sacrificed his wife to become a demon but messed the ritual up and became a MonsterClown instead, then in the FinalBattle, he gets the power of Sparda through the [[CoolSword Force Edge]] but soon dissolves into a hideous, amorphous blob. Dante lampshades it saying Arkham looks nothing like his father Sparda, [[ProudBeauty using himself]] as proof]].
** Backstory and supplementary material of ''VideoGame/DevilMayCry4'' mentioned that Nero obtained his Devil Bringer arm from a shoulder injury that transformed his arm into hard, demonic flesh, but it came along
with Trish and to a lesser extent [[spoiler: Nero from ''VideoGame/DevilMayCry5'' as the former just benefits of a PowerFist (mostly SuperStrength). This gets a BattleAura inverted by the end of ''VideoGame/DevilMayCry5''; [[spoiler:Nero regains his Devil Bringer arm and latter whose most powers stored within it after the old one was torn off by Vergil, but the new arm manages to match itself with his "human" appearance, and only becomes demonic flesh when he's in Devil Trigger is much more handsome than his father and uncle's transformations]]. form]].
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Skunk Stripe is no longer a trope. Zero Context Examples and examples that do fit existing tropes will be deleted.


** Guts receives a set of magic armor, the Berserker Armor, that ups his already amazing combat abilities to the point where he seems almost untouchable, and even Apostles have difficulty fighting him. However, he's been warned that using it for too long will result in him losing his humanity. He's already begun to feel the effects: there's a SkunkStripe in his hair, and he's lost some of his sense of taste and colors are dulled in his vision. It's implied that the Skull Knight, an undead armored skeleton, was turned into what he is via many years of using the Berserker Armor.

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** Guts receives a set of magic armor, the Berserker Armor, that ups his already amazing combat abilities to the point where he seems almost untouchable, and even Apostles have difficulty fighting him. However, he's been warned that using it for too long will result in him losing his humanity. He's already begun to feel the effects: there's a SkunkStripe white streak in his hair, and he's lost some of his sense of taste and colors are dulled in his vision. It's implied that the Skull Knight, an undead armored skeleton, was turned into what he is via many years of using the Berserker Armor.
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* ''Franchise/KamenRider'':
** ''Series/KamenRiderDouble'': Beyond the initial transformation into a superpowered monster, some Dopants can increase their power by transforming into even more inhuman forms, whether that's just a more elaborate costume or a CGI monster.
** ''Series/KamenRiderOOO'' can temporarily transform his legs into grasshopper legs, which he only does to perform his FinishingMove. Kazari also experiments with this when he absorbs Core Medals that aren't his matching type, which doesn't deform ''him'' but does cause the Yummies he creates to become disgusting animal hybrids, such as a lion monster with jellyfish forming cancerous growths on its body.
** ''Series/KamenRiderFourze'': Some of the Horoscopes have Supernova transformations that work like this. It's most notable with Scorpio and Cancer, who both turn their lower bodies into giant monsters while in Supernova form. The BigBad is the only one whose Supernova form instead crosses the BishonenLine.
** ''Series/KamenRiderRevice'' can temporarily transform his legs into dinosaur legs by stamping himself with the Rex Vistamp, which he only rarely does. Kamen Rider Demons can similarly mutate his body by using more Vistamps to give himself different powers, with the second user being especially fond of loading two or three on at once so that the resulting form is a barely-human monstrosity.
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* ''Film/TheTitan'' involves a project to transform volunteer test subjects into a new species of humanity who can survive on Titan. The scientist in charge of the project when giving a RousingSpeech tells them they will become like super men, but they're not so happy about the physical transformations (not to mention their tendency to go insane and kill their partners).
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* In the ComicBook/New52 reboot of ''ComicBook/AnimalMan'', Buddy Baker now actually physically changes shape when he uses animal powers. The transformations are NOT pretty.

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* In the ComicBook/New52 reboot [[ComicBook/AnimalMan2011 reboot]] of ''ComicBook/AnimalMan'', Buddy Baker now actually physically changes shape when he uses animal powers. The transformations are NOT pretty.
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* ''Literature/ChrysalisRinoZ'': Monsters routinely consume each other's biomass in order to mutate their body parts into superior forms. However, ''humans'' who eat biomass undergo a partial uncontrolled transformation into that monster type, leaving them swollen and misshapen but with potentially useful abilities, like acidic saliva or a hardened carapace. Most importantly, they are able to survive in the mana-rich Dungeon without becoming sick. It's not a tradeoff that most people would make, but the Abyssal Legion offers condemned criminals the option to eat biomass and become auxiliary soldiers instead of being executed.
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* ''Manga/{{Bleach}}'' gives us Ichigo's Hollowfication, as well as the Vizoreds who have similar powers. By tapping into their inner Hollow, they gain immense strength and speed, but have a bone-like demonic looking mask grafted onto their faces in the process. It is only temporary though. The mask can be broken off in battle, and it'll eventually crumble away in time. The mask's appearance varies from person to person, but all of them stop looking human.

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* ''Manga/{{Bleach}}'' gives us Ichigo's Hollowfication, as well as the Vizoreds Visoreds who have similar powers. By tapping into their inner Hollow, they gain immense strength and speed, but have a bone-like demonic looking mask grafted onto their faces in the process. It is only temporary though. The mask can be broken off in battle, and it'll eventually crumble away in time. The mask's appearance varies from person to person, but all of them stop looking human.

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* The Transmetals of the ''[[WesternAnimation/TransformersBeastWars Beast Wars]]'' toyline gain organic aspects in their robot modes (e.g. [[TheCaptain Optimux Primal]] and [[KidHero Cheetor]] sport fur on their chests) and mechanical aspects in their beast modes. They're much more powerful than regular Maximals and Predacons as a result, and even gain a tertiary "transport" mode that allows them to travel faster (e.g. [[BigBad Megatron]] gains hoverjets, allowing him to fly in his T-rex mode, while Rattrap can fold up his legs in rat mode, turning him into an approximation of a hot rod racer).
** The Transmetal2 upgrade is even closer to this trope, as exemplified by Cheetor's Transmetal2 form being hunched over with visible engines on his back. Megatron's upgrade into a dragon form makes him much more powerful, but he loses his right arm (replaced with the dragon's head).

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* The Transmetals of the ''[[WesternAnimation/TransformersBeastWars Beast Wars]]'' toyline gain organic aspects in their robot modes (e.g. [[TheCaptain Optimux Optimus Primal]] and [[KidHero Cheetor]] sport fur on their chests) and mechanical aspects in their beast modes. They're much more powerful than regular Maximals and Predacons as a result, and even gain a tertiary "transport" mode that allows them to travel faster (e.g. [[BigBad Megatron]] gains hoverjets, allowing him to fly in his T-rex mode, while Rattrap can fold up his legs in rat mode, turning him into an approximation of a hot rod racer).
** The Transmetal2 {{Transmetal2}} upgrade is even closer to this trope, as exemplified by Cheetor's Transmetal2 {{Transmetal2}} form being hunched over with visible engines on his back. Megatron's upgrade into a dragon form makes him much more powerful, but he loses his right arm (replaced with the dragon's head).



* Mutating in ''VideoGame/{{Cataclysm}}'' carries this as a downside. Each mutation has a visibility and ugliness rating, and visibly mutated players may have a harder time talking with other survivors.



* {{Deconstructed|Trope}} in ''VideoGame/ReadOnlyMemories''. Jess, a cancer patient, was able to recover from her condition via experimental gene therapy. Unfortunately, the genes in question were mostly derived from insects, causing her appearance to become bug-like and frightening, to the point where she lost her job. Fortunately, later therapies replaced the insect genes with cat genes, allowing her a much less horrifying visage. However, she is still traumatized and bitter over how quickly her life fell apart while she was a half-insect hybrid.



* {{Deconstructed|Trope}} in ''VideoGame/ReadOnlyMemories''. Jess, a cancer patient, was able to recover from her condition via experimental gene therapy. Unfortunately, the genes in question were mostly derived from insects, causing her appearance to become bug-like and frightening, to the point where she lost her job. Fortunately, later therapies replaced the insect genes with cat genes, allowing her a much less horrifying visage. However, she is still traumatized and bitter over how quickly her life fell apart while she was a half-insect hybrid.

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* {{Deconstructed|Trope}} in ''VideoGame/ReadOnlyMemories''. Jess, a cancer patient, was able The monsters of ''VideoGame/SoulSacrifice'' suffer this regularly. From tragic figures, unfortunate victims, to recover monsters from the get-go, there is no shortage of humans that are transformed into horrific, gut-churning, nightmare-inducing monsters, just enough human traits left for you to know what they once were. The sorcerers who exterminate them for a living are not spared, either, as their right arms can gradually grow more corrupted and inhuman because of the magic they use, and this is not even going into the Black Rites which totally sacrifice a body part like their ''skin'' for great power.
* In many ''Franchise/StarWars'' games, descending deeper and deeper into the Dark Side often results in the player character's skin becoming pale and fallow, with visible dark veins. In ''VideoGame/StarWarsTheOldRepublic'', a Sith player character can encounter a member of the Dark Council (the leaders of the Sith Empire) and observe that she's actually very attractive, especially for someone so powerful in the Dark Side (for comparison's sake, several Sith rely on illusions to make themselves look better than they really do). She jokingly responds that if she could only teach others
her condition via experimental gene therapy. Unfortunately, the genes in question were mostly derived from insects, causing her appearance to become bug-like and frightening, to the secret, it would make an excellent recruiting tool (since many Force users point where she lost her job. Fortunately, later therapies replaced out the insect genes with cat genes, allowing her deformation as a much less horrifying visage. However, she is still traumatized and bitter over how quickly her life fell apart while she was a half-insect hybrid.reason they don't want to dabble in the Dark Side).



* Mutating in ''VideoGame/{{Cataclysm}}'' carries this as a downside. Each mutation has a visibility and ugliness rating, and visibly mutated players may have a harder time talking with other survivors.



* The monsters of ''VideoGame/SoulSacrifice'' suffer this regularly. From tragic figures, unfortunate victims, to monsters from the get-go, there is no shortage of humans that are transformed into horrific, gut-churning, nightmare-inducing monsters, just enough human traits left for you to know what they once were. The sorcerers who exterminate them for a living are not spared, either, as their right arms can gradually grow more corrupted and inhuman because of the magic they use, and this is not even going into the Black Rites which totally sacrifice a body part like their ''skin'' for great power.
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* The Transmetals of the ''[[WesternAnimation/TransformersBeastWars Beast Wars]]'' toyline gain organic aspects in their robot modes (e.g. [[TheCaptain Optimux Primal]] and [[KidHero Cheetor]] sport fur on their chests) and mechanical aspects in their beast modes. They're much more powerful than regular Maximals and Predacons as a result, and even gain a tertiary "transport" mode that allows them to travel faster (e.g. [[BigBad Megatron]] gains hoverjets, allowing him to fly in his T-rex mode, while Rattrap can fold up his legs in rat mode, turning him into an approximation of a hot rod racer).
** The Transmetal2 upgrade is even closer to this trope, as exemplified by Cheetor's Transmetal2 form being hunched over with visible engines on his back. Megatron's upgrade into a dragon form makes him much more powerful, but he loses his right arm (replaced with the dragon's head).
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The deformation may be a mix of: permanent (requiring a cure to remove) or temporary (granting a SuperMode), and perfectly stable (no more {{muta|nt}}tions) or continuously changing (risking falling to TheCorruption or PowerDegeneration). Because its effects are so nasty taking it tends to be treated as a GodzillaThreshold, with [[EmergencyTransformation only the direst of situations meriting it]]. Villains like the MadScientist and EvilutionaryBiologist will delight in kidnapping victims to use this on… usually paired with a MindControlDevice of course! [[note]](Can't have a PhlebotinumRebel, now can we?)[[/note]] On the other hand, some villains may [[ProfessorGuineaPig take it themselves]], become a OneWingedAngel and proclaim AGodAmI! Truly, EvilMakesYouMonstrous. Mind the ClippedWingAngel from overdosing.

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The deformation may be a mix of: permanent (requiring a cure to remove) or temporary (granting a SuperMode), and perfectly stable (no more {{muta|nt}}tions) {{muta|nts}}tions) or continuously changing (risking falling to TheCorruption or PowerDegeneration). Because its effects are so nasty taking it tends to be treated as a GodzillaThreshold, with [[EmergencyTransformation only the direst of situations meriting it]]. Villains like the MadScientist and EvilutionaryBiologist will delight in kidnapping victims to use this on… on... usually paired with a MindControlDevice of course! [[note]](Can't have a PhlebotinumRebel, now can we?)[[/note]] On the other hand, some villains may [[ProfessorGuineaPig take it themselves]], become a OneWingedAngel and proclaim AGodAmI! Truly, EvilMakesYouMonstrous. Mind the ClippedWingAngel from overdosing.



* In ''Manga/{{Claymore}},'' this is how the titular SuperSoldiers are made, grafting in a piece of demon flesh to give them some of its powers, but they eventually succumb to TheCorruption, if they don't give in to their SuperpoweredEvilSide.

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* In ''Manga/{{Claymore}},'' this is how the titular SuperSoldiers {{Super Soldier}}s are made, grafting in a piece of demon flesh to give them some of its powers, but they eventually succumb to TheCorruption, if they don't give in to their SuperpoweredEvilSide.



* The Zoanoids in ''Manga/{{Guyver}}'' are basically mutated humans whose new (revolting) forms are always tailored to give them a specific strength or super attack. [[MonsterLord Zoalords]] are however higher on the BishonenLine and look far less ugly than their underlings. This seems to be at least partly design philosophy rather than anything inherent to the process. Later developments give us the relatively more huamn looking Bio-Freezer, Libertus and Griselda zoanoid forms.

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* The Zoanoids in ''Manga/{{Guyver}}'' are basically mutated humans whose new (revolting) forms are always tailored to give them a specific strength or super attack. [[MonsterLord Zoalords]] are however higher on the BishonenLine and look far less ugly than their underlings. This seems to be at least partly design philosophy rather than anything inherent to the process. Later developments give us the relatively more huamn looking human-looking Bio-Freezer, Libertus and Griselda zoanoid forms.



** [[Anime/DragonBallSuperBroly Broly]] and [[AmazonianBeauty Kale]] become more monstrous, the more they enter their "Legendary" aka [[TheBerserker berserker]] state.

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** [[Anime/DragonBallSuperBroly Broly]] and [[AmazonianBeauty Kale]] become more monstrous, monstrous the more they enter their "Legendary" aka [[TheBerserker berserker]] state.



** Frieza's transformations progress down this line, most notably his third form which turns him into a XenomorphXerox. This gets [[InvertedTrope inverted]] with his final transformation, where he crosses the BishonenLine and becomes more basic and appealing than his first appearance (which arguably makes him ''more'' terrifying). His transformations overall are another kind of inversion: he's actually ''suppressing'' his full power, and the transformations are to restrain it.
** Fused Zamasu initially averts this, but soon his HealingFactor can't cope with his [[TwoBeingsOneBody Semi-Immortal body]] [[EvilMakesYouUgly and the left side of him melts]].

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** Frieza's transformations progress down this line, most notably his third form which turns him into a XenomorphXerox. This gets [[InvertedTrope inverted]] {{inverted|Trope}} with his final transformation, where he crosses the BishonenLine and becomes more basic and appealing than his first appearance (which arguably makes him ''more'' terrifying). His transformations overall are another kind of inversion: he's actually ''suppressing'' his full power, and the transformations are to restrain it.
** Fused Zamasu initially averts this, but soon his HealingFactor can't cope with his [[TwoBeingsOneBody Semi-Immortal semi-immortal body]] [[EvilMakesYouUgly and the left side of him melts]].



* ''{{Manga/Jagaaaaaan}}'', the [[HumanoidAbomination Fractured Humans]] gain [[LovecraftianSuperpower lovecraftian superpowers]] from the [[UncannyValley Frenzied Frogs]] which has to merge with them in order to happen. The power-up comes with a disturbing,[[OneWingedAngel physical change]] that they can't control and makes them stand out like a sore thumb when among ordinary humans. That the change is permanent tends not to bother them, as they're [[UnstoppableRage far too out of their minds]] to care.

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* ''{{Manga/Jagaaaaaan}}'', the ''Manga/{{Jagaaaaaan}}'': The [[HumanoidAbomination Fractured Humans]] gain [[LovecraftianSuperpower lovecraftian superpowers]] from the [[UncannyValley Frenzied Frogs]] which has to merge with them in order to happen. The power-up comes with a disturbing,[[OneWingedAngel disturbing [[OneWingedAngel physical change]] that they can't control and makes them stand out like a sore thumb when among ordinary humans. That the change is permanent tends not to bother them, as they're [[UnstoppableRage far too out of their minds]] to care.



** The Cursed Seal Transformations (courtesy of Orochimaru). It grants the likes The Sound Four, Kimimaro and Sasuke an immense power boost, but it also changes users into [[https://vignette.wikia.nocookie.net/naruto/images/7/72/Curse_Seal.png/revision/latest?cb=20140421150228 fleshy horned dark-skinned monstrosities]]. Only Tayuya somewhat averts looking like a CuteMonsterGirl compared to the males.
** Naruto and Gaara when tapping into their Jinchūriki chakra would uncontrollably start taking on the characteristics of their respective Tailed Beasts (Kurama and Shukaku) i.e getting sharp teeth, claws, fur, scales, exoskeletons, increased sized and HellishPupils. Killer B averts thanks to taming his Tailed Beast Gyūki and is able to use Tailed Beast chakra without transforming, B teaches Naruto how to do the same. There are also partial transformations were only a limb becomes monstrous or in Killer B's case, a few tentacles come out of his back.
** The Ten-Tails Jinchūriki transformation turns Madara and [[spoiler: Obito]] pale and scaly.

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** The Cursed Seal Transformations (courtesy of Orochimaru). It grants the likes The Sound Four, Kimimaro and Sasuke an immense power boost, but it also changes users into [[https://vignette.wikia.nocookie.net/naruto/images/7/72/Curse_Seal.png/revision/latest?cb=20140421150228 fleshy horned dark-skinned monstrosities]]. Only Tayuya somewhat averts {{avert|edTrope}}s this, looking like a CuteMonsterGirl compared to the males.
** Naruto and Gaara when tapping into their Jinchūriki chakra would uncontrollably start taking on the characteristics of their respective Tailed Beasts (Kurama and Shukaku) Shukaku), i.e getting sharp teeth, claws, fur, scales, exoskeletons, increased sized and HellishPupils. Killer B averts thanks to taming his Tailed Beast Gyūki and is able to use Tailed Beast chakra without transforming, B teaches Naruto how to do the same. There are also partial transformations were only a limb becomes monstrous or in Killer B's case, a few tentacles come out of his back.
** The Ten-Tails Jinchūriki transformation turns Madara and [[spoiler: Obito]] [[spoiler:Obito]] pale and scaly.



** Played with in regards to Kaguya after she ate the chakra fruit she grew horns, spikes out of her back and a ThirdEye... otherwise she looks beautiful. Played straight with her unstable Tailed Beast Transformation when she becomes an Eldrich mass of monsters, but she got better.
* The Tavoo/Taboo race in ''Manga/{{Psyren}}'' all have a core known as an Illuminus, which heightens their psionic abilities, but often disfigures them to the point of not even looking human anymore, usually taking on an [[BeeAfraid insectoid]] appearance instead. The few exceptions are the high-ranking W.I.S.E. members, [[DoubleStandard and several others such as Tatsuo and Alfred.]]

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** Played with in regards to Kaguya after Kaguya. After she ate the chakra fruit fruit, she grew horns, spikes out of her back and a ThirdEye... but otherwise she looks beautiful. Played straight with her unstable Tailed Beast Transformation when she becomes an Eldrich eldritch mass of monsters, but she got better.
better.
* The Tavoo/Taboo race in ''Manga/{{Psyren}}'' all have a core known as an Illuminus, which heightens their psionic abilities, but often disfigures them to the point of not even looking human anymore, usually taking on an [[BeeAfraid insectoid]] appearance instead. The few exceptions are the high-ranking W.I.S.E. members, [[DoubleStandard and several others such as Tatsuo and Alfred.]]Alfred]].



** Devil Fruit Users certainly can go through this as the SuperPowerLottery can distort the user body into all kinds of crazy shapes, though most users can shift back to normal. Nami and others in East Blue were very freaked out at seeing Devil Fruit Users for the first time.
*** Paramecia types, while some Fruits in this category don't affect the body at all others like Luffy's [[RubberMan Gomu Gomu No mi]] allows him to transform into bloated or even monstrous (e.g Gear 4) shapes. We've seen some Paramecia Fruits that transform the user's bodies into blades, spikes, springs, extra limbs, gooey substances and much more.
*** Zoan types can be more horrifying than Paramecia types, as their {{Animorphism}} can turn users into often freakish hybrids (Chopper in particular went through a lot of trauma being ostracised for his appearance) though the advanced strength is pretty WorthIt in most user's minds. Kaku clearly wasn't happy with his bizarre giraffe form though he adapted well enough.
*** Logia types can be mixed bag a despite being essentially [[BlobMonster Blob Monsters]], this type of Fruit doesn't usually alter the user appearance, only their shape. Played straighter with the likes of Enel, Caesar Clown and Monet who become [[TurnsRed scarier looking once they get serious]].

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** Devil Fruit Users certainly can go through this as the SuperPowerLottery SuperpowerLottery can distort the user body into all kinds of crazy shapes, though most users can shift back to normal. Nami and others in East Blue were very freaked out at seeing Devil Fruit Users for the first time.
*** With Paramecia types, while some Fruits in this category don't affect the body body, at all others like Luffy's [[RubberMan Gomu Gomu No mi]] allows him to transform into bloated or even monstrous (e.g Gear 4) shapes. We've seen some Paramecia Fruits that transform the user's bodies into blades, spikes, springs, extra limbs, gooey substances and much more.
*** Zoan types can be more horrifying than Paramecia types, as their {{Animorphism}} can turn users into often freakish hybrids (Chopper in particular went through a lot of trauma being ostracised ostracized for his appearance) though the advanced strength is pretty WorthIt in most user's minds. Kaku clearly wasn't happy with his bizarre giraffe form form, though he adapted well enough.
*** Logia types can be mixed bag a despite being essentially [[BlobMonster Blob Monsters]], this type of Fruit doesn't usually alter the user appearance, only their shape. Played straighter with the likes of Enel, Caesar Clown and Monet who become [[TurnsRed scarier looking once they get serious]].serious.



* Similar to ''Claymore'' example, if the [[spoiler:Magical Girls]] of ''Anime/PuellaMagiMadokaMagica'' falls into DespairEventHorizon, they will turn into [[spoiler: [[EldritchAbomination Witches]]]]. This is actually a [[SubvertedTrope subversion]], since [[spoiler:Witches]] lose their sanity and acts purely on instinct, making them less effective in actual combat.

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* Similar to the ''Claymore'' example, if the [[spoiler:Magical Girls]] of ''Anime/PuellaMagiMadokaMagica'' falls into DespairEventHorizon, they will turn into [[spoiler: [[EldritchAbomination [[spoiler:[[EldritchAbomination Witches]]]]. This is actually a [[SubvertedTrope subversion]], {{subver|tedTrope}}sion, since [[spoiler:Witches]] lose their sanity and acts purely on instinct, making them less effective in actual combat.



* In ComicBook/TheNewUniverse in general and ''Comicbook/{{DP7}}'' in particular, [[MassEmpoweringEvent the White Event]] makes people suddenly have power-related mutations, many of which are like this. Moreso minor characters than the main ones, which [[CursedWithAwesome for all their complaints are really not that bad]].
* Creator/{{Marvel|Comics}}'s ''Comicbook/TheIncredibleHulk'', Dr Banner transforms into a giant green rage monster and has mega strength.

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* In ComicBook/TheNewUniverse in general and ''Comicbook/{{DP7}}'' in particular, [[MassEmpoweringEvent [[MassSuperEmpoweringEvent the White Event]] makes people suddenly have power-related mutations, many of which are like this. Moreso minor characters than the main ones, which [[CursedWithAwesome for all their complaints are really not that bad]].
* Creator/{{Marvel|Comics}}'s In ''Comicbook/TheIncredibleHulk'', Dr Dr. Banner transforms into a giant green rage monster and has mega strength.SuperStrength.



* The ''ComicBook/FantasticFour'''s The Thing is perhaps one of Creator/MarvelComics most iconic examples. After passing through a cloud of cosmic radiation he grew a [[SuperToughness super tough rock-like hide]] and SuperStrength to match. The downside is that unlike Reed, Sue and Johnny he ''can't'' turn his powers on and off, and is always the same huge frightening rock monster; an issue which has caused him no end of grief and in some continuities even suicide attempts.

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* The ''ComicBook/FantasticFour'''s The Thing of the ''ComicBook/FantasticFour'' is perhaps one of Creator/MarvelComics Creator/MarvelComics' most iconic examples. After passing through a cloud of cosmic radiation he grew a [[SuperToughness super tough rock-like hide]] and SuperStrength to match. The downside is that unlike Reed, Sue and Johnny he ''can't'' turn his powers on and off, and is always the same huge frightening rock monster; an issue which has caused him no end of grief and in [[ComicBook/UltimateFantasticFour some continuities continuities]] even suicide attempts.



** ''ComicBook/UltimateXMen'': While taking the drug Banshee Angel manifests a more avian physiology, becoming a humanoid eagle creature.

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** ''ComicBook/UltimateXMen'': While taking the drug Banshee Banshee, Angel manifests a more avian physiology, becoming a humanoid eagle creature.



** San and Vivienne Graham initially suffer this when they become TwoBeingsOneBody. Their first hybridized form is a OneManArmy against Jonah's mercenaries ''despite'' being crippled by [[PowerIncontinence an inability to access its bio-electricity]] and despite excruciating, movement-limiting chronic pain, able to survive and regenerate damage that would've blown Vivienne to bits when she was human; and it overall looks like a quadrupedal MonstrousHumanoid with a bony tail and [[https://en.wikipedia.org/wiki/Fibrodysplasia_ossificans_progressiva an extreme, badly visible case of this nasty disease]], not to mention Vivienne's head becoming skull-like and developing ingrown fangs. This trope is {{inverted}} by Viv and San's transformation into their second form, which though even more beastly is a lot more natural-looking than their diseased first form.

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** San and Vivienne Graham initially suffer this when they become TwoBeingsOneBody. Their first hybridized form is a OneManArmy against Jonah's mercenaries ''despite'' being crippled by [[PowerIncontinence an inability to access its bio-electricity]] and despite excruciating, movement-limiting chronic pain, able to survive and regenerate damage that would've blown Vivienne to bits when she was human; and it overall looks like a quadrupedal MonstrousHumanoid with a bony tail and [[https://en.wikipedia.org/wiki/Fibrodysplasia_ossificans_progressiva an extreme, badly visible case of this nasty disease]], not to mention Vivienne's head becoming skull-like and developing ingrown fangs. This trope is {{inverted}} {{inverted|Trope}} by Viv and San's transformation into their second form, which though even more beastly is a lot more natural-looking than their diseased first form.



* ''Fanfic/ChildOfTheStorm'' has this as a staple of Phoenix hosts who turn/are turning to the dark side. While Phoenix hosts are unsettling enough to begin with, they look more or less as they normally do. A Dark Phoenix, on the other hand, even a baby one, is a HumanoidAbomination with features that sufficiently elongated to enter the UncannyValley, burning white GlowingEyesOfDoom, and cracks in the skin that reveal [[LightIsNotGood yet more burning white light]], implying that the host's physical form is merely the shell for something horrifying that's growing within. This is proven by [[spoiler: Surtur]], a fully-fledged example, who's long since graduated to EldritchAbomination - and his empowered minions are arguably worse.
* In ''Fanfic/{{Origins}}'', a ''Franchise/MassEffect''[=/=]''Franchise/StarWars''[[spoiler:[=/=]''[=Borderlands=]''[=/=]''[=Halo=]'']] MassiveMultiplayerCrossover, this is discussed by an ex-Cerberus Phantom. The cybernetics process turns skin blue, leaves hardware sticking out, blood tends to seep out and cake in places, etc. In exchange, her weak biotics are massively enhanced (the Systems Alliance believed making such minimal talents military-grade to be excessively risky). Implied to apply to all Cerberus troops to some extent, as her engineer friend is just as ugly as she is.

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* ''Fanfic/ChildOfTheStorm'' has this as a staple of Phoenix hosts who turn/are turning to the dark side. While Phoenix hosts are unsettling enough to begin with, they look more or less as they normally do. A Dark Phoenix, on the other hand, even a baby one, is a HumanoidAbomination with features that sufficiently elongated to enter the UncannyValley, burning white GlowingEyesOfDoom, and cracks in the skin that reveal [[LightIsNotGood yet more burning white light]], implying that the host's physical form is merely the shell for something horrifying that's growing within. This is proven by [[spoiler: Surtur]], [[spoiler:Surtur]], a fully-fledged example, who's long since graduated to EldritchAbomination - -- and his empowered minions are arguably worse.
* In ''Fanfic/{{Origins}}'', a ''Franchise/MassEffect''[=/=]''Franchise/StarWars''[[spoiler:[=/=]''[=Borderlands=]''[=/=]''[=Halo=]'']] ''Franchise/MassEffect''/''Franchise/StarWars''[[spoiler:/''VideoGame/{{Borderlands}}''/''Franchise/{{Halo}}'']] MassiveMultiplayerCrossover, this is discussed by an ex-Cerberus Phantom. The cybernetics process turns skin blue, leaves hardware sticking out, blood tends to seep out and cake in places, etc. In exchange, her weak biotics are massively enhanced (the Systems Alliance believed making such minimal talents military-grade to be excessively risky). Implied to apply to all Cerberus troops to some extent, as her engineer friend is just as ugly as she is.



* In ''Franchise/PiratesOfTheCaribbean'', Davy Jones and his crew are immortal, but have spent so long neglecting their job of {{Psychopomp}} for the dead at sea that they've become [[HalfHumanHybrid half-morphed into sea creatures.]] On the plus side, they're now fully amphibious. It's not clear if their ability to walk through walls/teleport from ship to ship is part of their curse, but it's a great plus either way. By the fifth movie, Will has likewise begun to turn into a sea creature. [[spoiler:His son and Barbossa's daughter manage to break the curse, and Will returns to Elizabeth]].

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* In ''Franchise/PiratesOfTheCaribbean'', Davy Jones and his crew are immortal, but have spent so long neglecting their job of {{Psychopomp}} for the dead at sea that they've become [[HalfHumanHybrid half-morphed into sea creatures.]] creatures]]. On the plus side, they're now fully amphibious. It's not clear if their ability to walk through walls/teleport from ship to ship is part of their curse, but it's a great plus either way. By the fifth movie, Will has likewise begun to turn into a sea creature. [[spoiler:His son and Barbossa's daughter manage to break the curse, and Will returns to Elizabeth]].



* In ''Literature/TheElricSaga'', human soldiers pledging alliegence to Chaos gradually turn into monstrosities who are part-man, part animal. This makes them harder fighters but at the expense of human intellect and intelligence. Creator/MichaelMoorcock returns to this theme in the ''[[Literature/TheHistoryOfTheRunestaff Hawkmoon]]'' books, where the elite legions of [=GranBretan=] are human in form but wear realistic beast-masks according to their animal totem. And behave accordingly. Here, the degradation is more symbolic and internalised. And just as terrible.

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* In ''Literature/TheElricSaga'', human soldiers pledging alliegence allegiance to Chaos gradually turn into monstrosities who are part-man, part animal. This makes them harder fighters but at the expense of human intellect and intelligence. Creator/MichaelMoorcock returns to this theme in the ''[[Literature/TheHistoryOfTheRunestaff Hawkmoon]]'' books, where the elite legions of [=GranBretan=] are human in form but wear realistic beast-masks according to their animal totem. And behave accordingly. Here, the degradation is more symbolic and internalised.internalized. And just as terrible.



[[folder:TV Series]]
* In ''Series/{{Runaways}}'', as seen in ''Film/DoctorStrange'', tapping into the power Dark Dimension causes the skin around the wielder's eyes to blister and decay. Nico Minoru accidentally finds this out the hard way, without realizing what she is doing.

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[[folder:TV Series]]
[[folder:Live-Action Television]]
* In ''Series/{{Runaways}}'', ''Series/Runaways2017'', as seen in ''Film/DoctorStrange'', ''Film/{{Doctor Strange|2016}}'', tapping into the power Dark Dimension causes the skin around the wielder's eyes to blister and decay. Nico Minoru accidentally finds this out the hard way, without realizing what she is doing.



* Infernals in ''TabletopGame/{{Exalted}}'' have access to the Malfeas charms "By Rage Recast" and "Devil-Tyrant Avatar Shintai". When the Infernal's anima banner flares, Rage Recast means they manifest a selection of mutations from a library it grants them - because after the first couple of rounds you really want the guy running on radiation and crazy to gain an extra two feet of height and sprout batlike wings. The [[OneWingedAngel Shintai]] is even more extreme, manifesting the entire library at once - which, at high Essence, can provide a great many fangs, tentacles and horns.

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* Infernals in ''TabletopGame/{{Exalted}}'' have access to the Malfeas charms "By Rage Recast" and "Devil-Tyrant Avatar Shintai". When the Infernal's anima banner flares, Rage Recast means they manifest a selection of mutations from a library it grants them - -- because after the first couple of rounds you really want the guy running on radiation and crazy to gain an extra two feet of height and sprout batlike wings. The [[OneWingedAngel Shintai]] is even more extreme, manifesting the entire library at once - which, at high Essence, can provide a great many fangs, tentacles and horns.



* In the fifth story line of ''Toys/{{Bionicle}}'', the Toa Metru are captured and injected with [[TheCorruption Hordika venom]], which turns them into [[BeastMan half-animals]]. [[DownplayedTrope Downplayed]] in that while greatly increasing their physical strength, it also degrades their elemental abilities to some extent. The real downside, however, is they can't use any masks of power.

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* In the fifth story line of ''Toys/{{Bionicle}}'', the Toa Metru are captured and injected with [[TheCorruption Hordika venom]], which turns them into [[BeastMan half-animals]]. [[DownplayedTrope Downplayed]] {{Downplayed|Trope}} in that while greatly increasing their physical strength, it also degrades their elemental abilities to some extent. The real downside, however, is they can't use any masks of power.



* The basis for Splicers in the first two ''VideoGame/BioShock'' games. Specifically, they were users of a gene-modifying substance called ADAM- and along with the many cosmetic uses that it can be applied to, specially-prepared batches can give the user superpowers in the form of plasmids; unfortunately, abuse of the substance has resulted in addiction, disfiguration, and insanity. The main characters can also suffer a few of the tamer side-effects when they have plasmids equipped: [[PlayingWithFire Incinerate!]] clearly burns the wielder's hand; [[AnIcePerson Winter Blast]] causes icicles to grow through the user's flesh (complete with blood); finally, [[BeeBeeGun Insect Swarm]] results in a mixture of nasty-looking stings across the hand (in Jack's case) or a honeycomb forming out of the palm (in Delta's case).
* ''VideoGame/BioShockInfinite'' has Vigors, later revealed to be derived from early Plasmids. Vigors are drinkable plasmids that give the user powers similar to the first two games and generally serve the same roles with Possession/Hypnotize, Murder of Crows/Insect Swarm, Shock Jockey/Elecro Bolt, etc. Other Tonics introduce new attacks that serve as support in combat like Bucking Bronco,[[note]]Levitates foes[[/note]] Return to Sender,[[note]]Pulls in bullets to create an explosive cluster[[/note]] and Undertow.[[note]]Creates a water tentacle to catch and throw your opponents[[/note]] All of these warp Booker's hands to match their abilities and they were going to cause people to turn into Vigor Junkies, people who turned into Splicers from excessive ingestion of Vigors but instead of tumorous growths they gained massive crystals growing out of their bones and skin. Characters such as the Zealots of the Lady and Cornelius Slate,[[note]]He was intended to be a moderate Vigor Junkie, which explains why he has those growths on his head[[/note]] while early artwork was integrated as Frosty Splicers, who overdosed on the "Old Man Winter" Plasmid.

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* The basis for Splicers in the first two ''VideoGame/BioShock'' games. Specifically, they were users of a [[LEGOGenetics gene-modifying substance substance]] called ADAM- ADAM, and along with the many cosmetic uses that it can be applied to, specially-prepared batches can give the user superpowers in the form of plasmids; unfortunately, abuse of the substance has resulted in [[PsychoSerum addiction, disfiguration, and insanity.insanity]]. The main characters can also suffer a few of the tamer side-effects when they have plasmids equipped: [[PlayingWithFire Incinerate!]] clearly burns the wielder's hand; [[AnIcePerson Winter Blast]] causes icicles to grow through the user's flesh (complete with blood); finally, [[BeeBeeGun Insect Swarm]] results in a mixture of nasty-looking stings across the hand (in Jack's case) or a honeycomb forming out of the palm (in Delta's case).
* ''VideoGame/BioShockInfinite'' has Vigors, later revealed to be derived from early Plasmids. Vigors are drinkable plasmids that give the user powers similar to the first two games and generally serve the same roles with Possession/Hypnotize, Murder of Crows/Insect Swarm, Shock Jockey/Elecro Bolt, etc. Other Tonics introduce new attacks that serve as support in combat like Bucking Bronco,[[note]]Levitates foes[[/note]] Return to Sender,[[note]]Pulls in bullets to create an explosive cluster[[/note]] and Undertow.[[note]]Creates a water tentacle to catch and throw your opponents[[/note]] All of these warp Booker's hands to match their abilities and they [[WhatCouldHaveBeen were going to to]] cause people to turn into Vigor Junkies, people who turned into Splicers from excessive ingestion of Vigors but instead of tumorous growths they gained massive crystals growing out of their bones and skin. Characters such as the Zealots of the Lady and Cornelius Slate,[[note]]He was intended to be a moderate Vigor Junkie, which explains why he has those growths on his head[[/note]] while early artwork was integrated as Frosty Splicers, who overdosed on the "Old Man Winter" Plasmid.



** Arkham got this twice over [[spoiler: first when he sacrificed his wife to become a demon but messed the ritual up and became a MonsterClown instead, then in the FinalBattle he gets the power of Sparda through [[CoolSword Force Edge]] but soon dissolves into a hideous, amorphous blob. Dante lampshades it saying Arkham looks nothing like his father Sparda, [[ProudBeauty using himself]] as proof]].

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** Arkham got this twice over [[spoiler: first over, [[spoiler:first when he sacrificed his wife to become a demon but messed the ritual up and became a MonsterClown instead, then in the FinalBattle he gets the power of Sparda through [[CoolSword Force Edge]] but soon dissolves into a hideous, amorphous blob. Dante lampshades it saying Arkham looks nothing like his father Sparda, [[ProudBeauty using himself]] as proof]].



* Dr. N. Brio's appearances in the ''VideoGame/CrashBandicoot'' series usually involve him drinking [[PsychoSerum mutagen]] and turning into a [[ComicBook/IncredibleHulk hulking green monster]] (though by the time of ''Crash: Mind Over Mutant'', it seems like he needs the mutagen to ''keep'' from transforming). [[spoiler:At the end of ''Mind Over Mutant'', Dr. Cortex samples the mutagen himself, with similar results.]]
* ''VideoGame/TheBindingOfIsaac'' has this as the de jour - nearly half the permanent items upgrade Isaac at the cost of visually maiming him. For example, a coat hangar [[EyeScream goes straight through Isaac's eye socket to increase the firing rate of his tears.]]

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* Dr. N. Brio's appearances in the ''VideoGame/CrashBandicoot'' series usually involve him drinking [[PsychoSerum mutagen]] and turning into a [[ComicBook/IncredibleHulk [[HulkMashUp hulking green monster]] (though by the time of ''Crash: Mind Over Mutant'', it seems like he needs the mutagen to ''keep'' from transforming). [[spoiler:At the end of ''Mind Over Mutant'', Dr. Cortex samples the mutagen himself, with similar results.]]
* ''VideoGame/TheBindingOfIsaac'' has this as the de jour - -- nearly half the permanent items upgrade Isaac at the cost of visually maiming him. For example, a coat hangar [[EyeScream goes straight through Isaac's eye socket to increase the firing rate of his tears.]]tears]].



* ''VideoGame/ResidentEvil'' runs on this. The boss will inevitably be a normal human who becomes a grotesque abomination mere minutes before gameplay starts. Often happens more than once per game.
** The various Tyrant-type monsters will undergo mutations to gain muscle mass, new appendages, or grow in size either spontaneously or in response to serious injury. The result makes them a hell of a lot stronger and harder to kill, but it also makes them much more unpredictable and harder to control. To combat this Umbrella tends to fit them with large overcoats designed to prevent and limit these mutations, and it is ''not'' pretty if those coats get destroyed or burned off. [[VideoGame/ResidentEvil2 T-00 / Mr. X]] sprouts a pretty nasty set of claws and suddenly starts [[LightningBruiser moving a hell of a lot faster]], while [[VideoGame/ResidentEvil3Nemesis Nemesis]] sprouts CombatTentacles and the ability to take a lot more punishment.

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* ''VideoGame/ResidentEvil'' ''Franchise/ResidentEvil'' runs on this. The boss will inevitably be a normal human who becomes a grotesque abomination mere minutes before gameplay starts. Often happens more than once per game.
** The various Tyrant-type monsters will undergo mutations to gain muscle mass, new appendages, or grow in size either spontaneously or in response to serious injury. The result makes them a hell of a lot stronger and harder to kill, but it also makes them much more unpredictable and harder to control. To combat this Umbrella tends to fit them with large overcoats designed to prevent and limit these mutations, and it is ''not'' pretty if those coats get destroyed or burned off. [[VideoGame/ResidentEvil2 T-00 / Mr.T-00/Mr. X]] sprouts a pretty nasty set of claws and suddenly starts [[LightningBruiser moving a hell of a lot faster]], while [[VideoGame/ResidentEvil3Nemesis Nemesis]] sprouts CombatTentacles and the ability to take a lot more punishment.



** Manuela Hidalgo from ''VideoGame/ResidentEvilTheDarkSideChronicles'' also averts this despite being infected with the T-Virus [[MadScientistsBeautifulDaughter she still looks beautiful]], and the only drawback is that Manuela’s blood burns when exposed to oxygen but she can also FeelNoPain to compensate.
** Also initially averted with BigBad Wesker whose [[SuperSerum prototype virus]] which activated after his death only gave him red cat-like eyes but otherwise didn't alter his appearance, however [[VideoGame/ResidentEvil5 RE5]] reveals he needs a frequent and precise dose of the virus running through his body to keep him human-looking. Played straight in the FinalBattle where Wesker absorbs Ouroboros and becomes monstrous.
* {{Deconstructed|Trope}} in ''VideoGame/{{ReadOnlyMemories}}''. Jess, a cancer patient, was able to recover from her condition via experimental gene therapy. Unfortunately, the genes in question were mostly derived from insects, causing her appearance to become bug-like and frightening, to the point where she lost her job. Fortunately, later therapies replaced the insect genes with cat genes, allowing her a much less horrifying visage. However, she is still traumatised and bitter over how quickly her life fell apart while she was a half-insect hybrid.

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** Manuela Hidalgo from ''VideoGame/ResidentEvilTheDarkSideChronicles'' also averts {{avert|edTrope}}s this -- despite being infected with the T-Virus [[MadScientistsBeautifulDaughter she still looks beautiful]], and the beautiful]]. The only drawback is that Manuela’s blood burns when exposed to oxygen oxygen, but she can also FeelNoPain to compensate.
** Also initially averted {{averted|Trope}} with BigBad Wesker Wesker, whose [[SuperSerum prototype virus]] which activated after his death only gave him red [[RedEyesTakeWarning red]] [[AnimalEyes cat-like eyes eyes]] but otherwise didn't alter his appearance, however [[VideoGame/ResidentEvil5 RE5]] appearance. However, ''VideoGame/ResidentEvil5'' reveals he needs a frequent and precise dose of the virus running through his body to keep him human-looking. Played straight in the FinalBattle where Wesker absorbs Ouroboros and becomes monstrous.
* {{Deconstructed|Trope}} in ''VideoGame/{{ReadOnlyMemories}}''.''VideoGame/ReadOnlyMemories''. Jess, a cancer patient, was able to recover from her condition via experimental gene therapy. Unfortunately, the genes in question were mostly derived from insects, causing her appearance to become bug-like and frightening, to the point where she lost her job. Fortunately, later therapies replaced the insect genes with cat genes, allowing her a much less horrifying visage. However, she is still traumatised traumatized and bitter over how quickly her life fell apart while she was a half-insect hybrid.



* In WebAnimation/Qem95's project, ''Qem's Life Problems: Episode 1 - Tanning'', Qem gains the ability to blend in with his parrot red towel due to staying in the tanning machine for too long AND forgetting to put on his tanning lotion.

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* In WebAnimation/Qem95's project, ''Qem's Life Problems: Episode 1 - -- Tanning'', Qem gains the ability to blend in with his parrot red towel due to staying in the tanning machine for too long AND forgetting to put on his tanning lotion.



* Every ''Franchise/TeenageMutantNinjaTurtles'' cartoon had the mutagenic ooze which made them more human-like, while also mutating humans into uglier mutants. Quite notable ones include Baxter Stockman (who was transformed into a fly-man) and the 2012 incarnation of the Super Shredder, which discarded the usual "giant Shredder with larger spikes" for "mutated humanoid that almost looks like [[Franchise/{{Superman}} Doomsday]]".

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* Every ''Franchise/TeenageMutantNinjaTurtles'' cartoon had the mutagenic ooze MutagenicGoo which made them more human-like, while also mutating humans into uglier mutants. Quite notable ones include Baxter Stockman (who was transformed into a fly-man) and the 2012 incarnation of the Super Shredder, which discarded the usual "giant Shredder with larger spikes" for "mutated humanoid that almost looks like [[Franchise/{{Superman}} Doomsday]]".
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* ''Fanfic/AbraxasHrodvitnon'':
** San and Vivienne Graham initially suffer this when they become TwoBeingsOneBody. Their first hybridized form is a OneManArmy against Jonah's mercenaries ''despite'' being crippled by [[PowerIncontinence an inability to access its bio-electricity]] and despite excruciating, movement-limiting chronic pain, able to survive and regenerate damage that would've blown Vivienne to bits when she was human; and it overall looks like a quadrupedal MonstrousHumanoid with a bony tail and [[https://en.wikipedia.org/wiki/Fibrodysplasia_ossificans_progressiva an extreme, badly visible case of this nasty disease]], not to mention Vivienne's head becoming skull-like and developing ingrown fangs. This trope is {{inverted}} by Viv and San's transformation into their second form, which though even more beastly is a lot more natural-looking than their diseased first form.
** [[TheAssimilator The Many]]'s assimilated victims most certainly suffer this. Whilst gaining a Ghidorah-like HealingFactor and lack of concern for pain; infected Skullcrawlers look pretty diseased and half-rotting, whilst infected humans [[spoiler:basically become {{Monstrous Humanoid}}s who are half-made of bone cancer (look that up on Google Images to see how horrible it is), then when they merge into {{Kaiju}}-sized {{Mind Hive}}s they become little more than half-melted tumors with human features]]. And that's not even going into when the Many's forms perform {{Fusion Dance}}s!
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* ''Film/MortalKombatAnnihilation'' plays this straight, with Shao Kahn and Liu Kang upgrade their final battle by transforming into winged reptiles, and the transformation looks quite painful. Of course, [[Main/EvilOverlordList it doesn't help]], and both turn back into their normal forms to finish the fight.

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* ''Film/MortalKombatAnnihilation'' plays this straight, with when Shao Kahn and Liu Kang upgrade their final battle by transforming into winged reptiles, and the transformation looks quite painful. painful. Of course, [[Main/EvilOverlordList it doesn't help]], and both turn back into their normal forms to finish the fight.
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* ''Film/MortalKombatAnnihilation'' plays this straight, with Shao Kahn and Liu Kang upgrade their final battle by transforming into winged reptiles, and the transformation looks quite painful. Of course, [[Main/EvilOverlordList it doesn't help]], and both turn back into their normal forms to finish the fight.
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* It could be argued that Ganon going from a Gerudo man to a blue boar between ''VideoGame/TheLegendOfZeldaOcarinaOfTime'' and ''VideoGame/TheLegendOfZelda'' was the result of this but the real flip came in the time before ''VideoGame/TheLegendOfZeldaBreathOfTheWild'' when Ganon stopped being a biological organism and turned into a wave of destruction across Hyrule known as "the Calamity Ganon".

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* It could be argued that Ganon going from a Gerudo man to a blue boar between ''VideoGame/TheLegendOfZeldaOcarinaOfTime'' and ''VideoGame/TheLegendOfZelda'' ''VideoGame/TheLegendOfZeldaI'' was the result of this but the real flip came in the time before ''VideoGame/TheLegendOfZeldaBreathOfTheWild'' when Ganon stopped being a biological organism and turned into a wave of destruction across Hyrule known as "the Calamity Ganon".
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* It could be argued that Ganon going from a Gerudo man to a blue boar between ''VideoGame/TheLegendOfZeldaOcarinaOfTime'' and ''VideoGame/TheLegendOfZelda'' was the result of this but the real flip came in the time before ''VideoGame/TheLegendOfZeldaBreathOfTheWild'' when Ganon stopped being a biological organism and turned into a wave of destruction across Hyrule known as "the Calamity Ganon".
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* In ''Series/{{Runaways}}'', as seen in ''Film/DoctorStrange'', tapping into the power Dark Dimension causes the skin around the wielder's eyes to blister and decay. Nicco accidentally finds this out the hard way, without realizing what she is doing.

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* In ''Series/{{Runaways}}'', as seen in ''Film/DoctorStrange'', tapping into the power Dark Dimension causes the skin around the wielder's eyes to blister and decay. Nicco Nico Minoru accidentally finds this out the hard way, without realizing what she is doing.

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Runaways


* In ''Film/DoctorStrange2016'', the disciples of [[EldritchAbomination Dormammu]] (such as Kaecilius) tap into his power, at the cost of having their skin around the eyes to decay and turn purple. Strange is quick to note to Kaecilius that Dormammu's "blessing" seems like a crapshoot.

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* In ''Film/DoctorStrange2016'', the disciples of [[EldritchAbomination Dormammu]] (such as Kaecilius) tap into his power, the power of the Dark Dimension, at the cost of having their skin around the eyes to decay and turn purple. Strange is quick to note to Kaecilius that Dormammu's "blessing" seems like a crapshoot.


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[[folder:TV Series]]
* In ''Series/{{Runaways}}'', as seen in ''Film/DoctorStrange'', tapping into the power Dark Dimension causes the skin around the wielder's eyes to blister and decay. Nicco accidentally finds this out the hard way, without realizing what she is doing.
[[/folder]]
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*** Logia types can be mixed bag a despite being essentially BlobMonster(s) this type of Fruit doesn't usually alter the user appearance, only their shape. Played straighter with the likes of Enel, Caesar Clown and Monet who become [[TurnsRed scarier looking once they get serious]].

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*** Logia types can be mixed bag a despite being essentially BlobMonster(s) [[BlobMonster Blob Monsters]], this type of Fruit doesn't usually alter the user appearance, only their shape. Played straighter with the likes of Enel, Caesar Clown and Monet who become [[TurnsRed scarier looking once they get serious]].
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* Similarly to the ''VisualNovel/FateStayNight'' example in Visual Novels below, Lancer of Black in ''LightNovel/FateApocrypha'', who is UsefulNotes/VladTheImpaler, has the ability to tap into [[{{Dracula}} the legends surrounding him]] to transform into a vampire. In this form, he has an '''immense''' amount of raw power (the strength of a Servant in this series is greatly influenced by their fame, and Dracula's legend [[HistoricalVillainUpgrade has far outgrown the fame of the man he was inspired by]]), but he also turns into something inhuman in both body [[WithGreatPowerComesGreatInsanity and mind]]. Vlad himself '''absolutely hates''' this ability and refuses to use it, as he believes these legends tarnish his true legacy.
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** ''ComicBook/UltimateFantasticfour'': Reed Richards, in his identity as The Maker, [[https://static.comicvine.com/uploads/original/11/114265/2282692-urr__3_.jpg distorted his skull]] into an odd shape to better reconfigure his neural structure. Similarly, Rhona Burchill, the Ultimate version of The Mad Thinker, has a deformed skull from transplanting extra brain matter [[spoiler:from her brother]] into it.

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** ''ComicBook/UltimateFantasticfour'': ''ComicBook/UltimateFantasticFour'': Reed Richards, in his identity as The Maker, [[https://static.comicvine.com/uploads/original/11/114265/2282692-urr__3_.jpg distorted his skull]] into an odd shape to better reconfigure his neural structure. Similarly, Rhona Burchill, the Ultimate version of The Mad Thinker, has a deformed skull from transplanting extra brain matter [[spoiler:from her brother]] into it.

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