History Main / ImmuneToDrugs

* Pam from ''WesternAnimation/{{Archer}}''. In ''The Papal Chase'', Woodhouse accidentally injects two syringes full of heroin into her neck, with no noticeable effect at all. She's recently taken to using enough cocaine and amphetamines to keep a medium-sized city high for several days, and aside from a brief cardiac arrest (that ''also'' doesn't faze her), it hasn't affected her behavior in the least.

* Film/{{Blow}} : George claims human beings can tolerate 1 to 1.5 grams of coke. He was snorting five grams ''a day,'' and did ten grams in ten minutes once.

* Legolas in ''Film/TheLordOfTheRingsTheReturnOfTheKing'' [[OurElvesAreBetter claims to only feel a "slight tingling in [his] fingers"]] after drinking enough ale to make Gimli, a ''dwarf'', pass out.

* ''WesternAnimation/AmericanDad:'' Roger. If any drug on the show is mentioned, Roger has either tried it or is on it, with barely any side effects at all.

** Subverted again, when we discover one of the few things Jack can't stomach:

* Legolas in ''Film/TheLordOfTheRings'' [[OurElvesAreBetter claims to only feel a "slight tingling in [his] fingers"]] after drinking enough ale to make Gimli, a ''dwarf'', pass out.

* According to [[Wiki/{{Wikipedia}} the Other Wiki]], "Film/{{Withnail|AndI}} is shown drinking roughly nine and a half glasses of red wine, half a pint of cider, one shot of ''lighter fluid'' [emphasis added]..., two and a half shots of gin, six glasses of sherry, thirteen glasses of whisky and half a pint of ale" throughout the movie. And he also does pot. There's a supposed DrinkingGame where the player drinks everything Withnail drinks when he drinks it, with something else substituted for the lighter fluid. It's unlikely that anyone who has even attempted the game has actually completed it.
** In an earlier scene, he is offered a drug whose street name is "The Embalmer." His response? "Balls. I'll [[BadassBoast swallow it and run a mile]]."

* Raoul Duke and Dr. Gonzo in ''Literature/FearAndLoathingInLasVegas''. Seeing as Duke is a self-insert of author Creator/HunterSThompson (see RealLife below).

** Joshua Graham in ''VideoGame/FalloutNewVegas''. He is MadeOfIron and notoriously unkillable, so much that being ''thrown into the Grand Canyon '''while on fire''''' didn't even slow him down enough for the packs of assassins that were sent down after him to finish the job. However, the burns that cover his entire body do cause him agonizing pain, and ''because'' he is such a tough bastard, [[BlessedWithSuck no healing or pain-relieving chems work on him]].

* {{Aver|tedTrope}}sion: In ''Film/{{Dogma}}'', not only were angels vulnerable to alcohol, but God forbade them from drinking after a drunken Loki told God off after carrying out the ten plagues described in Exodus. Early on, we see the Metatron order tequila "and an empty glass" -- he can drink it for the taste but then has to spit it out.

* Michael Swaim from ''WebVideo/AgentsOfCracked'' is stated to be "immune to pills," from taking too many of them at one point.
* Nora Valkyrie in ''WebVideo/RWBYTheAbridgedSeries'' manages to eat pancakes with enough sedatives to kill half of the students attending Beacon Academy after putting ''at least'' twenty-five pounds worth of dust into her system only a few hours earlier ''at most'' and all it did was ''make her stronger''. [[LampshadeHanging Lie Ren even questions how the hell she’s still conscious]].

* Space Marines of ''TabletopGame/{{Warhammer 40000}}'' are generally immune to normal drugs due to their modifications, Fenrisian mead might be an exception, though, considering a [[SpaceVikings Space Wolf]] once claimed it would give you a hangover "like continents colliding." This one is actually explained in one of William King's ''Space Wolf'' novels: there's actually a chemical in Fenrisian mead (at least the variety served in the Fang) that shuts off the organ that grants Space Marines their immunity to drugs. [[AwesomeButImpractical It's specifically so they can get drunk.]]

[[folder:Web Original]]

* Bender from ''WesternAnimation/{{Futurama}}'' who, as a robot, is actually fuelled by booze. In a "what if?" episode, where he is turned into a human, his habits become worse and he dies of massive overindulgence. Bender develops the typical symptoms of a wino when he ''doesn't'' drink. In older episodes, he's seen getting drunk on alcohol, but this is no longer canon. Apparently, he can also power himself with nice, clean, mineral oil, similar to becoming a vegetarian. Lampshaded by Fry.

** Hilariously, Bender "grows" a BeardOfSorrow made out of ''rust'' if he doesn't drink enough.

* Wrestling/AndreTheGiant: "It usually takes two liters of vodka just to make me feel warm inside." Weighing somewhere between 475 and 540 pounds was almost certainly a factor.

* Subverted by Charlie in ''Series/ItsAlwaysSunnyInPhiladelphia''. The hard-drinking, glue-sniffing loon scarfs down some brownies spiked with downers, saying, "I can handle my sedatives." To the amazement of his friends, he's still standing hours later, but he's in a drugged-out fog, muttering gibberish. By the end of the episode, he's passed out and drooling.

* Music/OzzyOsbourne. Apparently now he's just on coffee, but at this point he probably doesn't need them anymore.
** This is a minor CrowningMomentOfFunny in his autobiography. '''Regular Dose of Anesthetic''': "Ooh, there's the good stuff!" '''Twice the Dose''': ''Doctor'': "Blink once if you can hear me." ''Ozzy'': "Why would I do that? I can talk to you just fine." '''Three Times the Dose''': ''Doctor'': "Jesus Christ, you're not human!"
** Ozzy's actually having his genome mapped, so scientists can figure out why he and others like him can survive what they do themselves. [[http://articles.chicagotribune.com/2010-07-01/news/sc-nw-dna-0702-20100701_1_genome-genetic-blueprint-gene-mapping Really!]]
** [[http://www.nydailynews.com/life-style/health/ozzy-osbourne-mutant-scientists-hard-partying-rocker-genes-explain-survival-article-1.450575 Turns out he's a mutant]]. It explains a lot, doesn't it?

* ''Film/CaptainAmericaTheFirstAvenger'': As mentioned in the Comics section above, Captain America can't get drunk because his sped-up metabolism metabolizes the alcohol before it has time to take effect.

* Subverted by Charlie in ''Series/ItsAlwaysSunnyInPhiladelphia''. The hard-drinking, glue-sniffing loon scarfs down some home-made brownies that he himself spiked with downers, saying, "I can handle my sedatives." To the amazement of his friends, he's still standing hours later, but he's in a drugged-out fog, muttering gibberish. By the end of the episode, he's passed out and drooling.

* The Vorta in ''Series/StarTrekDeepSpaceNine'' are immune to most poisons, a fact demonstrated when Weyoun takes a swig of poisoned ''kanar'' -- he ''detects'' the poison, but isn't otherwise affected by it.

* In ''Literature/{{Warbreaker}}, by the same author as ''Mistborn'', having additional Breaths (fragments of souls that can be moved from person to person) grants a wide variety of perks, including resistance to drugs and poisons. This particular boon tops out at the Fifth Heightening (somewhere around 2,000 Breaths), at which point the resistance reaches the point of total immunity. The quasi-divine Returned get a single "Divine Breath" that's so powerful it grants the first five Heightenings all on its own. Lightsong's high priest repeatedly informs his master that he cannot get drunk, to which Lightsong cheerfully replies that he can sure ''try''.