History Main / ImmuneToDrugs

There is also a second variety where characters from Sci-Fi and fantasy media are ''literally'' immune due to their race, a body augmentation, or some kind of GreenRocks. That overlaps with NeverGetsDrunk.

* On more than one occasion, ComicStrip/ZippyThePinhead inadvertently ingests a many-times-over-lethal amount of drugs, and though he may be wildly hallucinating, it's apparently no different than everyday life for him.
* Sociopathic drug addict FBI agent RedKetchup started taking drugs for the job. Then casually. Then to keep going. Then to keep his drug-fuelled metabolism from shutting down. By the time the sleazeball movie director boss of his sister tries to poison him with cyanide, he merely does a HeroicBSOD instead. An emergency room doctor is amazed at the content of his blood, which reads more like the description of Otto's urine below, with some trace amounts of actual blood.

* Feral and cured humans in ''Literature/JanitorsOfThePostApocalypse'' have altered physiology to the point where they can merrily ignore not just [[NoBiochemicalBarriers biochemical barriers]] but quite happily injest toxic substances with little effect. The majority of drugs simply don't work on them, including actual medical ones. As they don't feel pain and are extremely difficult to kill this is rarely an issue, but when an overactive immune system is involved...

* A small part of the population has a [[http://sciencenordic.com/genetic-defect-makes-some-nearly-immune-morphine genetic quirk]] that makes opioids of any kind have a drastically reduced effect; a much smaller group is ''completely'' immune.

* During TheSixties, Creator/JimHenson was curious to find out what LSD was like, but when he gave it a try, nothing happened. Given [[WhatDoYouMeanItWasntMadeOnDrugs the nature of some of his works]], one has to wonder.

* ''Series/{{Bottom}}'': Edward Elizabeth Hitler – a man who has only ever been drunk once. [[note]]For about seventeen years and counting.[[/note]] Managed to get blind—drunk [[note]]even by his own standards[[/note]] on ₤1·75 [[note]]“There’s a sale on at the chemist’s.” […] “Old Spice, 25''p'' a bottle!”[[/note]], leading him to be unable to find the front door or the floor ''[[EpicFail after]]'' falling over, finally finishing—up with a nightcap consisting of a bottle of bleach. He always carries a hip―flask which contains brandy[[spoiler:, meths, Pernod, paint stripper, Mister Sheen, brake fluid [[ArsonMurderAndJaywalking and Drambuie.]]]]

* ''Series/AlteredCarbon''. In Season 2, Takeshi Kovacs is [[BodySurf sleeved into a military-grade enhanced body]] and complains that it comes with a biofilter that's [[Drowning MySorrows preventing him from getting drunk]]. Takeshi says he'll keep drinking until he discovers the filter's limit, but Poe informs him that there's limited booze in the derelict hotel they're hiding out in.

* [[Series/MontyPythonsFlyingCircus Graham Chapman]].

** The Vorta are immune to most poisons due to genetic engineering by the Founders, a fact demonstrated when Weyoun takes a swig of poisoned ''kanar'' -- he ''detects'' the poison, but isn't otherwise affected by it.

-->'''Archer''': Luke, you're not thinking straight. You wildly underestimated my liver's ability to metabolize toxins.

* In ''Film/X2XMenUnited'', Wolverine gets shot with InstantSedation darts and doesn't stop charging. A moment later he yanks the darts out and shakes his head as if to clear it, but continues on like nothing happened.

** In "[[Recap/StarTrekDeepSpaceNineS04E08LittleGreenMen Little Green Men]]", Quark is given multiple injections of sodium pentothal and the only affect is the Ferengi squealing in pain from the needles.

* ''Film/GetHimToTheGreek'': Aldous Snow, as demonstrated especially by the infamous "Jeffrey" scene.
* ''Film/{{Blow}}'': George claims human beings can tolerate 1 to 1.5 grams of coke. He was snorting five grams ''a day,'' and did ten grams in ten minutes once.

* The original Spider-Woman, Jessica Drew, was affected upon first exposure to a particular toxin. Going foreward she was immune to its effects.

** [[spoiler:Spike]] is seen very drunk in the ''Buffy'' season 3 episode "Lovers Walk", though. Probably must have consumed a ton of hard liquor for that.
* In the ''Series/{{Supernatural}}'' episode "99 Problems", the angel Castiel remains alive, conscious and mostly ambulatory after drinking an entire liquor store.
* In the ''Series/{{The Flash|2014}}'' (2014) episode "Plastique", Barry discovers, to his chagrin, that his hyperaccelerated metabolism means that his body processes alcohol way too fast for him to even feel a buzz. He downs half-a-dozen shots in less than a second to demonstrate it. At the end of the episode, Caitlin mixes him up a potent 300-proof shot that does give him a buzz... for less than 5 seconds. She promises to work on the problem. Hmm. Guess that's what her Ph.D. is for: getting the fastest man alive drunk.
* The Vorta in ''Series/StarTrekDeepSpaceNine'' are immune to most poisons due to genetic engineering by the Founders, a fact demonstrated when Weyoun takes a swig of poisoned ''kanar'' -- he ''detects'' the poison, but isn't otherwise affected by it.
-->'''Weyoun:''' Oh, that is ''quite'' toxic....
** In another episode, Quark is given multiple injections of sodium pentothal and the only affect is the Ferengi squealing in pain from the needles.

* Between the amount of painkillers he throws back in the course of normal gameplay and the fact he somehow survived getting forcibly overdosed with Valkyrie, a drug best described as the retarded dumpster-baby of LSD and crystal meth, VideoGame/MaxPayne ''has'' to count. Deconstructed in the third game, where all the constant drug use finally catches up to him and he gets nailed with the mother and father of all addictions.

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-->'''Skoll:''' ''(with several empty glasses in front of her)'' Guys... I don't think I can get drunk anymore...\\

* Raoul Duke and Dr. Gonzo in ''Literature/FearAndLoathingInLasVegas''. take a ludicrous amount of drugs during a multi-day bender. They get pretty wrecked, but survive without any apparent physical damage. The characters were stand-ins for Creator/HunterSThompson and his friend Oscar Zeta Acosta, whose real-life drug intake during the period was mostly likely only embellished slightly.

* Cyborgs in ''Franchise/GhostInTheShell'' (Major Kusanagi's a full body cyborg, essentially a BrainInAJar in a FemBot body; Batou's heavily augmented and has the same ability) can filter alcohol straight out of their system to sober up. In [[Anime/GhostInTheShell the first movie]], The Major [[MasterOfYourDomain switches this off]] so she can actually get drunk on beer though. In ''Anime/GhostInTheShellStandAloneComplex,'' the Major isn't shown to eat out of any kind of necessity while Batou's heavy augmentation is shown by his need to eat rather bland-looking (and assumed to be disgusting to normals) cyborg food.

* Sweetheart of ''Webcomic/SkinHorse'' is a transgenic superdog with a minor HealingFactor and amped up toxin metabolism, despite that she still drinks enough to bypass it, for a few minutes.
--> ''[[http://skin-horse.com/comic/todays-comic-912 "You want room service to do '''what'''?"]]''\\
''Sweetheart: "Salt the rim of my bathtub! It's not... that... hard!"''

* Between the amount of painkillers he throws back in the course of normal gameplay and the fact he somehow survived getting forcibly overdosed with Valkyrie, a drug best described as the retarded dumpster-baby of LSD and crystal meth, VideoGame/MaxPayne ''has'' to count.

* Creator/HunterSThompson. Here's a page from his personal journal, which led to Literature/FearAndLoathingInLasVegas being published after sent it to his boss (who sent it to a publisher).

* Some girls from ''Manga/{{Claymore}}'' are once shown to go drinking. When one starts getting tipsy, somebody (either [[NaiveNewcomer a young Claymore]] or [[{{Muggle}} a human]], can't recall) asks if they weren't supposed to be immune to alcohol. Another one then explains that they are actually [[MasterOfYourDomain in control of their metabolism]], so they CAN get drunk, if they want.
* In ''Anime/HeatGuyJ'', Daisuke is immune to drugs and poisons, because he takes an herbal mix every morning to stave off food poisoning, as he eats most of his meals at a ramen cart. This is one reason why Clair's TruthSerum did not work on him. (The other being that Daisuke doesn't let the {{Angst}} he's faced bother him.)

* ''I am Snowflame! Every cell of my being burns with white-hot ecstasy. Cocaine is my God, and I am the human instrument of its will!'' Courtesy of the "New Guardians" run of books. Thanks, DC.

** A number of characters from this comic have been treated in such a way they can resist the effects of {{Truth Serum}}s. Also, the title character and his partner Eva, being [[ProperlyParanoid extremely paranoid and with full justification]], have treated themselves in such a way that mind-control drugs have extremely little effect on them.
** Inspector Ginko is not exactly immune to sedatives and drugs [[spoiler: (and in fact was once [[AggressiveDrugDealer forcefully addicted to heroin]] in revenge by some criminals)]], but {{Truth Serum}}s don't have the desired effect on him due [[HeroicWillpower sheer willpower]]. [[spoiler:The same willpower allowed him to completely recover in little time once he got treatment]].

** Fallout 4 allows you to become immune to both drug and alcahol addiction, leting you shoot up/drink every recrational chemical in the wasteland without consequence. Survival mode, does however add the potential problem of getting a disease from all the drug use.